SMAD4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SMAD family member 4|This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 4089)
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Genes

354 genes differentially expressed following the SMAD4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD19 CD19 molecule 3.59115
IDI2 isopentenyl-diphosphate delta isomerase 2 3.59115
MAGEA12 melanoma antigen family A12 3.59115
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.59115
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.59115
S100B S100 calcium binding protein B 3.59115
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 3.59115
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 3.59115
OVOL3 ovo-like zinc finger 3 3.59115
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.59115
TMEM74B transmembrane protein 74B 3.59115
NUTM2G NUT family member 2G 3.59115
SCN2B sodium channel, voltage gated, type II beta subunit 3.59115
CD177 CD177 molecule 3.59115
PCDHB4 protocadherin beta 4 3.59115
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.59115
FRG2C FSHD region gene 2 family, member C 3.59115
FAM216B family with sequence similarity 216, member B 3.59115
NLRP3 NLR family, pyrin domain containing 3 3.59115
C2CD2L C2CD2-like 3.59115
OPTC opticin 3.59115
CFAP276 cilia and flagella associated protein 276 3.59115
OTOA otoancorin 3.59115
TMEM176B transmembrane protein 176B 3.5566
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.5566
SSMEM1 serine-rich single-pass membrane protein 1 3.5566
RSPO3 R-spondin 3 3.5566
RSPO1 R-spondin 1 3.5566
NMUR1 neuromedin U receptor 1 3.5566
STAP1 signal transducing adaptor family member 1 3.5566
PAX2 paired box 2 3.5566
FFAR4 free fatty acid receptor 4 3.5566
MC4R melanocortin 4 receptor 3.5566
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.5566
SCIN scinderin 3.5566
PDYN prodynorphin 3.5566
MSX2 msh homeobox 2 3.5566
PDIA2 protein disulfide isomerase family A, member 2 3.5566
TRIM10 tripartite motif containing 10 3.5566
LRRC55 leucine rich repeat containing 55 3.5566
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.5566
SPACA1 sperm acrosome associated 1 3.5566
LRRC61 leucine rich repeat containing 61 3.5566
TTLL8 tubulin tyrosine ligase-like family member 8 3.5566
HBZ hemoglobin, zeta 3.5566
TREML4 triggering receptor expressed on myeloid cells-like 4 3.5566
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.5566
LBX2 ladybird homeobox 2 3.5566
FOXO3B forkhead box O3B pseudogene 3.5566
LCN12 lipocalin 12 3.5566
S100A1 S100 calcium binding protein A1 3.5566
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.5566
ADAMTSL5 ADAMTS-like 5 3.5566
SP7 Sp7 transcription factor 3.5566
HCRTR2 hypocretin (orexin) receptor 2 3.5566
PECAM1 platelet/endothelial cell adhesion molecule 1 3.5566
PBOV1 prostate and breast cancer overexpressed 1 3.5566
C2ORF78 chromosome 2 open reading frame 78 3.5566
LGI1 leucine-rich, glioma inactivated 1 3.5566
TMA7B translation machinery associated 7 homolog B 3.5566
RHCG Rh family, C glycoprotein 3.5566
SRGN serglycin 3.5566
C9ORF43 chromosome 9 open reading frame 43 3.5566
SPMAP1 sperm microtubule associated protein 1 3.5566
ASB4 ankyrin repeat and SOCS box containing 4 3.5566
C10ORF53 chromosome 10 open reading frame 53 3.5566
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.5566
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.5566
DYNAP dynactin associated protein 3.5566
CLDN16 claudin 16 3.5566
SPMIP1 sperm microtubule inner protein 1 3.5566
MYMK myomaker, myoblast fusion factor 3.5566
LY6L lymphocyte antigen 6 family member L 3.5566
TUBB8B tubulin beta 8B 3.5566
MEIOSIN meiosis initiator 3.5566
CFAP141 cilia and flagella associated protein 141 3.5566
AJM1 apical junction component 1 homolog 3.5566
DEPP1 DEPP autophagy regulator 1 3.5566
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.5566
ZNF71 zinc finger protein 71 3.5566
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.5566
TBX5 T-box 5 3.5566
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.5566
SYCP2 synaptonemal complex protein 2 3.5566
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.5566
TSSK4 testis-specific serine kinase 4 3.5566
FER1L6 fer-1-like family member 6 3.5566
LHCGR luteinizing hormone/choriogonadotropin receptor 3.5566
SIX2 SIX homeobox 2 3.5566
CD5 CD5 molecule 3.5566
EGFLAM EGF-like, fibronectin type III and laminin G domains 3.5566
CTRC chymotrypsin C (caldecrin) 3.5566
LIPJ lipase, family member J 3.5566
CCDC13 coiled-coil domain containing 13 3.5566
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 3.5566
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.5566
MIA melanoma inhibitory activity 3.5566
ULBP2 UL16 binding protein 2 3.5566
SLC22A25 solute carrier family 22, member 25 3.5566
ANXA13 annexin A13 3.5566
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.5566
CCR6 chemokine (C-C motif) receptor 6 3.5566
MAGEB2 melanoma antigen family B2 3.5566
DUXB double homeobox B 3.5566
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 3.5566
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.5566
WFDC8 WAP four-disulfide core domain 8 3.5566
TDRD10 tudor domain containing 10 3.5566
PKDREJ polycystin (PKD) family receptor for egg jelly 3.5566
AKNAD1 AKNA domain containing 1 3.5566
C16ORF78 chromosome 16 open reading frame 78 3.5566
PSKH2 protein serine kinase H2 3.5566
OR52K1 olfactory receptor, family 52, subfamily K, member 1 3.5566
MUC15 mucin 15, cell surface associated 3.5566
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.5566
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.5566
S100Z S100 calcium binding protein Z 3.5566
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.5566
GFI1B growth factor independent 1B transcription repressor 3.5566
CTAGE15 CTAGE family, member 15 3.5566
GPR12 G protein-coupled receptor 12 3.5566
DQX1 DEAQ box RNA-dependent ATPase 1 3.5566
RESP18 regulated endocrine-specific protein 18 3.5566
AQP8 aquaporin 8 3.5566
CRYBB3 crystallin, beta B3 3.5566
CLRN2 clarin 2 3.5566
TEX19 testis expressed 19 3.5566
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.5566
PFN4 profilin family, member 4 3.5566
ORM2 orosomucoid 2 3.5566
NYX nyctalopin 3.5566
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.5566
GOLGA8O golgin A8 family, member O 3.5566
GOLGA8T golgin A8 family, member T 3.5566
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.5566
SIDT1 SID1 transmembrane family, member 1 3.5566
PHOX2A paired-like homeobox 2a 3.5566
PPAT phosphoribosyl pyrophosphate amidotransferase 3.5566
SH2D1A SH2 domain containing 1A 3.5566
KLK12 kallikrein-related peptidase 12 3.5566
CATIP ciliogenesis associated TTC17 interacting protein 3.5566
EGR2 early growth response 2 3.5566
TBX1 T-box 1 3.5566
PTHLH parathyroid hormone-like hormone 3.5566
SI sucrase-isomaltase (alpha-glucosidase) 3.5566
TP63 tumor protein p63 3.5566
PRSS37 protease, serine, 37 3.5566
NT5C1B 5'-nucleotidase, cytosolic IB 3.5566
ART1 ADP-ribosyltransferase 1 3.5566
TBC1D26 TBC1 domain family, member 26 3.5566
MMEL1 membrane metallo-endopeptidase-like 1 3.5566
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.5566
SDSL serine dehydratase-like 3.5566
TMPRSS13 transmembrane protease, serine 13 3.5566
CARNS1 carnosine synthase 1 3.5566
PEAR1 platelet endothelial aggregation receptor 1 3.5566
ADGRF5 adhesion G protein-coupled receptor F5 3.5566
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.5566
RFC3 replication factor C (activator 1) 3, 38kDa 3.5566
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.5566
LAMP5 lysosomal-associated membrane protein family, member 5 3.5566
RAB7B RAB7B, member RAS oncogene family 3.5566
MYOZ2 myozenin 2 3.5566
NLRP6 NLR family, pyrin domain containing 6 3.5566
NPR3 natriuretic peptide receptor 3 3.5566
FXYD4 FXYD domain containing ion transport regulator 4 3.5566
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.5566
OR8H1 olfactory receptor, family 8, subfamily H, member 1 3.5566
OR56B4 olfactory receptor, family 56, subfamily B, member 4 3.5566
CIDEC cell death-inducing DFFA-like effector c 3.5566
VPREB3 pre-B lymphocyte 3 3.5566
DMBT1 deleted in malignant brain tumors 1 3.5566
FKBP4 FK506 binding protein 4, 59kDa 3.50632
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 3.00664
STXBP4 syntaxin binding protein 4 2.87669
WASF3 WAS protein family, member 3 2.86849
NLGN1 neuroligin 1 2.79422
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 2.77659
N4BP2L1 NEDD4 binding protein 2-like 1 2.71585
RGMB repulsive guidance molecule family member b 2.71041
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2.62025
GIPC2 GIPC PDZ domain containing family, member 2 2.61769
COL26A1 collagen, type XXVI, alpha 1 2.52573
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.51919
TMEM168 transmembrane protein 168 2.51347
SIT1 signaling threshold regulating transmembrane adaptor 1 2.50381
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.48725
PARD3 par-3 family cell polarity regulator 2.47878
PGAP6 post-GPI attachment to proteins 6 2.47319
C3ORF38 chromosome 3 open reading frame 38 2.46158
PCDHGB6 protocadherin gamma subfamily B, 6 2.4606
LRRC26 leucine rich repeat containing 26 2.4606
GHITM growth hormone inducible transmembrane protein 2.40923
IDO1 indoleamine 2,3-dioxygenase 1 2.40923
KAT2B K(lysine) acetyltransferase 2B 2.3904
LDLR low density lipoprotein receptor 2.37754
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 2.3771
RAVER2 ribonucleoprotein, PTB-binding 2 2.37624
TMSB4X thymosin beta 4, X-linked 2.36189
ZCCHC8 zinc finger, CCHC domain containing 8 2.3584
FAM149B1 family with sequence similarity 149, member B1 2.35539
HGH1 HGH1 homolog (S. cerevisiae) 2.34797
EXD1 exonuclease 3'-5' domain containing 1 2.34479
INHBE inhibin, beta E 2.34479
S100A2 S100 calcium binding protein A2 2.34479
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.34479
ZNF404 zinc finger protein 404 2.33907
IRF7 interferon regulatory factor 7 2.32498
RIMS2 regulating synaptic membrane exocytosis 2 2.3099
KASH5 KASH domain containing 5 2.3099
AMPH amphiphysin 2.26614
PARVB parvin, beta 2.26614
DAW1 dynein assembly factor with WDR repeat domains 1 2.24648
KIAA1328 KIAA1328 2.24327
CSE1L CSE1 chromosome segregation 1-like (yeast) 2.23804
PHYHD1 phytanoyl-CoA dioxygenase domain containing 1 2.23721
PKP2 plakophilin 2 2.23721
ZNF768 zinc finger protein 768 2.2245
ADRA2A adrenoceptor alpha 2A 2.19548
PPP1R16A protein phosphatase 1, regulatory subunit 16A 2.18679
PLXDC2 plexin domain containing 2 2.16631
CTNND2 catenin (cadherin-associated protein), delta 2 2.1657
ZFP91 ZFP91 zinc finger protein 2.1626
EXOSC6 exosome component 6 2.15698
ZDHHC3 zinc finger, DHHC-type containing 3 2.12502
FRYL FRY-like 2.12491
CTSV cathepsin V 2.11413
FOS FBJ murine osteosarcoma viral oncogene homolog 2.11077
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.10208
HMGN2 high mobility group nucleosomal binding domain 2 2.08321
TENM3 teneurin transmembrane protein 3 2.08205
SYT13 synaptotagmin XIII 2.03327
CCDC200 coiled-coil domain containing 200 2.02049
HMOX1 heme oxygenase 1 2.01201
FAM229B family with sequence similarity 229, member B 2.00835

decreased expression

Symbol Name Standardized Value
CSPG4 chondroitin sulfate proteoglycan 4 -3.59115
KLHDC8B kelch domain containing 8B -3.59115
CARMIL3 capping protein regulator and myosin 1 linker 3 -3.59115
NME8 NME/NM23 family member 8 -3.59115
RNF112 ring finger protein 112 -3.59115
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -3.59115
CD86 CD86 molecule -3.5566
CPB2 carboxypeptidase B2 (plasma) -3.5566
TMC3 transmembrane channel-like 3 -3.5566
DCHS1 dachsous cadherin-related 1 -3.5566
C5ORF47 chromosome 5 open reading frame 47 -3.5566
ACSM1 acyl-CoA synthetase medium-chain family member 1 -3.5566
ALOX15B arachidonate 15-lipoxygenase, type B -3.5566
CLPSL1 colipase-like 1 -3.5566
TRAF3IP3 TRAF3 interacting protein 3 -3.5566
ANXA1 annexin A1 -3.5566
SHISA7 shisa family member 7 -3.5566
BAAT bile acid CoA:amino acid N-acyltransferase -3.5566
NDRG1 N-myc downstream regulated 1 -3.5566
TMPRSS11F transmembrane protease, serine 11F -3.5566
AGTR1 angiotensin II receptor, type 1 -3.5566
BATF3 basic leucine zipper transcription factor, ATF-like 3 -3.5566
NXPH4 neurexophilin 4 -3.5566
GFRA3 GDNF family receptor alpha 3 -3.5566
TNNI1 troponin I type 1 (skeletal, slow) -3.5566
FOXN4 forkhead box N4 -3.5566
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -3.5566
PAX3 paired box 3 -3.5566
SLC39A5 solute carrier family 39 (zinc transporter), member 5 -3.5566
FAM221B family with sequence similarity 221, member B -3.5566
MYEOV myeloma overexpressed -3.5566
SMIM22 small integral membrane protein 22 -3.5566
H3-7 H3.7 histone (putative) -3.5566
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -3.5566
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -3.5566
CCDC175 coiled-coil domain containing 175 -3.5566
CCDC159 coiled-coil domain containing 159 -3.5566
SDS serine dehydratase -3.5566
PCDHA13 protocadherin alpha 13 -3.5566
SMIM41 small integral membrane protein 41 -3.5566
JSRP1 junctional sarcoplasmic reticulum protein 1 -3.5566
ANKLE1 ankyrin repeat and LEM domain containing 1 -3.5566
GPC6 glypican 6 -3.44209
PLPPR3 phospholipid phosphatase related 3 -3.31558
MTNR1A melatonin receptor 1A -3.18649
GPC4 glypican 4 -3.01705
LRRC39 leucine rich repeat containing 39 -2.95065
LAMC3 laminin, gamma 3 -2.8693
IL6R interleukin 6 receptor -2.82618
C13ORF42 chromosome 13 open reading frame 42 -2.76659
TMEM50A transmembrane protein 50A -2.76147
XBP1 X-box binding protein 1 -2.7555
CALD1 caldesmon 1 -2.74063
INSC inscuteable homolog (Drosophila) -2.736
PRICKLE3 prickle homolog 3 (Drosophila) -2.73283
NCAPG2 non-SMC condensin II complex, subunit G2 -2.73283
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.71041
MRPS33 mitochondrial ribosomal protein S33 -2.67018
ASIC2 acid sensing (proton gated) ion channel 2 -2.67018
SBF1 SET binding factor 1 -2.64033
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.6249
SMAD4 SMAD family member 4 -2.61938
EPHA8 EPH receptor A8 -2.59149
TMEM106C transmembrane protein 106C -2.59149
NEK5 NIMA-related kinase 5 -2.57605
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -2.54181
NRN1L neuritin 1-like -2.54181
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 -2.53751
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -2.53751
TNIP2 TNFAIP3 interacting protein 2 -2.51919
DEPDC7 DEP domain containing 7 -2.50452
ZNF285 zinc finger protein 285 -2.50361
SELENOW selenoprotein W -2.49591
FAM81A family with sequence similarity 81, member A -2.48934
PANK2 pantothenate kinase 2 -2.48725
SYT9 synaptotagmin IX -2.47319
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.46526
MRPL57 mitochondrial ribosomal protein L57 -2.46306
ATG101 autophagy related 101 -2.43436
SRF serum response factor (c-fos serum response element-binding transcription factor) -2.42862
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -2.40923
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.40923
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.38513
TMEM126A transmembrane protein 126A -2.38404
NUDCD1 NudC domain containing 1 -2.37113
ITGB5 integrin, beta 5 -2.37113
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.36189
ZNF582 zinc finger protein 582 -2.34453
ICAM1 intercellular adhesion molecule 1 -2.34453
TTLL12 tubulin tyrosine ligase-like family member 12 -2.31022
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -2.3099
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -2.29548
SLC45A4 solute carrier family 45, member 4 -2.29548
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.26614
ZFP14 ZFP14 zinc finger protein -2.24648
MYSM1 Myb-like, SWIRM and MPN domains 1 -2.23892
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -2.22479
BID BH3 interacting domain death agonist -2.22339
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.2204
CAMLG calcium modulating ligand -2.185
NECTIN2 nectin cell adhesion molecule 2 -2.185
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa -2.18445
MGAT4C MGAT4 family, member C -2.17529
NEK7 NIMA-related kinase 7 -2.16915
ORC2 origin recognition complex, subunit 2 -2.15859
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.15407
LASP1NB LASP1 neighbor -2.14197
PLD5 phospholipase D family, member 5 -2.13165
SMAD7 SMAD family member 7 -2.12769
MOSPD1 motile sperm domain containing 1 -2.0887
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.0884
PPARG peroxisome proliferator-activated receptor gamma -2.08578
HPSE2 heparanase 2 (inactive) -2.08578
RGS3 regulator of G-protein signaling 3 -2.08321
BIRC5 baculoviral IAP repeat containing 5 -2.08321
RPL10 ribosomal protein L10 -2.07824
TPT1 tumor protein, translationally-controlled 1 -2.07508
DCTN3 dynactin 3 (p22) -2.07212
CCNI cyclin I -2.05744