SMAD1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description SMAD family member 1|The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4086)
External Link http://www.ncbi.nlm.nih.gov/gene/4086
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262 interacting proteins for SMAD1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR1C activin A receptor, type IC
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
ACVRL1 activin A receptor type II-like 1
AES amino-terminal enhancer of split
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMH anti-Mullerian hormone
AMHR2 anti-Mullerian hormone receptor, type II
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARL13B ADP-ribosylation factor-like 13B
ARL4D ADP-ribosylation factor-like 4D
ARL5A ADP-ribosylation factor-like 5A
ATM ATM serine/threonine kinase
BMP1 bone morphogenetic protein 1
BMP10 bone morphogenetic protein 10
BMP15 bone morphogenetic protein 15
BMP2 bone morphogenetic protein 2
BMP3 bone morphogenetic protein 3
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BMP8A bone morphogenetic protein 8a
BMP8B bone morphogenetic protein 8b
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTBD2 BTB (POZ) domain containing 2
BTG2 BTG family, member 2
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBX4 chromobox homolog 4
CCNC cyclin C
CCNT1 cyclin T1
CDK7 cyclin-dependent kinase 7
CDK8 cyclin-dependent kinase 8
CDK9 cyclin-dependent kinase 9
CHMP3 charged multivesicular body protein 3
COL4A1 collagen, type IV, alpha 1
CREBBP CREB binding protein
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DROSHA drosha, ribonuclease type III
DVL1 dishevelled segment polarity protein 1
ECSIT ECSIT signalling integrator
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ELP3 elongator acetyltransferase complex subunit 3
ENG endoglin
EP300 E1A binding protein p300
ERBB2IP erbb2 interacting protein
EWSR1 EWS RNA-binding protein 1
FBXL12 F-box and leucine-rich repeat protein 12
FBXO24 F-box protein 24
FBXO3 F-box protein 3
FBXO30 F-box protein 30
FBXO44 F-box protein 44
FBXW5 F-box and WD repeat domain containing 5
FHL5 four and a half LIM domains 5
FOXG1 forkhead box G1
FOXO3 forkhead box O3
FRZB frizzled-related protein
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GDF1 growth differentiation factor 1
GDF10 growth differentiation factor 10
GDF11 growth differentiation factor 11
GDF15 growth differentiation factor 15
GDF2 growth differentiation factor 2
GDF3 growth differentiation factor 3
GDF5 growth differentiation factor 5
GDF6 growth differentiation factor 6
GDF7 growth differentiation factor 7
GDF9 growth differentiation factor 9
GDNF glial cell derived neurotrophic factor
GLI3 GLI family zinc finger 3
GMEB1 glucocorticoid modulatory element binding protein 1
GSC goosecoid homeobox
GSK3B glycogen synthase kinase 3 beta
HBP1 HMG-box transcription factor 1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC8 histone deacetylase 8
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIPK2 homeodomain interacting protein kinase 2
HMGA2 high mobility group AT-hook 2
HOXA13 homeobox A13
HOXA5 homeobox A5
HOXC8 homeobox C8
HOXD13 homeobox D13
ICK intestinal cell (MAK-like) kinase
ING2 inhibitor of growth family, member 2
INHBA inhibin, beta A
INHBB inhibin, beta B
INHBC inhibin, beta C
INHBE inhibin, beta E
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF2BP1 interferon regulatory factor 2 binding protein 1
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KDM6B lysine (K)-specific demethylase 6B
KMT2D lysine (K)-specific methyltransferase 2D
LEF1 lymphoid enhancer-binding factor 1
LEFTY1 left-right determination factor 1
LEFTY2 left-right determination factor 2
LEMD3 LEM domain containing 3
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
MBD1 methyl-CpG binding domain protein 1
MECOM MDS1 and EVI1 complex locus
MED15 mediator complex subunit 15
MED24 mediator complex subunit 24
MED6 mediator complex subunit 6
MEN1 multiple endocrine neoplasia I
MGA MGA, MAX dimerization protein
MKL2 MKL/myocardin-like 2
MSTN myostatin
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEUROG1 neurogenin 1
NKX3-2 NK3 homeobox 2
NODAL nodal growth differentiation factor
NOTCH2 notch 2
NUP214 nucleoporin 214kDa
OAZ1 ornithine decarboxylase antizyme 1
OAZ3 ornithine decarboxylase antizyme 3
OSBPL3 oxysterol binding protein-like 3
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARD3B par-3 family cell polarity regulator beta
PAX6 paired box 6
PDLIM7 PDZ and LIM domain 7 (enigma)
PIAS1 protein inhibitor of activated STAT, 1
PIAS4 protein inhibitor of activated STAT, 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PREB prolactin regulatory element binding
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PUM1 pumilio RNA-binding family member 1
RAB2B RAB2B, member RAS oncogene family
RAB30 RAB30, member RAS oncogene family
RAB34 RAB34, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAN RAN, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RAPSN receptor-associated protein of the synapse
RASD2 RASD family, member 2
RASL12 RAS-like, family 12
RFX1 regulatory factor X, 1 (influences HLA class II expression)
RGS3 regulator of G-protein signaling 3
RHEBL1 Ras homolog enriched in brain like 1
RHOBTB1 Rho-related BTB domain containing 1
RHOG ras homolog family member G
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF14 ring finger protein 14
RPS27A ribosomal protein S27a
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
SF3B1 splicing factor 3b, subunit 1, 155kDa
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNIP1 Smad nuclear interacting protein 1
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SOX5 SRY (sex determining region Y)-box 5
SQSTM1 sequestosome 1
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF20 transcription factor 20 (AR1)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGIF1 TGFB-induced factor homeobox 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 transducin-like enhancer of split 2
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
TLE6 transducin-like enhancer of split 6
TLL1 tolloid-like 1
TLL2 tolloid-like 2
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TP53 tumor protein p53
TRIM35 tripartite motif containing 35
TRIP6 thyroid hormone receptor interactor 6
TTF1 transcription termination factor, RNA polymerase I
TTF2 transcription termination factor, RNA polymerase II
TUBA4A tubulin, alpha 4a
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2Z ubiquitin-conjugating enzyme E2Z
UBXN1 UBX domain protein 1
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UHMK1 U2AF homology motif (UHM) kinase 1
USP15 ubiquitin specific peptidase 15
USP45 ubiquitin specific peptidase 45
USP9X ubiquitin specific peptidase 9, X-linked
VEPH1 ventricular zone expressed PH domain-containing 1
WDR77 WD repeat domain 77
WSB1 WD repeat and SOCS box containing 1
WWOX WW domain containing oxidoreductase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XPC xeroderma pigmentosum, complementation group C
XPO1 exportin 1
YAP1 Yes-associated protein 1
YY1 YY1 transcription factor
ZBTB44 zinc finger and BTB domain containing 44
ZCCHC12 zinc finger, CCHC domain containing 12
ZDHHC3 zinc finger, DHHC-type containing 3
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF251 zinc finger protein 251
ZNF423 zinc finger protein 423
ZNF510 zinc finger protein 510
ZNF512B zinc finger protein 512B
ZNF521 zinc finger protein 521
ZNF76 zinc finger protein 76
ZNF8 zinc finger protein 8
ZSCAN4 zinc finger and SCAN domain containing 4