SMAD6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description SMAD family member 6|The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 4091)
External Link http://www.ncbi.nlm.nih.gov/gene/4091
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230 interacting proteins for SMAD6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR2B activin A receptor, type IIB
ACVRL1 activin A receptor type II-like 1
AGO1 argonaute RISC catalytic component 1
AGO3 argonaute RISC catalytic component 3
ALYREF Aly/REF export factor
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARNT aryl hydrocarbon receptor nuclear translocator
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
BCLAF1 BCL2-associated transcription factor 1
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPIFA1 BPI fold containing family A, member 1
BYSL bystin-like
C14ORF166 chromosome 14 open reading frame 166
C1QBP complement component 1, q subcomponent binding protein
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CUL2 cullin 2
DAP3 death associated protein 3
DDA1 DET1 and DDB1 associated 1
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DYNLL1 dynein, light chain, LC8-type 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3CL eukaryotic translation initiation factor 3, subunit C-like
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3
ELAVL1 ELAV like RNA binding protein 1
ENG endoglin
ERH enhancer of rudimentary homolog (Drosophila)
EWSR1 EWS RNA-binding protein 1
FAF1 Fas (TNFRSF6) associated factor 1
FAM151B family with sequence similarity 151, member B
FKBP1A FK506 binding protein 1A, 12kDa
FNTA farnesyltransferase, CAAX box, alpha
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPC4 glypican 4
GTF2I general transcription factor IIi
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
H2AFJ H2A histone family, member J
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HBA2 hemoglobin, alpha 2
HIST1H1C histone cluster 1, H1c
HIST1H1D histone cluster 1, H1d
HIST1H2BN histone cluster 1, H2bn
HIST1H4F histone cluster 1, H4f
HIST2H2BE histone cluster 2, H2be
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXC8 homeobox C8
HSPA1B heat shock 70kDa protein 1B
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ITCH itchy E3 ubiquitin protein ligase
KDM1A lysine (K)-specific demethylase 1A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LYZ lysozyme
MAMDC2 MAM domain containing 2
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK6 mitogen-activated protein kinase 6
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRPS22 mitochondrial ribosomal protein S22
MRPS23 mitochondrial ribosomal protein S23
MRPS28 mitochondrial ribosomal protein S28
MRPS35 mitochondrial ribosomal protein S35
MYD88 myeloid differentiation primary response 88
MYH10 myosin, heavy chain 10, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NAP1L1 nucleosome assembly protein 1-like 1
NASP nuclear autoantigenic sperm protein (histone-binding)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO2 NAD(P)H dehydrogenase, quinone 2
OBSL1 obscurin-like 1
PABPC1 poly(A) binding protein, cytoplasmic 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIAS4 protein inhibitor of activated STAT, 4
PIGR polymeric immunoglobulin receptor
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRKX protein kinase, X-linked
PRPF19 pre-mRNA processing factor 19
PRPF8 pre-mRNA processing factor 8
RNF111 ring finger protein 111
RNF165 ring finger protein 165
RPL10 ribosomal protein L10
RPL10A ribosomal protein L10a
RPL11 ribosomal protein L11
RPL14 ribosomal protein L14
RPL18 ribosomal protein L18
RPL18A ribosomal protein L18a
RPL22 ribosomal protein L22
RPL23 ribosomal protein L23
RPL23A ribosomal protein L23a
RPL24 ribosomal protein L24
RPL27 ribosomal protein L27
RPL27A ribosomal protein L27a
RPL28 ribosomal protein L28
RPL29 ribosomal protein L29
RPL30 ribosomal protein L30
RPL31 ribosomal protein L31
RPL32 ribosomal protein L32
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPL8 ribosomal protein L8
RPLP0 ribosomal protein, large, P0
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS12 ribosomal protein S12
RPS13 ribosomal protein S13
RPS14 ribosomal protein S14
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS19 ribosomal protein S19
RPS2 ribosomal protein S2
RPS20 ribosomal protein S20
RPS23 ribosomal protein S23
RPS25 ribosomal protein S25
RPS27A ribosomal protein S27a
RPS27L ribosomal protein S27-like
RPS3 ribosomal protein S3
RPS4X ribosomal protein S4, X-linked
RPS5 ribosomal protein S5
RPS6 ribosomal protein S6
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS8 ribosomal protein S8
RPS9 ribosomal protein S9
RPSA ribosomal protein SA
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
RUNX2 runt-related transcription factor 2
S100A8 S100 calcium binding protein A8
SART3 squamous cell carcinoma antigen recognized by T cells 3
SERBP1 SERPINE1 mRNA binding protein 1
SET SET nuclear proto-oncogene
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
STAMBP STAM binding protein
STRAP serine/threonine kinase receptor associated protein
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TCEAL1 transcription elongation factor A (SII)-like 1
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRAP3 thyroid hormone receptor associated protein 3
TICAM2 toll-like receptor adaptor molecule 2
TMED1 transmembrane emp24 protein transport domain containing 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TMED7 transmembrane emp24 protein transport domain containing 7
TMED9 transmembrane emp24 protein transport domain containing 9
TNRC6B trinucleotide repeat containing 6B
TOB1 transducer of ERBB2, 1
TRIM11 tripartite motif containing 11
TSC22D1 TSC22 domain family, member 1
TSLIG3A tRNA splicing ligase complex subunit 3A
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TTC37 tetratricopeptide repeat domain 37
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2O ubiquitin-conjugating enzyme E2O
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USP11 ubiquitin specific peptidase 11
USP15 ubiquitin specific peptidase 15
USP34 ubiquitin specific peptidase 34
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP9X ubiquitin specific peptidase 9, X-linked
VPRBP Vpr (HIV-1) binding protein
WDR5 WD repeat domain 5
WDR61 WD repeat domain 61
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YAP1 Yes-associated protein 1
YBEY ybeY metallopeptidase (putative)
YBX1 Y box binding protein 1
YBX3 Y box binding protein 3
ZEB1 zinc finger E-box binding homeobox 1
ZRANB2 zinc finger, RAN-binding domain containing 2