| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | SMAD family member 4|This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 4089) |
| External Link | https://ncbi.nlm.nih.gov/gene/4089 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the SMAD4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CALML5 | calmodulin-like 5 | 0.0174943 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.0162737 |
| NVL | nuclear VCP-like | 0.0161714 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.015906 |
| KRT1 | keratin 1, type II | 0.0151124 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0150911 |
| KRT14 | keratin 14, type I | 0.0150351 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.0148056 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0135796 |
| DSG1 | desmoglein 1 | 0.0135322 |
| CST6 | cystatin E/M | 0.0133901 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.0126424 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.0126315 |
| MLPH | melanophilin | 0.0124843 |
| PEG10 | paternally expressed 10 | 0.0124319 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.0121553 |
| LOR | loricrin | 0.0118165 |
| SFN | stratifin | 0.0116315 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0115364 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0114782 |
| DSC1 | desmocollin 1 | 0.011081 |
| MAP7 | microtubule-associated protein 7 | 0.0108702 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.0108523 |
| KRT16 | keratin 16, type I | 0.0108507 |
| DSP | desmoplakin | 0.01084 |
| RAB38 | RAB38, member RAS oncogene family | 0.0106142 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.010527 |
| KRT2 | keratin 2, type II | 0.010514 |
| NXN | nucleoredoxin | 0.0104022 |
| CALML3 | calmodulin-like 3 | 0.0103618 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.0102322 |
| DCLK1 | doublecortin-like kinase 1 | 0.0101857 |
| ARG1 | arginase 1 | 0.0101228 |
| TUBB2A | tubulin, beta 2A class IIa | 0.0098354 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00981862 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00967353 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00963147 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.00962 |
| PPL | periplakin | 0.00953663 |
| TUFT1 | tuftelin 1 | 0.00946175 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.00940154 |
| TYRP1 | tyrosinase-related protein 1 | 0.00933588 |
| CWH43 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) | 0.00933094 |
| TUBA4A | tubulin, alpha 4a | 0.009299 |
| CDSN | corneodesmosin | 0.00917705 |
| HOPX | HOP homeobox | 0.00895803 |
| RNF167 | ring finger protein 167 | 0.0088693 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.0088649 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.0088438 |
| TMEM45A | transmembrane protein 45A | 0.00883882 |
| RUNX3 | runt-related transcription factor 3 | 0.0087883 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.00866518 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.0086449 |
| LCE2B | late cornified envelope 2B | 0.00861281 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00855559 |
| KLK5 | kallikrein-related peptidase 5 | 0.00836889 |
| TOX3 | TOX high mobility group box family member 3 | 0.00829225 |
| KRT17 | keratin 17, type I | 0.00828648 |
| PON3 | paraoxonase 3 | 0.00816766 |
| GAL | galanin/GMAP prepropeptide | 0.00806521 |
| SEMA4C | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | 0.00804911 |
| ANO10 | anoctamin 10 | 0.007868 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.00785696 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00784276 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 0.00782555 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.00769953 |
| ZNF750 | zinc finger protein 750 | 0.00767762 |
| RTN2 | reticulon 2 | 0.00766525 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00760116 |
| NAV2 | neuron navigator 2 | 0.00759108 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.00756884 |
| PERP | PERP, TP53 apoptosis effector | 0.00752927 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00751117 |
| CHKB | choline kinase beta | 0.00742915 |
| PKP1 | plakophilin 1 | 0.00742894 |
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 0.00741121 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00739416 |
| SDC4 | syndecan 4 | 0.00736748 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 0.0073062 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00730579 |
| EPHX3 | epoxide hydrolase 3 | 0.00729586 |
| STIP1 | stress-induced phosphoprotein 1 | 0.00727438 |
| DUSP2 | dual specificity phosphatase 2 | 0.00725674 |
| QPCT | glutaminyl-peptide cyclotransferase | 0.00722702 |
| IGSF3 | immunoglobulin superfamily, member 3 | 0.00722586 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.00722579 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.00721612 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | 0.00717147 |
| EXPH5 | exophilin 5 | 0.00715694 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00710604 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 0.00709647 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00704661 |
| DCT | dopachrome tautomerase | 0.00704495 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.00703522 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00701548 |
| SIDT2 | SID1 transmembrane family, member 2 | 0.00701092 |
| MOSPD1 | motile sperm domain containing 1 | 0.00699336 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | 0.00698092 |
| KRT10 | keratin 10, type I | 0.00697765 |
| SLC38A1 | solute carrier family 38, member 1 | 0.006939 |
| JUP | junction plakoglobin | 0.00688964 |
| SFTPB | surfactant protein B | 0.00686224 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | 0.00685404 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.00684519 |
| L1CAM | L1 cell adhesion molecule | 0.006837 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | 0.00681786 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | 0.00680161 |
| CLCA2 | chloride channel accessory 2 | 0.00680123 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.00678798 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.00678084 |
| CADM1 | cell adhesion molecule 1 | 0.00677092 |
| PMEL | premelanosome protein | 0.00676957 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | 0.00675416 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.0067503 |
| DSTN | destrin (actin depolymerizing factor) | 0.00674065 |
| HAL | histidine ammonia-lyase | 0.00672705 |
| SLURP1 | secreted LY6/PLAUR domain containing 1 | 0.00671828 |
| BSG | basigin (Ok blood group) | 0.00670459 |
| AVPI1 | arginine vasopressin-induced 1 | 0.00669842 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.00667684 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | 0.00667559 |
| G6PD | glucose-6-phosphate dehydrogenase | 0.00666665 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.00665478 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.00665451 |
| RPS5 | ribosomal protein S5 | 0.00663528 |
| EGR3 | early growth response 3 | 0.00663207 |
| S100A7 | S100 calcium binding protein A7 | 0.00662463 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.00660031 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.00660007 |
| COL7A1 | collagen, type VII, alpha 1 | 0.00658338 |
| INSM1 | insulinoma-associated 1 | 0.00658149 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00657119 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.00655939 |
| PLD3 | phospholipase D family, member 3 | 0.0065429 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.00652004 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00651572 |
| CRCT1 | cysteine-rich C-terminal 1 | 0.00645314 |
| RBPMS | RNA binding protein with multiple splicing | 0.00643197 |
| LY6G6C | lymphocyte antigen 6 complex, locus G6C | 0.00643013 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.00642729 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.00641604 |
| AMDHD2 | amidohydrolase domain containing 2 | 0.00638112 |
| DVL1 | dishevelled segment polarity protein 1 | 0.00636968 |
| CST7 | cystatin F (leukocystatin) | 0.00634532 |
| CD82 | CD82 molecule | 0.00631228 |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | 0.00630492 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | 0.00629819 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.00628971 |
| SIRT1 | sirtuin 1 | 0.0062878 |
| MAPK6 | mitogen-activated protein kinase 6 | 0.00624644 |
| HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | 0.00623734 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.00623406 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | 0.00623317 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00620408 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.0062031 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00619732 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | 0.0061873 |
| IRF8 | interferon regulatory factor 8 | 0.0061683 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 0.00615596 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.0061502 |
| XCL1 | chemokine (C motif) ligand 1 | 0.006135 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00613447 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.00613161 |
| PRSS8 | protease, serine, 8 | 0.00611876 |
| RTL8C | retrotransposon Gag like 8C | 0.00610517 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00609648 |
| MEST | mesoderm specific transcript | 0.00609272 |
| IDS | iduronate 2-sulfatase | 0.00609113 |
| ORC1 | origin recognition complex, subunit 1 | 0.00608576 |
| CD22 | CD22 molecule | 0.00608346 |
| APOD | apolipoprotein D | 0.00607592 |
| CTSA | cathepsin A | 0.00606675 |
| NPR3 | natriuretic peptide receptor 3 | 0.00604859 |
| SHROOM2 | shroom family member 2 | 0.00604817 |
| EZR | ezrin | 0.00604242 |
| EXT1 | exostosin glycosyltransferase 1 | 0.00603557 |
| ACTN4 | actinin, alpha 4 | 0.00602038 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.00601977 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 0.00600586 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.00600382 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0059934 |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | 0.00598964 |
| CCN3 | cellular communication network factor 3 | 0.00594912 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.00594585 |
| SST | somatostatin | 0.00594281 |
| PHTF2 | putative homeodomain transcription factor 2 | 0.00594146 |
| AP1M2 | adaptor-related protein complex 1, mu 2 subunit | 0.00593232 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00592239 |
| ELOVL4 | ELOVL fatty acid elongase 4 | 0.00591721 |
| IL18 | interleukin 18 | 0.0059112 |
| OSR2 | odd-skipped related transciption factor 2 | 0.00587103 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | 0.00586538 |
| CGA | glycoprotein hormones, alpha polypeptide | 0.00586399 |
| IFI44L | interferon-induced protein 44-like | 0.00586356 |
| PRKCZ | protein kinase C, zeta | 0.00584755 |
| TES | testin LIM domain protein | 0.00583006 |
| SIK1 | salt-inducible kinase 1 | 0.00582832 |
| PENK | proenkephalin | 0.00577428 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.00577128 |
| PMP22 | peripheral myelin protein 22 | 0.00575868 |
| ACP3 | acid phosphatase 3 | 0.00575211 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.00573486 |
| NKG7 | natural killer cell granule protein 7 | 0.00572595 |
| GCG | glucagon | 0.00572543 |
| FZD5 | frizzled class receptor 5 | 0.0057103 |
| ACOT7 | acyl-CoA thioesterase 7 | 0.00570038 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00569688 |
| ESRP2 | epithelial splicing regulatory protein 2 | 0.00568938 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.00568686 |
| AKAP8L | A kinase (PRKA) anchor protein 8-like | 0.00568442 |
| TP63 | tumor protein p63 | 0.00568189 |
| CIT | citron rho-interacting serine/threonine kinase | 0.00567571 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.00566768 |
| DDI2 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) | 0.00566228 |
| ENO1 | enolase 1, (alpha) | 0.00565791 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.00565697 |
| IER2 | immediate early response 2 | 0.00564723 |
| GLS | glutaminase | 0.00564423 |
| TSPAN9 | tetraspanin 9 | 0.00564305 |
| MORC2 | MORC family CW-type zinc finger 2 | 0.00563757 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00563036 |
| DGS2 | DiGeorge syndrome/velocardiofacial syndrome complex 2 | 0.00562794 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00560602 |
| LMNA | lamin A/C | 0.00560133 |
| EBI3 | Epstein-Barr virus induced 3 | 0.00559174 |
| IER5 | immediate early response 5 | 0.00558299 |
| INHBB | inhibin, beta B | 0.00556814 |
| SLC16A6 | solute carrier family 16, member 6 | 0.00556694 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00556281 |
| CD8A | CD8a molecule | 0.00555494 |
| ACO2 | aconitase 2, mitochondrial | 0.00549798 |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.00549291 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00549207 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00548453 |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | 0.00548179 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.00548048 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 | 0.00547058 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.00545667 |
| CLEC3B | C-type lectin domain family 3, member B | 0.00544939 |
| HAUS3 | HAUS augmin-like complex, subunit 3 | 0.00544628 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.00543275 |
| JMJD6 | jumonji domain containing 6 | 0.00542985 |
| RAPSN | receptor-associated protein of the synapse | 0.00542828 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | 0.00541629 |
| CTSH | cathepsin H | 0.00539665 |
| TTC39A | tetratricopeptide repeat domain 39A | 0.00538097 |
| ATG4B | autophagy related 4B, cysteine peptidase | 0.00536999 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.00536785 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00536569 |
| KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 | 0.00535908 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CFI | complement factor I | -0.0203854 |
| ANXA1 | annexin A1 | -0.0196616 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.016251 |
| MGP | matrix Gla protein | -0.0151729 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.0145987 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.014345 |
| NRN1 | neuritin 1 | -0.0137833 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.0134973 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.0128731 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0125175 |
| GLUL | glutamate-ammonia ligase | -0.0123409 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0123269 |
| LYZ | lysozyme | -0.0122518 |
| ADD3 | adducin 3 (gamma) | -0.0121777 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.0120859 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0120573 |
| VCAN | versican | -0.0116863 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0111437 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0109084 |
| LXN | latexin | -0.0108058 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0107621 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -0.0107618 |
| RGS4 | regulator of G-protein signaling 4 | -0.0107533 |
| FHL1 | four and a half LIM domains 1 | -0.0107062 |
| SPRR3 | small proline-rich protein 3 | -0.0106714 |
| CTSZ | cathepsin Z | -0.0105858 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.0104327 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.0103371 |
| METTL7A | methyltransferase like 7A | -0.010327 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0102154 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0101776 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | -0.0100827 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00988564 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00984643 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.00983114 |
| TSPAN8 | tetraspanin 8 | -0.00980748 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.00956667 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00942475 |
| AEBP1 | AE binding protein 1 | -0.00935456 |
| RCAN1 | regulator of calcineurin 1 | -0.00935153 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00931711 |
| MBD2 | methyl-CpG binding domain protein 2 | -0.00928799 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.00922706 |
| ELOVL2 | ELOVL fatty acid elongase 2 | -0.00920679 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.00916662 |
| NID2 | nidogen 2 (osteonidogen) | -0.00914862 |
| OPHN1 | oligophrenin 1 | -0.0090654 |
| IFRD2 | interferon-related developmental regulator 2 | -0.00899611 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00899095 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.00897455 |
| MECOM | MDS1 and EVI1 complex locus | -0.00893419 |
| PCDH9 | protocadherin 9 | -0.0088138 |
| PRKCA | protein kinase C, alpha | -0.00880382 |
| SORD | sorbitol dehydrogenase | -0.0087511 |
| FPR1 | formyl peptide receptor 1 | -0.00868852 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00862674 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00862471 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00858091 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00857817 |
| BEX1 | brain expressed, X-linked 1 | -0.00855224 |
| DOK5 | docking protein 5 | -0.00853555 |
| DUOX2 | dual oxidase 2 | -0.00852155 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.00845076 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00842008 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -0.00832867 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00832065 |
| TFF1 | trefoil factor 1 | -0.00832 |
| FKBP5 | FK506 binding protein 5 | -0.00830764 |
| GAP43 | growth associated protein 43 | -0.00825334 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00817746 |
| RGS10 | regulator of G-protein signaling 10 | -0.00812233 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | -0.00810653 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | -0.0080217 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.0079962 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.00792733 |
| TFDP1 | transcription factor Dp-1 | -0.00788719 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00788483 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | -0.00786856 |
| CNTN1 | contactin 1 | -0.00786225 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00785108 |
| PLSCR4 | phospholipid scramblase 4 | -0.00782634 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.00782349 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | -0.00780209 |
| PMP2 | peripheral myelin protein 2 | -0.007802 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00779369 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0077758 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.00776814 |
| CD93 | CD93 molecule | -0.00776628 |
| TLR4 | toll-like receptor 4 | -0.00771503 |
| CLIC5 | chloride intracellular channel 5 | -0.00768122 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.00767158 |
| REG1A | regenerating islet-derived 1 alpha | -0.00763249 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00761702 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00761619 |
| GPX2 | glutathione peroxidase 2 | -0.00753739 |
| LEPROT | leptin receptor overlapping transcript | -0.00753551 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00751913 |
| SMAGP | small cell adhesion glycoprotein | -0.00751765 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.00749239 |
| C3 | complement component 3 | -0.00748422 |
| PLSCR1 | phospholipid scramblase 1 | -0.0074369 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.00743634 |
| BGN | biglycan | -0.00742615 |
| LCN2 | lipocalin 2 | -0.00741187 |
| TRIM22 | tripartite motif containing 22 | -0.00740638 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.00740445 |
| PLN | phospholamban | -0.0073892 |
| FAM171A1 | family with sequence similarity 171, member A1 | -0.007317 |
| BMP7 | bone morphogenetic protein 7 | -0.00731334 |
| THBS2 | thrombospondin 2 | -0.00730062 |
| CFB | complement factor B | -0.00729824 |
| DPEP1 | dipeptidase 1 (renal) | -0.00729403 |
| SLC16A4 | solute carrier family 16, member 4 | -0.007262 |
| MERTK | MER proto-oncogene, tyrosine kinase | -0.00724 |
| GCA | grancalcin, EF-hand calcium binding protein | -0.00723611 |
| DYNC1I1 | dynein, cytoplasmic 1, intermediate chain 1 | -0.00723079 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00722953 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.00722778 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.00721989 |
| NLGN4X | neuroligin 4, X-linked | -0.00717588 |
| ACYP2 | acylphosphatase 2, muscle type | -0.00716465 |
| FYB1 | FYN binding protein 1 | -0.00714394 |
| CHPT1 | choline phosphotransferase 1 | -0.00713889 |
| FLI1 | Fli-1 proto-oncogene, ETS transcription factor | -0.00713783 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | -0.00713658 |
| LTF | lactotransferrin | -0.00713313 |
| MFAP5 | microfibrillar associated protein 5 | -0.00712786 |
| CCN2 | cellular communication network factor 2 | -0.00711849 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.00706689 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.00704789 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | -0.00704074 |
| PLLP | plasmolipin | -0.00703078 |
| EVI2A | ecotropic viral integration site 2A | -0.00701946 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.00700556 |
| CLINT1 | clathrin interactor 1 | -0.00699098 |
| PF4 | platelet factor 4 | -0.00694906 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.00693459 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.00690173 |
| ASRGL1 | asparaginase like 1 | -0.00689861 |
| FAM169A | family with sequence similarity 169, member A | -0.00689241 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.00687871 |
| EMP1 | epithelial membrane protein 1 | -0.0068361 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00683443 |
| ITGA6 | integrin, alpha 6 | -0.00680927 |
| FCGBP | Fc fragment of IgG binding protein | -0.00679991 |
| CDC42SE1 | CDC42 small effector 1 | -0.00679297 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | -0.00679067 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00678872 |
| EIF6 | eukaryotic translation initiation factor 6 | -0.00677712 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00677205 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0067598 |
| SSBP1 | single-stranded DNA binding protein 1, mitochondrial | -0.00675525 |
| CTSB | cathepsin B | -0.00670699 |
| GIMAP6 | GTPase, IMAP family member 6 | -0.00670222 |
| SLA | Src-like-adaptor | -0.00670199 |
| SERINC5 | serine incorporator 5 | -0.00667408 |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | -0.0066655 |
| CSPG5 | chondroitin sulfate proteoglycan 5 (neuroglycan C) | -0.00664762 |
| CYRIA | CYFIP related Rac1 interactor A | -0.00663387 |
| CLDN10 | claudin 10 | -0.00662392 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | -0.00662188 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | -0.00660247 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -0.0065816 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00656193 |
| LAPTM5 | lysosomal protein transmembrane 5 | -0.00656094 |
| IL6ST | interleukin 6 signal transducer | -0.00655804 |
| KIAA0226L | KIAA0226-like | -0.00655141 |
| MSR1 | macrophage scavenger receptor 1 | -0.00653374 |
| FZD6 | frizzled class receptor 6 | -0.00651914 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00651656 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0064894 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.0064866 |
| CD302 | CD302 molecule | -0.00648475 |
| ABAT | 4-aminobutyrate aminotransferase | -0.00648211 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00647745 |
| CTSS | cathepsin S | -0.00646426 |
| SULF1 | sulfatase 1 | -0.00646223 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00645002 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.00644843 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0064264 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00642479 |
| CCNG1 | cyclin G1 | -0.0063597 |
| COQ8A | coenzyme Q8A | -0.00635043 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00633897 |
| TMEM100 | transmembrane protein 100 | -0.00632828 |
| DNTT | DNA nucleotidylexotransferase | -0.006324 |
| ARMT1 | acidic residue methyltransferase 1 | -0.00631304 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00631143 |
| LIPG | lipase, endothelial | -0.00629743 |
| NUDT11 | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | -0.00628498 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.00627179 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.00627031 |
| GRIA1 | glutamate receptor, ionotropic, AMPA 1 | -0.00625687 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | -0.00625647 |
| S100B | S100 calcium binding protein B | -0.00625013 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.00624197 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.00621799 |
| SYBU | syntabulin (syntaxin-interacting) | -0.0062086 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.00619711 |
| BRD2 | bromodomain containing 2 | -0.0061867 |
| IL33 | interleukin 33 | -0.00618319 |
| GSTK1 | glutathione S-transferase kappa 1 | -0.00615607 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.00613975 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | -0.0061311 |
| CEL | carboxyl ester lipase | -0.00612297 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.00611634 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.00610597 |
| C7 | complement component 7 | -0.00607794 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.00607633 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.00606414 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.00606195 |
| S1PR1 | sphingosine-1-phosphate receptor 1 | -0.00606039 |
| ALB | albumin | -0.00605184 |
| G0S2 | G0/G1 switch 2 | -0.00604367 |
| S100A8 | S100 calcium binding protein A8 | -0.00603053 |
| MAL | mal, T-cell differentiation protein | -0.00602742 |
| MRPL22 | mitochondrial ribosomal protein L22 | -0.00602129 |
| MT1H | metallothionein 1H | -0.00601894 |
| MEG3 | maternally expressed 3 (non-protein coding) | -0.00600721 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.00600428 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00600312 |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | -0.0059832 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | -0.00598017 |
| TADA2A | transcriptional adaptor 2A | -0.00597149 |
| LAMB1 | laminin, beta 1 | -0.00595644 |
| MRFAP1L1 | Morf4 family associated protein 1-like 1 | -0.00594542 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.00594365 |
| ADAM28 | ADAM metallopeptidase domain 28 | -0.00593089 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.00592224 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | -0.00590456 |
| CES1 | carboxylesterase 1 | -0.00589897 |
| AK4 | adenylate kinase 4 | -0.00589578 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00587756 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.00587638 |
| RGS5 | regulator of G-protein signaling 5 | -0.00586773 |
| MXRA5 | matrix-remodelling associated 5 | -0.00586487 |
| NAP1L3 | nucleosome assembly protein 1-like 3 | -0.00585448 |
| FHIT | fragile histidine triad | -0.0058511 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00585055 |
| PTDSS1 | phosphatidylserine synthase 1 | -0.00584142 |
| H1-10 | H1.10 linker histone | -0.0058358 |
| EPS8L3 | EPS8-like 3 | -0.00582739 |
| AGPS | alkylglycerone phosphate synthase | -0.00582472 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.00582228 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00582207 |
| GPC3 | glypican 3 | -0.00582051 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.00581015 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.00580901 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00580833 |
| PRRX1 | paired related homeobox 1 | -0.00580699 |
