SLX4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description SLX4 structure-specific endonuclease subunit|This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 84464)
External Link http://www.ncbi.nlm.nih.gov/gene/84464
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230 interacting proteins for SLX4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
AHCYL1 adenosylhomocysteinase-like 1
AHCYL2 adenosylhomocysteinase-like 2
AKAP11 A kinase (PRKA) anchor protein 11
ALB albumin
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
ANKRD17 ankyrin repeat domain 17
ANXA1 annexin A1
AP3M1 adaptor-related protein complex 3, mu 1 subunit
APP amyloid beta (A4) precursor protein
ASPRV1 aspartic peptidase, retroviral-like 1
ATG3 autophagy related 3
ATG4B autophagy related 4B, cysteine peptidase
ATG7 autophagy related 7
ATM ATM serine/threonine kinase
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
BAG5 BCL2-associated athanogene 5
BICD2 bicaudal D homolog 2 (Drosophila)
BORA bora, aurora kinase A activator
C11ORF58 chromosome 11 open reading frame 58
C2ORF44 chromosome 2 open reading frame 44
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CAND1 cullin-associated and neddylation-dissociated 1
CDSN corneodesmosin
CEP97 centrosomal protein 97kDa
CHEK1 checkpoint kinase 1
CNN3 calponin 3, acidic
COPG1 coatomer protein complex, subunit gamma 1
COPS7A COP9 signalosome subunit 7A
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTTN cortactin
CUL1 cullin 1
CUL4A cullin 4A
CWC15 CWC15 spliceosome-associated protein
DCAF10 DDB1 and CUL4 associated factor 10
DCLRE1B DNA cross-link repair 1B
DDA1 DET1 and DDB1 associated 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC7 DEP domain containing 7
DMWD dystrophia myotonica, WD repeat containing
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSC1 desmocollin 1
EME1 essential meiotic structure-specific endonuclease 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERCC1 excision repair cross-complementation group 1
ERCC4 excision repair cross-complementation group 4
ERCC6L excision repair cross-complementation group 6-like
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM192A family with sequence similarity 192, member A
FARSB phenylalanyl-tRNA synthetase, beta subunit
FBXW4 F-box and WD repeat domain containing 4
FKBP10 FK506 binding protein 10, 65 kDa
FLG filaggrin
FLNA filamin A, alpha
FTO fat mass and obesity associated
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GFM1 G elongation factor, mitochondrial 1
GFM2 G elongation factor, mitochondrial 2
GID8 GID complex subunit 8
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNPAT glyceronephosphate O-acyltransferase
GPATCH4 G patch domain containing 4
GPHN gephyrin
GPN3 GPN-loop GTPase 3
GYS1 glycogen synthase 1 (muscle)
HAUS1 HAUS augmin-like complex, subunit 1
HAUS5 HAUS augmin-like complex, subunit 5
HAUS8 HAUS augmin-like complex, subunit 8
HCFC1 host cell factor C1
HOXB9 homeobox B9
HOXC9 homeobox C9
HP haptoglobin
HSPB1 heat shock 27kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICT1 immature colon carcinoma transcript 1
IGHA1 immunoglobulin heavy constant alpha 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IPO7 importin 7
KEAP1 kelch-like ECH-associated protein 1
KIF24 kinesin family member 24
KNSTRN kinetochore-localized astrin/SPAG5 binding protein
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT3 keratin 3, type II
KRT4 keratin 4, type II
KRT84 keratin 84, type II
LARP7 La ribonucleoprotein domain family, member 7
LRRC1 leucine rich repeat containing 1
MAGED1 melanoma antigen family D1
MEPCE methylphosphate capping enzyme
MICU1 mitochondrial calcium uptake 1
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MRPL15 mitochondrial ribosomal protein L15
MRPL41 mitochondrial ribosomal protein L41
MRPL44 mitochondrial ribosomal protein L44
MRPL9 mitochondrial ribosomal protein L9
MRPS11 mitochondrial ribosomal protein S11
MRPS16 mitochondrial ribosomal protein S16
MRPS21 mitochondrial ribosomal protein S21
MRPS31 mitochondrial ribosomal protein S31
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MUS81 MUS81 structure-specific endonuclease subunit
MYH11 myosin, heavy chain 11, smooth muscle
MYO1C myosin IC
NCAPD3 non-SMC condensin II complex, subunit D3
NMD3 NMD3 ribosome export adaptor
NRD1 nardilysin (N-arginine dibasic convertase)
NRF1 nuclear respiratory factor 1
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NUP153 nucleoporin 153kDa
NUP155 nucleoporin 155kDa
NUP188 nucleoporin 188kDa
NUP214 nucleoporin 214kDa
NUP50 nucleoporin 50kDa
NUP93 nucleoporin 93kDa
PAGR1 PAXIP1 associated glutamate-rich protein 1
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDCD2L programmed cell death 2-like
PEX5 peroxisomal biogenesis factor 5
PGAM5 phosphoglycerate mutase family member 5
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK1 polo-like kinase 1
PLS3 plastin 3
PNMA2 paraneoplastic Ma antigen 2
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRKCI protein kinase C, iota
PRPF31 pre-mRNA processing factor 31
PRRC1 proline-rich coiled-coil 1
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAI14 retinoic acid induced 14
RAN RAN, member RAS oncogene family
RANBP2 RAN binding protein 2
RANBP9 RAN binding protein 9
RANGAP1 Ran GTPase activating protein 1
RGPD8 RANBP2-like and GRIP domain containing 8
RNASEH1 ribonuclease H1
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNH1 ribonuclease/angiogenin inhibitor 1
RPN1 ribophorin I
RRBP1 ribosome binding protein 1
S100A8 S100 calcium binding protein A8
SART1 squamous cell carcinoma antigen recognized by T cells
SCRIB scribbled planar cell polarity protein
SDE2 SDE2 telomere maintenance homolog (S. pombe)
SEH1L SEH1-like (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLIRP SRA stem-loop interacting RNA binding protein
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
SLX4IP SLX4 interacting protein
SMN2 survival of motor neuron 2, centromeric
SPAG5 sperm associated antigen 5
SPAG9 sperm associated antigen 9
SPRTN SprT-like N-terminal domain
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STK4 serine/threonine kinase 4
STRAP serine/threonine kinase receptor associated protein
STXBP4 syntaxin binding protein 4
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D4 TBC1 domain family, member 4
TCOF1 Treacher Collins-Franceschetti syndrome 1
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX10 testis expressed 10
TF transferrin
TGM3 transglutaminase 3
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)
TIPRL TOR signaling pathway regulator
TK1 thymidine kinase 1, soluble
TOPBP1 topoisomerase (DNA) II binding protein 1
TRIOBP TRIO and F-actin binding protein
TSPYL1 TSPY-like 1
TTLL12 tubulin tyrosine ligase-like family member 12
UBA5 ubiquitin-like modifier activating enzyme 5
UBC ubiquitin C
UBE2O ubiquitin-conjugating enzyme E2O
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UQCRC2 ubiquinol-cytochrome c reductase core protein II
USMG5 up-regulated during skeletal muscle growth 5 homolog (mouse)
VARS valyl-tRNA synthetase
VCP valosin containing protein
VPRBP Vpr (HIV-1) binding protein
ZNF282 zinc finger protein 282
ZYX zyxin