SMI-16a Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/25102785
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Genes

199 proteins with high or low expression in SMI-16a relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MDM1 Mdm1 nuclear protein homolog (mouse) 1.86
MID2 midline 2 1.7
TRIM23 tripartite motif containing 23 1.68
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 1.59
VAV1 vav 1 guanine nucleotide exchange factor 1.5
NHP2 NHP2 ribonucleoprotein 1.13
RPL26 ribosomal protein L26 0.88
KIAA1107 KIAA1107 0.74
RPS14 ribosomal protein S14 0.73
TPM4 tropomyosin 4 0.69
C6ORF141 chromosome 6 open reading frame 141 0.68
ACTBL2 actin, beta-like 2 0.65
UCK1 uridine-cytidine kinase 1 0.63
NACA nascent polypeptide-associated complex alpha subunit 0.63
BHMT betaine--homocysteine S-methyltransferase 0.63
FRMPD3 FERM and PDZ domain containing 3 0.61
EGR1 early growth response 1 0.58
PLA2G12A phospholipase A2, group XIIA 0.54
TEAD3 TEA domain family member 3 0.54
ATXN7L3B ataxin 7-like 3B 0.52
C12ORF60 chromosome 12 open reading frame 60 0.51
GRAMD2B GRAM domain containing 2B 0.51
HMGN4 high mobility group nucleosomal binding domain 4 0.5
SUB1 SUB1 homolog (S. cerevisiae) 0.5
MYH13 myosin, heavy chain 13, skeletal muscle 0.49
HMGB1 high mobility group box 1 0.49
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 0.47
C2ORF72 chromosome 2 open reading frame 72 0.46
TEX9 testis expressed 9 0.45
BMP8A bone morphogenetic protein 8a 0.44
LDHB lactate dehydrogenase B 0.44
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.44
HOXB7 homeobox B7 0.44
JPT1 Jupiter microtubule associated homolog 1 0.41
CYB5A cytochrome b5 type A (microsomal) 0.41
HSPA1A heat shock 70kDa protein 1A 0.41
PHC1 polyhomeotic homolog 1 (Drosophila) 0.41
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.4
CHRAC1 chromatin accessibility complex 1 0.4
RPL27A ribosomal protein L27a 0.4
HIST2H3A histone cluster 2, H3a 0.4
TUBB3 tubulin, beta 3 class III 0.39
MSX1 msh homeobox 1 0.39
HIST2H2BC histone cluster 2, H2bc (pseudogene) 0.39
H1-3 H1.3 linker histone, cluster member 0.39
RHOA ras homolog family member A 0.39
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.39
RAN RAN, member RAS oncogene family 0.39
ZNF485 zinc finger protein 485 0.38
CCDC150 coiled-coil domain containing 150 0.38
COQ9 coenzyme Q9 0.38
DENND5A DENN/MADD domain containing 5A 0.38
RPS28 ribosomal protein S28 0.38
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.37
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.37
ENO1 enolase 1, (alpha) 0.37
AVEN apoptosis, caspase activation inhibitor 0.36
NEK4 NIMA-related kinase 4 0.36
TOR1AIP2 torsin A interacting protein 2 0.36
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.36
DUSP5 dual specificity phosphatase 5 0.35
XTBD1 XRN2 binding domain containing 1 0.35
ZNF428 zinc finger protein 428 0.35
LMOD1 leiomodin 1 (smooth muscle) 0.35
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.35
ZSCAN31 zinc finger and SCAN domain containing 31 0.34
TMSB10 thymosin beta 10 0.34
PER2 period circadian clock 2 0.34
MYH16 myosin, heavy chain 16 pseudogene 0.33
TTC19 tetratricopeptide repeat domain 19 0.33
ATG12 autophagy related 12 0.33
PCLO piccolo presynaptic cytomatrix protein 0.33
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.33
AADAT aminoadipate aminotransferase 0.33
EIF5A eukaryotic translation initiation factor 5A 0.33
RPLP2 ribosomal protein, large, P2 0.33
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.32
C12ORF57 chromosome 12 open reading frame 57 0.32
SUMO2 small ubiquitin-like modifier 2 0.32
TATDN2 TatD DNase domain containing 2 0.32
RILPL2 Rab interacting lysosomal protein-like 2 0.32
MT2A metallothionein 2A 0.32
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.32
GPRC5C G protein-coupled receptor, class C, group 5, member C 0.32
IGFBP3 insulin-like growth factor binding protein 3 0.32
RPL38 ribosomal protein L38 0.31
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.31
ICAM5 intercellular adhesion molecule 5, telencephalin 0.31
RAD23B RAD23 homolog B (S. cerevisiae) 0.31
CLTA clathrin, light chain A 0.31
S100A14 S100 calcium binding protein A14 0.31
USPL1 ubiquitin specific peptidase like 1 0.3
SUGCT succinyl-CoA:glutarate-CoA transferase 0.3
ONECUT2 one cut homeobox 2 0.3
SNX3 sorting nexin 3 0.3
RWDD1 RWD domain containing 1 0.3
TMEM165 transmembrane protein 165 0.3
PTPRB protein tyrosine phosphatase, receptor type, B 0.3
ADI1 acireductone dioxygenase 1 0.29

low expression

Symbol Name Standardized Value
HSP90AB3P heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene -1.29
FAM104A family with sequence similarity 104, member A -1.04
GUCD1 guanylyl cyclase domain containing 1 -0.99
JRKL JRK-like -0.81
FBXL2 F-box and leucine-rich repeat protein 2 -0.73
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.67
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -0.64
DNAH9 dynein, axonemal, heavy chain 9 -0.64
CEP152 centrosomal protein 152kDa -0.64
PSEN2 presenilin 2 -0.63
PRG4 proteoglycan 4 -0.62
PIP prolactin-induced protein -0.62
FKBP1A FK506 binding protein 1A, 12kDa -0.56
ZNF552 zinc finger protein 552 -0.56
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.54
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.54
ADM adrenomedullin -0.53
ZBTB44 zinc finger and BTB domain containing 44 -0.52
COL7A1 collagen, type VII, alpha 1 -0.52
HSPA8 heat shock 70kDa protein 8 -0.5
CCAR2 cell cycle and apoptosis regulator 2 -0.5
COMMD1 copper metabolism (Murr1) domain containing 1 -0.49
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.49
SPATA31D1 SPATA31 subfamily D, member 1 -0.48
SFXN5 sideroflexin 5 -0.47
NAP1L1 nucleosome assembly protein 1-like 1 -0.46
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 -0.46
NIPSNAP3A nipsnap homolog 3A (C. elegans) -0.46
YIPF1 Yip1 domain family, member 1 -0.46
PRDM4 PR domain containing 4 -0.44
HSP90AB4P heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene -0.43
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) -0.42
AGTPBP1 ATP/GTP binding protein 1 -0.42
ZNF142 zinc finger protein 142 -0.42
FRRS1 ferric-chelate reductase 1 -0.42
MYADM myeloid-associated differentiation marker -0.41
DAAM1 dishevelled associated activator of morphogenesis 1 -0.4
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.4
ALPK1 alpha-kinase 1 -0.39
CCSER2 coiled-coil serine-rich protein 2 -0.39
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.38
RAD9A RAD9 homolog A (S. pombe) -0.38
FSTL3 follistatin-like 3 (secreted glycoprotein) -0.38
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -0.38
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.38
PTPRD protein tyrosine phosphatase, receptor type, D -0.38
KLHL25 kelch-like family member 25 -0.38
SPATA33 spermatogenesis associated 33 -0.37
LMF1 lipase maturation factor 1 -0.37
ADCY9 adenylate cyclase 9 -0.37
SLC45A4 solute carrier family 45, member 4 -0.37
LAMC2 laminin, gamma 2 -0.37
ALS2CL ALS2 C-terminal like -0.37
WDFY2 WD repeat and FYVE domain containing 2 -0.37
RFXAP regulatory factor X-associated protein -0.37
ANKRD44 ankyrin repeat domain 44 -0.37
ACTN3 actinin, alpha 3 (gene/pseudogene) -0.37
LRRC28 leucine rich repeat containing 28 -0.37
MEX3C mex-3 RNA binding family member C -0.36
MRPL55 mitochondrial ribosomal protein L55 -0.36
SSPO SCO-spondin -0.36
LTBP1 latent transforming growth factor beta binding protein 1 -0.36
TMEM98 transmembrane protein 98 -0.36
ZNF189 zinc finger protein 189 -0.36
SMIM12 small integral membrane protein 12 -0.36
PPP1R3D protein phosphatase 1, regulatory subunit 3D -0.36
HSP90AA4P heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene -0.36
LTBP3 latent transforming growth factor beta binding protein 3 -0.35
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.35
LYST lysosomal trafficking regulator -0.35
SESN1 sestrin 1 -0.35
TMEM59 transmembrane protein 59 -0.34
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.34
GLRX2 glutaredoxin 2 -0.34
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -0.33
PGPEP1 pyroglutamyl-peptidase I -0.33
ZNF496 zinc finger protein 496 -0.33
UBE2F ubiquitin-conjugating enzyme E2F (putative) -0.33
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -0.33
POLH polymerase (DNA directed), eta -0.33
SMAD3 SMAD family member 3 -0.33
GTDC1 glycosyltransferase-like domain containing 1 -0.33
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -0.33
SNX18 sorting nexin 18 -0.33
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -0.32
MKNK1 MAP kinase interacting serine/threonine kinase 1 -0.32
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.32
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -0.32
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -0.31
SFR1 SWI5-dependent recombination repair 1 -0.31
TM2D3 TM2 domain containing 3 -0.31
TMEM222 transmembrane protein 222 -0.31
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.31
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.31
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 -0.31
ARSK arylsulfatase family, member K -0.3
DGKD diacylglycerol kinase, delta 130kDa -0.3
MLXIPL MLX interacting protein-like -0.3
CCN3 cellular communication network factor 3 -0.3