SMURF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SMAD specific E3 ubiquitin protein ligase 1|This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 57154)
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Genes

335 genes differentially expressed following the SMURF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TTC29 tetratricopeptide repeat domain 29 2.80486
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.80486
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.80486
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.80486
HEATR9 HEAT repeat containing 9 2.80486
ZMYND15 zinc finger, MYND-type containing 15 2.80486
UTS2R urotensin 2 receptor 2.80486
SPATA22 spermatogenesis associated 22 2.80486
GJB1 gap junction protein, beta 1, 32kDa 2.80486
IL36R interleukin 36 receptor 2.80486
CNTNAP4 contactin associated protein-like 4 2.80486
ASIC4 acid sensing (proton gated) ion channel family member 4 2.80486
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.80486
GPR183 G protein-coupled receptor 183 2.80486
CXCR4 chemokine (C-X-C motif) receptor 4 2.80486
NANOS3 nanos homolog 3 (Drosophila) 2.80486
THSD8 thrombospondin type 1 domain containing 8 2.80486
SEZ6L seizure related 6 homolog (mouse)-like 2.80486
CLEC14A C-type lectin domain family 14, member A 2.80486
RGS11 regulator of G-protein signaling 11 2.80486
DUSP26 dual specificity phosphatase 26 (putative) 2.80486
CERKL ceramide kinase-like 2.80486
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.79293
IL22RA1 interleukin 22 receptor, alpha 1 2.79293
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.79293
IGFL2 IGF-like family member 2 2.79293
WDR87 WD repeat domain 87 2.79293
ALB albumin 2.79293
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.79293
BTN1A1 butyrophilin, subfamily 1, member A1 2.79293
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.79293
IGFL4 IGF-like family member 4 2.79293
PKP1 plakophilin 1 2.79293
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.79293
OR5A2 olfactory receptor, family 5, subfamily A, member 2 2.79293
F2 coagulation factor II (thrombin) 2.79293
MAGED4 melanoma antigen family D4 2.79293
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.79293
SOWAHB sosondowah ankyrin repeat domain family member B 2.79293
HMX3 H6 family homeobox 3 2.79293
MPL MPL proto-oncogene, thrombopoietin receptor 2.79293
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.79293
RAPSN receptor-associated protein of the synapse 2.79293
TCHP trichoplein, keratin filament binding 2.79293
ESX1 ESX homeobox 1 2.79293
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.79293
MUSK muscle, skeletal, receptor tyrosine kinase 2.79293
TLX3 T-cell leukemia homeobox 3 2.79293
VAMP8 vesicle-associated membrane protein 8 2.79293
ARSF arylsulfatase F 2.79293
SPRR1B small proline-rich protein 1B 2.79293
SP6 Sp6 transcription factor 2.79293
CD5 CD5 molecule 2.79293
IQCF1 IQ motif containing F1 2.79293
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.79293
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.79293
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.79293
FIMP1 fertilization-influencing membrane protein 1 2.79293
CAPN9 calpain 9 2.79293
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.79293
PHF24 PHD finger protein 24 2.79293
CCN3 cellular communication network factor 3 2.79293
PLAAT4 phospholipase A and acyltransferase 4 2.79293
CCDC198 coiled-coil domain containing 198 2.79293
MINAR2 membrane integral NOTCH2 associated receptor 2 2.79293
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.79293
GARIN1A golgi associated RAB2 interactor 1A 2.79293
MEIOSIN meiosis initiator 2.79293
CFAP276 cilia and flagella associated protein 276 2.79293
LOC124902436 talanin 2.79293
ADRB1 adrenoceptor beta 1 2.79293
ASB9 ankyrin repeat and SOCS box containing 9 2.79293
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.79293
CES3 carboxylesterase 3 2.79293
LIPC lipase, hepatic 2.79293
DTHD1 death domain containing 1 2.79293
PRB4 proline-rich protein BstNI subfamily 4 2.79293
DSG1 desmoglein 1 2.79293
MAG myelin associated glycoprotein 2.79293
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.79293
DMBX1 diencephalon/mesencephalon homeobox 1 2.79293
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.79293
TMEM179 transmembrane protein 179 2.79293
FOXI2 forkhead box I2 2.79293
C9 complement component 9 2.79293
PGA4 pepsinogen 4, group I (pepsinogen A) 2.79293
SAMD15 sterile alpha motif domain containing 15 2.79293
GDF6 growth differentiation factor 6 2.79293
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.79293
GATA5 GATA binding protein 5 2.79293
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.79293
OR2B11 olfactory receptor, family 2, subfamily B, member 11 2.79293
SLC36A3 solute carrier family 36, member 3 2.79293
CPSF4L cleavage and polyadenylation specific factor 4-like 2.79293
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.79293
GOLGA6C golgin A6 family, member C 2.79293
NPFFR1 neuropeptide FF receptor 1 2.79293
SERINC4 serine incorporator 4 2.79293
APOC4 apolipoprotein C-IV 2.79293
IRGC immunity-related GTPase family, cinema 2.79293
CGB2 chorionic gonadotropin, beta polypeptide 2 2.79293
RESP18 regulated endocrine-specific protein 18 2.79293
THTPA thiamine triphosphatase 2.79293
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.79293
CIDEA cell death-inducing DFFA-like effector a 2.79293
CLPS colipase, pancreatic 2.79293
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.79293
CCL22 chemokine (C-C motif) ligand 22 2.79293
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.79293
KLF2 Kruppel-like factor 2 2.79293
CH25H cholesterol 25-hydroxylase 2.79293
VWA3A von Willebrand factor A domain containing 3A 2.79293
COMP cartilage oligomeric matrix protein 2.79293
CLEC1A C-type lectin domain family 1, member A 2.79293
FAIM2 Fas apoptotic inhibitory molecule 2 2.79293
OPTC opticin 2.79293
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.79293
BTG4 B-cell translocation gene 4 2.79293
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.79293
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.79293
CFH complement factor H 2.79293
IDI2 isopentenyl-diphosphate delta isomerase 2 2.79293
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.79293
CER1 cerberus 1, DAN family BMP antagonist 2.79293
SPMAP1 sperm microtubule associated protein 1 2.79293
TEX12 testis expressed 12 2.79293
SVOP SV2 related protein homolog (rat) 2.79293
ITGB7 integrin, beta 7 2.79293
MYLK2 myosin light chain kinase 2 2.79293
TPPP2 tubulin polymerization-promoting protein family member 2 2.79293
PLA2G12B phospholipase A2, group XIIB 2.79293
TBC1D21 TBC1 domain family, member 21 2.79293
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.79293
CLNK cytokine-dependent hematopoietic cell linker 2.79293
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.79293
BPIFC BPI fold containing family C 2.79293
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.79293
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.79293
PANO1 proapoptotic nucleolar protein 1 2.79293
COL22A1 collagen, type XXII, alpha 1 2.79293
TEX38 testis expressed 38 2.79293
RNASE6 ribonuclease, RNase A family, k6 2.79293
IL17B interleukin 17B 2.79293
SPDEF SAM pointed domain containing ETS transcription factor 2.79293
LDHC lactate dehydrogenase C 2.79293
MAP2K5 mitogen-activated protein kinase kinase 5 2.79293
EMCN endomucin 2.79293
POU3F2 POU class 3 homeobox 2 2.79293
CYGB cytoglobin 2.79293
POTEJ POTE ankyrin domain family, member J 2.79293
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.77801
FKBP8 FK506 binding protein 8, 38kDa 2.76989
DUSP2 dual specificity phosphatase 2 2.73734
CCDC81 coiled-coil domain containing 81 2.66304
ZNF878 zinc finger protein 878 2.65922
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.63878
ZNF74 zinc finger protein 74 2.51491
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 2.5091
LCOR ligand dependent nuclear receptor corepressor 2.5091
SKAP2 src kinase associated phosphoprotein 2 2.5091
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.46597
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 2.45885
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.45885
SV2B synaptic vesicle glycoprotein 2B 2.41553
TENT5D terminal nucleotidyltransferase 5D 2.402
ELMOD2 ELMO/CED-12 domain containing 2 2.39731
BOLA1 bolA family member 1 2.39064
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 2.37464
TMEM107 transmembrane protein 107 2.3517
UHMK1 U2AF homology motif (UHM) kinase 1 2.3517
RNMT RNA (guanine-7-) methyltransferase 2.31869
MTMR9 myotubularin related protein 9 2.29903
KIAA0930 KIAA0930 2.29903
GLRX5 glutaredoxin 5 2.29903
SPTBN2 spectrin, beta, non-erythrocytic 2 2.2874
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.26889
SUOX sulfite oxidase 2.24935
PDE12 phosphodiesterase 12 2.24935
SLC16A9 solute carrier family 16, member 9 2.23787
THRAP3 thyroid hormone receptor associated protein 3 2.23372
NADK2 NAD kinase 2, mitochondrial 2.21368
IFT43 intraflagellar transport 43 2.20802
SEPTIN2 septin 2 2.20802
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 2.16294
SNIP1 Smad nuclear interacting protein 1 2.15661
ACSL1 acyl-CoA synthetase long-chain family member 1 2.15542
TAOK3 TAO kinase 3 2.15276
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 2.12276
RGS17 regulator of G-protein signaling 17 2.12003
FBXO8 F-box protein 8 2.1057
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.10254
SEC24B SEC24 family member B 2.08405
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.0725
IPCEF1 interaction protein for cytohesin exchange factors 1 2.05482
SOX13 SRY (sex determining region Y)-box 13 2.02911
OOEP oocyte expressed protein 2.0185
IL17RD interleukin 17 receptor D 2.01554
ING2 inhibitor of growth family, member 2 2.01527
TBCA tubulin folding cofactor A 2.0044
UNC119B unc-119 homolog B (C. elegans) 2.0044
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.0044
EBF3 early B-cell factor 3 2.0044
COL9A2 collagen, type IX, alpha 2 2.0044
SLC22A24 solute carrier family 22, member 24 2.0044
TDRD1 tudor domain containing 1 2.0044
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.00298
ACOX3 acyl-CoA oxidase 3, pristanoyl 2.00298
RPL10A ribosomal protein L10a 2.00291
SHB Src homology 2 domain containing adaptor protein B 2.00291

decreased expression

Symbol Name Standardized Value
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.79293
BHLHE40 basic helix-loop-helix family, member e40 -2.79293
KLK8 kallikrein-related peptidase 8 -2.79293
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.79293
TP53TG5 TP53 target 5 -2.79293
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) -2.79293
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.79293
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.79293
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.79293
CILP2 cartilage intermediate layer protein 2 -2.79293
IQCN IQ motif containing N -2.79293
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.79293
SCAMP1 secretory carrier membrane protein 1 -2.65922
RELL2 RELT-like 2 -2.65205
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.63878
FNTA farnesyltransferase, CAAX box, alpha -2.63878
CAPN3 calpain 3, (p94) -2.61629
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -2.60538
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -2.59499
ZMAT3 zinc finger, matrin-type 3 -2.56742
PRRT1 proline-rich transmembrane protein 1 -2.53588
CLCF1 cardiotrophin-like cytokine factor 1 -2.5091
FNDC7 fibronectin type III domain containing 7 -2.5091
TUBB8 tubulin, beta 8 class VIII -2.5091
SPX spexin hormone -2.5091
TRPV5 transient receptor potential cation channel, subfamily V, member 5 -2.5091
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.5091
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) -2.5091
ASB12 ankyrin repeat and SOCS box containing 12 -2.5091
GFAP glial fibrillary acidic protein -2.5091
PKD1L1 polycystic kidney disease 1 like 1 -2.5091
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -2.5091
LGSN lengsin, lens protein with glutamine synthetase domain -2.5091
TIMD4 T-cell immunoglobulin and mucin domain containing 4 -2.5091
RPS21-DT RPS21 divergent transcript -2.5091
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.5091
CKM creatine kinase, muscle -2.5091
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -2.5091
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -2.5091
KLHL31 kelch-like family member 31 -2.5091
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E -2.5091
ZNF580 zinc finger protein 580 -2.5091
UPK3A uroplakin 3A -2.5091
ZNF492 zinc finger protein 492 -2.5091
PCDHGA9 protocadherin gamma subfamily A, 9 -2.5091
SPINK9 serine peptidase inhibitor, Kazal type 9 -2.5091
ADM2 adrenomedullin 2 -2.5091
POU5F2 POU domain class 5, transcription factor 2 -2.5091
MMP19 matrix metallopeptidase 19 -2.5091
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -2.5091
TBXA2R thromboxane A2 receptor -2.5091
LOC114841035 uncharacterized LOC114841035 -2.5091
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.5091
SPATA32 spermatogenesis associated 32 -2.5091
CTSC cathepsin C -2.5091
PCDHGB7 protocadherin gamma subfamily B, 7 -2.5091
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -2.5091
KRTAP13-4 keratin associated protein 13-4 -2.5091
FXYD2 FXYD domain containing ion transport regulator 2 -2.5091
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.5091
STRC stereocilin -2.5091
ARGFX arginine-fifty homeobox -2.5091
MFAP1 microfibrillar-associated protein 1 -2.50787
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -2.49715
SMAP1 small ArfGAP 1 -2.49101
KLF12 Kruppel-like factor 12 -2.47135
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) -2.41553
CCDC47 coiled-coil domain containing 47 -2.402
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.37735
PLAG1 pleiomorphic adenoma gene 1 -2.36033
XIRP2 xin actin binding repeat containing 2 -2.36033
DPYSL4 dihydropyrimidinase-like 4 -2.36033
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -2.3517
PLK5 polo-like kinase 5 -2.3517
HSH2D hematopoietic SH2 domain containing -2.3517
NOXA1 NADPH oxidase activator 1 -2.3517
INHBA inhibin, beta A -2.3517
COL8A1 collagen, type VIII, alpha 1 -2.3517
PROM2 prominin 2 -2.3517
NEMP1 nuclear envelope integral membrane protein 1 -2.34467
ATP13A2 ATPase type 13A2 -2.28916
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -2.28879
ZCCHC3 zinc finger, CCHC domain containing 3 -2.28523
ZNF761 zinc finger protein 761 -2.27236
ARL16 ADP-ribosylation factor-like 16 -2.26479
TMEM91 transmembrane protein 91 -2.25055
CXCL17 chemokine (C-X-C motif) ligand 17 -2.243
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.243
CRYBG3 beta-gamma crystallin domain containing 3 -2.23787
CHD9NB CHD9 neighbor -2.23787
ACAD8 acyl-CoA dehydrogenase family, member 8 -2.21708
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) -2.21682
VAMP5 vesicle-associated membrane protein 5 -2.2162
ADISSP adipose secreted signaling protein -2.2158
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.21368
CFAP58 cilia and flagella associated protein 58 -2.20269
TMEM53 transmembrane protein 53 -2.15661
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -2.15661
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.15527
EXOSC6 exosome component 6 -2.15229
NKD2 naked cuticle homolog 2 (Drosophila) -2.15229
SOCS5 suppressor of cytokine signaling 5 -2.13804
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough -2.13749
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.13385
NLGN1 neuroligin 1 -2.1262
TRIO trio Rho guanine nucleotide exchange factor -2.11041
MVK mevalonate kinase -2.10733
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.1057
NPR1 natriuretic peptide receptor 1 -2.08405
NEK11 NIMA-related kinase 11 -2.07185
NSD1 nuclear receptor binding SET domain protein 1 -2.07006
GCDH glutaryl-CoA dehydrogenase -2.0692
ATL3 atlastin GTPase 3 -2.0609
ARMCX4 armadillo repeat containing, X-linked 4 -2.06049
TMEM52 transmembrane protein 52 -2.06049
TOP1MT topoisomerase (DNA) I, mitochondrial -2.05918
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -2.04868
NAIP NLR family, apoptosis inhibitory protein -2.02911
MRPS12 mitochondrial ribosomal protein S12 -2.02338
CCDC178 coiled-coil domain containing 178 -2.0192
MT1E metallothionein 1E -2.0192
GSTM3 glutathione S-transferase mu 3 (brain) -2.0192
IFT22 intraflagellar transport 22 -2.01092
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q -2.0044
TBC1D2 TBC1 domain family, member 2 -2.0044
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -2.0044