SKP2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description S-phase kinase-associated protein 2, E3 ubiquitin protein ligase|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 6502)
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Genes

342 genes differentially expressed following the SKP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TRHR thyrotropin-releasing hormone receptor 2.53702
LEF1 lymphoid enhancer-binding factor 1 2.53702
CFAP65 cilia and flagella associated protein 65 2.53702
IYD iodotyrosine deiodinase 2.53702
LRRC19 leucine rich repeat containing 19 2.53702
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.53702
GREM1 gremlin 1, DAN family BMP antagonist 2.53702
VN1R1 vomeronasal 1 receptor 1 2.53702
LMOD2 leiomodin 2 (cardiac) 2.53702
PCDHGA7 protocadherin gamma subfamily A, 7 2.53702
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.53702
C6ORF163 chromosome 6 open reading frame 163 2.53702
ARR3 arrestin 3, retinal (X-arrestin) 2.53702
SSTR1 somatostatin receptor 1 2.53702
TM4SF1 transmembrane 4 L six family member 1 2.53702
CLEC4G C-type lectin domain family 4, member G 2.53702
PKP1 plakophilin 1 2.53702
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.53702
TEX53 testis expressed 53 2.53702
SHCBP1L SHC SH2-domain binding protein 1-like 2.53702
RHOXF2 Rhox homeobox family, member 2 2.53702
LOC114841035 uncharacterized LOC114841035 2.53702
VAX2 ventral anterior homeobox 2 2.53702
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.53702
MSX1 msh homeobox 1 2.53702
GZMM granzyme M (lymphocyte met-ase 1) 2.53702
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.53702
ANGPT4 angiopoietin 4 2.44428
FUCA2 fucosidase, alpha-L- 2, plasma 2.44428
ZNF98 zinc finger protein 98 2.44428
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.44428
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.44428
VCX2 variable charge, X-linked 2 2.44428
GJA3 gap junction protein, alpha 3, 46kDa 2.44428
TMPRSS11F transmembrane protease, serine 11F 2.44428
PI16 peptidase inhibitor 16 2.44428
TMPRSS11A transmembrane protease, serine 11A 2.44428
LRRD1 leucine-rich repeats and death domain containing 1 2.44428
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 2.44428
TRIM15 tripartite motif containing 15 2.44428
TRIM10 tripartite motif containing 10 2.44428
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.44428
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.44428
GPR21 G protein-coupled receptor 21 2.44428
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.44428
C11ORF87 chromosome 11 open reading frame 87 2.44428
SFTPB surfactant protein B 2.44428
C1ORF141 chromosome 1 open reading frame 141 2.44428
LGI1 leucine-rich, glioma inactivated 1 2.44428
S100A9 S100 calcium binding protein A9 2.44428
ASB10 ankyrin repeat and SOCS box containing 10 2.44428
PAX9 paired box 9 2.44428
MILR1 mast cell immunoglobulin-like receptor 1 2.44428
GPR151 G protein-coupled receptor 151 2.44428
PGBDF plakoglobin binding and degradation factor 2.44428
DDN dendrin 2.44428
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.44428
KATNAL2 katanin p60 subunit A-like 2 2.44428
CCL5 chemokine (C-C motif) ligand 5 2.44428
MTTP microsomal triglyceride transfer protein 2.44428
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.44428
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.44428
SAXO6 stabilizer of axonemal microtubules 6 2.44428
NFILZ NFIL3 like basic leucine zipper 2.44428
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.44428
HTD2 hydroxyacyl-thioester dehydratase type 2 2.44428
MRM2 mitochondrial rRNA methyltransferase 2 2.44428
MT3 metallothionein 3 2.44428
KY kyphoscoliosis peptidase 2.44428
AVPR1A arginine vasopressin receptor 1A 2.44428
AHCYL2 adenosylhomocysteinase-like 2 2.44428
PNLIPRP3 pancreatic lipase-related protein 3 2.44428
GARIN4 golgi associated RAB2 interactor family member 4 2.44428
STPG3 sperm-tail PG-rich repeat containing 3 2.44428
CFAP276 cilia and flagella associated protein 276 2.44428
FAM90A12 family with sequence similarity 90 member A12 2.44428
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.44428
TEKTL1 tektin like 1 2.44428
SPATA31H1 SPATA31 subfamily H member 1 2.44428
ZC3H11C zinc finger CCCH-type containing 11C 2.44428
AGA-DT AGA divergent transcript 2.44428
GREP1 glycine rich extracellular protein 1 2.44428
RHEX regulator of hemoglobinization and erythroid cell expansion 2.44428
MUCL3 mucin like 3 2.44428
ZG16 zymogen granule protein 16 2.44428
GRID2 glutamate receptor, ionotropic, delta 2 2.44428
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.44428
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.44428
MYH13 myosin, heavy chain 13, skeletal muscle 2.44428
C1ORF162 chromosome 1 open reading frame 162 2.44428
C10ORF67 chromosome 10 open reading frame 67 2.44428
LDHAL6B lactate dehydrogenase A-like 6B 2.44428
TUBA3D tubulin, alpha 3d 2.44428
OASL 2'-5'-oligoadenylate synthetase-like 2.44428
GRXCR1 glutaredoxin, cysteine rich 1 2.44428
LIN28B lin-28 homolog B (C. elegans) 2.44428
BLNK B-cell linker 2.44428
ASIC3 acid sensing (proton gated) ion channel 3 2.44428
SAG S-antigen; retina and pineal gland (arrestin) 2.44428
ASB4 ankyrin repeat and SOCS box containing 4 2.44428
DOK7 docking protein 7 2.44428
MYL10 myosin, light chain 10, regulatory 2.44428
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.44428
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.44428
FAM107A family with sequence similarity 107, member A 2.44428
CCDC42 coiled-coil domain containing 42 2.44428
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.44428
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.44428
PRND prion protein 2 (dublet) 2.44428
MR1 major histocompatibility complex, class I-related 2.44428
EDN3 endothelin 3 2.44428
CSTA cystatin A (stefin A) 2.44428
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.44428
CLRN1 clarin 1 2.44428
PCP2 Purkinje cell protein 2 2.44428
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.44428
WFDC1 WAP four-disulfide core domain 1 2.44428
CLEC4M C-type lectin domain family 4, member M 2.44428
AKR1B15 aldo-keto reductase family 1, member B15 2.44428
PALMD palmdelphin 2.44428
EBF2 early B-cell factor 2 2.44428
ANKRD62 ankyrin repeat domain 62 2.44428
PLA2G4E phospholipase A2, group IVE 2.44428
DYTN dystrotelin 2.44428
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.44428
CABP5 calcium binding protein 5 2.44428
APOH apolipoprotein H (beta-2-glycoprotein I) 2.44428
PCDHGB5 protocadherin gamma subfamily B, 5 2.44428
PCDHGB2 protocadherin gamma subfamily B, 2 2.44428
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 2.44428
MAMLD1 mastermind-like domain containing 1 2.44428
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.44428
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.44428
C1ORF105 chromosome 1 open reading frame 105 2.44428
KLHL18 kelch-like family member 18 2.44428
FOXF2 forkhead box F2 2.44428
GPR150 G protein-coupled receptor 150 2.44428
GPR149 G protein-coupled receptor 149 2.44428
ADAM17 ADAM metallopeptidase domain 17 2.44428
LRRN4 leucine rich repeat neuronal 4 2.44428
C22ORF31 chromosome 22 open reading frame 31 2.44428
ZPBP zona pellucida binding protein 2.44428
CSF1R colony stimulating factor 1 receptor 2.44428
PSG9 pregnancy specific beta-1-glycoprotein 9 2.44428
BCL2L15 BCL2-like 15 2.44428
BCL2A1 BCL2-related protein A1 2.44428
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.44428
C8ORF89 chromosome 8 open reading frame 89 2.44428
SIRPG signal-regulatory protein gamma 2.44428
ZC3H12D zinc finger CCCH-type containing 12D 2.44428
PIP prolactin-induced protein 2.44428
SMIM14 small integral membrane protein 14 2.44428
C7ORF33 chromosome 7 open reading frame 33 2.44428
ADGRD1 adhesion G protein-coupled receptor D1 2.44428
FOXN1 forkhead box N1 2.44428
CHRM4 cholinergic receptor, muscarinic 4 2.44428
RTP3 receptor (chemosensory) transporter protein 3 2.44428
ANXA1 annexin A1 2.44428
HES2 hes family bHLH transcription factor 2 2.44428
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.44428
RNF224 ring finger protein 224 2.44428
TENM3 teneurin transmembrane protein 3 2.44428
ZC2HC1B zinc finger, C2HC-type containing 1B 2.44428
BTBD16 BTB (POZ) domain containing 16 2.44428
GPBAR1 G protein-coupled bile acid receptor 1 2.44428
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.44428
APOL3 apolipoprotein L, 3 2.44428
TMPRSS13 transmembrane protease, serine 13 2.44428
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 2.44428
NUTM2A NUT family member 2A 2.44428
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.44428
CREM cAMP responsive element modulator 2.44428
DIO1 deiodinase, iodothyronine, type I 2.44428
CLEC2B C-type lectin domain family 2, member B 2.44428
AGR2 anterior gradient 2 2.44428
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.44428
LIMS3 LIM and senescent cell antigen-like domains 3 2.44428
BMP5 bone morphogenetic protein 5 2.44428
ICAM5 intercellular adhesion molecule 5, telencephalin 2.44428
NPR3 natriuretic peptide receptor 3 2.44428
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.44428
C5AR2 complement component 5a receptor 2 2.44428
MSLN mesothelin 2.44428
LAMA4 laminin, alpha 4 2.43184
ZNF451 zinc finger protein 451 2.43184
GPR20 G protein-coupled receptor 20 2.43184
STC1 stanniocalcin 1 2.43184
KPNA3 karyopherin alpha 3 (importin alpha 4) 2.43184
GCFC2 GC-rich sequence DNA-binding factor 2 2.43184
USO1 USO1 vesicle transport factor 2.43184
ERCC1 excision repair cross-complementation group 1 2.43184
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.43184
CNIH4 cornichon family AMPA receptor auxiliary protein 4 2.42504
LEP leptin 2.40901
LRRC47 leucine rich repeat containing 47 2.40016
TUBB3 tubulin, beta 3 class III 2.37354
ADGRF5 adhesion G protein-coupled receptor F5 2.37327
RASAL2 RAS protein activator like 2 2.34272
EEF2 eukaryotic translation elongation factor 2 2.33414
ANKH ANKH inorganic pyrophosphate transport regulator 2.32034
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 2.26312
SPRY3 sprouty homolog 3 (Drosophila) 2.24942
MYBPC2 myosin binding protein C, fast type 2.24441
CNTN1 contactin 1 2.24441
CELF1 CUGBP, Elav-like family member 1 2.24441
SMO smoothened, frizzled class receptor 2.24023
PRSS50 protease, serine, 50 2.21472
RNFT2 ring finger protein, transmembrane 2 2.18965
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.16578
LRRC9 leucine rich repeat containing 9 2.15968
TUBGCP3 tubulin, gamma complex associated protein 3 2.14593
ZMAT4 zinc finger, matrin-type 4 2.14569
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.14133
PRDX6 peroxiredoxin 6 2.12306
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.11261
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.09752
FBXO32 F-box protein 32 2.07419
EMP2 epithelial membrane protein 2 2.07165
VCAN versican 2.07165
FTCD formimidoyltransferase cyclodeaminase 2.0628
TSPOAP1 TSPO associated protein 1 2.04983
CNTNAP1 contactin associated protein 1 2.04803
PWWP3A PWWP domain containing 3A, DNA repair factor 2.02376
PRR13 proline rich 13 2.0209
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 2.02055
TM6SF1 transmembrane 6 superfamily member 1 2.00875
FAM76B family with sequence similarity 76, member B 2.00389
PBX1 pre-B-cell leukemia homeobox 1 2.0018

decreased expression

Symbol Name Standardized Value
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -2.53702
POU5F2 POU domain class 5, transcription factor 2 -2.53702
RPL19 ribosomal protein L19 -2.44428
SPICP3 Spi-C transcription factor pseudogene 3 -2.44428
TM2D2 TM2 domain containing 2 -2.44428
RAD51D RAD51 paralog D -2.44428
GANC glucosidase, alpha; neutral C -2.44428
CLDN1 claudin 1 -2.44428
IGFBP5 insulin-like growth factor binding protein 5 -2.44428
SYCP3 synaptonemal complex protein 3 -2.44428
TMEM107 transmembrane protein 107 -2.44428
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -2.44428
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -2.44428
DYNLL1 dynein, light chain, LC8-type 1 -2.44428
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4 -2.44428
GRIK4 glutamate receptor, ionotropic, kainate 4 -2.44428
METTL25B methyltransferase like 25B -2.44428
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -2.44428
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.44428
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -2.44428
ZNF404 zinc finger protein 404 -2.44428
NR6A1 nuclear receptor subfamily 6, group A, member 1 -2.44428
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.44428
CPOX coproporphyrinogen oxidase -2.4417
GDNF glial cell derived neurotrophic factor -2.43184
PRSS36 protease, serine, 36 -2.43184
PAX7 paired box 7 -2.43184
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.43184
LMNTD1 lamin tail domain containing 1 -2.43184
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -2.43184
SPHK1 sphingosine kinase 1 -2.43184
P4HB prolyl 4-hydroxylase, beta polypeptide -2.43184
GLUD2 glutamate dehydrogenase 2 -2.43184
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.43184
H2BC3 H2B clustered histone 3 -2.43184
SMIM36 small integral membrane protein 36 -2.43184
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -2.43184
OPRM1 opioid receptor, mu 1 -2.43184
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -2.43184
RASD1 RAS, dexamethasone-induced 1 -2.43184
TSPAN8 tetraspanin 8 -2.43184
ARMC12 armadillo repeat containing 12 -2.43184
ARHGAP15 Rho GTPase activating protein 15 -2.43184
CD48 CD48 molecule -2.43184
IRF8 interferon regulatory factor 8 -2.43184
ITK IL2-inducible T-cell kinase -2.43184
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -2.43184
CARD18 caspase recruitment domain family, member 18 -2.43184
IGFL4 IGF-like family member 4 -2.43184
TENT5D terminal nucleotidyltransferase 5D -2.43184
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.43184
CDC20B cell division cycle 20B -2.43184
FIBIN fin bud initiation factor homolog (zebrafish) -2.43184
EPO erythropoietin -2.43184
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.43184
CLEC4A C-type lectin domain family 4, member A -2.43184
IFITM10 interferon induced transmembrane protein 10 -2.43184
QRFP pyroglutamylated RFamide peptide -2.43184
LAMB3 laminin, beta 3 -2.43184
DCST1 DC-STAMP domain containing 1 -2.43184
TOM1L2 target of myb1-like 2 (chicken) -2.43184
SMIM17 small integral membrane protein 17 -2.43184
NPPA natriuretic peptide A -2.43184
ACOX2 acyl-CoA oxidase 2, branched chain -2.43184
SLITRK5 SLIT and NTRK-like family, member 5 -2.39758
C9ORF85 chromosome 9 open reading frame 85 -2.38538
C6ORF136 chromosome 6 open reading frame 136 -2.3558
KDSR 3-ketodihydrosphingosine reductase -2.35415
TLK1 tousled-like kinase 1 -2.32615
FGFR4 fibroblast growth factor receptor 4 -2.32034
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase -2.30235
ANKRD54 ankyrin repeat domain 54 -2.29532
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -2.28222
CCSER2 coiled-coil serine-rich protein 2 -2.25137
A2ML1 alpha-2-macroglobulin-like 1 -2.24441
EIF4B eukaryotic translation initiation factor 4B -2.24252
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.23945
TMEM35A transmembrane protein 35A -2.23674
PHF10 PHD finger protein 10 -2.20359
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.18926
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 -2.18083
TMEM254 transmembrane protein 254 -2.17828
SYT12 synaptotagmin XII -2.17039
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -2.16287
LRR1 leucine rich repeat protein 1 -2.16287
RAB4A RAB4A, member RAS oncogene family -2.16287
NTNG2 netrin G2 -2.15814
PUS3 pseudouridylate synthase 3 -2.11959
MTG1 mitochondrial ribosome-associated GTPase 1 -2.11959
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 -2.11261
NMRAL1 NmrA-like family domain containing 1 -2.09752
PRRC2C proline-rich coiled-coil 2C -2.08896
STXBP2 syntaxin binding protein 2 -2.08789
TWF2 twinfilin actin binding protein 2 -2.08426
SSBP4 single stranded DNA binding protein 4 -2.08107
TROAP trophinin associated protein -2.07419
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.07419
SCN3B sodium channel, voltage gated, type III beta subunit -2.07419
COMMD5 COMM domain containing 5 -2.07419
CA1 carbonic anhydrase I -2.07419
EGFL8 EGF-like-domain, multiple 8 -2.07165
ANG angiogenin, ribonuclease, RNase A family, 5 -2.07165
SNIP1 Smad nuclear interacting protein 1 -2.07165
CKS1B CDC28 protein kinase regulatory subunit 1B -2.04803
CEBPZOS CEBPZ opposite strand -2.04298
RAB9A RAB9A, member RAS oncogene family -2.04074
RHOBTB2 Rho-related BTB domain containing 2 -2.03648
TRIM47 tripartite motif containing 47 -2.03648
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 -2.03464
TCHP trichoplein, keratin filament binding -2.03247
CLPSL2 colipase-like 2 -2.0209
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.01125
ZNF510 zinc finger protein 510 -2.00389
CHD7 chromodomain helicase DNA binding protein 7 -2.00128