SMAD7 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description SMAD family member 7|The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 4092)
External Link http://www.ncbi.nlm.nih.gov/gene/4092
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Genes

105 interacting proteins for SMAD7 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR2B activin A receptor, type IIB
ACVRL1 activin A receptor type II-like 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATM ATM serine/threonine kinase
AXIN1 axin 1
AXIN2 axin 2
BAMBI BMP and activin membrane-bound inhibitor
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COPS5 COP9 signalosome subunit 5
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXXC5 CXXC finger protein 5
DVL1 dishevelled segment polarity protein 1
ENG endoglin
EP300 E1A binding protein p300
ERBB2IP erbb2 interacting protein
FKBP1A FK506 binding protein 1A, 12kDa
HAT1 histone acetyltransferase 1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC5 histone deacetylase 5
HDAC6 histone deacetylase 6
HEYL hes-related family bHLH transcription factor with YRPW motif-like
ITCH itchy E3 ubiquitin protein ligase
KAT2B K(lysine) acetyltransferase 2B
KDM2A lysine (K)-specific demethylase 2A
LEF1 lymphoid enhancer-binding factor 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK14 mitogen-activated protein kinase 14
MBD1 methyl-CpG binding domain protein 1
MKL2 MKL/myocardin-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOD1 myogenic differentiation 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PARD3 par-3 family cell polarity regulator
PARD3B par-3 family cell polarity regulator beta
PDPK1 3-phosphoinositide dependent protein kinase 1
PIAS1 protein inhibitor of activated STAT, 1
PIAS4 protein inhibitor of activated STAT, 4
PML promyelocytic leukemia
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RNF111 ring finger protein 111
RNF165 ring finger protein 165
RPS27A ribosomal protein S27a
SASH3 SAM and SH3 domain containing 3
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD6 SMAD family member 6
SMAD9 SMAD family member 9
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX13 SRY (sex determining region Y)-box 13
SOX5 SRY (sex determining region Y)-box 5
SOX7 SRY (sex determining region Y)-box 7
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAMBP STAM binding protein
STAMBPL1 STAM binding protein-like 1
STRAP serine/threonine kinase receptor associated protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOLLIP toll interacting protein
TP53 tumor protein p53
TSC22D1 TSC22 domain family, member 1
TTF1 transcription termination factor, RNA polymerase I
TTF2 transcription termination factor, RNA polymerase II
UBB ubiquitin B
UBC ubiquitin C
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2O ubiquitin-conjugating enzyme E2O
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP11 ubiquitin specific peptidase 11
USP15 ubiquitin specific peptidase 15
WISP1 WNT1 inducible signaling pathway protein 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YAP1 Yes-associated protein 1
ZBTB11 zinc finger and BTB domain containing 11
ZBTB44 zinc finger and BTB domain containing 44
ZEB1 zinc finger E-box binding homeobox 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF107 zinc finger protein 107