SMO Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description smoothened, frizzled class receptor|The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 6608)
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Genes

288 genes differentially expressed following the SMO gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MYH15 myosin, heavy chain 15 2.98382
HRH1 histamine receptor H1 2.98382
FOLR1 folate receptor 1 (adult) 2.98382
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.98382
LURAP1L leucine rich adaptor protein 1-like 2.98382
MAP3K7CL MAP3K7 C-terminal like 2.98382
KNG1 kininogen 1 2.98382
CD1C CD1c molecule 2.98382
CABP4 calcium binding protein 4 2.98382
SYCP2 synaptonemal complex protein 2 2.98382
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.98382
GDF10 growth differentiation factor 10 2.98382
TLR6 toll-like receptor 6 2.98382
TLR1 toll-like receptor 1 2.98382
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.98382
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.98382
MTNR1B melatonin receptor 1B 2.98382
SLFN14 schlafen family member 14 2.98382
ACTL8 actin-like 8 2.98382
HES3 hes family bHLH transcription factor 3 2.98382
TM4SF20 transmembrane 4 L six family member 20 2.98382
PCDHGB3 protocadherin gamma subfamily B, 3 2.98382
TTLL8 tubulin tyrosine ligase-like family member 8 2.98382
GMNC geminin coiled-coil domain containing 2.98382
S100A1 S100 calcium binding protein A1 2.98382
AVP arginine vasopressin 2.98382
PRDM13 PR domain containing 13 2.98382
CLEC14A C-type lectin domain family 14, member A 2.98382
KLLN killin, p53-regulated DNA replication inhibitor 2.98382
SP6 Sp6 transcription factor 2.98382
SMIM5 small integral membrane protein 5 2.98382
ZNF556 zinc finger protein 556 2.98382
GSTM5 glutathione S-transferase mu 5 2.98382
GJB5 gap junction protein, beta 5, 31.1kDa 2.98382
GJB3 gap junction protein, beta 3, 31kDa 2.98382
PTH2 parathyroid hormone 2 2.98382
C6ORF58 chromosome 6 open reading frame 58 2.98382
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 2.98382
RSPO1 R-spondin 1 2.98382
SHCBP1L SHC SH2-domain binding protein 1-like 2.98382
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.98382
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.98382
FAM240C family with sequence similarity 240 member C 2.98382
PLAAT2 phospholipase A and acyltransferase 2 2.98382
TMEM271 transmembrane protein 271 2.98382
TTLL13 tubulin tyrosine ligase like 13 2.98382
NIBAN3 niban apoptosis regulator 3 2.98382
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.98382
ROPN1B rhophilin associated tail protein 1B 2.98382
AVPR1A arginine vasopressin receptor 1A 2.98382
GPR35 G protein-coupled receptor 35 2.98382
ANKRD40CL ANKRD40 C-terminal like 2.98382
CCDC187 coiled-coil domain containing 187 2.98382
CFAP97D2 CFAP97 domain containing 2 2.98382
SPAAR small regulatory polypeptide of amino acid response 2.98382
H4C14 H4 clustered histone 14 2.98382
EZHIP EZH inhibitory protein 2.98382
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.98382
GARIN6 golgi associated RAB2 interactor family member 6 2.98382
DEFB131B defensin beta 131B 2.98382
PCARE photoreceptor cilium actin regulator 2.98382
TMPRSS4 transmembrane protease, serine 4 2.98382
GC group-specific component (vitamin D binding protein) 2.98382
DOK7 docking protein 7 2.98382
VCX3A variable charge, X-linked 3A 2.98382
OR56B2 olfactory receptor family 56 subfamily B member 2 2.98382
UTS2 urotensin 2 2.98382
TSPO2 translocator protein 2 2.98382
TCF23 transcription factor 23 2.98382
MYOG myogenin (myogenic factor 4) 2.98382
MYOT myotilin 2.98382
GLP2R glucagon-like peptide 2 receptor 2.98382
PXDC1 PX domain containing 1 2.98382
HNF1B HNF1 homeobox B 2.98382
DOK2 docking protein 2, 56kDa 2.98382
LY6K lymphocyte antigen 6 complex, locus K 2.98382
VSIG8 V-set and immunoglobulin domain containing 8 2.98382
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.98382
GATA2 GATA binding protein 2 2.98382
MLANA melan-A 2.98382
DYNAP dynactin associated protein 2.98382
HNF1A HNF1 homeobox A 2.98382
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.98382
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.98382
DHH desert hedgehog 2.98382
CCL27 chemokine (C-C motif) ligand 27 2.98382
KLK5 kallikrein-related peptidase 5 2.98382
VAX2 ventral anterior homeobox 2 2.98382
DYTN dystrotelin 2.98382
TBX1 T-box 1 2.98382
IL12A interleukin 12A 2.98382
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.98382
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.98382
TRIM29 tripartite motif containing 29 2.98382
ANKRD55 ankyrin repeat domain 55 2.98382
PRSS33 protease, serine, 33 2.98382
ANKRD33 ankyrin repeat domain 33 2.98382
NUTM2D NUT family member 2D 2.98382
NUTM2B NUT family member 2B 2.98382
LST1 leukocyte specific transcript 1 2.98382
AKR1B15 aldo-keto reductase family 1, member B15 2.98382
LCNL1 lipocalin-like 1 2.98382
IL11 interleukin 11 2.98382
C6ORF15 chromosome 6 open reading frame 15 2.98382
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.98382
C2CD4D C2 calcium-dependent domain containing 4D 2.98382
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.98382
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 2.98382
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.98382
KLHL41 kelch-like family member 41 2.98382
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.98382
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.98382
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 2.98382
HCRT hypocretin (orexin) neuropeptide precursor 2.98382
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.98382
EFCAB3 EF-hand calcium binding domain 3 2.98382
FBXO47 F-box protein 47 2.98382
PATE1 prostate and testis expressed 1 2.98382
ERMN ermin, ERM-like protein 2.98382
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.98382
NLRP1 NLR family, pyrin domain containing 1 2.98382
C10ORF90 chromosome 10 open reading frame 90 2.98382
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.98382
IFNK interferon, kappa 2.98382
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.98382
OR56B4 olfactory receptor, family 56, subfamily B, member 4 2.98382
CCNA1 cyclin A1 2.98382
MEIOB meiosis specific with OB domains 2.98382
MROH2A maestro heat-like repeat family member 2A 2.98382
EOMES eomesodermin 2.98382
GSDMB gasdermin B 2.98382
MNX1 motor neuron and pancreas homeobox 1 2.98382
BCL2A1 BCL2-related protein A1 2.98382
ARSH arylsulfatase family, member H 2.98382
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.98382
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.98382
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.98382
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.98382
TM4SF19 transmembrane 4 L six family member 19 2.98382
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.98382
LAMP3 lysosomal-associated membrane protein 3 2.98382
RHAG Rh-associated glycoprotein 2.98382
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.98382
GCM1 glial cells missing homolog 1 (Drosophila) 2.98382
IGIP IgA-inducing protein 2.98382
FGF7 fibroblast growth factor 7 2.98382
DPH5 diphthamide biosynthesis 5 2.98382
CORIN corin, serine peptidase 2.97392
EPN1 epsin 1 2.96945
RAB35 RAB35, member RAS oncogene family 2.95631
TIGD6 tigger transposable element derived 6 2.92502
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.92502
PLAAT4 phospholipase A and acyltransferase 4 2.92502
SPACA9 sperm acrosome associated 9 2.92502
KASH5 KASH domain containing 5 2.91199
NCBP1 nuclear cap binding protein subunit 1, 80kDa 2.91019
ARHGAP39 Rho GTPase activating protein 39 2.88023
CREG1 cellular repressor of E1A-stimulated genes 1 2.8409
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.77419
ZMPSTE24 zinc metallopeptidase STE24 2.72535
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 2.70106
RANBP6 RAN binding protein 6 2.69168
CACTIN cactin, spliceosome C complex subunit 2.6089
MEF2C myocyte enhancer factor 2C 2.57163
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.50008
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.49749
ATXN7L2 ataxin 7-like 2 2.49749
MROH6 maestro heat-like repeat family member 6 2.42665
NPAP1 nuclear pore associated protein 1 2.42665
VN1R1 vomeronasal 1 receptor 1 2.42665
SRSF5 serine/arginine-rich splicing factor 5 2.36727
CCND3 cyclin D3 2.36688
PLCD4 phospholipase C, delta 4 2.36432
WDR87 WD repeat domain 87 2.36432
CNTN6 contactin 6 2.33154
PCDHGB4 protocadherin gamma subfamily B, 4 2.33154
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.33154
PRNP prion protein 2.32792
AUH AU RNA binding protein/enoyl-CoA hydratase 2.32194
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 2.31587
CYB5A cytochrome b5 type A (microsomal) 2.31028
GRM6 glutamate receptor, metabotropic 6 2.30843
EXOG endo/exonuclease (5'-3'), endonuclease G-like 2.30533
GPR135 G protein-coupled receptor 135 2.28979
IDE insulin-degrading enzyme 2.27254
PCDHB15 protocadherin beta 15 2.25323
ZNF442 zinc finger protein 442 2.25041
METRNL meteorin, glial cell differentiation regulator-like 2.24952
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 2.22494
MAPRE3 microtubule-associated protein, RP/EB family, member 3 2.21804
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 2.17989
COMMD2 COMM domain containing 2 2.16491
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 2.16307
PEX2 peroxisomal biogenesis factor 2 2.1528
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 2.15149
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 2.10415
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) 2.09895
ARMC7 armadillo repeat containing 7 2.09895
CLEC11A C-type lectin domain family 11, member A 2.08448
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.06979
RAI2 retinoic acid induced 2 2.06979
LYST lysosomal trafficking regulator 2.06979
MSRB3 methionine sulfoxide reductase B3 2.06979
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.06979
DIAPH1 diaphanous-related formin 1 2.06979
GIPR gastric inhibitory polypeptide receptor 2.06979
KDM2B lysine (K)-specific demethylase 2B 2.06025
CRY1 cryptochrome circadian clock 1 2.04986
SIDT2 SID1 transmembrane family, member 2 2.03501
BCL2L12 BCL2-like 12 (proline rich) 2.02725
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.01876
CALCOCO2 calcium binding and coiled-coil domain 2 2.00525
CACHD1 cache domain containing 1 2.00122
ZNF85 zinc finger protein 85 2.0011

decreased expression

Symbol Name Standardized Value
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.98382
C2CD4C C2 calcium-dependent domain containing 4C -2.98382
ICAM1 intercellular adhesion molecule 1 -2.98382
PTRH1 peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) -2.95293
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 -2.93761
S100A16 S100 calcium binding protein A16 -2.91425
RTCA RNA 3'-terminal phosphate cyclase -2.9073
ARHGAP30 Rho GTPase activating protein 30 -2.87474
NIM1K NIM1 serine/threonine protein kinase -2.87474
ALPK2 alpha-kinase 2 -2.87474
TMEM179 transmembrane protein 179 -2.87474
CA1 carbonic anhydrase I -2.87474
DEFB134 defensin, beta 134 -2.87474
CFAP141 cilia and flagella associated protein 141 -2.87474
RPL3L ribosomal protein L3-like -2.87474
TRAM1L1 translocation associated membrane protein 1-like 1 -2.87474
ZEB2 zinc finger E-box binding homeobox 2 -2.87474
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.87474
ANKRD63 ankyrin repeat domain 63 -2.87474
CDHR4 cadherin-related family member 4 -2.87474
INSM1 insulinoma-associated 1 -2.87474
NUP62 nucleoporin 62kDa -2.87474
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -2.87474
TSPAN1 tetraspanin 1 -2.87474
COX8C cytochrome c oxidase subunit VIIIC -2.87474
FAM209B family with sequence similarity 209, member B -2.87474
PLET1 placenta expressed transcript 1 -2.87474
LIX1L Lix1 homolog (chicken) like -2.82224
AK2 adenylate kinase 2 -2.67894
BEX1 brain expressed, X-linked 1 -2.63251
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -2.5913
PCGF1 polycomb group ring finger 1 -2.58107
URGCP upregulator of cell proliferation -2.58107
PNMA3 paraneoplastic Ma antigen 3 -2.57798
NONO non-POU domain containing, octamer-binding -2.54281
RCC1 regulator of chromosome condensation 1 -2.53055
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -2.47971
ACOT2 acyl-CoA thioesterase 2 -2.46101
FSCN3 fascin actin-bundling protein 3, testicular -2.45173
PKD1L1 polycystic kidney disease 1 like 1 -2.45173
NOTCH4 notch 4 -2.45173
SYNM synemin, intermediate filament protein -2.32563
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.31028
COX6C cytochrome c oxidase subunit VIc -2.30533
FGF22 fibroblast growth factor 22 -2.30248
VDAC1 voltage-dependent anion channel 1 -2.29821
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.29821
SNAP29 synaptosomal-associated protein, 29kDa -2.26201
ATRAID all-trans retinoic acid-induced differentiation factor -2.24348
LMOD1 leiomodin 1 (smooth muscle) -2.24161
TRIM69 tripartite motif containing 69 -2.24161
GRIK2 glutamate receptor, ionotropic, kainate 2 -2.24161
C19ORF84 chromosome 19 open reading frame 84 -2.21011
TOR3A torsin family 3, member A -2.20079
LAGE3 L antigen family, member 3 -2.16579
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.16579
TTYH1 tweety family member 1 -2.14969
SERP1 stress-associated endoplasmic reticulum protein 1 -2.09863
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.09694
NUBP2 nucleotide binding protein 2 -2.09694
MPI mannose phosphate isomerase -2.08472
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -2.08355
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0753
SNRPG small nuclear ribonucleoprotein polypeptide G -2.06468
TRAF1 TNF receptor-associated factor 1 -2.06444
COQ9 coenzyme Q9 -2.0522
IQUB IQ motif and ubiquitin domain containing -2.04907
THBS4 thrombospondin 4 -2.03501
RBM6 RNA binding motif protein 6 -2.03309
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.03104
PRPF4 pre-mRNA processing factor 4 -2.02999
PRIM2 primase, DNA, polypeptide 2 (58kDa) -2.02536
ELP5 elongator acetyltransferase complex subunit 5 -2.01876
ZNF77 zinc finger protein 77 -2.0011