| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | SMAD family member 2|The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 4087) |
| External Link | https://ncbi.nlm.nih.gov/gene/4087 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the SMAD2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0211219 |
| LCN2 | lipocalin 2 | 0.017279 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0158733 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.0125424 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0124953 |
| PCP4 | Purkinje cell protein 4 | 0.0124921 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.012241 |
| GMPR | guanosine monophosphate reductase | 0.012196 |
| ANO10 | anoctamin 10 | 0.0121043 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.011853 |
| PRAME | preferentially expressed antigen in melanoma | 0.0115229 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.0115151 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0113374 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0110807 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.0110166 |
| OLFM4 | olfactomedin 4 | 0.0107419 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0105618 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.0105055 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0103615 |
| REG1A | regenerating islet-derived 1 alpha | 0.0100278 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.0100187 |
| LTF | lactotransferrin | 0.0099973 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.0098828 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00986371 |
| NIBAN1 | niban apoptosis regulator 1 | 0.00977886 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00968597 |
| IPO13 | importin 13 | 0.00959887 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00958478 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.00956657 |
| IL7R | interleukin 7 receptor | 0.00953148 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00950373 |
| BIN1 | bridging integrator 1 | 0.009412 |
| DPEP1 | dipeptidase 1 (renal) | 0.00937914 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00935442 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.00926587 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00920408 |
| UROD | uroporphyrinogen decarboxylase | 0.00920139 |
| HTRA1 | HtrA serine peptidase 1 | 0.00915604 |
| PYGB | phosphorylase, glycogen; brain | 0.00914139 |
| GPX2 | glutathione peroxidase 2 | 0.00905553 |
| C9ORF16 | chromosome 9 open reading frame 16 | 0.00899943 |
| ACP3 | acid phosphatase 3 | 0.00884498 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.00880025 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.00877019 |
| NTS | neurotensin | 0.00875404 |
| KLK11 | kallikrein-related peptidase 11 | 0.00871568 |
| PRKCA | protein kinase C, alpha | 0.00857706 |
| CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase | 0.00857693 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00855505 |
| DCT | dopachrome tautomerase | 0.00855224 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 0.00854171 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00850878 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00844559 |
| PDLIM4 | PDZ and LIM domain 4 | 0.00842691 |
| PYCARD | PYD and CARD domain containing | 0.00839987 |
| TARP | TCR gamma alternate reading frame protein | 0.00837196 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00835312 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 0.00834614 |
| KIAA0930 | KIAA0930 | 0.00834105 |
| TOR3A | torsin family 3, member A | 0.00821321 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00818934 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00815631 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.0081351 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00807782 |
| NEFH | neurofilament, heavy polypeptide | 0.00807501 |
| TSPO | translocator protein (18kDa) | 0.00805335 |
| IFI35 | interferon-induced protein 35 | 0.00804587 |
| CFB | complement factor B | 0.0080312 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00802931 |
| TTC38 | tetratricopeptide repeat domain 38 | 0.00801597 |
| NKX3-1 | NK3 homeobox 1 | 0.0079778 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00793721 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00793422 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 0.00790322 |
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.00786924 |
| FLOT2 | flotillin 2 | 0.00784368 |
| RTN1 | reticulon 1 | 0.00781078 |
| EPHB2 | EPH receptor B2 | 0.00780636 |
| AOC1 | amine oxidase, copper containing 1 | 0.0077953 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | 0.00776811 |
| TRIB2 | tribbles pseudokinase 2 | 0.00771392 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | 0.00771315 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00770861 |
| HBZ | hemoglobin, zeta | 0.00770684 |
| WNT5B | wingless-type MMTV integration site family, member 5B | 0.00770016 |
| HEPH | hephaestin | 0.00769783 |
| PF4 | platelet factor 4 | 0.00767125 |
| PLK1 | polo-like kinase 1 | 0.0075925 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 0.00758141 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00751021 |
| PPP1R7 | protein phosphatase 1, regulatory subunit 7 | 0.00749857 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.00747938 |
| NDRG1 | N-myc downstream regulated 1 | 0.00746602 |
| FASN | fatty acid synthase | 0.00745781 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.00742932 |
| RGS4 | regulator of G-protein signaling 4 | 0.00741015 |
| TSPAN4 | tetraspanin 4 | 0.00738139 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.00737884 |
| FADS1 | fatty acid desaturase 1 | 0.00736779 |
| ICAM2 | intercellular adhesion molecule 2 | 0.00735338 |
| LST1 | leukocyte specific transcript 1 | 0.00735076 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.00735042 |
| ARPC4 | actin related protein 2/3 complex, subunit 4, 20kDa | 0.00734011 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 0.00733229 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.00726015 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00725764 |
| PKM | pyruvate kinase, muscle | 0.00724494 |
| KAT2B | K(lysine) acetyltransferase 2B | 0.00720936 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00720427 |
| FGR | FGR proto-oncogene, Src family tyrosine kinase | 0.0071908 |
| RCAN1 | regulator of calcineurin 1 | 0.00718403 |
| S100A9 | S100 calcium binding protein A9 | 0.00718396 |
| EMP3 | epithelial membrane protein 3 | 0.00718198 |
| DES | desmin | 0.00717642 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.00715589 |
| LRP3 | low density lipoprotein receptor-related protein 3 | 0.00715478 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00714607 |
| SMTN | smoothelin | 0.0070875 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00708565 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.00706852 |
| ZDHHC4 | zinc finger, DHHC-type containing 4 | 0.00705687 |
| TMEM164 | transmembrane protein 164 | 0.00704926 |
| REG1B | regenerating islet-derived 1 beta | 0.00704895 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00702986 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.00701986 |
| NEO1 | neogenin 1 | 0.00701237 |
| GTPBP1 | GTP binding protein 1 | 0.00699954 |
| SDC1 | syndecan 1 | 0.0069932 |
| MICALL2 | MICAL-like 2 | 0.00696515 |
| S100A12 | S100 calcium binding protein A12 | 0.00695595 |
| TEAD4 | TEA domain family member 4 | 0.00695446 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 0.00695353 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.00694007 |
| SLC5A1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | 0.00693857 |
| SCAND1 | SCAN domain containing 1 | 0.00692032 |
| AP2S1 | adaptor-related protein complex 2, sigma 1 subunit | 0.00690393 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00690371 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.00690154 |
| PLBD1 | phospholipase B domain containing 1 | 0.00690072 |
| TFPT | TCF3 (E2A) fusion partner (in childhood Leukemia) | 0.00690038 |
| COG4 | component of oligomeric golgi complex 4 | 0.00689017 |
| THY1 | Thy-1 cell surface antigen | 0.00687383 |
| CDC45 | cell division cycle 45 | 0.00687354 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.00686242 |
| SPON2 | spondin 2, extracellular matrix protein | 0.00685474 |
| RNF144A | ring finger protein 144A | 0.00684849 |
| CLIP3 | CAP-GLY domain containing linker protein 3 | 0.00680906 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | 0.00680459 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.00679839 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.00679075 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.00677413 |
| EPHB6 | EPH receptor B6 | 0.00675729 |
| HBD | hemoglobin, delta | 0.00673187 |
| PRR5 | proline rich 5 (renal) | 0.0067309 |
| NMU | neuromedin U | 0.0067254 |
| BLVRB | biliverdin reductase B | 0.00672047 |
| ZIC1 | Zic family member 1 | 0.00671972 |
| REX1BD | required for excision 1-B domain containing | 0.00671605 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00671494 |
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.00671148 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.00669926 |
| BCL7C | B-cell CLL/lymphoma 7C | 0.0066795 |
| CCNF | cyclin F | 0.00665031 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.00665029 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | 0.00664211 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.00663482 |
| CNN1 | calponin 1, basic, smooth muscle | 0.00663298 |
| RGS10 | regulator of G-protein signaling 10 | 0.00663245 |
| FST | follistatin | 0.00662556 |
| FLNC | filamin C, gamma | 0.00662399 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | 0.00661839 |
| PCGF2 | polycomb group ring finger 2 | 0.00661376 |
| INTS1 | integrator complex subunit 1 | 0.00660882 |
| RNF187 | ring finger protein 187 | 0.00657664 |
| ATP5F1D | ATP synthase F1 subunit delta | 0.006567 |
| PHGDH | phosphoglycerate dehydrogenase | 0.00656468 |
| ALAS2 | 5'-aminolevulinate synthase 2 | 0.00656274 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00656163 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.00654756 |
| GPI | glucose-6-phosphate isomerase | 0.00653797 |
| MPP1 | membrane protein, palmitoylated 1, 55kDa | 0.00653633 |
| SPCS3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 0.00651244 |
| IL2RG | interleukin 2 receptor, gamma | 0.00650447 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00650289 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00648103 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.00647636 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00647365 |
| TGFB1 | transforming growth factor, beta 1 | 0.00647335 |
| RNASE6 | ribonuclease, RNase A family, k6 | 0.00647157 |
| PALM | paralemmin | 0.00646422 |
| ERCC1 | excision repair cross-complementation group 1 | 0.00644883 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | 0.00643401 |
| VEGFA | vascular endothelial growth factor A | 0.00642658 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00642106 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00640958 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00640552 |
| FGL2 | fibrinogen-like 2 | 0.00639517 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00639312 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.00638941 |
| PCOLCE | procollagen C-endopeptidase enhancer | 0.00638533 |
| ECHS1 | enoyl CoA hydratase, short chain, 1, mitochondrial | 0.00637946 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.00637702 |
| PFKL | phosphofructokinase, liver | 0.00635946 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00634696 |
| SCAMP4 | secretory carrier membrane protein 4 | 0.00633444 |
| NANS | N-acetylneuraminic acid synthase | 0.00632781 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.00632207 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00632128 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.00631698 |
| RUVBL1 | RuvB-like AAA ATPase 1 | 0.00630867 |
| SRM | spermidine synthase | 0.00630532 |
| TCL1A | T-cell leukemia/lymphoma 1A | 0.00629984 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | 0.00629656 |
| SNX6 | sorting nexin 6 | 0.00629339 |
| TUBA4A | tubulin, alpha 4a | 0.00628742 |
| GLUD1 | glutamate dehydrogenase 1 | 0.00628315 |
| TGFA | transforming growth factor, alpha | 0.00627373 |
| HDAC9 | histone deacetylase 9 | 0.00626979 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.00626742 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.00626582 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00626556 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.00626425 |
| GPR137B | G protein-coupled receptor 137B | 0.00626098 |
| BGN | biglycan | 0.00625033 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | 0.00624517 |
| GCAT | glycine C-acetyltransferase | 0.00624061 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.00623714 |
| CLTB | clathrin, light chain B | 0.00623556 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0062243 |
| CD38 | CD38 molecule | 0.0062196 |
| NPY | neuropeptide Y | 0.00620167 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.00619989 |
| ILVBL | ilvB (bacterial acetolactate synthase)-like | 0.00619585 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | 0.00616121 |
| ZNF580 | zinc finger protein 580 | 0.00615725 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0061511 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0061468 |
| TSPAN8 | tetraspanin 8 | 0.00614414 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 0.00613446 |
| PMEL | premelanosome protein | 0.00613147 |
| SYNGR3 | synaptogyrin 3 | 0.00612564 |
| NOSIP | nitric oxide synthase interacting protein | 0.00612513 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | 0.00612118 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 0.00611891 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00611032 |
| DACT1 | dishevelled-binding antagonist of beta-catenin 1 | 0.00610159 |
| TPM2 | tropomyosin 2 (beta) | 0.00609981 |
| CST7 | cystatin F (leukocystatin) | 0.00608487 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00608368 |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase | 0.00608208 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0266899 |
| GNAS | GNAS complex locus | -0.0190391 |
| MAP7 | microtubule-associated protein 7 | -0.0185671 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.0150439 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0149109 |
| XIC | X chromosome inactivation center | -0.0143623 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0142562 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.013841 |
| ITGA6 | integrin, alpha 6 | -0.0130441 |
| PRNP | prion protein | -0.0129478 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0127554 |
| RGCC | regulator of cell cycle | -0.0125478 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0124743 |
| ANXA3 | annexin A3 | -0.0124468 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0124065 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0121293 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0121134 |
| CCNA2 | cyclin A2 | -0.0120235 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0118386 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.0116622 |
| KRT7 | keratin 7, type II | -0.0114805 |
| CLDND1 | claudin domain containing 1 | -0.0113692 |
| S100A2 | S100 calcium binding protein A2 | -0.0112703 |
| MSX1 | msh homeobox 1 | -0.011257 |
| CCN2 | cellular communication network factor 2 | -0.0112032 |
| TMEM230 | transmembrane protein 230 | -0.011175 |
| ZNF281 | zinc finger protein 281 | -0.0110563 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0110047 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.0108888 |
| MIR22HG | MIR22 host gene | -0.0108537 |
| SFTPB | surfactant protein B | -0.0107069 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -0.0105947 |
| ANOS1 | anosmin 1 | -0.0104735 |
| KLF6 | Kruppel-like factor 6 | -0.0104632 |
| CLEC2B | C-type lectin domain family 2, member B | -0.0103872 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0103239 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0102258 |
| MYO1B | myosin IB | -0.0101199 |
| TMEM100 | transmembrane protein 100 | -0.0101114 |
| EXOC5 | exocyst complex component 5 | -0.0100856 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0100472 |
| MGP | matrix Gla protein | -0.0100465 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00995111 |
| HMBOX1 | homeobox containing 1 | -0.00992173 |
| HOPX | HOP homeobox | -0.0099149 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.00987169 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00986845 |
| CAVIN2 | caveolae associated protein 2 | -0.0098591 |
| TRAM1 | translocation associated membrane protein 1 | -0.00985235 |
| EFHD1 | EF-hand domain family, member D1 | -0.00976726 |
| IL6ST | interleukin 6 signal transducer | -0.00974933 |
| SCARB2 | scavenger receptor class B, member 2 | -0.00966056 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0096401 |
| EMCN | endomucin | -0.00957755 |
| EMP1 | epithelial membrane protein 1 | -0.00954898 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00943685 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.00939427 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.00937945 |
| MCL1 | myeloid cell leukemia 1 | -0.00930263 |
| FAM120A | family with sequence similarity 120A | -0.00929984 |
| CTTN | cortactin | -0.009289 |
| PNN | pinin, desmosome associated protein | -0.00928815 |
| EZR | ezrin | -0.00928709 |
| MYO5C | myosin VC | -0.00925441 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.00924546 |
| NPR3 | natriuretic peptide receptor 3 | -0.00922347 |
| RAB1A | RAB1A, member RAS oncogene family | -0.00917817 |
| KIF14 | kinesin family member 14 | -0.00917061 |
| CAPRIN1 | cell cycle associated protein 1 | -0.00905675 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.00904159 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.00900102 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.00897123 |
| CALCRL | calcitonin receptor-like | -0.00891416 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00890461 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.00884454 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00880372 |
| FAM198B | family with sequence similarity 198, member B | -0.00880335 |
| CCL14 | chemokine (C-C motif) ligand 14 | -0.00878048 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | -0.00875012 |
| PON3 | paraoxonase 3 | -0.00874003 |
| SFTPD | surfactant protein D | -0.00870876 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | -0.00864437 |
| CD93 | CD93 molecule | -0.00864378 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -0.00862766 |
| IFNGR1 | interferon gamma receptor 1 | -0.0086273 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.0086213 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00859594 |
| NDNF | neuron-derived neurotrophic factor | -0.00857956 |
| FZD6 | frizzled class receptor 6 | -0.00857713 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.00857608 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.00857123 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.00854554 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.00853899 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00853355 |
| SRSF10 | serine/arginine-rich splicing factor 10 | -0.00852041 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.00850456 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00850265 |
| MEX3C | mex-3 RNA binding family member C | -0.00849832 |
| TSPAN13 | tetraspanin 13 | -0.00847824 |
| NKX2-1 | NK2 homeobox 1 | -0.00844131 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.00843391 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00842529 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.00841905 |
| PODXL | podocalyxin-like | -0.00841845 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | -0.00841154 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.00841044 |
| EPAS1 | endothelial PAS domain protein 1 | -0.00840921 |
| PRDX1 | peroxiredoxin 1 | -0.00837764 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.0083514 |
| SRSF5 | serine/arginine-rich splicing factor 5 | -0.00831559 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00829094 |
| MECOM | MDS1 and EVI1 complex locus | -0.00828079 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00826797 |
| FADD | Fas (TNFRSF6)-associated via death domain | -0.00826652 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.00825569 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0082179 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.00818541 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.00812647 |
| ZNF165 | zinc finger protein 165 | -0.00812374 |
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | -0.00811014 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.00810408 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0080785 |
| MRPS28 | mitochondrial ribosomal protein S28 | -0.0080783 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | -0.00803741 |
| SCAMP1 | secretory carrier membrane protein 1 | -0.00802043 |
| RHOA | ras homolog family member A | -0.00801612 |
| TFDP1 | transcription factor Dp-1 | -0.00800177 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0080015 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | -0.00800072 |
| S100A10 | S100 calcium binding protein A10 | -0.00799081 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.00798974 |
| CTSC | cathepsin C | -0.00795804 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0079178 |
| RASA4 | RAS p21 protein activator 4 | -0.00790085 |
| LEPROT | leptin receptor overlapping transcript | -0.00787642 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00784993 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.0078489 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00783971 |
| RDX | radixin | -0.00782848 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.00782074 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.00782031 |
| MOB4 | MOB family member 4, phocein | -0.00781076 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.0077743 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | -0.00777165 |
| ACTB | actin, beta | -0.00776267 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00774289 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | -0.0077365 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00773023 |
| SERINC1 | serine incorporator 1 | -0.00772187 |
| HIPK3 | homeodomain interacting protein kinase 3 | -0.00771585 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -0.00770059 |
| ETV1 | ets variant 1 | -0.00764668 |
| HDGFL3 | HDGF like 3 | -0.00763562 |
| CAV2 | caveolin 2 | -0.00761757 |
| YIPF5 | Yip1 domain family, member 5 | -0.00761648 |
| CUX1 | cut-like homeobox 1 | -0.00761544 |
| EGFL6 | EGF-like-domain, multiple 6 | -0.00760546 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | -0.00757529 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00757163 |
| RAB9A | RAB9A, member RAS oncogene family | -0.00754193 |
| ZNF207 | zinc finger protein 207 | -0.00752471 |
| ITM2A | integral membrane protein 2A | -0.00750355 |
| UBXN7 | UBX domain protein 7 | -0.00747343 |
| ZWILCH | zwilch kinetochore protein | -0.00746547 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.00746165 |
| SETD5 | SET domain containing 5 | -0.00745975 |
| PEG10 | paternally expressed 10 | -0.00742412 |
| PBK | PDZ binding kinase | -0.00741729 |
| DPP8 | dipeptidyl-peptidase 8 | -0.00740255 |
| SELENOT | selenoprotein T | -0.0073806 |
| KRT17 | keratin 17, type I | -0.00735227 |
| DSTN | destrin (actin depolymerizing factor) | -0.00734107 |
| GPR87 | G protein-coupled receptor 87 | -0.00733342 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00733262 |
| DUSP1 | dual specificity phosphatase 1 | -0.00732742 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | -0.00732353 |
| PALLD | palladin, cytoskeletal associated protein | -0.00728736 |
| DCTN6 | dynactin 6 | -0.00727736 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00726035 |
| SFTPC | surfactant protein C | -0.00722721 |
| SPARCL1 | SPARC-like 1 (hevin) | -0.00720929 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.00720879 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00718963 |
| PSMA1 | proteasome (prosome, macropain) subunit, alpha type, 1 | -0.00718219 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.00716907 |
| SELE | selectin E | -0.00716532 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.00716248 |
| EFNA1 | ephrin-A1 | -0.00715598 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.00715477 |
| INSR | insulin receptor | -0.00714233 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.00713763 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.00713026 |
| ABLIM1 | actin binding LIM protein 1 | -0.0071238 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.00709739 |
| RNF146 | ring finger protein 146 | -0.00709679 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.00709298 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.00707608 |
| EMP2 | epithelial membrane protein 2 | -0.00706355 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.00705149 |
| F2R | coagulation factor II (thrombin) receptor | -0.00704558 |
| RNFT1 | ring finger protein, transmembrane 1 | -0.0070434 |
| LMAN1 | lectin, mannose-binding, 1 | -0.00704235 |
| MED6 | mediator complex subunit 6 | -0.00703193 |
| ADIRF | adipogenesis regulatory factor | -0.00701595 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.00700993 |
| SPRR3 | small proline-rich protein 3 | -0.00700481 |
| YIPF6 | Yip1 domain family, member 6 | -0.0069929 |
| CA2 | carbonic anhydrase II | -0.00698741 |
| TAF9 | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa | -0.00698178 |
| EDNRB | endothelin receptor type B | -0.00697677 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | -0.00695667 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00694554 |
| GTF2I | general transcription factor IIi | -0.00694258 |
| SIX1 | SIX homeobox 1 | -0.00692012 |
| CPM | carboxypeptidase M | -0.00691682 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00690739 |
| CD34 | CD34 molecule | -0.00689725 |
| BAALC | brain and acute leukemia, cytoplasmic | -0.0068928 |
| USP34 | ubiquitin specific peptidase 34 | -0.00688919 |
| CHMP5 | charged multivesicular body protein 5 | -0.00687763 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.0068723 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00685731 |
| CCNG1 | cyclin G1 | -0.0068479 |
| FIGF | c-fos induced growth factor (vascular endothelial growth factor D) | -0.00683944 |
| MRPL18 | mitochondrial ribosomal protein L18 | -0.00683148 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00682927 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00680797 |
| OSMR | oncostatin M receptor | -0.00680251 |
| NCOA3 | nuclear receptor coactivator 3 | -0.00680224 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | -0.00678 |
| FCN3 | ficolin (collagen/fibrinogen domain containing) 3 | -0.00677998 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0067755 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0067673 |
| UTRN | utrophin | -0.00676629 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0067607 |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | -0.00675905 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | -0.00674096 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.00674073 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.006733 |
| ABHD17B | abhydrolase domain containing 17B | -0.00672052 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0067163 |
| GSN | gelsolin | -0.00671606 |
| HSPE1 | heat shock 10kDa protein 1 | -0.00671462 |
| THBD | thrombomodulin | -0.00671372 |
| MRPL42 | mitochondrial ribosomal protein L42 | -0.00670749 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.0067026 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00669028 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | -0.00667141 |
| PERP | PERP, TP53 apoptosis effector | -0.00666984 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | -0.00666788 |
