SMS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description spermine synthase|This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 6611)
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Genes

232 genes differentially expressed following the SMS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.1784
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.1784
SHISA7 shisa family member 7 3.1784
PCDH8 protocadherin 8 3.1784
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.1784
SSTR4 somatostatin receptor 4 3.1784
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.1784
LRRC56 leucine rich repeat containing 56 3.1784
AMTN amelotin 3.1784
SIRPB2 signal-regulatory protein beta 2 3.1784
MYBPC3 myosin binding protein C, cardiac 3.1784
ADGRG4 adhesion G protein-coupled receptor G4 3.1784
GLUD2 glutamate dehydrogenase 2 3.1784
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.1784
CABP4 calcium binding protein 4 3.1784
ENTHD1 ENTH domain containing 1 3.1784
TTLL8 tubulin tyrosine ligase-like family member 8 3.1784
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.1784
TGM5 transglutaminase 5 3.1784
HEPACAM hepatic and glial cell adhesion molecule 3.1784
SSX1 synovial sarcoma, X breakpoint 1 3.1784
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.1784
NLRP9 NLR family, pyrin domain containing 9 3.1784
NRGN neurogranin (protein kinase C substrate, RC3) 3.1784
PASD1 PAS domain containing 1 3.1784
DCST1 DC-STAMP domain containing 1 3.1784
ANKRD30A ankyrin repeat domain 30A 3.1784
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.1784
PODN podocan 3.1784
ATOH1 atonal homolog 1 (Drosophila) 3.1784
IL2RA interleukin 2 receptor, alpha 3.1784
PTK6 protein tyrosine kinase 6 3.1784
LBX2 ladybird homeobox 2 3.1784
GPR55 G protein-coupled receptor 55 3.1784
SCG2 secretogranin II 3.1784
FGF21 fibroblast growth factor 21 3.1784
BDKRB1 bradykinin receptor B1 3.1784
KRT83 keratin 83, type II 3.1784
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.1784
GBP6 guanylate binding protein family, member 6 3.1784
CCDC9B coiled-coil domain containing 9B 3.1784
HTD2 hydroxyacyl-thioester dehydratase type 2 3.1784
MINAR2 membrane integral NOTCH2 associated receptor 2 3.1784
H2BC3 H2B clustered histone 3 3.1784
MYMK myomaker, myoblast fusion factor 3.1784
SMIM35 small integral membrane protein 35 3.1784
LOC124903372 uncharacterized LOC124903372 3.1784
LOC122526780 uncharacterized LOC122526780 3.1784
IFT70A intraflagellar transport 70A 3.1784
EXOC1L exocyst complex component 1 like 3.1784
SPATA31H1 SPATA31 subfamily H member 1 3.1784
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.1784
TSPAN1 tetraspanin 1 3.1784
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.1784
RAB44 RAB44, member RAS oncogene family 3.1784
FOXD1 forkhead box D1 3.1784
CCDC17 coiled-coil domain containing 17 3.1784
MAL mal, T-cell differentiation protein 3.1784
GAST gastrin 3.1784
SCRT2 scratch family zinc finger 2 3.1784
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.1784
SPDYC speedy/RINGO cell cycle regulator family member C 3.1784
EXOC3L4 exocyst complex component 3-like 4 3.1784
TACR2 tachykinin receptor 2 3.1784
SASH3 SAM and SH3 domain containing 3 3.1784
PGA3 pepsinogen 3, group I (pepsinogen A) 3.1784
PRG4 proteoglycan 4 3.1784
KL klotho 3.1784
SPATA31G1 SPATA31 subfamily G member 1 3.1784
ITGAD integrin, alpha D 3.1784
PROK1 prokineticin 1 3.1784
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.1784
ODF1 outer dense fiber of sperm tails 1 3.1784
TBXA2R thromboxane A2 receptor 3.1784
CGB1 chorionic gonadotropin, beta polypeptide 1 3.1784
IL36R interleukin 36 receptor 3.1784
CLEC4D C-type lectin domain family 4, member D 3.1784
HKDC1 hexokinase domain containing 1 3.1784
AKNAD1 AKNA domain containing 1 3.1784
TPSB2 tryptase beta 2 (gene/pseudogene) 3.1784
HPX hemopexin 3.1784
GOLGA6A golgin A6 family, member A 3.1784
CRYBB2 crystallin, beta B2 3.1784
ZNF541 zinc finger protein 541 3.1784
MR1 major histocompatibility complex, class I-related 3.1784
ITGA10 integrin, alpha 10 3.1784
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.1784
CFB complement factor B 3.1784
RAD9B RAD9 homolog B (S. pombe) 3.1784
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.1784
GOLGA8M golgin A8 family, member M 3.1784
MB myoglobin 3.1784
PLA2G2F phospholipase A2, group IIF 3.1784
RIPK3 receptor-interacting serine-threonine kinase 3 3.1784
NMBR neuromedin B receptor 3.1784
OR10S1 olfactory receptor, family 10, subfamily S, member 1 3.1784
PLCD4 phospholipase C, delta 4 3.1784
DAW1 dynein assembly factor with WDR repeat domains 1 3.1784
GPR68 G protein-coupled receptor 68 3.1784
OTOP3 otopetrin 3 3.1784
LRRC3 leucine rich repeat containing 3 3.1784
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.1784
LMOD2 leiomodin 2 (cardiac) 3.1784
KCNK2 potassium channel, two pore domain subfamily K, member 2 3.1784
NUTM2A NUT family member 2A 3.1784
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 3.1784
PCDHGB5 protocadherin gamma subfamily B, 5 3.1784
APOB apolipoprotein B 3.1784
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.1784
PLA2G4E phospholipase A2, group IVE 3.1784
SPRN shadow of prion protein homolog (zebrafish) 3.1784
FZD1 frizzled class receptor 1 3.1784
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.1784
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.1784
ADGRF5 adhesion G protein-coupled receptor F5 3.1784
CCDC152 coiled-coil domain containing 152 3.1784
FNDC9 fibronectin type III domain containing 9 3.1784
TMEM86B transmembrane protein 86B 3.1784
WFDC10A WAP four-disulfide core domain 10A 3.1784
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.1784
MMP7 matrix metallopeptidase 7 3.1784
CCL25 chemokine (C-C motif) ligand 25 3.1784
FNDC8 fibronectin type III domain containing 8 3.1784
SLITRK6 SLIT and NTRK-like family, member 6 3.1784
TRPC6 transient receptor potential cation channel, subfamily C, member 6 3.12697
UPK1A uroplakin 1A 3.12697
MYORG myogenesis regulating glycosidase (putative) 3.0902
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 3.08452
PDIA4 protein disulfide isomerase family A, member 4 3.06511
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 3.00747
H2BC26 H2B clustered histone 26 2.58942
SLC43A3 solute carrier family 43, member 3 2.56997
EXOSC5 exosome component 5 2.55258
CEP350 centrosomal protein 350kDa 2.55258
CNOT8 CCR4-NOT transcription complex, subunit 8 2.53833
NALF1 NALCN channel auxiliary factor 1 2.49649
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 2.47984
KCTD10 potassium channel tetramerization domain containing 10 2.44072
RSPH3 radial spoke 3 homolog (Chlamydomonas) 2.3755
RNF39 ring finger protein 39 2.30793
SFXN3 sideroflexin 3 2.28917
LIPT2-AS1 LIPT2 antisense RNA 1 2.28917
TTC29 tetratricopeptide repeat domain 29 2.28917
RNF112 ring finger protein 112 2.28917
BRICD5 BRICHOS domain containing 5 2.28917
ROM1 retinal outer segment membrane protein 1 2.28917
NEGR1 neuronal growth regulator 1 2.28917
ESR1 estrogen receptor 1 2.28917
SLC22A31 solute carrier family 22, member 31 2.28917
KRTAP5-11 keratin associated protein 5-11 2.28917
JAG2 jagged 2 2.26828
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 2.2477
PDE4C phosphodiesterase 4C, cAMP-specific 2.15011
MALL mal, T-cell differentiation protein-like 2.11253
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2.11158
CRMP1 collapsin response mediator protein 1 2.10307
QPCTL glutaminyl-peptide cyclotransferase-like 2.086
STC2 stanniocalcin 2 2.03065
MYO10 myosin X 2.02397
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 2.00969

decreased expression

Symbol Name Standardized Value
PLAC8L1 PLAC8-like 1 -3.1784
RIN1 Ras and Rab interactor 1 -3.1784
SMS spermine synthase -3.1784
GRM2 glutamate receptor, metabotropic 2 -3.1784
SYTL5 synaptotagmin-like 5 -3.1784
ENKUR enkurin, TRPC channel interacting protein -3.1784
SNAI2 snail family zinc finger 2 -3.1784
TSHR thyroid stimulating hormone receptor -3.1784
HIPK4 homeodomain interacting protein kinase 4 -3.1784
PGAM1 phosphoglycerate mutase 1 (brain) -3.07155
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 -3.0484
RTKN2 rhotekin 2 -3.00583
CENPE centromere protein E, 312kDa -3.00568
SPMIP3 sperm microtubule inner protein 3 -2.91787
NRSN1 neurensin 1 -2.91787
CA9 carbonic anhydrase IX -2.91787
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.91787
ATP5MGL ATP synthase membrane subunit g like -2.91787
GOLGA6L7 golgin A6 family like 7 -2.91787
KY kyphoscoliosis peptidase -2.91787
ACE2 angiotensin I converting enzyme 2 -2.91787
TEX101 testis expressed 101 -2.91787
ZBTB16 zinc finger and BTB domain containing 16 -2.91787
DNAI2 dynein, axonemal, intermediate chain 2 -2.91787
STKLD1 serine/threonine kinase-like domain containing 1 -2.91787
N4BP2 NEDD4 binding protein 2 -2.91787
GGN gametogenetin -2.91787
CHADL chondroadherin-like -2.91787
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.91787
ALAS2 5'-aminolevulinate synthase 2 -2.91787
ARR3 arrestin 3, retinal (X-arrestin) -2.91787
MORN5 MORN repeat containing 5 -2.91787
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 -2.91787
IL1A interleukin 1, alpha -2.91787
ACOX2 acyl-CoA oxidase 2, branched chain -2.91787
THEM6 thioesterase superfamily member 6 -2.91787
CCNO cyclin O -2.91787
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.91787
C19ORF73 chromosome 19 open reading frame 73 -2.78873
PTPRO protein tyrosine phosphatase, receptor type, O -2.58617
IDO1 indoleamine 2,3-dioxygenase 1 -2.5727
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.53833
LRRC1 leucine rich repeat containing 1 -2.53833
NUTM1 NUT midline carcinoma, family member 1 -2.53833
TSPAN14 tetraspanin 14 -2.5228
HDAC7 histone deacetylase 7 -2.47673
KIF2C kinesin family member 2C -2.4468
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -2.43607
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.29866
DOCK9 dedicator of cytokinesis 9 -2.29501
PROX1 prospero homeobox 1 -2.29501
ZNF142 zinc finger protein 142 -2.28917
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -2.27939
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -2.1995
STK25 serine/threonine kinase 25 -2.18551
ZNF652 zinc finger protein 652 -2.16102
DUSP15 dual specificity phosphatase 15 -2.15061
GTF2A1 general transcription factor IIA, 1, 19/37kDa -2.15011
HSPB8 heat shock 22kDa protein 8 -2.13475
ZNF770 zinc finger protein 770 -2.11974
ERAP1 endoplasmic reticulum aminopeptidase 1 -2.11667
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -2.086
INO80E INO80 complex subunit E -2.086
ACAN aggrecan -2.05662
CAV2 caveolin 2 -2.05662
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -2.05662
POMT2 protein-O-mannosyltransferase 2 -2.04604
GSTCD glutathione S-transferase, C-terminal domain containing -2.02287
CCDC148 coiled-coil domain containing 148 -2.02287
LACTB2 lactamase, beta 2 -2.00969
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.00754
NBN nibrin -2.00754