SNAPIN Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SNAP-associated protein|The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] (NCBI Entrez Gene Database, 23557)
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Genes

356 genes differentially expressed following the SNAPIN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.43787
CD1D CD1d molecule 2.43787
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.43787
PPP1R9A protein phosphatase 1, regulatory subunit 9A 2.43787
MUC1 mucin 1, cell surface associated 2.43787
GAL galanin/GMAP prepropeptide 2.43787
RAB17 RAB17, member RAS oncogene family 2.43787
HES3 hes family bHLH transcription factor 3 2.43787
RIMBP2 RIMS binding protein 2 2.43787
DRICH1 aspartate-rich 1 2.43787
NME5 NME/NM23 family member 5 2.43787
CORT cortistatin 2.43787
MC4R melanocortin 4 receptor 2.43787
CLU clusterin 2.43787
DUXB double homeobox B 2.43787
LIPF lipase, gastric 2.43787
ISM2 isthmin 2 2.43787
SYCP2 synaptonemal complex protein 2 2.43787
GPR4 G protein-coupled receptor 4 2.43787
GJA5 gap junction protein, alpha 5, 40kDa 2.43787
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.43787
LY86 lymphocyte antigen 86 2.43787
FGF21 fibroblast growth factor 21 2.43787
UCN urocortin 2.43787
IYD iodotyrosine deiodinase 2.43787
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.43787
BMP8B bone morphogenetic protein 8b 2.43787
ADAM33 ADAM metallopeptidase domain 33 2.43787
SIGLEC9 sialic acid binding Ig-like lectin 9 2.43787
RGPD3 RANBP2-like and GRIP domain containing 3 2.43787
CPB2 carboxypeptidase B2 (plasma) 2.43787
FABP12 fatty acid binding protein 12 2.43787
CCDC38 coiled-coil domain containing 38 2.43787
SHE Src homology 2 domain containing E 2.43787
S100A5 S100 calcium binding protein A5 2.43787
COL15A1 collagen, type XV, alpha 1 2.43787
LGALS2 lectin, galactoside-binding, soluble, 2 2.43787
KLLN killin, p53-regulated DNA replication inhibitor 2.43787
SP6 Sp6 transcription factor 2.43787
TCEAL4 transcription elongation factor A (SII)-like 4 2.43787
GPHB5 glycoprotein hormone beta 5 2.43787
GMFG glia maturation factor, gamma 2.43787
TDRD6 tudor domain containing 6 2.43787
MSC musculin 2.43787
OPRL1 opiate receptor-like 1 2.43787
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 2.43787
FAM86B2 family with sequence similarity 86, member B2 2.43787
ASPA aspartoacylase 2.43787
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.43787
TNIP3 TNFAIP3 interacting protein 3 2.43787
THRSP thyroid hormone responsive 2.43787
POSTN periostin, osteoblast specific factor 2.43787
RPL26L1 ribosomal protein L26-like 1 2.43787
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.43787
C2ORF78 chromosome 2 open reading frame 78 2.43787
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.43787
SMIM33 small integral membrane protein 33 2.43787
STING1 stimulator of interferon response cGAMP interactor 1 2.43787
GOLGA6L7 golgin A6 family like 7 2.43787
TYROBP TYRO protein tyrosine kinase binding protein 2.43787
SPRR2F small proline-rich protein 2F 2.43787
ANO7 anoctamin 7 2.43787
LMNTD2 lamin tail domain containing 2 2.43787
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.43787
MYPN myopalladin 2.43787
DOK7 docking protein 7 2.43787
DOK2 docking protein 2, 56kDa 2.43787
PYDC5 pyrin domain containing 5 2.43787
DIPK2B divergent protein kinase domain 2B 2.43787
TAMALIN trafficking regulator and scaffold protein tamalin 2.43787
SPMIP1 sperm microtubule inner protein 1 2.43787
ZC3H11C zinc finger CCCH-type containing 11C 2.43787
FAM240C family with sequence similarity 240 member C 2.43787
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.43787
H3C13 H3 clustered histone 13 2.43787
GREP1 glycine rich extracellular protein 1 2.43787
TMEM272 transmembrane protein 272 2.43787
TMEM273 transmembrane protein 273 2.43787
FREY1 Frey regulator of sperm-oocyte fusion 1 2.43787
RNF227 ring finger protein 227 2.43787
KASH5 KASH domain containing 5 2.43787
F5 coagulation factor V (proaccelerin, labile factor) 2.43787
CCDC42 coiled-coil domain containing 42 2.43787
HNF1A HNF1 homeobox A 2.43787
MSX2 msh homeobox 2 2.43787
CATSPER3 cation channel, sperm associated 3 2.43787
CD79A CD79a molecule, immunoglobulin-associated alpha 2.43787
SCN10A sodium channel, voltage gated, type X alpha subunit 2.43787
AXDND1 axonemal dynein light chain domain containing 1 2.43787
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.43787
TMIE transmembrane inner ear 2.43787
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.43787
PCDHB11 protocadherin beta 11 2.43787
KLHL33 kelch-like family member 33 2.43787
PCDHA7 protocadherin alpha 7 2.43787
TLR7 toll-like receptor 7 2.43787
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.43787
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.43787
DLK1 delta-like 1 homolog (Drosophila) 2.43787
NPIPB8 nuclear pore complex interacting protein family, member B8 2.43787
GPR83 G protein-coupled receptor 83 2.43787
ZAR1L zygote arrest 1-like 2.43787
TAS1R1 taste receptor, type 1, member 1 2.43787
ARHGAP15 Rho GTPase activating protein 15 2.43787
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 2.43787
CCR7 chemokine (C-C motif) receptor 7 2.43787
EXOC3L4 exocyst complex component 3-like 4 2.43787
AMY2A amylase, alpha 2A (pancreatic) 2.43787
ESR1 estrogen receptor 1 2.43787
FOXD1 forkhead box D1 2.43787
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.43787
RPL5 ribosomal protein L5 2.43787
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.43787
ADORA3 adenosine A3 receptor 2.43787
HHATL hedgehog acyltransferase-like 2.43787
HSPA1L heat shock 70kDa protein 1-like 2.43787
SMIM23 small integral membrane protein 23 2.43787
ZNF784 zinc finger protein 784 2.43787
CDHR5 cadherin-related family member 5 2.43787
LCN2 lipocalin 2 2.43787
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.43787
RPL9 ribosomal protein L9 2.43787
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.43787
CFH complement factor H 2.43787
BOLL boule-like RNA-binding protein 2.43787
HSF4 heat shock transcription factor 4 2.43787
PMP2 peripheral myelin protein 2 2.43787
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 2.43787
PCDHGB5 protocadherin gamma subfamily B, 5 2.43787
RPA4 replication protein A4, 30kDa 2.43787
NPPA natriuretic peptide A 2.43787
LRRC43 leucine rich repeat containing 43 2.43787
ARHGAP20 Rho GTPase activating protein 20 2.43787
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.43787
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.43787
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.43787
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.43787
PRTN3 proteinase 3 2.43787
PGR progesterone receptor 2.43787
SH2D1A SH2 domain containing 1A 2.43787
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.43787
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 2.43787
LAMB4 laminin, beta 4 2.43787
CCNA1 cyclin A1 2.43787
GBX2 gastrulation brain homeobox 2 2.43787
TEX29 testis expressed 29 2.43787
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.43787
AICDA activation-induced cytidine deaminase 2.43787
CHIT1 chitinase 1 (chitotriosidase) 2.43787
C16ORF78 chromosome 16 open reading frame 78 2.43787
CTTNBP2NL CTTNBP2 N-terminal like 2.43787
RANBP3L RAN binding protein 3-like 2.43787
CCDC27 coiled-coil domain containing 27 2.43787
VWA3A von Willebrand factor A domain containing 3A 2.43787
COL17A1 collagen, type XVII, alpha 1 2.43787
PLA1A phospholipase A1 member A 2.43787
ZNF596 zinc finger protein 596 2.43787
COPS3 COP9 signalosome subunit 3 2.43787
KLK4 kallikrein-related peptidase 4 2.43787
GOLGA8N golgin A8 family, member N 2.43787
PRR22 proline rich 22 2.43787
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.43787
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.43787
PRR29 proline rich 29 2.43787
SPAG8 sperm associated antigen 8 2.43787
CD80 CD80 molecule 2.43787
CD8B CD8b molecule 2.43787
BRI3 brain protein I3 2.43787
IL17B interleukin 17B 2.43787
ARGFX arginine-fifty homeobox 2.43787
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.43787
CD22 CD22 molecule 2.43787
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.43787
TMEM88 transmembrane protein 88 2.43787
ASCL5 achaete-scute family bHLH transcription factor 5 2.43787
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.43787
HRG histidine-rich glycoprotein 2.43787
DCST1 DC-STAMP domain containing 1 2.43787
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.43787
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.43787
LIMS3 LIM and senescent cell antigen-like domains 3 2.43787
CARNS1 carnosine synthase 1 2.43787
SYTL5 synaptotagmin-like 5 2.43787
ADGRF4 adhesion G protein-coupled receptor F4 2.43787
NRGN neurogranin (protein kinase C substrate, RC3) 2.43787
ZNF648 zinc finger protein 648 2.43787
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.43787
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.43787
FAM161B family with sequence similarity 161, member B 2.43787
GH1 growth hormone 1 2.43787
BLVRB biliverdin reductase B 2.43787
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.43787
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.40373
JADE3 jade family PHD finger 3 2.38096
MADD MAP-kinase activating death domain 2.38096
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 2.38096
JPH2 junctophilin 2 2.38096
RREB1 ras responsive element binding protein 1 2.38096
GHDC GH3 domain containing 2.38096
MAN2B2 mannosidase, alpha, class 2B, member 2 2.38096
FAM169A family with sequence similarity 169, member A 2.38096
COQ6 coenzyme Q6 monooxygenase 2.38096
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.38096
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 2.38096
PROSER1 proline and serine rich 1 2.38096
RAB7A RAB7A, member RAS oncogene family 2.36981
IFT54 intraflagellar transport 54 2.36981
PLAAT3 phospholipase A and acyltransferase 3 2.35565
KLF12 Kruppel-like factor 12 2.34506
GPC6 glypican 6 2.33376
GAR1 GAR1 ribonucleoprotein 2.33376
JMY junction mediating and regulatory protein, p53 cofactor 2.31652
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 2.29666
UXS1 UDP-glucuronate decarboxylase 1 2.29666
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.29246
TASOR2 transcription activation suppressor family member 2 2.28651
CAGE1 cancer antigen 1 2.28214
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.28178
RPSA ribosomal protein SA 2.25205
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 2.23919
TMSB4X thymosin beta 4, X-linked 2.23919
DCC DCC netrin 1 receptor 2.20707
ARL8B ADP-ribosylation factor-like 8B 2.19813
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 2.17797
COL6A2 collagen, type VI, alpha 2 2.13956
TIGD7 tigger transposable element derived 7 2.13318
NEURL1B neuralized E3 ubiquitin protein ligase 1B 2.13268
THOC3 THO complex 3 2.1308
GDI1 GDP dissociation inhibitor 1 2.10149
SENP8 SUMO/sentrin specific peptidase family member 8 2.08607
CUTA cutA divalent cation tolerance homolog (E. coli) 2.08374
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 2.08042
NPPC natriuretic peptide C 2.08042
EPHB1 EPH receptor B1 2.07966
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 2.07527
LMCD1 LIM and cysteine-rich domains 1 2.07374
COPS5 COP9 signalosome subunit 5 2.07319
GALNS galactosamine (N-acetyl)-6-sulfatase 2.06444
TMCO1 transmembrane and coiled-coil domains 1 2.04891
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 2.04458
RIPK2 receptor-interacting serine-threonine kinase 2 2.00688
KLHDC10 kelch domain containing 10 2.00623

decreased expression

Symbol Name Standardized Value
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.43787
TMPRSS11D transmembrane protease, serine 11D -2.43787
FAM3A family with sequence similarity 3, member A -2.43787
ZNF282 zinc finger protein 282 -2.43787
FCHO1 FCH domain only 1 -2.43787
TERT telomerase reverse transcriptase -2.43787
PRKD3 protein kinase D3 -2.43787
CCDC74B coiled-coil domain containing 74B -2.43787
ADGRA3 adhesion G protein-coupled receptor A3 -2.43787
USP21 ubiquitin specific peptidase 21 -2.43787
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.43787
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit -2.43787
ELN elastin -2.43787
ADRA2A adrenoceptor alpha 2A -2.43787
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -2.43787
EXOC8 exocyst complex component 8 -2.43787
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.43787
CHD9 chromodomain helicase DNA binding protein 9 -2.43787
SNAPIN SNAP-associated protein -2.43787
CACFD1 calcium channel flower domain containing 1 -2.43787
MOG myelin oligodendrocyte glycoprotein -2.43787
MAN2A1 mannosidase, alpha, class 2A, member 1 -2.43787
KMT2D lysine (K)-specific methyltransferase 2D -2.43224
OMG oligodendrocyte myelin glycoprotein -2.42363
RAB1A RAB1A, member RAS oncogene family -2.42137
PRSS36 protease, serine, 36 -2.38096
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.38096
IDUA iduronidase, alpha-L- -2.38096
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.38096
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.38096
CAMK1G calcium/calmodulin-dependent protein kinase IG -2.38096
PARP10 poly (ADP-ribose) polymerase family, member 10 -2.38096
LCN10 lipocalin 10 -2.38096
C19ORF85 chromosome 19 open reading frame 85 -2.38096
LOC124906010 uncharacterized LOC124906010 -2.38096
CFAP276 cilia and flagella associated protein 276 -2.38096
LINGO3 leucine rich repeat and Ig domain containing 3 -2.38096
DDTL D-dopachrome tautomerase-like -2.38096
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -2.38096
MAGEB1 melanoma antigen family B1 -2.38096
HRH4 histamine receptor H4 -2.38096
MAGEA4 melanoma antigen family A4 -2.38096
MTTP microsomal triglyceride transfer protein -2.38096
TRIL TLR4 interactor with leucine-rich repeats -2.38096
VEZF1 vascular endothelial zinc finger 1 -2.38096
KCNRG potassium channel regulator -2.38096
SPMIP10 sperm microtubule inner protein 10 -2.38096
SCIN scinderin -2.38096
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.38096
BHMT betaine--homocysteine S-methyltransferase -2.38096
OPTC opticin -2.38096
ERVV-2 endogenous retrovirus group V, member 2 -2.38096
FNDC8 fibronectin type III domain containing 8 -2.38096
CPZ carboxypeptidase Z -2.38096
CISH cytokine inducible SH2-containing protein -2.38096
LRRC32 leucine rich repeat containing 32 -2.38096
RECK reversion-inducing-cysteine-rich protein with kazal motifs -2.38096
NKPD1 NTPase, KAP family P-loop domain containing 1 -2.38096
DNAH6 dynein, axonemal, heavy chain 6 -2.38096
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -2.38096
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.38096
ELL3 elongation factor RNA polymerase II-like 3 -2.38096
C6ORF163 chromosome 6 open reading frame 163 -2.38096
CTF1 cardiotrophin 1 -2.38096
CCR10 chemokine (C-C motif) receptor 10 -2.38096
ABHD14A abhydrolase domain containing 14A -2.34159
GPM6A glycoprotein M6A -2.33286
BMP1 bone morphogenetic protein 1 -2.33286
ZNF883 zinc finger protein 883 -2.32531
UFM1 ubiquitin-fold modifier 1 -2.31653
DPPA5 developmental pluripotency associated 5 -2.29155
ZNF584 zinc finger protein 584 -2.29155
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -2.28229
CTTN cortactin -2.28178
SNRK SNF related kinase -2.26103
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.25614
FBN2 fibrillin 2 -2.24817
CYB5R1 cytochrome b5 reductase 1 -2.23919
EVI5 ecotropic viral integration site 5 -2.21484
FLT1 fms-related tyrosine kinase 1 -2.20738
TSC22D3 TSC22 domain family, member 3 -2.20402
EMILIN2 elastin microfibril interfacer 2 -2.1817
MITF microphthalmia-associated transcription factor -2.1817
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.17891
CCDC150 coiled-coil domain containing 150 -2.17797
HDIP1 HDAC and MIER1 interacting protein 1 -2.17155
EIF3E eukaryotic translation initiation factor 3, subunit E -2.11802
CUEDC2 CUE domain containing 2 -2.1116
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -2.10519
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.10519
EPSTI1 epithelial stromal interaction 1 (breast) -2.10519
LMO2 LIM domain only 2 (rhombotin-like 1) -2.10519
MCPH1 microcephalin 1 -2.10391
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -2.09769
FAM217A family with sequence similarity 217, member A -2.09162
PRIM1 primase, DNA, polypeptide 1 (49kDa) -2.08607
CLPSL2 colipase-like 2 -2.08607
FLAD1 flavin adenine dinucleotide synthetase 1 -2.08374
ZNF337 zinc finger protein 337 -2.07385
KLHDC3 kelch domain containing 3 -2.07374
SHPK sedoheptulokinase -2.07374
RTTN rotatin -2.07153
ZNF816 zinc finger protein 816 -2.06916
IGSF9 immunoglobulin superfamily, member 9 -2.05379
SHISAL2B shisa like 2B -2.05025
CDHR1 cadherin-related family member 1 -2.04891
WLS wntless Wnt ligand secretion mediator -2.04891
ZNF772 zinc finger protein 772 -2.04891
CUX2 cut-like homeobox 2 -2.0374
PPP1R3F protein phosphatase 1, regulatory subunit 3F -2.03256
ATG10 autophagy related 10 -2.02722
BRI3BP BRI3 binding protein -2.00839
CHLSN cholesin -2.00688
NCOR1 nuclear receptor corepressor 1 -2.00588