SKP2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description S-phase kinase-associated protein 2, E3 ubiquitin protein ligase|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 6502)
External Link http://www.ncbi.nlm.nih.gov/gene/6502
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332 interacting proteins for SKP2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
AARSD1 alanyl-tRNA synthetase domain containing 1
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
AHNAK AHNAK nucleoprotein
AIP aryl hydrocarbon receptor interacting protein
AKAP2 A kinase (PRKA) anchor protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
AMOTL1 angiomotin like 1
ANAPC1 anaphase promoting complex subunit 1
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANXA4 annexin A4
ANXA8 annexin A8
ANXA8L1 annexin A8-like 1
AR androgen receptor
ARF4 ADP-ribosylation factor 4
ASB2 ankyrin repeat and SOCS box containing 2
ATM ATM serine/threonine kinase
BARD1 BRCA1 associated RING domain 1
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BSG basigin (Ok blood group)
BTBD1 BTB (POZ) domain containing 1
BTBD2 BTB (POZ) domain containing 2
BTBD9 BTB (POZ) domain containing 9
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CA2 carbonic anhydrase II
CACYBP calcyclin binding protein
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNG2 cyclin G2
CCNJ cyclin J
CCNO cyclin O
CCNT1 cyclin T1
CDC14B cell division cycle 14B
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC25C cell division cycle 25C
CDC27 cell division cycle 27
CDC34 cell division cycle 34
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK13 cyclin-dependent kinase 13
CDK17 cyclin-dependent kinase 17
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDT1 chromatin licensing and DNA replication factor 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP192 centrosomal protein 192kDa
CEP97 centrosomal protein 97kDa
CHKA choline kinase alpha
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COPS2 COP9 signalosome subunit 2
COPS3 COP9 signalosome subunit 3
COPS4 COP9 signalosome subunit 4
COPS5 COP9 signalosome subunit 5
COPS6 COP9 signalosome subunit 6
COPS7A COP9 signalosome subunit 7A
COPS7B COP9 signalosome subunit 7B
COPS8 COP9 signalosome subunit 8
CORO1C coronin, actin binding protein, 1C
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CRBN cereblon
CREBBP CREB binding protein
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
CUL7 cullin 7
DCAF11 DDB1 and CUL4 associated factor 11
DCAF4 DDB1 and CUL4 associated factor 4
DCAF7 DDB1 and CUL4 associated factor 7
DDA1 DET1 and DDB1 associated 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
E2F1 E2F transcription factor 1
ECD ecdysoneless homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF4A1 eukaryotic translation initiation factor 4A1
ELAVL1 ELAV like RNA binding protein 1
ELF4 E74-like factor 4 (ets domain transcription factor)
EP300 E1A binding protein p300
ERCC8 excision repair cross-complementation group 8
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZR ezrin
FBXL16 F-box and leucine-rich repeat protein 16
FBXO11 F-box protein 11
FBXO17 F-box protein 17
FBXO22 F-box protein 22
FBXO44 F-box protein 44
FBXO7 F-box protein 7
FBXW8 F-box and WD repeat domain containing 8
FBXW9 F-box and WD repeat domain containing 9
FEM1B fem-1 homolog b (C. elegans)
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FKBPL FK506 binding protein like
FOLR1 folate receptor 1 (adult)
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GDI2 GDP dissociation inhibitor 2
GMNN geminin, DNA replication inhibitor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GOLGA2 golgin A2
GPS1 G protein pathway suppressor 1
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IDE insulin-degrading enzyme
IFI27 interferon, alpha-inducible protein 27
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INADL InaD-like (Drosophila)
ING3 inhibitor of growth family, member 3
IQGAP1 IQ motif containing GTPase activating protein 1
JAK2 Janus kinase 2
KCTD3 potassium channel tetramerization domain containing 3
KIF24 kinesin family member 24
KLHL13 kelch-like family member 13
KLHL15 kelch-like family member 15
KLHL18 kelch-like family member 18
KLHL20 kelch-like family member 20
KLHL22 kelch-like family member 22
KLHL24 kelch-like family member 24
KLHL42 kelch-like family member 42
KLHL8 kelch-like family member 8
KLHL9 kelch-like family member 9
KMT2A lysine (K)-specific methyltransferase 2A
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA5 karyopherin alpha 5 (importin alpha 6)
KPNA6 karyopherin alpha 6 (importin alpha 7)
LATS2 large tumor suppressor kinase 2
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LNX2 ligand of numb-protein X 2
LONP1 lon peptidase 1, mitochondrial
LRR1 leucine rich repeat protein 1
LRRC14 leucine rich repeat containing 14
LRRC40 leucine rich repeat containing 40
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAPK15 mitogen-activated protein kinase 15
MAX MYC associated factor X
MISP mitotic spindle positioning
MLF1 myeloid leukemia factor 1
MLF2 myeloid leukemia factor 2
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MNAT1 MNAT CDK-activating kinase assembly factor 1
MOB1A MOB kinase activator 1A
MPDZ multiple PDZ domain protein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYEOV2 myeloma overexpressed 2
NBN nibrin
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NEXN nexilin (F actin binding protein)
NLK nemo-like kinase
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NUDCD3 NudC domain containing 3
ORC1 origin recognition complex, subunit 1
PARD3 par-3 family cell polarity regulator
PDLIM7 PDZ and LIM domain 7 (enigma)
PFDN1 prefoldin subunit 1
PFDN5 prefoldin subunit 5
PGK1 phosphoglycerate kinase 1
PHB prohibitin
PHGDH phosphoglycerate dehydrogenase
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKM pyruvate kinase, muscle
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PNMA2 paraneoplastic Ma antigen 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPL periplakin
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRPF8 pre-mRNA processing factor 8
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAD50 RAD50 homolog (S. cerevisiae)
RAG2 recombination activating gene 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RND3 Rho family GTPase 3
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNF7 ring finger protein 7
RRM2 ribonucleotide reductase M2
RSU1 Ras suppressor protein 1
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SAMHD1 SAM domain and HD domain 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SF3B3 splicing factor 3b, subunit 3, 130kDa
SHKBP1 SH3KBP1 binding protein 1
SIRT3 sirtuin 3
SIRT4 sirtuin 4
SIRT6 sirtuin 6
SKP1 S-phase kinase-associated protein 1
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SP1 Sp1 transcription factor
SPDYA speedy/RINGO cell cycle regulator family member A
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SPRR2A small proline-rich protein 2A
SPRR2B small proline-rich protein 2B
SPRR2E small proline-rich protein 2E
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAP1 signal transducing adaptor family member 1
STIP1 stress-induced phosphoprotein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP4 syntaxin binding protein 4
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SVIL supervillin
TAL1 T-cell acute lymphocytic leukemia 1
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCF3 transcription factor 3
TCOF1 Treacher Collins-Franceschetti syndrome 1
TJP1 tight junction protein 1
TMOD3 tropomodulin 3 (ubiquitous)
TOB1 transducer of ERBB2, 1
TOR1AIP2 torsin A interacting protein 2
TP53 tumor protein p53
TRIM21 tripartite motif containing 21
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TYMP thymidine phosphorylase
UBA1 ubiquitin-like modifier activating enzyme 1
UBB ubiquitin B
UBC ubiquitin C
UBD ubiquitin D
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
URI1 URI1, prefoldin-like chaperone
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP18 ubiquitin specific peptidase 18
USP9X ubiquitin specific peptidase 9, X-linked
UTRN utrophin
UXT ubiquitously-expressed, prefoldin-like chaperone
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPRBP Vpr (HIV-1) binding protein
WEE1 WEE1 G2 checkpoint kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YY1 YY1 transcription factor
ZYG11B zyg-11 family member B, cell cycle regulator