SNU-475 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
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Genes

324 genes with high or low expression in SNU-475 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 3.60177
LMOD1 leiomodin 1 (smooth muscle) 3.39007
NINJ1 ninjurin 1 3.10715
TMEM134 transmembrane protein 134 3.09055
CDK18 cyclin-dependent kinase 18 2.9833
AIP aryl hydrocarbon receptor interacting protein 2.79485
CETP cholesteryl ester transfer protein, plasma 2.70934
ERCC2 excision repair cross-complementation group 2 2.55281
CORO1B coronin, actin binding protein, 1B 2.4366
CLUL1 clusterin-like 1 (retinal) 2.41266
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 2.39235
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 2.31598
SDS serine dehydratase 2.30429
WDR25 WD repeat domain 25 2.30393
BTN3A2 butyrophilin, subfamily 3, member A2 2.26669
ACTA2 actin, alpha 2, smooth muscle, aorta 2.26513
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.2623
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 2.25283
IL17B interleukin 17B 2.24376
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 2.23525
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.2262
PLXND1 plexin D1 2.22595
C2 complement component 2 2.20243
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.1964
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.18583
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.18551
CSF1 colony stimulating factor 1 (macrophage) 2.14467
PLXDC1 plexin domain containing 1 2.14086
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.13897
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 2.13419
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.10737
COL4A4 collagen, type IV, alpha 4 2.08315
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.07945
MYLK myosin light chain kinase 2.065
ACTC1 actin, alpha, cardiac muscle 1 2.0605
CUL7 cullin 7 2.04961
ZDHHC7 zinc finger, DHHC-type containing 7 2.0062
PFKP phosphofructokinase, platelet 2.00496
MSC musculin 1.99936
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 1.99375
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 1.99275
CNN1 calponin 1, basic, smooth muscle 1.96861
MYL9 myosin, light chain 9, regulatory 1.94333
SNX6 sorting nexin 6 1.92486
TCEA2 transcription elongation factor A (SII), 2 1.90892
TAGLN transgelin 1.89287
ACTG2 actin, gamma 2, smooth muscle, enteric 1.89171
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 1.89022
ABHD4 abhydrolase domain containing 4 1.88877
IGF1 insulin-like growth factor 1 (somatomedin C) 1.88735
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 1.81873
SPON2 spondin 2, extracellular matrix protein 1.80461
MYBPH myosin binding protein H 1.80292
ST5 suppression of tumorigenicity 5 1.7903
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.78405
GREM1 gremlin 1, DAN family BMP antagonist 1.77648
XCR1 chemokine (C motif) receptor 1 1.77525
G6PD glucose-6-phosphate dehydrogenase 1.76803
HACD1 3-hydroxyacyl-CoA dehydratase 1 1.75412
STK19 serine/threonine kinase 19 1.75312
CHKA choline kinase alpha 1.74554
SNTA1 syntrophin, alpha 1 1.74191
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.71668
LRP5 low density lipoprotein receptor-related protein 5 1.71072
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 1.70625
HLA-E major histocompatibility complex, class I, E 1.69979
FZD2 frizzled class receptor 2 1.69778
SSTR3 somatostatin receptor 3 1.69565
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 1.69304
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 1.68549
IGHMBP2 immunoglobulin mu binding protein 2 1.68431
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 1.6815
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.68039
PIEZO2 piezo-type mechanosensitive ion channel component 2 1.6761
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 1.6737
OPTN optineurin 1.67329
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.67253
TMEM8A transmembrane protein 8A 1.6649
STX12 syntaxin 12 1.646
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 1.64562
AFG3L2 AFG3-like AAA ATPase 2 1.6365
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 1.63401
GALE UDP-galactose-4-epimerase 1.63385
KIAA0232 KIAA0232 1.63311
SIDT2 SID1 transmembrane family, member 2 1.62617
CD36 CD36 molecule (thrombospondin receptor) 1.61788
YME1L1 YME1-like 1 ATPase 1.61645
ORM1 orosomucoid 1 1.61603
MTX1 metaxin 1 1.61432
MAN1C1 mannosidase, alpha, class 1C, member 1 1.60595
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 1.60149
BHMT2 betaine--homocysteine S-methyltransferase 2 1.60138
IVNS1ABP influenza virus NS1A binding protein 1.59725
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.5969
BTN3A1 butyrophilin, subfamily 3, member A1 1.59677
SPEG SPEG complex locus 1.59304
FLNA filamin A, alpha 1.59168
CTIF CBP80/20-dependent translation initiation factor 1.59136
RIT1 Ras-like without CAAX 1 1.58887
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 1.58245
SLC12A8 solute carrier family 12, member 8 1.58074
ADORA1 adenosine A1 receptor 1.57873
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 1.57779
TEK TEK tyrosine kinase, endothelial 1.57768
VAMP5 vesicle-associated membrane protein 5 1.57361
GNG5 guanine nucleotide binding protein (G protein), gamma 5 1.57167
PPP6R3 protein phosphatase 6, regulatory subunit 3 1.57129
BIN1 bridging integrator 1 1.56804
RAD9A RAD9 homolog A (S. pombe) 1.5671
HTT huntingtin 1.55683
BTN3A3 butyrophilin, subfamily 3, member A3 1.54843
EHD2 EH-domain containing 2 1.54333
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 1.5419
RGS9 regulator of G-protein signaling 9 1.54102
DXO decapping exoribonuclease 1.53459
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 1.5327
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.53116
BAG6 BCL2-associated athanogene 6 1.52826
CH25H cholesterol 25-hydroxylase 1.52756
TSKU tsukushi, small leucine rich proteoglycan 1.52397
SLCO2B1 solute carrier organic anion transporter family, member 2B1 1.52317
LRRC32 leucine rich repeat containing 32 1.52115
APH1B APH1B gamma secretase subunit 1.52067
SPANXC SPANX family, member C 1.51515
ACBD3 acyl-CoA binding domain containing 3 1.51369
LOC257152 uncharacterized LOC257152 1.5129
ADD1 adducin 1 (alpha) 1.51063
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 1.50842
COL3A1 collagen, type III, alpha 1 1.50745
MFGE8 milk fat globule-EGF factor 8 protein 1.50336
CTSA cathepsin A 1.4979
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.49709
AMBP alpha-1-microglobulin/bikunin precursor 1.49693
FLNC filamin C, gamma 1.49373
TRAPPC8 trafficking protein particle complex 8 1.47546
ACTN1 actinin, alpha 1 1.46784
TNS2 tensin 2 1.46147
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 1.45904
POR P450 (cytochrome) oxidoreductase 1.45835
TKT transketolase 1.45714
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 1.45063
GTF2IRD1 GTF2I repeat domain containing 1 1.44805
RNF4 ring finger protein 4 1.44258
PRL prolactin 1.43363
PC pyruvate carboxylase 1.43077
COLEC12 collectin sub-family member 12 1.42843
DSTN destrin (actin depolymerizing factor) 1.42747
STK32B serine/threonine kinase 32B 1.42105
SEC23A Sec23 homolog A (S. cerevisiae) 1.41695

low expression

Symbol Name Standardized Value
AXIN1 axin 1 -3.53725
DLX4 distal-less homeobox 4 -3.44072
CREB1 cAMP responsive element binding protein 1 -3.27708
FGF5 fibroblast growth factor 5 -3.13802
IL5RA interleukin 5 receptor, alpha -3.00925
RPL35A ribosomal protein L35a -2.81125
EXOC4 exocyst complex component 4 -2.77186
TAT tyrosine aminotransferase -2.75122
SRSF1 serine/arginine-rich splicing factor 1 -2.73804
FHIT fragile histidine triad -2.65486
HIST1H2AI histone cluster 1, H2ai -2.65115
API5 apoptosis inhibitor 5 -2.60116
IQSEC1 IQ motif and Sec7 domain 1 -2.59805
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.53763
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -2.50847
CEP97 centrosomal protein 97kDa -2.41046
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.37754
MGEA5 meningioma expressed antigen 5 (hyaluronidase) -2.37719
RBMX RNA binding motif protein, X-linked -2.35835
ZNF227 zinc finger protein 227 -2.32855
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.30204
SAP30L SAP30-like -2.26428
CAPN5 calpain 5 -2.20426
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.19088
HIST1H2AK histone cluster 1, H2ak -2.1753
TRA2B transformer 2 beta homolog (Drosophila) -2.17003
DSC3 desmocollin 3 -2.16087
HIST1H4F histone cluster 1, H4f -2.14593
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -2.13278
CCP110 centriolar coiled coil protein 110kDa -2.11267
RPL36 ribosomal protein L36 -2.09534
TMEM47 transmembrane protein 47 -2.04917
RASL11B RAS-like, family 11, member B -2.03709
ARHGAP19 Rho GTPase activating protein 19 -2.03081
TSPAN31 tetraspanin 31 -2.01932
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.01268
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -2.00081
ZNF267 zinc finger protein 267 -1.99912
H2AFV H2A histone family, member V -1.99736
TAS2R4 taste receptor, type 2, member 4 -1.98159
RAD51C RAD51 paralog C -1.97035
RIMS2 regulating synaptic membrane exocytosis 2 -1.9659
HIRIP3 HIRA interacting protein 3 -1.96206
HNRNPM heterogeneous nuclear ribonucleoprotein M -1.95
LPCAT3 lysophosphatidylcholine acyltransferase 3 -1.92243
KDR kinase insert domain receptor -1.90561
KCNK5 potassium channel, two pore domain subfamily K, member 5 -1.90159
H3F3B H3 histone, family 3B (H3.3B) -1.89374
LAD1 ladinin 1 -1.88779
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -1.88607
UBA5 ubiquitin-like modifier activating enzyme 5 -1.87994
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -1.87911
ORC1 origin recognition complex, subunit 1 -1.86428
ZBTB11 zinc finger and BTB domain containing 11 -1.84987
MYNN myoneurin -1.84459
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -1.83725
HIST1H3H histone cluster 1, H3h -1.83537
RAB8A RAB8A, member RAS oncogene family -1.82231
NYX nyctalopin -1.81335
AMD1 adenosylmethionine decarboxylase 1 -1.80844
NUP50 nucleoporin 50kDa -1.79286
PTPRS protein tyrosine phosphatase, receptor type, S -1.79178
CD83 CD83 molecule -1.76703
DOCK1 dedicator of cytokinesis 1 -1.75697
GP1BA glycoprotein Ib (platelet), alpha polypeptide -1.75375
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -1.74366
EPPIN epididymal peptidase inhibitor -1.74175
PTK7 protein tyrosine kinase 7 (inactive) -1.73872
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -1.73399
MMP16 matrix metallopeptidase 16 (membrane-inserted) -1.73134
RANBP17 RAN binding protein 17 -1.7252
KIAA1654 KIAA1654 protein -1.72244
SH3GL3 SH3-domain GRB2-like 3 -1.71708
BUB3 BUB3 mitotic checkpoint protein -1.71493
ATG13 autophagy related 13 -1.71466
ETNK1 ethanolamine kinase 1 -1.71324
WFDC8 WAP four-disulfide core domain 8 -1.70537
TDRD1 tudor domain containing 1 -1.70403
HIST1H1D histone cluster 1, H1d -1.7013
PHF14 PHD finger protein 14 -1.70071
RPL24 ribosomal protein L24 -1.69541
MED9 mediator complex subunit 9 -1.68952
AFF4 AF4/FMR2 family, member 4 -1.6862
TNRC6B trinucleotide repeat containing 6B -1.67258
MAU2 MAU2 sister chromatid cohesion factor -1.67185
MREG melanoregulin -1.66684
PEX6 peroxisomal biogenesis factor 6 -1.65866
PTPRO protein tyrosine phosphatase, receptor type, O -1.65611
NCBP2 nuclear cap binding protein subunit 2, 20kDa -1.65307
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -1.65114
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -1.63062
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -1.62908
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 -1.62621
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -1.62189
NECAP1 NECAP endocytosis associated 1 -1.61937
PIP prolactin-induced protein -1.61883
ACTN2 actinin, alpha 2 -1.61406
ZDHHC6 zinc finger, DHHC-type containing 6 -1.61398
MEFV Mediterranean fever -1.6098
SFPQ splicing factor proline/glutamine-rich -1.60701
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -1.60474
RS1 retinoschisin 1 -1.60445
IRF4 interferon regulatory factor 4 -1.60367
TFCP2 transcription factor CP2 -1.59725
TMEM39A transmembrane protein 39A -1.59635
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -1.5954
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -1.59539
CLK1 CDC-like kinase 1 -1.58598
JAK2 Janus kinase 2 -1.58386
BRD8 bromodomain containing 8 -1.58026
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -1.57991
CPB2 carboxypeptidase B2 (plasma) -1.57849
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 -1.57787
PURG purine-rich element binding protein G -1.57092
THUMPD1 THUMP domain containing 1 -1.5695
ADNP activity-dependent neuroprotector homeobox -1.5692
PAQR4 progestin and adipoQ receptor family member IV -1.56186
IFNA2 interferon, alpha 2 -1.56175
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -1.55405
CCNJ cyclin J -1.54961
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) -1.54787
KLHL29 kelch-like family member 29 -1.54618
PMCH pro-melanin-concentrating hormone -1.54499
NUP54 nucleoporin 54kDa -1.54381
DKFZP564C152 DKFZP564C152 protein -1.53763
LY9 lymphocyte antigen 9 -1.52317
BACE2 beta-site APP-cleaving enzyme 2 -1.52223
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -1.52024
CCDC14 coiled-coil domain containing 14 -1.51835
HMGN1 high mobility group nucleosome binding domain 1 -1.51018
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -1.5094
SPO11 SPO11 meiotic protein covalently bound to DSB -1.50827
GHRH growth hormone releasing hormone -1.50339
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -1.50195
CNBP CCHC-type zinc finger, nucleic acid binding protein -1.49876
EDN3 endothelin 3 -1.49803
PDZK1IP1 PDZK1 interacting protein 1 -1.49775
OXNAD1 oxidoreductase NAD-binding domain containing 1 -1.49382
NEO1 neogenin 1 -1.49101
ING1 inhibitor of growth family, member 1 -1.48808
CNOT8 CCR4-NOT transcription complex, subunit 8 -1.48732
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -1.48512
SH3PXD2A SH3 and PX domains 2A -1.4834
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -1.48283
NR6A1 nuclear receptor subfamily 6, group A, member 1 -1.47813
PTK2B protein tyrosine kinase 2 beta -1.47494
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 -1.47467
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.47258
RPL35 ribosomal protein L35 -1.47257
FNBP4 formin binding protein 4 -1.46884
KDM4A lysine (K)-specific demethylase 4A -1.46734
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -1.46717
ZNF197 zinc finger protein 197 -1.46356
SLFN12 schlafen family member 12 -1.45702
BCL2A1 BCL2-related protein A1 -1.45427
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -1.4538
CCDC47 coiled-coil domain containing 47 -1.45239
TXK TXK tyrosine kinase -1.44873
KLF15 Kruppel-like factor 15 -1.44615
DUSP6 dual specificity phosphatase 6 -1.44458
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.44155
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -1.44081
ANKFY1 ankyrin repeat and FYVE domain containing 1 -1.43583
TSPYL1 TSPY-like 1 -1.43306
TFR2 transferrin receptor 2 -1.43239
YTHDC2 YTH domain containing 2 -1.43127
CCL16 chemokine (C-C motif) ligand 16 -1.43069
GDAP1 ganglioside induced differentiation associated protein 1 -1.42817
STAG1 stromal antigen 1 -1.42731
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -1.42688
RHCE Rh blood group, CcEe antigens -1.42639
IL22 interleukin 22 -1.42374
TBL1X transducin (beta)-like 1X-linked -1.42102
SPATA6 spermatogenesis associated 6 -1.41911
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -1.41669