SNU61 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from large intestine (Cancer Cell Line Encyclopedia)
External Link https://depmap.org/portal/cell_line/ACH-000532
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Genes

361 gene knockdowns changing fitness of SNU61 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
PRR15 proline rich 15 11.91
ATXN3 ataxin 3 10.794
AXIN2 axin 2 10.76
ATG13 autophagy related 13 10.2433
MAP3K2 mitogen-activated protein kinase kinase kinase 2 7.86031
ATG12 autophagy related 12 7.60095
DIO3 deiodinase, iodothyronine, type III 7.31884
MAP2K5 mitogen-activated protein kinase kinase 5 6.94771
ATG101 autophagy related 101 6.84479
FER1L6 fer-1-like family member 6 6.13015
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 6.06582
RNF139 ring finger protein 139 5.99425
JUP junction plakoglobin 5.96066
SLC26A5 solute carrier family 26 (anion exchanger), member 5 5.85761
ELMO3 engulfment and cell motility 3 5.73747
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 5.73318
LSR lipolysis stimulated lipoprotein receptor 5.72692
MAPK7 mitogen-activated protein kinase 7 5.71654
KLC1 kinesin light chain 1 5.70464
PTPRE protein tyrosine phosphatase, receptor type, E 5.66754
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae) 5.44875
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 5.43249
APOPT1 apoptogenic 1, mitochondrial 5.42992
HMOX2 heme oxygenase 2 5.42771
SMAD4 SMAD family member 4 5.42271
EEF1AKMT4 EEF1A lysine methyltransferase 4 5.40043
NOXRED1 NADP-dependent oxidoreductase domain containing 1 5.38573
ATG7 autophagy related 7 5.28082
TMEM136 transmembrane protein 136 5.2109
NMRAL1 NmrA-like family domain containing 1 5.13149
HDAC8 histone deacetylase 8 5.07808
CTNNBIP1 catenin, beta interacting protein 1 5.02783
UBR1 ubiquitin protein ligase E3 component n-recognin 1 4.94785
ADNP2 ADNP homeobox 2 4.70136
ABI1 abl-interactor 1 4.67539
GLIS2 GLIS family zinc finger 2 4.63925
LRRC6 leucine rich repeat containing 6 4.63215
ZBTB7B zinc finger and BTB domain containing 7B 4.62739
FAM189B family with sequence similarity 189, member B 4.61369
TCAF1 TRPM8 channel-associated factor 1 4.60818
ARMCX6 armadillo repeat containing, X-linked 6 4.52001
TIGD7 tigger transposable element derived 7 4.35127
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 4.34635
VILL villin-like 4.29217
PRMT2IP PRMT2 interacting protein 4.2714
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 4.21042
DAGLB diacylglycerol lipase, beta 4.16393
MTSS1 metastasis suppressor 1 4.11676
BTBD6 BTB (POZ) domain containing 6 4.10488
CDIP1 cell death-inducing p53 target 1 4.09987
AMER1 APC membrane recruitment protein 1 4.0844
SIRT7 sirtuin 7 4.06902
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 4.06113
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.93567
DEF8 differentially expressed in FDCP 8 homolog (mouse) 3.92327
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 3.90768
WIPI2 WD repeat domain, phosphoinositide interacting 2 3.88445
THSD1 thrombospondin, type I, domain containing 1 3.8526
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 3.84801
JPT2 Jupiter microtubule associated homolog 2 3.84387
ADGRE3 adhesion G protein-coupled receptor E3 3.76568
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 3.74296
SLA Src-like-adaptor 3.70217
PRMT7 protein arginine methyltransferase 7 3.66241
DSG3 desmoglein 3 3.66215
CD48 CD48 molecule 3.6491
CYBA cytochrome b-245, alpha polypeptide 3.58816
ATG9A autophagy related 9A 3.58729
WASF2 WAS protein family, member 2 3.57631
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 3.57153
PCNT pericentrin 3.536
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.52912
HK3 hexokinase 3 (white cell) 3.51693
OR1L3 olfactory receptor, family 1, subfamily L, member 3 3.50551
MAP1S microtubule-associated protein 1S 3.49595
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) 3.49267
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 3.45827
HDGFL2 HDGF like 2 3.43462
ACTL8 actin-like 8 3.42873
TEX264 testis expressed 264 3.40584
FAHD2A fumarylacetoacetate hydrolase domain containing 2A 3.39093
ZNF705G zinc finger protein 705G 3.37373
TKTL1 transketolase-like 1 3.32136
DGKH diacylglycerol kinase, eta 3.31533
VDAC3 voltage-dependent anion channel 3 3.31435
CDK5 cyclin-dependent kinase 5 3.30263
ZNF384 zinc finger protein 384 3.30167
PEPD peptidase D 3.29017
TMED8 transmembrane emp24 protein transport domain containing 8 3.27205
ZDHHC7 zinc finger, DHHC-type containing 7 3.27031
RB1CC1 RB1-inducible coiled-coil 1 3.26299
PARK2 parkin RBR E3 ubiquitin protein ligase 3.2498
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 3.21286
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 3.20995
BMPR1A bone morphogenetic protein receptor, type IA 3.18966
NUDCD1 NudC domain containing 1 3.18044
ATP7A ATPase, Cu++ transporting, alpha polypeptide 3.17538
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 3.17172
HSBP1 heat shock factor binding protein 1 3.16547
ANK1 ankyrin 1, erythrocytic 3.15563
HTT huntingtin 3.13976
GSC goosecoid homeobox 3.13447
TRPC5 transient receptor potential cation channel, subfamily C, member 5 3.11676
CLCN2 chloride channel, voltage-sensitive 2 3.11354
PTPRF protein tyrosine phosphatase, receptor type, F 3.1069
ZNF638 zinc finger protein 638 3.08731
KMT2B lysine (K)-specific methyltransferase 2B 3.08313
TMED3 transmembrane emp24 protein transport domain containing 3 3.07417
FAM131A family with sequence similarity 131, member A 3.07089
WDR86 WD repeat domain 86 3.07078
SGSM3 small G protein signaling modulator 3 3.06638
LRRC73 leucine rich repeat containing 73 3.0651
ATG3 autophagy related 3 3.06063
AP4B1 adaptor-related protein complex 4, beta 1 subunit 3.0587
NRG4 neuregulin 4 3.0582
AHNAK2 AHNAK nucleoprotein 2 3.05151
WBP4 WW domain binding protein 4 3.04492
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 3.03343
TNR tenascin R 3.02553
WBP1L WW domain binding protein 1-like 3.01266
RPH3A rabphilin 3A 3.01202
C14ORF180 chromosome 14 open reading frame 180 3.01141
LRATD2 LRAT domain containing 2 3.01006
SCUBE2 signal peptide, CUB domain, EGF-like 2 3.00728
PXMP2 peroxisomal membrane protein 2, 22kDa 3.00646
C6ORF118 chromosome 6 open reading frame 118 3.00359
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.98825
TEAD4 TEA domain family member 4 2.97931
FAM149B1 family with sequence similarity 149, member B1 2.9766
ASPG asparaginase 2.91354
ZNF276 zinc finger protein 276 2.89825
EIPR1 EARP complex and GARP complex interacting protein 1 2.89401
HRG histidine-rich glycoprotein 2.89294
ZC4H2 zinc finger, C4H2 domain containing 2.87903
ZNF581 zinc finger protein 581 2.86861
MACF1 microtubule-actin crosslinking factor 1 2.85127
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 2.84194
MYO1H myosin IH 2.82871
PPP1R26 protein phosphatase 1, regulatory subunit 26 2.82818
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 2.8122
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 2.80901
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.80063
COL4A1 collagen, type IV, alpha 1 2.79327
DCAF15 DDB1 and CUL4 associated factor 15 2.79094
APC adenomatous polyposis coli 2.79012
OR2T2 olfactory receptor, family 2, subfamily T, member 2 2.78866
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.78639
C11ORF49 chromosome 11 open reading frame 49 2.78384
C8ORF76 chromosome 8 open reading frame 76 2.77998
ANXA13 annexin A13 2.77861
CIZ1 CDKN1A interacting zinc finger protein 1 2.76643
UBE2Z ubiquitin-conjugating enzyme E2Z 2.75476
RAB11FIP3 RAB11 family interacting protein 3 (class II) 2.71195
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 2.70171
MFSD9 major facilitator superfamily domain containing 9 2.69606
EPHA3 EPH receptor A3 2.69287
NDEL1 nudE neurodevelopment protein 1-like 1 2.68692
AGXT alanine-glyoxylate aminotransferase 2.67644
NEBL nebulette 2.67316
PARM1 prostate androgen-regulated mucin-like protein 1 2.66973
ATF7IP activating transcription factor 7 interacting protein 2.66771
BAIAP2 BAI1-associated protein 2 2.66425
BIN1 bridging integrator 1 2.65678
IGF2R insulin-like growth factor 2 receptor 2.65454
PEAR1 platelet endothelial aggregation receptor 1 2.64422
LURAP1 leucine rich adaptor protein 1 2.64042
MORN4 MORN repeat containing 4 2.63456
SMIM5 small integral membrane protein 5 2.63387
DRICH1 aspartate-rich 1 2.62595
GAB4 GRB2-associated binding protein family, member 4 2.62137
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 2.61066
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 2.60944
CD4 CD4 molecule 2.59367
BAG6 BCL2-associated athanogene 6 2.59144
CD8A CD8a molecule 2.58887
CRYGS crystallin, gamma S 2.58854
SLC25A52 solute carrier family 25, member 52 2.5717
ZNF79 zinc finger protein 79 2.56845
C16ORF90 chromosome 16 open reading frame 90 2.56202
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.55129
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.55081
CLIP1 CAP-GLY domain containing linker protein 1 2.55001
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 2.547
RAB11A RAB11A, member RAS oncogene family 2.54419
MTMR4 myotubularin related protein 4 2.53381
WDR38 WD repeat domain 38 2.52956
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.52801
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 2.52768
WDR27 WD repeat domain 27 2.5173
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 2.51341
TTLL11 tubulin tyrosine ligase-like family member 11 2.50764
EDF1 endothelial differentiation-related factor 1 2.50662
HNF1B HNF1 homeobox B 2.5021
PAGE2 P antigen family, member 2 (prostate associated) 2.50045
FAM181A family with sequence similarity 181, member A 2.49578
CXCL11 chemokine (C-X-C motif) ligand 11 2.49251
BDKRB2 bradykinin receptor B2 2.47885
TADA2B transcriptional adaptor 2B 2.47578
PRRC2B proline-rich coiled-coil 2B 2.47141
ANHX anomalous homeobox 2.46506
CXCR2 chemokine (C-X-C motif) receptor 2 2.46322
CACYBP calcyclin binding protein 2.46027
IL36G interleukin 36, gamma 2.45182
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 2.45043
CFC1 cripto, FRL-1, cryptic family 1 2.45035
KIF13B kinesin family member 13B 2.44365
ZBTB48 zinc finger and BTB domain containing 48 2.43466
C6ORF136 chromosome 6 open reading frame 136 2.43191
CSNK2A1 casein kinase 2, alpha 1 polypeptide 2.4315
KRT81 keratin 81, type II 2.42885
PODNL1 podocan-like 1 2.42022
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.41931
PHACTR3 phosphatase and actin regulator 3 2.41775
FXYD5 FXYD domain containing ion transport regulator 5 2.41578
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.41181
APCDD1L adenomatosis polyposis coli down-regulated 1-like 2.40956
SYNDIG1L synapse differentiation inducing 1-like 2.40726
PAQR4 progestin and adipoQ receptor family member IV 2.40464
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.40458
CRAMP1 cramped chromatin regulator homolog 1 2.40175
KIF1B kinesin family member 1B 2.40048
ZNF831 zinc finger protein 831 2.39898
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.3908
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.38236
EGFR epidermal growth factor receptor 2.37875
RBM5 RNA binding motif protein 5 2.3768
TJAP1 tight junction associated protein 1 (peripheral) 2.3742
CLCNKA chloride channel, voltage-sensitive Ka 2.37182
LAMA3 laminin, alpha 3 2.37086
HYDIN HYDIN, axonemal central pair apparatus protein 2.3629
LIME1 Lck interacting transmembrane adaptor 1 2.36162
C3 complement component 3 2.35949
CXORF65 chromosome X open reading frame 65 2.35908
SRSF9 serine/arginine-rich splicing factor 9 2.3576
CCDC51 coiled-coil domain containing 51 2.35561
SSX7 synovial sarcoma, X breakpoint 7 2.35517
ZFP92 ZFP92 zinc finger protein 2.35357
ZFYVE1 zinc finger, FYVE domain containing 1 2.35337
OR4D2 olfactory receptor, family 4, subfamily D, member 2 2.35032
ALG10 ALG10, alpha-1,2-glucosyltransferase 2.34948
BGLAP bone gamma-carboxyglutamate (gla) protein 2.34765
THAP9 THAP domain containing 9 2.33552
BICDL2 BICD family like cargo adaptor 2 2.33065
METRNL meteorin, glial cell differentiation regulator-like 2.32863
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.32704
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.31819
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 2.31774
ARID3C AT rich interactive domain 3C (BRIGHT-like) 2.30888
RPL3L ribosomal protein L3-like 2.308
BTNL8 butyrophilin-like 8 2.30542
PPHLN1 periphilin 1 2.30372
PRODH proline dehydrogenase (oxidase) 1 2.30284
CDKN2AIP CDKN2A interacting protein 2.29995
ULK1 unc-51 like autophagy activating kinase 1 2.29822
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 2.28257
CORO7 coronin 7 2.27871
KIRREL3 kin of IRRE like 3 (Drosophila) 2.27486
ZNF500 zinc finger protein 500 2.27375
AGTR1 angiotensin II receptor, type 1 2.27201
NME5 NME/NM23 family member 5 2.27149
PSENEN presenilin enhancer gamma secretase subunit 2.27066
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.26665
TP53I13 tumor protein p53 inducible protein 13 2.26602
AFF1 AF4/FMR2 family, member 1 2.26594
CEP290 centrosomal protein 290kDa 2.26439
SPATS1 spermatogenesis associated, serine-rich 1 2.2608
ZNF157 zinc finger protein 157 2.25956
SLC22A14 solute carrier family 22, member 14 2.25438
TMSB4X thymosin beta 4, X-linked 2.24375
DHCR24 24-dehydrocholesterol reductase 2.24262
TM2D3 TM2 domain containing 3 2.23755
DHRS13 dehydrogenase/reductase (SDR family) member 13 2.2357
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 2.23135
HEBP1 heme binding protein 1 2.2313
ZNF559 zinc finger protein 559 2.22616
C1ORF43 chromosome 1 open reading frame 43 2.22535
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 2.22508
OR2A2 olfactory receptor, family 2, subfamily A, member 2 2.2192
TMEM184A transmembrane protein 184A 2.21657
FBXW12 F-box and WD repeat domain containing 12 2.21502
DENND2A DENN/MADD domain containing 2A 2.21484
MYO3B myosin IIIB 2.21416
CCDC74B coiled-coil domain containing 74B 2.2137
STK32C serine/threonine kinase 32C 2.21368
KLHL25 kelch-like family member 25 2.21279
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.21168
KRTAP4-3 keratin associated protein 4-3 2.20327
SPRN shadow of prion protein homolog (zebrafish) 2.20317
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.19642
ERC1 ELKS/RAB6-interacting/CAST family member 1 2.18841
CSNK2A2 casein kinase 2, alpha prime polypeptide 2.1774
RAB5A RAB5A, member RAS oncogene family 2.17658
RIMBP3 RIMS binding protein 3 2.17247
ZHX1 zinc fingers and homeoboxes 1 2.16985
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase 2.16878
ARPC5L actin related protein 2/3 complex, subunit 5-like 2.16864
FBXO24 F-box protein 24 2.15777
TLR3 toll-like receptor 3 2.15746
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.15442
TMEM89 transmembrane protein 89 2.15121
ANKMY1 ankyrin repeat and MYND domain containing 1 2.15113
CAPNS1 calpain, small subunit 1 2.15028
EML5 echinoderm microtubule associated protein like 5 2.14978
JRKL JRK-like 2.14817
HARBI1 harbinger transposase derived 1 2.14498
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.1441
ARNT aryl hydrocarbon receptor nuclear translocator 2.1392
ADAMTSL4 ADAMTS-like 4 2.13902
KRTAP12-4 keratin associated protein 12-4 2.13104
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.13039
HOXC13 homeobox C13 2.12946
RNF123 ring finger protein 123 2.12806
FAM163A family with sequence similarity 163, member A 2.1264
TADA3 transcriptional adaptor 3 2.11993
PFN3 profilin 3 2.1191
PCDHA1 protocadherin alpha 1 2.1185
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.11608
SQLE squalene epoxidase 2.11408
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.11187
FAM170B family with sequence similarity 170, member B 2.11127
FBXO30 F-box protein 30 2.11067
TRIM27 tripartite motif containing 27 2.10717
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.10509
BIRC6 baculoviral IAP repeat containing 6 2.10459
CCDC132 coiled-coil domain containing 132 2.1023
NMUR1 neuromedin U receptor 1 2.09966
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 2.09887
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 2.0978
CASKIN2 CASK interacting protein 2 2.09658
MYLK2 myosin light chain kinase 2 2.0939
CNOT10 CCR4-NOT transcription complex, subunit 10 2.09344
CPD carboxypeptidase D 2.08432
MALL mal, T-cell differentiation protein-like 2.0838
TADA1 transcriptional adaptor 1 2.08184
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.07877
TPCN1 two pore segment channel 1 2.07056
IGF1R insulin-like growth factor 1 receptor 2.06962
GDF1 growth differentiation factor 1 2.06924
RAB13 RAB13, member RAS oncogene family 2.06863
POLH polymerase (DNA directed), eta 2.06481
ORM2 orosomucoid 2 2.06481
CRIP2 cysteine-rich protein 2 2.0614
DOCK5 dedicator of cytokinesis 5 2.05898
LCN2 lipocalin 2 2.05319
PRIMA1 proline rich membrane anchor 1 2.04964
FAAH fatty acid amide hydrolase 2.04825
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.04407
TPRG1L tumor protein p63 regulated 1-like 2.04109
TMEM63B transmembrane protein 63B 2.04078
DPY19L2 dpy-19-like 2 (C. elegans) 2.03417
JOSD1 Josephin domain containing 1 2.03403
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 2.02673
GCC1 GRIP and coiled-coil domain containing 1 2.02263
ANO4 anoctamin 4 2.02062
CPLX3 complexin 3 2.01741
ALX4 ALX homeobox 4 2.01194
IMPACT impact RWD domain protein 2.01128
NPDC1 neural proliferation, differentiation and control, 1 2.00827
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.00721
H2AC21 H2A clustered histone 21 2.00428
FAM214B family with sequence similarity 214, member B 2.00306