SNF5_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/SNF5_DN.V1_UP
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Genes

336 genes differentially expressed following the SNF5_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABHD14A abhydrolase domain containing 14A
ABI3BP ABI family, member 3 (NESH) binding protein
ACTL6A actin-like 6A
ADI1 acireductone dioxygenase 1
AGTR2 angiotensin II receptor, type 2
AIF1 allograft inflammatory factor 1
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
APOE apolipoprotein E
AQP5 aquaporin 5
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKB aurora kinase B
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF37 chromosome 14 open reading frame 37
C17ORF49 chromosome 17 open reading frame 49
C19ORF48 chromosome 19 open reading frame 48
C1QC complement component 1, q subcomponent, C chain
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3AR1 complement component 3a receptor 1
C5ORF28 chromosome 5 open reading frame 28
CCDC132 coiled-coil domain containing 132
CCL3 chemokine (C-C motif) ligand 3
CD109 CD109 molecule
CD48 CD48 molecule
CD52 CD52 molecule
CD53 CD53 molecule
CD68 CD68 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDO1 cysteine dioxygenase type 1
CFP complement factor properdin
CKAP2 cytoskeleton associated protein 2
COL15A1 collagen, type XV, alpha 1
COL26A1 collagen, type XXVI, alpha 1
COPS4 COP9 signalosome subunit 4
CORO1C coronin, actin binding protein, 1C
CSF1R colony stimulating factor 1 receptor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DARS aspartyl-tRNA synthetase
DCAKD dephospho-CoA kinase domain containing
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND4C DENN/MADD domain containing 4C
DHRS1 dehydrogenase/reductase (SDR family) member 1
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGFL6 EGF-like-domain, multiple 6
EGR2 early growth response 2
ELN elastin
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
ERAP1 endoplasmic reticulum aminopeptidase 1
EVI2A ecotropic viral integration site 2A
EVL Enah/Vasp-like
EWSR1 EWS RNA-binding protein 1
FABP7 fatty acid binding protein 7, brain
FAM105A family with sequence similarity 105, member A
FAM65B family with sequence similarity 65, member B
FBLN1 fibulin 1
FBXO6 F-box protein 6
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FDPS farnesyl diphosphate synthase
FGF18 fibroblast growth factor 18
FMOD fibromodulin
FNBP1 formin binding protein 1
FNDC1 fibronectin type III domain containing 1
FYB FYN binding protein
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GALC galactosylceramidase
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRK6 G protein-coupled receptor kinase 6
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF3A general transcription factor IIIA
HAPLN2 hyaluronan and proteoglycan link protein 2
HAT1 histone acetyltransferase 1
IARS isoleucyl-tRNA synthetase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5L immediate early response 5-like
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KIAA1524 KIAA1524
KIF20A kinesin family member 20A
KLHL42 kelch-like family member 42
LAMB2 laminin, beta 2 (laminin S)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHX2 LIM homeobox 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIX1 Lix1 homolog (chicken)
LMO2 LIM domain only 2 (rhombotin-like 1)
LRP5 low density lipoprotein receptor-related protein 5
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY86 lymphocyte antigen 86
MCM5 minichromosome maintenance complex component 5
MEDAG mesenteric estrogen-dependent adipogenesis
MEST mesoderm specific transcript
MKL1 megakaryoblastic leukemia (translocation) 1
MLF2 myeloid leukemia factor 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MSX1 msh homeobox 1
MT3 metallothionein 3
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NCAN neurocan
NCAPG2 non-SMC condensin II complex, subunit G2
NDE1 nudE neurodevelopment protein 1
NRROS negative regulator of reactive oxygen species
OASL 2'-5'-oligoadenylate synthetase-like
OLIG1 oligodendrocyte transcription factor 1
PENK proenkephalin
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PITPNB phosphatidylinositol transfer protein, beta
PLCE1 phospholipase C, epsilon 1
PLD3 phospholipase D family, member 3
PLD4 phospholipase D family, member 4
PLEK pleckstrin
PNN pinin, desmosome associated protein
POFUT2 protein O-fucosyltransferase 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP4C protein phosphatase 4, catalytic subunit
PRKCDBP protein kinase C, delta binding protein
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRRX2 paired related homeobox 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTPRC protein tyrosine phosphatase, receptor type, C
RABAC1 Rab acceptor 1 (prenylated)
RBL1 retinoblastoma-like 1
RCC1 regulator of chromosome condensation 1
RNF13 ring finger protein 13
SCG2 secretogranin II
SELPLG selectin P ligand
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFRP2 secreted frizzled-related protein 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMAD2 SMAD family member 2
SOSTDC1 sclerostin domain containing 1
SOX2 SRY (sex determining region Y)-box 2
SPI1 Spi-1 proto-oncogene
SRPX sushi-repeat containing protein, X-linked
STOML2 stomatin (EPB72)-like 2
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TF transferrin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB3 transforming growth factor, beta 3
TIPIN TIMELESS interacting protein
TMEM106A transmembrane protein 106A
TREX1 three prime repair exonuclease 1
UBE2C ubiquitin-conjugating enzyme E2C
USP15 ubiquitin specific peptidase 15
VAMP5 vesicle-associated membrane protein 5
WAS Wiskott-Aldrich syndrome
ZMYND19 zinc finger, MYND-type containing 19
ZNFX1 zinc finger, NFX1-type containing 1
ZWILCH zwilch kinetochore protein

decreased expression

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ACYP2 acylphosphatase 2, muscle type
ANGPTL4 angiopoietin-like 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANXA8 annexin A8
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATP9A ATPase, class II, type 9A
BEX1 brain expressed, X-linked 1
BNC1 basonuclin 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
C8ORF4 chromosome 8 open reading frame 4
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CARD10 caspase recruitment domain family, member 10
CBR3 carbonyl reductase 3
CCDC109B coiled-coil domain containing 109B
CCR7 chemokine (C-C motif) receptor 7
CD99L2 CD99 molecule-like 2
CDH10 cadherin 10, type 2 (T2-cadherin)
CDKN2A cyclin-dependent kinase inhibitor 2A
CELF4 CUGBP, Elav-like family member 4
CHODL chondrolectin
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLCA1 chloride channel accessory 1
CLEC1B C-type lectin domain family 1, member B
CNTN1 contactin 1
CP ceruloplasmin (ferroxidase)
CRCT1 cysteine-rich C-terminal 1
CRMP1 collapsin response mediator protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DES desmin
DIO2 deiodinase, iodothyronine, type II
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNASE2 deoxyribonuclease II, lysosomal
DPEP1 dipeptidase 1 (renal)
DSG2 desmoglein 2
DSP desmoplakin
EBF2 early B-cell factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA3 ephrin-A3
ENO3 enolase 3 (beta, muscle)
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FBLIM1 filamin binding LIM protein 1
FGF13 fibroblast growth factor 13
FLT4 fms-related tyrosine kinase 4
FLYWCH2 FLYWCH family member 2
FOXD1 forkhead box D1
FOXG1 forkhead box G1
FRZB frizzled-related protein
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GATAD2A GATA zinc finger domain containing 2A
GDNF glial cell derived neurotrophic factor
GPX3 glutathione peroxidase 3
GRIA3 glutamate receptor, ionotropic, AMPA 3
HOXA5 homeobox A5
HOXB9 homeobox B9
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IL11 interleukin 11
IL13RA2 interleukin 13 receptor, alpha 2
IL3RA interleukin 3 receptor, alpha (low affinity)
IRS4 insulin receptor substrate 4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA7 integrin, alpha 7
IVL involucrin
IZUMO1R IZUMO1 receptor, JUNO
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIRREL kin of IRRE like (Drosophila)
KLK11 kallikrein-related peptidase 11
KNG1 kininogen 1
KRT18 keratin 18, type I
KRT27 keratin 27, type I
LMOD1 leiomodin 1 (smooth muscle)
LOC100129361
LOXL4 lysyl oxidase-like 4
LTB4R2 leukotriene B4 receptor 2
LY75 lymphocyte antigen 75
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
MAPK13 mitogen-activated protein kinase 13
MGST2 microsomal glutathione S-transferase 2
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
MRVI1 murine retrovirus integration site 1 homolog
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYLK myosin light chain kinase
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NIPAL2 NIPA-like domain containing 2
NNMT nicotinamide N-methyltransferase
NPR1 natriuretic peptide receptor 1
NPR3 natriuretic peptide receptor 3
NSG1 neuron specific gene family member 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OTUD7A OTU deubiquitinase 7A
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PANX1 pannexin 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDLIM5 PDZ and LIM domain 5
PDZK1 PDZ domain containing 1
PIP prolactin-induced protein
PKP1 plakophilin 1
PKP2 plakophilin 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKG2 protein kinase, cGMP-dependent, type II
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRVP protein tyrosine phosphatase, receptor type, V, pseudogene
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RABEPK Rab9 effector protein with kelch motifs
RAG2 recombination activating gene 2
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBP4 retinol binding protein 4, plasma
RCAN2 regulator of calcineurin 2
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RIMKLB ribosomal modification protein rimK-like family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAD Ras-related associated with diabetes
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3RF1 SH3 domain containing ring finger 1
SIM2 single-minded family bHLH transcription factor 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC30A4 solute carrier family 30 (zinc transporter), member 4
SLC38A10 solute carrier family 38, member 10
SLC44A4 solute carrier family 44, member 4
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPEG SPEG complex locus
STAR steroidogenic acute regulatory protein
STK26 serine/threonine protein kinase 26
STMN4 stathmin-like 4
SYTL2 synaptotagmin-like 2
TET1 tet methylcytosine dioxygenase 1
TFPI2 tissue factor pathway inhibitor 2
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM53 transmembrane protein 53
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT2 troponin T type 2 (cardiac)
TPD52L1 tumor protein D52-like 1
TRAPPC6A trafficking protein particle complex 6A
TRO trophinin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VNN1 vanin 1
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
XIST X inactive specific transcript (non-protein coding)
YIPF2 Yip1 domain family, member 2