SKP1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description S-phase kinase-associated protein 1|This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6500)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_SKP1A
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Genes

202 co-expressed genes for SKP1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ARF3 ADP-ribosylation factor 3
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
AZIN1 antizyme inhibitor 1
BAG5 BCL2-associated athanogene 5
BANF1 barrier to autointegration factor 1
BCAP31 B-cell receptor-associated protein 31
BTF3 basic transcription factor 3
BUD31 BUD31 homolog (S. cerevisiae)
BZW1 basic leucine zipper and W2 domains 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CANX calnexin
CBX3 chromobox homolog 3
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC123 cell division cycle 123
CFDP1 craniofacial development protein 1
CLTA clathrin, light chain A
CNBP CCHC-type zinc finger, nucleic acid binding protein
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COIL coilin
COPB1 coatomer protein complex, subunit beta 1
COPE coatomer protein complex, subunit epsilon
COPS5 COP9 signalosome subunit 5
COX11 COX11 cytochrome c oxidase copper chaperone
COX4I1 cytochrome c oxidase subunit IV isoform 1
COX5A cytochrome c oxidase subunit Va
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
COX6C cytochrome c oxidase subunit VIc
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
COX7B cytochrome c oxidase subunit VIIb
COX7C cytochrome c oxidase subunit VIIc
CSNK2B casein kinase 2, beta polypeptide
CTCF CCCTC-binding factor (zinc finger protein)
CYC1 cytochrome c-1
DAP death-associated protein
DCTN2 dynactin 2 (p50)
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
DEK DEK proto-oncogene
DNPEP aspartyl aminopeptidase
DRG1 developmentally regulated GTP binding protein 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF3C eukaryotic translation initiation factor 3, subunit C
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4H eukaryotic translation initiation factor 4H
ENSA endosulfine alpha
ETFA electron-transfer-flavoprotein, alpha polypeptide
GABARAPL2 GABA(A) receptor-associated protein-like 2
GDE1 glycerophosphodiester phosphodiesterase 1
GGCT gamma-glutamylcyclotransferase
GMFB glia maturation factor, beta
H2AFZ H2A histone family, member Z
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HAT1 histone acetyltransferase 1
HDGF hepatoma-derived growth factor
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HMGN1 high mobility group nucleosome binding domain 1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSBP1 heat shock factor binding protein 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA9 heat shock 70kDa protein 9 (mortalin)
ILF3 interleukin enhancer binding factor 3, 90kDa
IST1 increased sodium tolerance 1 homolog (yeast)
JTB jumping translocation breakpoint
KARS lysyl-tRNA synthetase
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0101 KIAA0101
KIF2A kinesin heavy chain member 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYPLA1 lysophospholipase I
MAD2L1BP MAD2L1 binding protein
MAML1 mastermind-like 1 (Drosophila)
MBD4 methyl-CpG binding domain protein 4
MDH1 malate dehydrogenase 1, NAD (soluble)
MORF4L2 mortality factor 4 like 2
MRPL9 mitochondrial ribosomal protein L9
MTDH metadherin
MYL12B myosin, light chain 12B, regulatory
NACA nascent polypeptide-associated complex alpha subunit
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NONO non-POU domain containing, octamer-binding
NSDHL NAD(P) dependent steroid dehydrogenase-like
PARK7 parkinson protein 7
PDAP1 PDGFA associated protein 1
PDCD6 programmed cell death 6
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP6C protein phosphatase 6, catalytic subunit
PRMT1 protein arginine methyltransferase 1
PRRC2C proline-rich coiled-coil 2C
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PUF60 poly-U binding splicing factor 60KDa
RAB14 RAB14, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD21 RAD21 homolog (S. pombe)
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RALY RALY heterogeneous nuclear ribonucleoprotein
RAN RAN, member RAS oncogene family
RBMX RNA binding motif protein, X-linked
RER1 retention in endoplasmic reticulum sorting receptor 1
RHEB Ras homolog enriched in brain
RNF6 ring finger protein (C3H2C3 type) 6
RPL36AL ribosomal protein L36a-like
SEC13 SEC13 homolog (S. cerevisiae)
SEPT2 septin 2
SET SET nuclear proto-oncogene
SF3B2 splicing factor 3b, subunit 2, 145kDa
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SKP1 S-phase kinase-associated protein 1
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMG7 SMG7 nonsense mediated mRNA decay factor
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPG small nuclear ribonucleoprotein polypeptide G
SNX3 sorting nexin 3
SOD1 superoxide dismutase 1, soluble
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRP19 signal recognition particle 19kDa
SRP9 signal recognition particle 9kDa
SRSF3 serine/arginine-rich splicing factor 3
SRSF9 serine/arginine-rich splicing factor 9
SSR2 signal sequence receptor, beta (translocon-associated protein beta)
STARD7 StAR-related lipid transfer (START) domain containing 7
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
SYPL1 synaptophysin-like 1
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TBCA tubulin folding cofactor A
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TLK1 tousled-like kinase 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM183A transmembrane protein 183A
TRAPPC3 trafficking protein particle complex 3
TRIM28 tripartite motif containing 28
TUG1 taurine up-regulated 1 (non-protein coding)
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBA1 ubiquitin-like modifier activating enzyme 1
UBA2 ubiquitin-like modifier activating enzyme 2
UBAP2L ubiquitin associated protein 2-like
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2N ubiquitin-conjugating enzyme E2N
UBE4A ubiquitination factor E4A
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UQCRB ubiquinol-cytochrome c reductase binding protein
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
URM1 ubiquitin related modifier 1
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VCP valosin containing protein
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VTI1B vesicle transport through interaction with t-SNAREs 1B
WBP2 WW domain binding protein 2
WIPI2 WD repeat domain, phosphoinositide interacting 2
YME1L1 YME1-like 1 ATPase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
YY1 YY1 transcription factor