SMAD3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SMAD family member 3|The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009] (NCBI Entrez Gene Database, 4088)
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Genes

295 genes differentially expressed following the SMAD3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM3D family with sequence similarity 3, member D 4.62336
CELF6 CUGBP, Elav-like family member 6 4.62336
DNASE1L2 deoxyribonuclease I-like 2 4.62336
GLUD2 glutamate dehydrogenase 2 4.62336
TM4SF1 transmembrane 4 L six family member 1 4.62336
PGBDF plakoglobin binding and degradation factor 4.62336
CNTNAP4 contactin associated protein-like 4 4.62336
NCF4 neutrophil cytosolic factor 4, 40kDa 4.62336
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 4.62336
KLRK1 killer cell lectin-like receptor subfamily K, member 1 4.62336
ENTHD1 ENTH domain containing 1 4.62336
SCG2 secretogranin II 4.62336
USH1G Usher syndrome 1G (autosomal recessive) 4.62336
MEP1A meprin A, alpha (PABA peptide hydrolase) 4.62336
WEE2 WEE1 homolog 2 (S. pombe) 4.62336
RNF17 ring finger protein 17 4.62336
SOX1 SRY (sex determining region Y)-box 1 4.62336
SELPLG selectin P ligand 4.62336
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 4.62336
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 4.62336
GJA10 gap junction protein, alpha 10, 62kDa 4.62336
PAX9 paired box 9 4.62336
PAX4 paired box 4 4.62336
DIO3 deiodinase, iodothyronine, type III 4.62336
CORO6 coronin 6 4.62336
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 4.62336
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 4.62336
PRR29 proline rich 29 4.62336
HIC1 hypermethylated in cancer 1 4.62336
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 4.62336
TLDC2 TBC/LysM-associated domain containing 2 4.62336
OXT oxytocin/neurophysin I prepropeptide 4.62336
OR5V1 olfactory receptor, family 5, subfamily V, member 1 4.62336
CELA1 chymotrypsin-like elastase family, member 1 4.62336
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 4.62336
SCNN1G sodium channel, non voltage gated 1 gamma subunit 4.62336
SFXN3 sideroflexin 3 4.62336
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 4.62336
SPINT3 serine peptidase inhibitor, Kunitz type, 3 4.62336
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 4.62336
ADAMTSL5 ADAMTS-like 5 4.62336
SMIM5 small integral membrane protein 5 4.62336
SOST sclerostin 4.62336
FPR2 formyl peptide receptor 2 4.62336
CIMIP2C ciliary microtubule inner protein 2C 4.62336
HAO2 hydroxyacid oxidase 2 (long chain) 4.62336
GBP4 guanylate binding protein 4 4.62336
GBP6 guanylate binding protein family, member 6 4.62336
AVPR1A arginine vasopressin receptor 1A 4.62336
ALX4 ALX homeobox 4 4.62336
HTRA4 HtrA serine peptidase 4 4.62336
PKD2L1 polycystic kidney disease 2-like 1 4.62336
OR6F1 olfactory receptor, family 6, subfamily F, member 1 4.62336
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 4.62336
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 4.62336
ANGPTL8 angiopoietin like 8 4.62336
FAM240C family with sequence similarity 240 member C 4.62336
LINC02268 long intergenic non-protein coding RNA 2268 4.62336
LOC124902436 talanin 4.62336
NFILZ NFIL3 like basic leucine zipper 4.62336
ODAPH odontogenesis associated phosphoprotein 4.62336
CFAP141 cilia and flagella associated protein 141 4.62336
GASK1B golgi associated kinase 1B 4.62336
DEPP1 DEPP autophagy regulator 1 4.62336
CATSPERH catsper channel auxiliary subunit eta 4.62336
BDKRB1 bradykinin receptor B1 4.62336
FOXC2 forkhead box C2 4.62336
UROC1 urocanate hydratase 1 4.62336
NR1I3 nuclear receptor subfamily 1, group I, member 3 4.62336
CBLN3 cerebellin 3 precursor 4.62336
LIX1 Lix1 homolog (chicken) 4.62336
IL31RA interleukin 31 receptor A 4.62336
CLDN9 claudin 9 4.62336
CCDC17 coiled-coil domain containing 17 4.62336
PCDHA3 protocadherin alpha 3 4.62336
SCRT1 scratch family zinc finger 1 4.62336
C1ORF162 chromosome 1 open reading frame 162 4.62336
GJD4 gap junction protein, delta 4, 40.1kDa 4.62336
TBX10 T-box 10 4.62336
GATA1 GATA binding protein 1 (globin transcription factor 1) 4.62336
MROH5 maestro heat-like repeat family member 5 4.62336
HAL histidine ammonia-lyase 4.62336
IL7R interleukin 7 receptor 4.62336
UTS2 urotensin 2 4.62336
CCR9 chemokine (C-C motif) receptor 9 4.62336
CCR7 chemokine (C-C motif) receptor 7 4.62336
OR2A1 olfactory receptor, family 2, subfamily A, member 1 4.62336
WFDC13 WAP four-disulfide core domain 13 4.62336
ANKRD55 ankyrin repeat domain 55 4.62336
WFDC9 WAP four-disulfide core domain 9 4.62336
ERICH6B glutamate-rich 6B 4.62336
HMGB4 high mobility group box 4 4.62336
CFAP126 cilia and flagella associated protein 126 4.62336
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 4.62336
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 4.62336
PLA2G2C phospholipase A2, group IIC 4.62336
SMIM23 small integral membrane protein 23 4.62336
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 4.62336
RETNLB resistin like beta 4.62336
PCDHAC2 protocadherin alpha subfamily C, 2 4.62336
DQX1 DEAQ box RNA-dependent ATPase 1 4.62336
EDN2 endothelin 2 4.62336
CT55 cancer/testis antigen 55 4.62336
NIM1K NIM1 serine/threonine protein kinase 4.62336
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 4.62336
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 4.62336
TYMP thymidine phosphorylase 4.62336
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 4.62336
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 4.62336
ANKRD53 ankyrin repeat domain 53 4.62336
SCNN1B sodium channel, non voltage gated 1 beta subunit 4.62336
MYADML2 myeloid-associated differentiation marker-like 2 4.62336
PLD6 phospholipase D family, member 6 4.62336
SPHKAP SPHK1 interactor, AKAP domain containing 4.62336
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 4.62336
RGCC regulator of cell cycle 4.62336
ISL2 ISL LIM homeobox 2 4.62336
LMOD3 leiomodin 3 (fetal) 4.62336
LMOD2 leiomodin 2 (cardiac) 4.62336
NT5C1A 5'-nucleotidase, cytosolic IA 4.62336
IL36R interleukin 36 receptor 4.62336
CLEC4D C-type lectin domain family 4, member D 4.62336
CTSS cathepsin S 4.62336
TREH trehalase (brush-border membrane glycoprotein) 4.62336
ENDOU endonuclease, polyU-specific 4.62336
LAMB3 laminin, beta 3 4.62336
ST18 suppression of tumorigenicity 18, zinc finger 4.62336
GH1 growth hormone 1 4.62336
ZNF534 zinc finger protein 534 4.62336
NLRP3 NLR family, pyrin domain containing 3 4.62336
SLC36A3 solute carrier family 36, member 3 4.62336
BTG4 B-cell translocation gene 4 4.62336
ARGFX arginine-fifty homeobox 4.62336
PLET1 placenta expressed transcript 1 4.62336
SOX30 SRY (sex determining region Y)-box 30 4.62336
TTC36 tetratricopeptide repeat domain 36 4.62336
SDSL serine dehydratase-like 4.62336
SMIM24 small integral membrane protein 24 4.62336
SIDT1 SID1 transmembrane family, member 1 4.62336
IRX4 iroquois homeobox 4 4.62336
XCR1 chemokine (C motif) receptor 1 4.62336
MORC1 MORC family CW-type zinc finger 1 4.62336
NGB neuroglobin 4.62336
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 4.62336
PHOSPHO1 phosphatase, orphan 1 4.62336
ORM2 orosomucoid 2 4.62336
OR3A1 olfactory receptor, family 3, subfamily A, member 1 4.62336
ADAM18 ADAM metallopeptidase domain 18 4.62336
AGR2 anterior gradient 2 4.62336
TBC1D21 TBC1 domain family, member 21 4.62336
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 4.62336
ROM1 retinal outer segment membrane protein 1 4.62336
NUTM2F NUT family member 2F 4.62336
NPY2R neuropeptide Y receptor Y2 4.62336
CASS4 Cas scaffolding protein family member 4 4.54728
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 4.08262
RWDD2B RWD domain containing 2B 3.9837
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 3.95662
DNAH8 dynein, axonemal, heavy chain 8 3.47684
OVCH2 ovochymase 2 (gene/pseudogene) 3.47684
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 3.47684
BTK Bruton agammaglobulinemia tyrosine kinase 3.47684
RPS21-DT RPS21 divergent transcript 3.47684
SRL sarcalumenin 3.47684
CFAP299 cilia and flagella associated protein 299 3.47684
PLCL2 phospholipase C-like 2 3.46007
ZNF613 zinc finger protein 613 3.23649
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 3.16124
NPIPB6 nuclear pore complex interacting protein family, member B6 2.86534
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 2.86534
HEXB hexosaminidase B (beta polypeptide) 2.8192
VEGFB vascular endothelial growth factor B 2.79238
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.79055
MYOF myoferlin 2.79045
THBS3 thrombospondin 3 2.77259
NMI N-myc (and STAT) interactor 2.70253
UBALD1 UBA-like domain containing 1 2.59415
TGFBI transforming growth factor, beta-induced, 68kDa 2.48473
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 2.46219
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 2.45969
ATP5MF ATP synthase membrane subunit f 2.40703
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.38184
MRPL39 mitochondrial ribosomal protein L39 2.35496
PRPH2 peripherin 2 (retinal degeneration, slow) 2.34648
MRPS34 mitochondrial ribosomal protein S34 2.33457
WIZ widely interspaced zinc finger motifs 2.29848
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.23497
UPK3B uroplakin 3B 2.23497
MYH15 myosin, heavy chain 15 2.22999
IFT140 intraflagellar transport 140 2.21698
CDH4 cadherin 4, type 1, R-cadherin (retinal) 2.21319
MEGF8 multiple EGF-like-domains 8 2.19455
CDC42SE2 CDC42 small effector 2 2.15242
PRKCZ protein kinase C, zeta 2.14364
RAB7A RAB7A, member RAS oncogene family 2.12334
RNF126 ring finger protein 126 2.1221
USP22 ubiquitin specific peptidase 22 2.11649
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 2.10748
DPY19L3 dpy-19-like 3 (C. elegans) 2.09961
ST7 suppression of tumorigenicity 7 2.08958
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.08689
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.08508
MCTP2 multiple C2 domains, transmembrane 2 2.07688
ENOX1 ecto-NOX disulfide-thiol exchanger 1 2.07688
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.06713
KIAA0586 KIAA0586 2.04274
THOC5 THO complex 5 2.03154
TUBGCP2 tubulin, gamma complex associated protein 2 2.02629
ZMYM2 zinc finger, MYM-type 2 2.00709

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -4.62336
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -4.62336
ACTL10 actin-like 10 -4.62336
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -4.62336
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -4.62336
PDCD1 programmed cell death 1 -4.62336
NAP1L5 nucleosome assembly protein 1-like 5 -4.62336
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 -4.62336
HES4 hes family bHLH transcription factor 4 -4.62336
TMEM86B transmembrane protein 86B -4.62336
IQCC IQ motif containing C -4.62336
THSD1 thrombospondin, type I, domain containing 1 -4.62336
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -4.62336
PNMA8C PNMA family member 8C -4.62336
PGA5 pepsinogen 5, group I (pepsinogen A) -4.62336
ANAPC2 anaphase promoting complex subunit 2 -4.62336
FMO3 flavin containing monooxygenase 3 -4.62336
WDR64 WD repeat domain 64 -4.62336
LRRC3 leucine rich repeat containing 3 -4.62336
CSAG3 CSAG family, member 3 -4.62336
PMP22 peripheral myelin protein 22 -4.62336
MEIS1 Meis homeobox 1 -4.62336
CFAP47 cilia and flagella associated protein 47 -4.62336
FYB2 FYN binding protein 2 -4.62336
TEKT2 tektin 2 (testicular) -4.62336
ALS2CL ALS2 C-terminal like -4.59508
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 -4.41805
GPR87 G protein-coupled receptor 87 -3.54484
C9ORF153 chromosome 9 open reading frame 153 -2.8262
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.75928
MTDH metadherin -2.72958
TIMP2 TIMP metallopeptidase inhibitor 2 -2.71903
MIMS1 mitochondrial inner membrane scaffold 1 -2.5089
TMEM165 transmembrane protein 165 -2.49416
MBD5 methyl-CpG binding domain protein 5 -2.44543
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.38184
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.32257
TRMT9B tRNA methyltransferase 9B (putative) -2.28528
ABI3BP ABI family, member 3 (NESH) binding protein -2.2653
ANGPT4 angiopoietin 4 -2.2653
ZNF138 zinc finger protein 138 -2.2653
ARL17B ADP-ribosylation factor-like 17B -2.26027
PLSCR4 phospholipid scramblase 4 -2.24828
RCSD1 RCSD domain containing 1 -2.2316
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 -2.22999
LDAH lipid droplet associated hydrolase -2.2291
SPAG16 sperm associated antigen 16 -2.22478
EXO1 exonuclease 1 -2.22478
PNCK pregnancy up-regulated nonubiquitous CaM kinase -2.21319
RRM1 ribonucleotide reductase M1 -2.21319
ATG9B autophagy related 9B -2.21319
MXD4 MAX dimerization protein 4 -2.21319
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -2.21319
ARRDC2 arrestin domain containing 2 -2.21192
NOS3 nitric oxide synthase 3 (endothelial cell) -2.21192
RASA4B RAS p21 protein activator 4B -2.21192
WDR53 WD repeat domain 53 -2.18508
PIGBOS1 PIGB opposite strand 1 -2.18478
FOXN3 forkhead box N3 -2.18478
ZNF70 zinc finger protein 70 -2.18478
FLACC1 flagellum associated containing coiled-coil domains 1 -2.18478
ZNG1F Zn regulated GTPase metalloprotein activator 1F -2.18478
CHAC2 ChaC, cation transport regulator homolog 2 (E. coli) -2.16602
TMEM43 transmembrane protein 43 -2.16602
KCMF1 potassium channel modulatory factor 1 -2.15742
TMEM82 transmembrane protein 82 -2.15457
DNAI2 dynein, axonemal, intermediate chain 2 -2.15457
TM9SF1 transmembrane 9 superfamily member 1 -2.1346
MOB4 MOB family member 4, phocein -2.1336
CORO7 coronin 7 -2.11914
NLE1 notchless homolog 1 (Drosophila) -2.11649
SUCLG1 succinate-CoA ligase, alpha subunit -2.11649
CAMK4 calcium/calmodulin-dependent protein kinase IV -2.11649
SUOX sulfite oxidase -2.11301
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.10316
MEF2A myocyte enhancer factor 2A -2.09961
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.09139
UNC119 unc-119 homolog (C. elegans) -2.08508
GOLIM4 golgi integral membrane protein 4 -2.07688
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.07502
FMC1 formation of mitochondrial complex V assembly factor 1 homolog -2.05633
GRHPR glyoxylate reductase/hydroxypyruvate reductase -2.04762
ORC1 origin recognition complex, subunit 1 -2.03048
NUDCD1 NudC domain containing 1 -2.02296
UPK3BL1 uroplakin 3B like 1 -2.00654
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.00312