| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/753704 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in SKI II relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 1.8 |
| SEC24D | SEC24 family member D | 1.36 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 1.34 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 1.33 |
| AGRN | agrin | 1.1 |
| CTSL | cathepsin L | 1.09 |
| HID1 | HID1 domain containing | 1.09 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 1.07 |
| JAG1 | jagged 1 | 1.05 |
| GDF15 | growth differentiation factor 15 | 1.04 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 1.04 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | 1.03 |
| NUCB2 | nucleobindin 2 | 0.98 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.95 |
| C18ORF32 | chromosome 18 open reading frame 32 | 0.93 |
| HMOX1 | heme oxygenase 1 | 0.89 |
| NRP1 | neuropilin 1 | 0.85 |
| RABAC1 | Rab acceptor 1 (prenylated) | 0.84 |
| FGF19 | fibroblast growth factor 19 | 0.82 |
| PLAU | plasminogen activator, urokinase | 0.82 |
| LAMC2 | laminin, gamma 2 | 0.82 |
| LAMB3 | laminin, beta 3 | 0.81 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.81 |
| RAET1G | retinoic acid early transcript 1G | 0.79 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.78 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.78 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.77 |
| NIBAN1 | niban apoptosis regulator 1 | 0.77 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.76 |
| KLK6 | kallikrein-related peptidase 6 | 0.76 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.76 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.76 |
| SRXN1 | sulfiredoxin 1 | 0.75 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.74 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.73 |
| HYOU1 | hypoxia up-regulated 1 | 0.73 |
| ATF6 | activating transcription factor 6 | 0.71 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.71 |
| COL12A1 | collagen, type XII, alpha 1 | 0.69 |
| FTL | ferritin, light polypeptide | 0.69 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.67 |
| PLAUR | plasminogen activator, urokinase receptor | 0.67 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.67 |
| HSPA13 | heat shock protein 70kDa family, member 13 | 0.66 |
| FNDC3B | fibronectin type III domain containing 3B | 0.65 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.65 |
| PGM3 | phosphoglucomutase 3 | 0.65 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.64 |
| UPP1 | uridine phosphorylase 1 | 0.63 |
| EFNB2 | ephrin-B2 | 0.63 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.62 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.62 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.62 |
| CLU | clusterin | 0.62 |
| SIL1 | SIL1 nucleotide exchange factor | 0.62 |
| GMPPA | GDP-mannose pyrophosphorylase A | 0.61 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.61 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | 0.61 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.6 |
| EXT2 | exostosin glycosyltransferase 2 | 0.59 |
| FAM126B | family with sequence similarity 126, member B | 0.59 |
| SEC61B | Sec61 beta subunit | 0.58 |
| PCDH1 | protocadherin 1 | 0.58 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.58 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.57 |
| ERLEC1 | endoplasmic reticulum lectin 1 | 0.57 |
| LRIG2 | leucine-rich repeats and immunoglobulin-like domains 2 | 0.57 |
| PXDN | peroxidasin | 0.57 |
| TSPYL2 | TSPY-like 2 | 0.56 |
| SUCO | SUN domain containing ossification factor | 0.56 |
| NDRG1 | N-myc downstream regulated 1 | 0.56 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.55 |
| TRIB3 | tribbles pseudokinase 3 | 0.55 |
| ABHD2 | abhydrolase domain containing 2 | 0.55 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.55 |
| SLFN5 | schlafen family member 5 | 0.55 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.55 |
| CCN3 | cellular communication network factor 3 | 0.54 |
| TMEM9 | transmembrane protein 9 | 0.54 |
| SDF2L1 | stromal cell-derived factor 2-like 1 | 0.53 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.53 |
| TRIM16 | tripartite motif containing 16 | 0.53 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.53 |
| TMEM263 | transmembrane protein 263 | 0.53 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.53 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | 0.53 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.52 |
| TRAM1 | translocation associated membrane protein 1 | 0.52 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.52 |
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | 0.52 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.52 |
| CPA4 | carboxypeptidase A4 | 0.51 |
| SRPRB | signal recognition particle receptor, B subunit | 0.51 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | 0.51 |
| KIAA1217 | KIAA1217 | 0.5 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.5 |
| HFM1 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | 0.5 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | 0.5 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -2.14 |
| PLIN2 | perilipin 2 | -1.54 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | -1.19 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -1.17 |
| MYO3A | myosin IIIA | -1.1 |
| SPATA2 | spermatogenesis associated 2 | -1.07 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.83 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.8 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | -0.77 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.76 |
| KIAA1324L | KIAA1324-like | -0.73 |
| ODC1 | ornithine decarboxylase 1 | -0.71 |
| METTL6 | methyltransferase like 6 | -0.7 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.67 |
| CHID1 | chitinase domain containing 1 | -0.67 |
| ZNF367 | zinc finger protein 367 | -0.66 |
| RNF145 | ring finger protein 145 | -0.66 |
| AHR | aryl hydrocarbon receptor | -0.65 |
| TNIP2 | TNFAIP3 interacting protein 2 | -0.63 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | -0.63 |
| CYB5D2 | cytochrome b5 domain containing 2 | -0.62 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | -0.6 |
| TRIB1 | tribbles pseudokinase 1 | -0.58 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.58 |
| CD320 | CD320 molecule | -0.56 |
| SCARA3 | scavenger receptor class A, member 3 | -0.55 |
| SP110 | SP110 nuclear body protein | -0.53 |
| CNTLN | centlein, centrosomal protein | -0.53 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.53 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | -0.53 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.52 |
| ZNF624 | zinc finger protein 624 | -0.52 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.52 |
| ADCY9 | adenylate cyclase 9 | -0.51 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | -0.51 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.5 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -0.49 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.49 |
| FGA | fibrinogen alpha chain | -0.49 |
| COX19 | COX19 cytochrome c oxidase assembly factor | -0.49 |
| ABHD5 | abhydrolase domain containing 5 | -0.48 |
| TGOLN2 | trans-golgi network protein 2 | -0.48 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.48 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.46 |
| ANO8 | anoctamin 8 | -0.45 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.45 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | -0.45 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.45 |
| CRLF1 | cytokine receptor-like factor 1 | -0.45 |
| CLIC6 | chloride intracellular channel 6 | -0.44 |
| PEG10 | paternally expressed 10 | -0.44 |
| HOXB8 | homeobox B8 | -0.44 |
| TOR4A | torsin family 4, member A | -0.43 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.43 |
| KIF20A | kinesin family member 20A | -0.43 |
| BMP4 | bone morphogenetic protein 4 | -0.42 |
| ONECUT3 | one cut homeobox 3 | -0.42 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.41 |
| ZBTB9 | zinc finger and BTB domain containing 9 | -0.41 |
| WDR60 | WD repeat domain 60 | -0.41 |
| KEAP1 | kelch-like ECH-associated protein 1 | -0.41 |
| PLK1 | polo-like kinase 1 | -0.41 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.41 |
| FBRSL1 | fibrosin-like 1 | -0.4 |
| HOXB7 | homeobox B7 | -0.4 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.39 |
| PTTG1 | pituitary tumor-transforming 1 | -0.39 |
| ZSCAN31 | zinc finger and SCAN domain containing 31 | -0.39 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | -0.39 |
| PCLAF | PCNA clamp associated factor | -0.39 |
| AXIN2 | axin 2 | -0.39 |
| KITLG | KIT ligand | -0.39 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | -0.39 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.39 |
| CCNB1 | cyclin B1 | -0.39 |
| DNAH2 | dynein, axonemal, heavy chain 2 | -0.39 |
| CCNB2 | cyclin B2 | -0.39 |
| WTIP | Wilms tumor 1 interacting protein | -0.39 |
| IP6K2 | inositol hexakisphosphate kinase 2 | -0.38 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.38 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.38 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | -0.38 |
| DUSP6 | dual specificity phosphatase 6 | -0.38 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.38 |
| TM2D3 | TM2 domain containing 3 | -0.37 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -0.37 |
| MTFR2 | mitochondrial fission regulator 2 | -0.37 |
| FAM111B | family with sequence similarity 111, member B | -0.37 |
| RNF141 | ring finger protein 141 | -0.37 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.37 |
| SORT1 | sortilin 1 | -0.37 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.37 |
| UBN1 | ubinuclein 1 | -0.37 |
| RARA | retinoic acid receptor, alpha | -0.36 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -0.36 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.36 |
| MID2 | midline 2 | -0.36 |
| TTPA | tocopherol (alpha) transfer protein | -0.36 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.36 |
| ANKRD36 | ankyrin repeat domain 36 | -0.35 |
