SMURF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description SMAD specific E3 ubiquitin protein ligase 1|This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 57154)
External Link http://www.ncbi.nlm.nih.gov/gene/57154
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359 interacting proteins for SMURF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACTB actin, beta
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ANAPC5 anaphase promoting complex subunit 5
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APP amyloid beta (A4) precursor protein
ARHGAP15 Rho GTPase activating protein 15
ARHGAP31 Rho GTPase activating protein 31
ARHGAP32 Rho GTPase activating protein 32
ARHGAP5 Rho GTPase activating protein 5
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARL14 ADP-ribosylation factor-like 14
ARL4D ADP-ribosylation factor-like 4D
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
AVEN apoptosis, caspase activation inhibitor
AXIN1 axin 1
BCLAF1 BCL2-associated transcription factor 1
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BYSL bystin-like
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CCAR1 cell division cycle and apoptosis regulator 1
CCDC88A coiled-coil domain containing 88A
CCDC88C coiled-coil domain containing 88C
CCM2 cerebral cavernous malformation 2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDC40 cell division cycle 40
CDK14 cyclin-dependent kinase 14
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEP164 centrosomal protein 164kDa
CFL1 cofilin 1 (non-muscle)
CIRBP cold inducible RNA binding protein
CLASP2 cytoplasmic linker associated protein 2
CLNS1A chloride channel, nucleotide-sensitive, 1A
CLTC clathrin, heavy chain (Hc)
CMBL carboxymethylenebutenolidase homolog (Pseudomonas)
COPRS coordinator of PRMT5, differentiation stimulator
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CSNK2A2 casein kinase 2, alpha prime polypeptide
CUL5 cullin 5
CXXC1 CXXC finger protein 1
DCTN1 dynactin 1
DCTN2 dynactin 2 (p50)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DUSP13 dual specificity phosphatase 13
DVL2 dishevelled segment polarity protein 2
E2F7 E2F transcription factor 7
ECSIT ECSIT signalling integrator
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EFNB1 ephrin-B1
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF4B eukaryotic translation initiation factor 4B
ELP3 elongator acetyltransferase complex subunit 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESR1 estrogen receptor 1
ETV6 ets variant 6
FASN fatty acid synthase
FBXL15 F-box and leucine-rich repeat protein 15
FBXL5 F-box and leucine-rich repeat protein 5
FBXO21 F-box protein 21
FBXO24 F-box protein 24
FBXO3 F-box protein 3
FBXO30 F-box protein 30
FBXO42 F-box protein 42
FBXO44 F-box protein 44
FCHO1 FCH domain only 1
FHL1 four and a half LIM domains 1
FKBP1A FK506 binding protein 1A, 12kDa
FLNA filamin A, alpha
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAR1 GAR1 ribonucleoprotein
GAS7 growth arrest-specific 7
GDI2 GDP dissociation inhibitor 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA3 golgin A3
GRIP1 glutamate receptor interacting protein 1
GRIPAP1 GRIP1 associated protein 1
GTF2B general transcription factor IIB
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC8 histone deacetylase 8
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IRAK2 interleukin-1 receptor-associated kinase 2
ITCH itchy E3 ubiquitin protein ligase
IVNS1ABP influenza virus NS1A binding protein
JAK1 Janus kinase 1
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KIF11 kinesin family member 11
KLF2 Kruppel-like factor 2
KPNB1 karyopherin (importin) beta 1
LDHB lactate dehydrogenase B
LHX9 LIM homeobox 9
LIMS1 LIM and senescent cell antigen-like domains 1
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRPPRC leucine-rich pentatricopeptide repeat containing
LTBP1 latent transforming growth factor beta binding protein 1
MAP1B microtubule-associated protein 1B
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAT2A methionine adenosyltransferase II, alpha
MAVS mitochondrial antiviral signaling protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MRPS22 mitochondrial ribosomal protein S22
MRPS23 mitochondrial ribosomal protein S23
MRPS27 mitochondrial ribosomal protein S27
MYD88 myeloid differentiation primary response 88
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit
NDFIP1 Nedd4 family interacting protein 1
NDFIP2 Nedd4 family interacting protein 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NUCLEOLIN nucleolin multifunctional protein
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5
NUMA1 nuclear mitotic apparatus protein 1
OCLN occludin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSBPL3 oxysterol binding protein-like 3
OXSR1 oxidative stress responsive 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK1IP1 PAK1 interacting protein 1
PARD3B par-3 family cell polarity regulator beta
PARD6A par-6 family cell polarity regulator alpha
PDIA6 protein disulfide isomerase family A, member 6
PDLIM7 PDZ and LIM domain 7 (enigma)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPAT phosphoribosyl pyrophosphate amidotransferase
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PQBP1 polyglutamine binding protein 1
PRICKLE1 prickle homolog 1 (Drosophila)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRMT1 protein arginine methyltransferase 1
PRMT5 protein arginine methyltransferase 5
PRPF31 pre-mRNA processing factor 31
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTCH1 patched 1
PTS 6-pyruvoyltetrahydropterin synthase
PWP1 PWP1 homolog (S. cerevisiae)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPSN receptor-associated protein of the synapse
RASD2 RASD family, member 2
RBM10 RNA binding motif protein 10
RBM17 RNA binding motif protein 17
RHOA ras homolog family member A
RHOBTB1 Rho-related BTB domain containing 1
RHPN2 rhophilin, Rho GTPase binding protein 2
RIOK1 RIO kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RIT1 Ras-like without CAAX 1
RLIM ring finger protein, LIM domain interacting
RNF11 ring finger protein 11
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF14 ring finger protein 14
RNF141 ring finger protein 141
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL17 ribosomal protein L17
RPL22 ribosomal protein L22
RPL23 ribosomal protein L23
RPL24 ribosomal protein L24
RPL31 ribosomal protein L31
RPS10 ribosomal protein S10
RPS11 ribosomal protein S11
RPS12 ribosomal protein S12
RPS13 ribosomal protein S13
RPS14 ribosomal protein S14
RPS15 ribosomal protein S15
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS17 ribosomal protein S17
RPS18 ribosomal protein S18
RPS19 ribosomal protein S19
RPS20 ribosomal protein S20
RPS24 ribosomal protein S24
RPS25 ribosomal protein S25
RPS27A ribosomal protein S27a
RPS3 ribosomal protein S3
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
RPS5 ribosomal protein S5
RPS6 ribosomal protein S6
RPS8 ribosomal protein S8
RPS9 ribosomal protein S9
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RTKN rhotekin
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
SASH3 SAM and SH3 domain containing 3
SENP8 SUMO/sentrin specific peptidase family member 8
SF3A1 splicing factor 3a, subunit 1, 120kDa
SF3B1 splicing factor 3b, subunit 1, 155kDa
SF3B2 splicing factor 3b, subunit 2, 145kDa
SKI SKI proto-oncogene
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPIN1 spindlin 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SRSF1 serine/arginine-rich splicing factor 1
SRSF4 serine/arginine-rich splicing factor 4
SRSF5 serine/arginine-rich splicing factor 5
SSB Sjogren syndrome antigen B (autoantigen La)
STAT1 signal transducer and activator of transcription 1, 91kDa
STK35 serine/threonine kinase 35
STK38 serine/threonine kinase 38
STK38L serine/threonine kinase 38 like
STRAP serine/threonine kinase receptor associated protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUB1 SUB1 homolog (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBL2 transducin (beta)-like 2
TCERG1 transcription elongation regulator 1
TCP1 t-complex 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLN1 talin 1
TMPO thymopoietin
TNK2 tyrosine kinase, non-receptor, 2
TNNT1 troponin T type 1 (skeletal, slow)
TP53 tumor protein p53
TRAF4 TNF receptor-associated factor 4
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TRIM28 tripartite motif containing 28
TRIM35 tripartite motif containing 35
TTC17 tetratricopeptide repeat domain 17
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUFM Tu translation elongation factor, mitochondrial
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E2 ubiquitin-conjugating enzyme E2E 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2K ubiquitin-conjugating enzyme E2K
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBE2M ubiquitin-conjugating enzyme E2M
UBE2N ubiquitin-conjugating enzyme E2N
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBE2S ubiquitin-conjugating enzyme E2S
UBE2T ubiquitin-conjugating enzyme E2T
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UBTF upstream binding transcription factor, RNA polymerase I
UBXN1 UBX domain protein 1
UHMK1 U2AF homology motif (UHM) kinase 1
ULK4 unc-51 like kinase 4
USP15 ubiquitin specific peptidase 15
USP45 ubiquitin specific peptidase 45
USP9X ubiquitin specific peptidase 9, X-linked
VCP valosin containing protein
VIM vimentin
WBP4 WW domain binding protein 4
WDR61 WD repeat domain 61
WDR77 WD repeat domain 77
WEE1 WEE1 G2 checkpoint kinase
WFS1 Wolfram syndrome 1 (wolframin)
WWOX WW domain containing oxidoreductase
XPO1 exportin 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YY1AP1 YY1 associated protein 1
ZBTB8B zinc finger and BTB domain containing 8B
ZRANB2 zinc finger, RAN-binding domain containing 2