SMAD7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SMAD family member 7|The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 4092)
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Genes

334 genes differentially expressed following the SMAD7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.33468
WDR93 WD repeat domain 93 2.33468
TRAF1 TNF receptor-associated factor 1 2.33468
SLFN12L schlafen family member 12-like 2.33468
SLC25A41 solute carrier family 25, member 41 2.33468
ERICH6B glutamate-rich 6B 2.33468
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.33468
ACER1 alkaline ceramidase 1 2.33468
C9ORF43 chromosome 9 open reading frame 43 2.33468
TRAF3IP3 TRAF3 interacting protein 3 2.33468
CELF6 CUGBP, Elav-like family member 6 2.33468
AMN amnion associated transmembrane protein 2.33468
CCNI2 cyclin I family, member 2 2.33468
SCN2B sodium channel, voltage gated, type II beta subunit 2.33468
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.33468
LHCGR luteinizing hormone/choriogonadotropin receptor 2.33468
PCDHGB2 protocadherin gamma subfamily B, 2 2.33468
ETV2 ets variant 2 2.33468
LYG2 lysozyme G-like 2 2.33468
MT1E metallothionein 1E 2.33468
TMEM71 transmembrane protein 71 2.33468
MSMP microseminoprotein, prostate associated 2.33468
ESR1 estrogen receptor 1 2.33468
C10ORF67 chromosome 10 open reading frame 67 2.33468
HELQ helicase, POLQ-like 2.33399
TMEM176B transmembrane protein 176B 2.31057
PRELP proline/arginine-rich end leucine-rich repeat protein 2.31057
AKR1C4 aldo-keto reductase family 1, member C4 2.31057
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.31057
SEC23IP SEC23 interacting protein 2.31057
FUCA1 fucosidase, alpha-L- 1, tissue 2.31057
IGFL4 IGF-like family member 4 2.31057
ALOX15 arachidonate 15-lipoxygenase 2.31057
WDR87 WD repeat domain 87 2.31057
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.31057
CDH5 cadherin 5, type 2 (vascular endothelium) 2.31057
LRRD1 leucine-rich repeats and death domain containing 1 2.31057
TRIM15 tripartite motif containing 15 2.31057
PDIA2 protein disulfide isomerase family A, member 2 2.31057
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.31057
RAPSN receptor-associated protein of the synapse 2.31057
GADL1 glutamate decarboxylase-like 1 2.31057
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.31057
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.31057
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.31057
SPNS2 spinster homolog 2 (Drosophila) 2.31057
SMIM5 small integral membrane protein 5 2.31057
NPIPA7 nuclear pore complex interacting protein family, member A7 2.31057
PTK6 protein tyrosine kinase 6 2.31057
ATOH1 atonal homolog 1 (Drosophila) 2.31057
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.31057
C11ORF86 chromosome 11 open reading frame 86 2.31057
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.31057
PCDHB1 protocadherin beta 1 2.31057
HES4 hes family bHLH transcription factor 4 2.31057
RIMBP2 RIMS binding protein 2 2.31057
ADTRP androgen-dependent TFPI-regulating protein 2.31057
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.31057
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.31057
ASPA aspartoacylase 2.31057
GPR20 G protein-coupled receptor 20 2.31057
KCNRG potassium channel regulator 2.31057
DIO3 deiodinase, iodothyronine, type III 2.31057
SPATA31G1 SPATA31 subfamily G member 1 2.31057
CFAP65 cilia and flagella associated protein 65 2.31057
MCHR1 melanin-concentrating hormone receptor 1 2.31057
CCER2 coiled-coil glutamate-rich protein 2 2.31057
MGAM maltase-glucoamylase 2.31057
BNC1 basonuclin 1 2.31057
PLCZ1 phospholipase C, zeta 1 2.31057
TMPRSS4 transmembrane protease, serine 4 2.31057
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.31057
NHLH1 nescient helix loop helix 1 2.31057
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.31057
EPOP elongin BC and polycomb repressive complex 2 associated protein 2.31057
FAM237B family with sequence similarity 237 member B 2.31057
TEKTIP1 tektin bundle interacting protein 1 2.31057
FAM90A12 family with sequence similarity 90 member A12 2.31057
FAM240C family with sequence similarity 240 member C 2.31057
EXOC1L exocyst complex component 1 like 2.31057
ZNF593OS ZNF593 opposite strand 2.31057
SMIM35 small integral membrane protein 35 2.31057
ACP7 acid phosphatase 7, tartrate resistant (putative) 2.31057
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.31057
MINDY4B MINDY family member 4B 2.31057
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.31057
H4C13 H4 clustered histone 13 2.31057
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.31057
FAM107A family with sequence similarity 107, member A 2.31057
TEX101 testis expressed 101 2.31057
PTPRC protein tyrosine phosphatase, receptor type, C 2.31057
ACTL10 actin-like 10 2.31057
EFHB EF-hand domain family, member B 2.31057
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.31057
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.31057
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.31057
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.31057
OVGP1 oviductal glycoprotein 1, 120kDa 2.31057
CCDC116 coiled-coil domain containing 116 2.31057
SERTAD4 SERTA domain containing 4 2.31057
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.31057
IL6 interleukin 6 2.31057
GPR83 G protein-coupled receptor 83 2.31057
LRRC72 leucine rich repeat containing 72 2.31057
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.31057
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.31057
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.31057
GJD2 gap junction protein, delta 2, 36kDa 2.31057
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.31057
C1QL2 complement component 1, q subcomponent-like 2 2.31057
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.31057
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.31057
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.31057
EBF3 early B-cell factor 3 2.31057
FAM177B family with sequence similarity 177, member B 2.31057
CREG2 cellular repressor of E1A-stimulated genes 2 2.31057
B9D1 B9 protein domain 1 2.31057
CLEC4G C-type lectin domain family 4, member G 2.31057
MAMLD1 mastermind-like domain containing 1 2.31057
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.31057
TBXA2R thromboxane A2 receptor 2.31057
C22ORF42 chromosome 22 open reading frame 42 2.31057
BAHCC1 BAH domain and coiled-coil containing 1 2.31057
LMOD2 leiomodin 2 (cardiac) 2.31057
ADAM2 ADAM metallopeptidase domain 2 2.31057
WFDC6 WAP four-disulfide core domain 6 2.31057
AKR1B15 aldo-keto reductase family 1, member B15 2.31057
EREG epiregulin 2.31057
ETNPPL ethanolamine-phosphate phospho-lyase 2.31057
CXCR4 chemokine (C-X-C motif) receptor 4 2.31057
CTAGE4 CTAGE family, member 4 2.31057
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.31057
SMIM23 small integral membrane protein 23 2.31057
CDHR5 cadherin-related family member 5 2.31057
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.31057
PRM1 protamine 1 2.31057
C17ORF99 chromosome 17 open reading frame 99 2.31057
RGCC regulator of cell cycle 2.31057
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.31057
LOXHD1 lipoxygenase homology domains 1 2.31057
C1ORF105 chromosome 1 open reading frame 105 2.31057
IGIP IgA-inducing protein 2.31057
GPR150 G protein-coupled receptor 150 2.31057
RIN1 Ras and Rab interactor 1 2.31057
PLA2G2C phospholipase A2, group IIC 2.31057
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.31057
PLA2G5 phospholipase A2, group V 2.31057
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.31057
CCDC178 coiled-coil domain containing 178 2.31057
CD28 CD28 molecule 2.31057
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.31057
KLK11 kallikrein-related peptidase 11 2.31057
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.31057
HK3 hexokinase 3 (white cell) 2.31057
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.31057
SPHKAP SPHK1 interactor, AKAP domain containing 2.31057
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.31057
OTOP2 otopetrin 2 2.31057
GPR61 G protein-coupled receptor 61 2.31057
B9D2 B9 protein domain 2 2.31057
F13B coagulation factor XIII, B polypeptide 2.31057
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.31057
ACOT12 acyl-CoA thioesterase 12 2.31057
BCL2L15 BCL2-like 15 2.31057
IRX5 iroquois homeobox 5 2.31057
VWC2L von Willebrand factor C domain containing protein 2-like 2.31057
MMEL1 membrane metallo-endopeptidase-like 1 2.31057
FRMPD1 FERM and PDZ domain containing 1 2.31057
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.31057
MYOZ1 myozenin 1 2.31057
ALLC allantoicase 2.31057
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.31057
CD33 CD33 molecule 2.31057
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.31057
PRDM12 PR domain containing 12 2.31057
BMP5 bone morphogenetic protein 5 2.31057
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.31057
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.31057
IL18R1 interleukin 18 receptor 1 2.31057
PLA2G10 phospholipase A2, group X 2.31057
NPB neuropeptide B 2.31057
RPL37 ribosomal protein L37 2.31057
CCDC87 coiled-coil domain containing 87 2.31057
APOL6 apolipoprotein L, 6 2.31057
CLCA1 chloride channel accessory 1 2.31057
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.31057
EPO erythropoietin 2.31057
SLITRK1 SLIT and NTRK-like family, member 1 2.31057
ZNF473 zinc finger protein 473 2.31057
PLGLB1 plasminogen-like B1 2.31057
ACKR2 atypical chemokine receptor 2 2.31057
MT1A metallothionein 1A 2.31057
KRT17 keratin 17, type I 2.31057
MMP3 matrix metallopeptidase 3 2.31057
RPA4 replication protein A4, 30kDa 2.31057
MT1X metallothionein 1X 2.31057
FAM9C family with sequence similarity 9, member C 2.31057
NPPA natriuretic peptide A 2.31057
STAB1 stabilin 1 2.31057
RERGL RERG/RAS-like 2.31057
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.31057
F3 coagulation factor III (thromboplastin, tissue factor) 2.29548
KLK5 kallikrein-related peptidase 5 2.293
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 2.24158
ZNF433 zinc finger protein 433 2.23456
IRF2BPL interferon regulatory factor 2 binding protein-like 2.20155
MAU2 MAU2 sister chromatid cohesion factor 2.20034
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 2.14549
HGH1 HGH1 homolog (S. cerevisiae) 2.14549
CAT catalase 2.13764
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 2.12077
COPS2 COP9 signalosome subunit 2 2.11693
KIF15 kinesin family member 15 2.11502
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.11458
TNK2 tyrosine kinase, non-receptor, 2 2.11458
PTBP1 polypyrimidine tract binding protein 1 2.11458
RPL22 ribosomal protein L22 2.11458
DCPH1 damage control phosphatase 1 2.1067
TRMT6 tRNA methyltransferase 6 2.09526
SQSTM1 sequestosome 1 2.07378
GPHA2 glycoprotein hormone alpha 2 2.07183
KIAA1671 KIAA1671 2.05212
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.05146
HTRA2 HtrA serine peptidase 2 2.04558
GTF2IRD2B GTF2I repeat domain containing 2B 2.0288
FGF1 fibroblast growth factor 1 (acidic) 2.01875

decreased expression

Symbol Name Standardized Value
GLUD1 glutamate dehydrogenase 1 -2.33468
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.33468
CENPK centromere protein K -2.33468
SYT10 synaptotagmin X -2.33468
KLK1 kallikrein 1 -2.33468
PDIK1L PDLIM1 interacting kinase 1 like -2.33399
ZC3H10 zinc finger CCCH-type containing 10 -2.31057
C8ORF58 chromosome 8 open reading frame 58 -2.31057
ADCY7 adenylate cyclase 7 -2.31057
AS3MT arsenite methyltransferase -2.31057
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.31057
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.31057
DNAH11 dynein, axonemal, heavy chain 11 -2.31057
BOLA3 bolA family member 3 -2.31057
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.31057
MTX3 metaxin 3 -2.31057
ZFYVE28 zinc finger, FYVE domain containing 28 -2.31057
CA14 carbonic anhydrase XIV -2.31057
NME6 NME/NM23 nucleoside diphosphate kinase 6 -2.31057
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.31057
TTF2 transcription termination factor, RNA polymerase II -2.31057
CRIPTO3 cripto, EGF-CFC family member 3 -2.31057
FSBP fibrinogen silencer binding protein -2.31057
MAP2 microtubule-associated protein 2 -2.31057
TICRR TOPBP1-interacting checkpoint and replication regulator -2.31057
TXNL1 thioredoxin-like 1 -2.31057
BST1 bone marrow stromal cell antigen 1 -2.31057
CISH cytokine inducible SH2-containing protein -2.31057
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) -2.31057
H2BC15 H2B clustered histone 15 -2.31057
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.31057
RPS27A ribosomal protein S27a -2.31057
METTL4 methyltransferase like 4 -2.31057
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 -2.31057
WIPF3 WAS/WASL interacting protein family, member 3 -2.31057
IK IK cytokine, down-regulator of HLA II -2.29548
IRF2BP2 interferon regulatory factor 2 binding protein 2 -2.27994
PXYLP1 2-phosphoxylose phosphatase 1 -2.2777
TSNAX translin-associated factor X -2.25251
FOXH1 forkhead box H1 -2.24896
KLHDC7A kelch domain containing 7A -2.24896
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.24896
CDC26 cell division cycle 26 -2.24771
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.2419
ZNF253 zinc finger protein 253 -2.23939
BOP1 block of proliferation 1 -2.23511
C22ORF15 chromosome 22 open reading frame 15 -2.23069
ISY1 ISY1 splicing factor homolog (S. cerevisiae) -2.23069
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -2.20439
BLACAT1 bladder cancer associated transcript 1 (non-protein coding) -2.19853
GSTP1 glutathione S-transferase pi 1 -2.15473
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.15231
TCN2 transcobalamin II -2.14969
SPDYE10 speedy/RINGO cell cycle regulator family member E10 -2.11458
PGLYRP1 peptidoglycan recognition protein 1 -2.11458
TACSTD2 tumor-associated calcium signal transducer 2 -2.11458
AKR1D1 aldo-keto reductase family 1, member D1 -2.11458
ADORA3 adenosine A3 receptor -2.11458
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.11458
LTC4S leukotriene C4 synthase -2.11458
EBF2 early B-cell factor 2 -2.11458
CD96 CD96 molecule -2.11458
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -2.11458
PCDH19 protocadherin 19 -2.11458
CCDC170 coiled-coil domain containing 170 -2.11458
PLN phospholamban -2.11458
HLA-DMB major histocompatibility complex, class II, DM beta -2.11458
GCSAM germinal center-associated, signaling and motility -2.11458
DND1 DND microRNA-mediated repression inhibitor 1 -2.11458
LAMA4 laminin, alpha 4 -2.11458
KCNK5 potassium channel, two pore domain subfamily K, member 5 -2.11458
BEAN1 brain expressed, associated with NEDD4, 1 -2.11458
KLF5 Kruppel-like factor 5 (intestinal) -2.11458
TPM2 tropomyosin 2 (beta) -2.11458
ZNF396 zinc finger protein 396 -2.11458
SLC44A4 solute carrier family 44, member 4 -2.11458
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.11458
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.11458
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.11458
TMEM217 transmembrane protein 217 -2.11458
MUC6 mucin 6, oligomeric mucus/gel-forming -2.11458
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.11458
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.11458
PON1 paraoxonase 1 -2.11458
TECTA tectorin alpha -2.11458
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 -2.11402
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.1067
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 -2.102
PRDX2 peroxiredoxin 2 -2.1011
SLC30A8 solute carrier family 30 (zinc transporter), member 8 -2.10017
ZNHIT2 zinc finger, HIT-type containing 2 -2.09252
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.08152
RAB35 RAB35, member RAS oncogene family -2.08152
SLC39A13 solute carrier family 39 (zinc transporter), member 13 -2.07695
SNX13 sorting nexin 13 -2.0598
NOTCH2 notch 2 -2.05494
GULP1 GULP, engulfment adaptor PTB domain containing 1 -2.05276
GRAMD2A GRAM domain containing 2A -2.05276
GSPT2 G1 to S phase transition 2 -2.05276
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.05276
IGSF23 immunoglobulin superfamily, member 23 -2.05104
FBXW5 F-box and WD repeat domain containing 5 -2.04054
HDAC10 histone deacetylase 10 -2.0399
FSD2 fibronectin type III and SPRY domain containing 2 -2.0399
WIPI2 WD repeat domain, phosphoinositide interacting 2 -2.02677
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific -2.01986
TSSC4 tumor suppressing subtransferable candidate 4 -2.01875
IL18BP interleukin 18 binding protein -2.00723