SMAD6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SMAD family member 6|The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 4091)
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Genes

311 genes differentially expressed following the SMAD6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.76627
OPRL1 opiate receptor-like 1 2.76627
CFAP119 cilia and flagella associated protein 119 2.76627
ALLC allantoicase 2.76627
CSMD3 CUB and Sushi multiple domains 3 2.76627
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.76627
ZNF560 zinc finger protein 560 2.76627
SH2D7 SH2 domain containing 7 2.76627
PXT1 peroxisomal, testis specific 1 2.76627
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.76627
TAPBPL TAP binding protein-like 2.76627
PCDHGC3 protocadherin gamma subfamily C, 3 2.76627
MUC13 mucin 13, cell surface associated 2.76627
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.76627
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.76627
MMP20 matrix metallopeptidase 20 2.76627
C10ORF105 chromosome 10 open reading frame 105 2.76627
TMPRSS11F transmembrane protease, serine 11F 2.76627
MSMP microseminoprotein, prostate associated 2.76627
ZNF804B zinc finger protein 804B 2.76627
TDRD9 tudor domain containing 9 2.76627
ART1 ADP-ribosyltransferase 1 2.76627
COL19A1 collagen, type XIX, alpha 1 2.76627
SRL sarcalumenin 2.74283
NKAPL NFKB activating protein-like 2.74283
WDR87 WD repeat domain 87 2.74283
GPR75 G protein-coupled receptor 75 2.74283
USP26 ubiquitin specific peptidase 26 2.74283
CEMP1 cementum protein 1 2.74283
FOXQ1 forkhead box Q1 2.74283
PRR18 proline rich 18 2.74283
MAP3K7CL MAP3K7 C-terminal like 2.74283
CPLX3 complexin 3 2.74283
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.74283
VWA5B2 von Willebrand factor A domain containing 5B2 2.74283
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.74283
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.74283
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.74283
PEX26 peroxisomal biogenesis factor 26 2.74283
OR51T1 olfactory receptor, family 51, subfamily T, member 1 2.74283
CD68 CD68 molecule 2.74283
OR51L1 olfactory receptor, family 51, subfamily L, member 1 2.74283
TPSD1 tryptase delta 1 2.74283
SFTPD surfactant protein D 2.74283
GPR21 G protein-coupled receptor 21 2.74283
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.74283
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.74283
SCGB3A1 secretoglobin, family 3A, member 1 2.74283
PLIN1 perilipin 1 2.74283
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.74283
FBXL8 F-box and leucine-rich repeat protein 8 2.74283
ANKH ANKH inorganic pyrophosphate transport regulator 2.74283
KLHL34 kelch-like family member 34 2.74283
SPMIP9 sperm microtubule inner protein 9 2.74283
ELOA2 elongin A2 2.74283
DYNLT4 dynein light chain Tctex-type 4 2.74283
CCDC190 coiled-coil domain containing 190 2.74283
RTL5 retrotransposon Gag like 5 2.74283
CALHM5 calcium homeostasis modulator family member 5 2.74283
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.74283
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.74283
KRT80 keratin 80, type II 2.74283
TMEM270 transmembrane protein 270 2.74283
SMIM31 small integral membrane protein 31 2.74283
CIMIP2A ciliary microtubule inner protein 2A 2.74283
LY6S lymphocyte antigen 6 family member S 2.74283
ERLN endoregulin 2.74283
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.74283
LRRC8C-DT LRRC8C divergent transcript 2.74283
NOTCH2NLB notch 2 N-terminal like B 2.74283
DEFB109B defensin beta 109B 2.74283
TMEM238L transmembrane protein 238 like 2.74283
RDH8 retinol dehydrogenase 8 (all-trans) 2.74283
GC group-specific component (vitamin D binding protein) 2.74283
DOK2 docking protein 2, 56kDa 2.74283
DAO D-amino-acid oxidase 2.74283
DSG1 desmoglein 1 2.74283
IRF5 interferon regulatory factor 5 2.74283
IZUMO4 IZUMO family member 4 2.74283
LOC390937 Ets2 repressor factor-like 2.74283
SPATA31F3 SPATA31 subfamily F member 3 2.74283
TBX21 T-box 21 2.74283
MCEMP1 mast cell-expressed membrane protein 1 2.74283
CBLN2 cerebellin 2 precursor 2.74283
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.74283
RNF183 ring finger protein 183 2.74283
LRRN4CL LRRN4 C-terminal like 2.74283
IL16 interleukin 16 2.74283
GDF9 growth differentiation factor 9 2.74283
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.74283
CCR4 chemokine (C-C motif) receptor 4 2.74283
GJD4 gap junction protein, delta 4, 40.1kDa 2.74283
PGC progastricsin (pepsinogen C) 2.74283
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.74283
NOX1 NADPH oxidase 1 2.74283
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.74283
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.74283
MAMLD1 mastermind-like domain containing 1 2.74283
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.74283
PCDHGA2 protocadherin gamma subfamily A, 2 2.74283
FOXE3 forkhead box E3 2.74283
COMP cartilage oligomeric matrix protein 2.74283
HELT helt bHLH transcription factor 2.74283
CPA2 carboxypeptidase A2 (pancreatic) 2.74283
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.74283
C11ORF16 chromosome 11 open reading frame 16 2.74283
STAB1 stabilin 1 2.74283
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.74283
GAB4 GRB2-associated binding protein family, member 4 2.74283
C20ORF173 chromosome 20 open reading frame 173 2.74283
HCRT hypocretin (orexin) neuropeptide precursor 2.74283
AQP7 aquaporin 7 2.74283
DCN decorin 2.74283
SMIM23 small integral membrane protein 23 2.74283
SLC22A24 solute carrier family 22, member 24 2.74283
SAMD9 sterile alpha motif domain containing 9 2.74283
TBX1 T-box 1 2.74283
ORM2 orosomucoid 2 2.74283
LDLRAD2 low density lipoprotein receptor class A domain containing 2 2.74283
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.74283
TM4SF19 transmembrane 4 L six family member 19 2.74283
FKBP1C FK506 binding protein 1C 2.74283
CNGB1 cyclic nucleotide gated channel beta 1 2.74283
EVI2A ecotropic viral integration site 2A 2.74283
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.74283
MOBP myelin-associated oligodendrocyte basic protein 2.74283
CD27 CD27 molecule 2.74283
SLC38A3 solute carrier family 38, member 3 2.74283
PRR35 proline rich 35 2.74283
TF transferrin 2.74283
RETN resistin 2.74283
CRHBP corticotropin releasing hormone binding protein 2.74283
GPR65 G protein-coupled receptor 65 2.74283
CTSF cathepsin F 2.74283
NOBOX NOBOX oogenesis homeobox 2.74283
PGR progesterone receptor 2.74283
CFH complement factor H 2.74283
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.74283
MROH2A maestro heat-like repeat family member 2A 2.74283
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.74283
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.74283
MMP10 matrix metallopeptidase 10 2.74283
LRRC74A leucine rich repeat containing 74A 2.74283
SEC31A SEC31 homolog A (S. cerevisiae) 2.74283
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.74283
ADAM29 ADAM metallopeptidase domain 29 2.74283
IFITM10 interferon induced transmembrane protein 10 2.74283
TAS2R46 taste receptor, type 2, member 46 2.74283
MMEL1 membrane metallo-endopeptidase-like 1 2.74283
TMPRSS13 transmembrane protease, serine 13 2.74283
ST18 suppression of tumorigenicity 18, zinc finger 2.74283
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 2.74283
AMER2 APC membrane recruitment protein 2 2.74283
KRT17 keratin 17, type I 2.74283
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.74283
NBPF4 neuroblastoma breakpoint family, member 4 2.74283
NEUROD2 neuronal differentiation 2 2.74283
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.74283
SDSL serine dehydratase-like 2.74283
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.74283
ZNF775 zinc finger protein 775 2.67559
GSDMA gasdermin A 2.6468
GPRASP2 G protein-coupled receptor associated sorting protein 2 2.64387
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.63876
TRIM59 tripartite motif containing 59 2.58926
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.58019
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 2.52215
PLAAT4 phospholipase A and acyltransferase 4 2.51526
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 2.47824
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 2.43824
GUCD1 guanylyl cyclase domain containing 1 2.43051
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.41158
TBCB tubulin folding cofactor B 2.40033
USP51 ubiquitin specific peptidase 51 2.39687
DEPDC7 DEP domain containing 7 2.39511
MSRB3 methionine sulfoxide reductase B3 2.39063
KLF7 Kruppel-like factor 7 (ubiquitous) 2.38981
E2F8 E2F transcription factor 8 2.37499
ANKRD13D ankyrin repeat domain 13 family, member D 2.36614
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.36566
SBNO1 strawberry notch homolog 1 (Drosophila) 2.33977
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 2.32704
PROCA1 protein interacting with cyclin A1 2.31482
LRRC37A leucine rich repeat containing 37A 2.283
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.25886
HIP1 huntingtin interacting protein 1 2.20644
SSH1 slingshot protein phosphatase 1 2.20398
SPDYE3 speedy/RINGO cell cycle regulator family member E3 2.20083
RBM15 RNA binding motif protein 15 2.19823
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.19366
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 2.13093
CBY1 chibby homolog 1 (Drosophila) 2.12824
FRMD5 FERM domain containing 5 2.12585
CADPS Ca++-dependent secretion activator 2.11913
ITPRID2 ITPR interacting domain containing 2 2.10465
MRPL33 mitochondrial ribosomal protein L33 2.10457
FKRP fukutin related protein 2.09316
FLRT3 fibronectin leucine rich transmembrane protein 3 2.08854
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 2.07986
MORN3 MORN repeat containing 3 2.06708
FRYL FRY-like 2.06451
CSK c-src tyrosine kinase 2.06253
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.05671
SIGMAR1 sigma non-opioid intracellular receptor 1 2.03984
XKR9 XK, Kell blood group complex subunit-related family, member 9 2.01664
MDFI MyoD family inhibitor 2.01202
CENPN centromere protein N 2.01082
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.00444

decreased expression

Symbol Name Standardized Value
SHD Src homology 2 domain containing transforming protein D -2.76627
EDA ectodysplasin A -2.76627
NKD2 naked cuticle homolog 2 (Drosophila) -2.76627
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.74283
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.74283
TPPP tubulin polymerization promoting protein -2.74283
PCDHGA12 protocadherin gamma subfamily A, 12 -2.74283
SPRR2F small proline-rich protein 2F -2.74283
IL17B interleukin 17B -2.74283
ANPEP alanyl (membrane) aminopeptidase -2.74283
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) -2.74283
SNTN sentan, cilia apical structure protein -2.74283
NAT16 N-acetyltransferase 16 (GCN5-related, putative) -2.74283
CHAD chondroadherin -2.74283
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -2.74283
CLPSL1 colipase-like 1 -2.74283
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.74283
SPHK1 sphingosine kinase 1 -2.74283
FAM3D family with sequence similarity 3, member D -2.74283
LDHAL6A lactate dehydrogenase A-like 6A -2.74283
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 -2.74283
ZNF492 zinc finger protein 492 -2.74283
HPCAL4 hippocalcin like 4 -2.74283
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.74283
OVOL1 ovo-like zinc finger 1 -2.74283
TMEM196 transmembrane protein 196 -2.74283
TUBB1 tubulin, beta 1 class VI -2.74283
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 -2.74283
C19ORF38 chromosome 19 open reading frame 38 -2.74283
SENP5 SUMO1/sentrin specific peptidase 5 -2.74283
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.74283
DEFB134 defensin, beta 134 -2.74283
UNC93A unc-93 homolog A (C. elegans) -2.74283
POTEI POTE ankyrin domain family, member I -2.74283
S100A14 S100 calcium binding protein A14 -2.74283
CRYBB3 crystallin, beta B3 -2.74283
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.74283
NRIP2 nuclear receptor interacting protein 2 -2.74283
KIF3A kinesin family member 3A -2.74283
H2BC14 H2B clustered histone 14 -2.74283
KLK7 kallikrein-related peptidase 7 -2.74283
CTSO cathepsin O -2.74283
GLB1L3 galactosidase, beta 1-like 3 -2.74283
NTN5 netrin 5 -2.74283
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.74283
NLRC3 NLR family, CARD domain containing 3 -2.74283
NMBR neuromedin B receptor -2.74283
CCDC83 coiled-coil domain containing 83 -2.74283
SLC7A4 solute carrier family 7, member 4 -2.74283
CARD6 caspase recruitment domain family, member 6 -2.74283
ODAD1 outer dynein arm docking complex subunit 1 -2.74283
NGF nerve growth factor (beta polypeptide) -2.74283
CTSS cathepsin S -2.74283
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -2.74283
FNDC8 fibronectin type III domain containing 8 -2.74283
MEIS1 Meis homeobox 1 -2.74283
TIMP3 TIMP metallopeptidase inhibitor 3 -2.65507
INTS6 integrator complex subunit 6 -2.60778
ANO1 anoctamin 1, calcium activated chloride channel -2.59844
SOX15 SRY (sex determining region Y)-box 15 -2.59844
GSDME gasdermin E -2.58926
RTL8C retrotransposon Gag like 8C -2.5615
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.52334
YPEL1 yippee-like 1 (Drosophila) -2.45107
CCDC85A coiled-coil domain containing 85A -2.41559
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.39554
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.38714
GLP1R glucagon-like peptide 1 receptor -2.35669
HSF2 heat shock transcription factor 2 -2.3559
GGT1 gamma-glutamyltransferase 1 -2.34457
GNMT glycine N-methyltransferase -2.33977
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.33659
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.26157
KLHL13 kelch-like family member 13 -2.23649
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -2.21222
TP53TG5 TP53 target 5 -2.20644
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -2.20165
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.20145
INTS7 integrator complex subunit 7 -2.19823
ZBTB12 zinc finger and BTB domain containing 12 -2.19366
TMEM108 transmembrane protein 108 -2.17621
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.16903
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -2.1602
SPAG4 sperm associated antigen 4 -2.15094
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -2.15074
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -2.14894
PEDS1 plasmanylethanolamine desaturase 1 -2.12808
MYO18A myosin XVIIIA -2.1275
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.1275
TYW5 tRNA-yW synthesizing protein 5 -2.12129
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.11913
DYNLT2 dynein light chain Tctex-type 2 -2.11072
IPO9 importin 9 -2.10308
ASIP agouti signaling protein -2.09922
R3HCC1 R3H domain and coiled-coil containing 1 -2.09647
ACAD9 acyl-CoA dehydrogenase family, member 9 -2.06008
MRPL14 mitochondrial ribosomal protein L14 -2.04325
H2BC5 H2B clustered histone 5 -2.04191
GNB5 guanine nucleotide binding protein (G protein), beta 5 -2.03987
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 -2.03987
PCNP PEST proteolytic signal containing nuclear protein -2.01608
DEDD2 death effector domain containing 2 -2.01082
TONSL tonsoku-like, DNA repair protein -2.00444