SNX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description sorting nexin 1|This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6642)
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Genes

334 genes differentially expressed following the SNX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CTRC chymotrypsin C (caldecrin) 3.11132
LRRC52 leucine rich repeat containing 52 3.11132
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 3.11132
ASB10 ankyrin repeat and SOCS box containing 10 3.11132
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 3.11132
GYPB glycophorin B (MNS blood group) 3.11132
NUGGC nuclear GTPase, germinal center associated 3.11132
MYOM3 myomesin 3 3.11132
ALPK2 alpha-kinase 2 3.11132
GSTM5 glutathione S-transferase mu 5 3.11132
CXORF65 chromosome X open reading frame 65 3.11132
CRISP1 cysteine-rich secretory protein 1 3.11132
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.11132
HCRTR1 hypocretin (orexin) receptor 1 3.11132
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.11132
TM4SF1 transmembrane 4 L six family member 1 3.11132
SSTR1 somatostatin receptor 1 3.11132
GLYAT glycine-N-acyltransferase 3.11132
DDN dendrin 3.11132
TBX18 T-box 18 3.11132
SLC39A2 solute carrier family 39 (zinc transporter), member 2 3.11132
THRSP thyroid hormone responsive 3.11132
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 3.11132
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.11132
BFSP2 beaded filament structural protein 2, phakinin 3.11132
TRPC5OS TRPC5 opposite strand 3.11132
AVP arginine vasopressin 3.11132
BMP3 bone morphogenetic protein 3 3.11132
HMX1 H6 family homeobox 1 3.11132
C2ORF78 chromosome 2 open reading frame 78 3.11132
PTK6 protein tyrosine kinase 6 3.11132
TBATA thymus, brain and testes associated 3.11132
HBB hemoglobin, beta 3.11132
LY6G6F lymphocyte antigen 6 complex, locus G6F 3.11132
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.11132
PGAM4 phosphoglycerate mutase family member 4 3.11132
SMIM5 small integral membrane protein 5 3.11132
RLN3 relaxin 3 3.11132
PNOC prepronociceptin 3.11132
NPIPA3 nuclear pore complex interacting protein family, member A3 3.11132
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.11132
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.11132
NPAP1 nuclear pore associated protein 1 3.11132
ACKR5 atypical chemokine receptor 5 3.11132
TBXT T-box transcription factor T 3.11132
FAM237B family with sequence similarity 237 member B 3.11132
STING1 stimulator of interferon response cGAMP interactor 1 3.11132
LRTM3 leucine rich repeat transmembrane protein 3 3.11132
CES4A carboxylesterase 4A 3.11132
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.11132
HBG2 hemoglobin, gamma G 3.11132
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.11132
ELOA2 elongin A2 3.11132
SOFU1 sperm-oocyte fusion factor 1 3.11132
FREY1 Frey regulator of sperm-oocyte fusion 1 3.11132
SPMIP11 sperm microtubule inner protein 11 3.11132
PNMA6F PNMA family member 6F 3.11132
TBC1D3I TBC1 domain family member 3I 3.11132
LINC02268 long intergenic non-protein coding RNA 2268 3.11132
CFAP97D2 CFAP97 domain containing 2 3.11132
H4C14 H4 clustered histone 14 3.11132
EZHIP EZH inhibitory protein 3.11132
CFAP206 cilia and flagella associated protein 206 3.11132
GATA6 GATA binding protein 6 3.11132
SYT15 synaptotagmin XV 3.11132
THPO thrombopoietin 3.11132
MAGEB1 melanoma antigen family B1 3.11132
PRB4 proline-rich protein BstNI subfamily 4 3.11132
LBHD1 LBH domain containing 1 3.11132
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.11132
SLC22A10 solute carrier family 22, member 10 3.11132
HLX H2.0-like homeobox 3.11132
FAM187B family with sequence similarity 187, member B 3.11132
GZMM granzyme M (lymphocyte met-ase 1) 3.11132
PGC progastricsin (pepsinogen C) 3.11132
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.11132
GPR83 G protein-coupled receptor 83 3.11132
ARHGAP15 Rho GTPase activating protein 15 3.11132
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.11132
GSC goosecoid homeobox 3.11132
CCR8 chemokine (C-C motif) receptor 8 3.11132
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.11132
PRR18 proline rich 18 3.11132
CREB3L3 cAMP responsive element binding protein 3-like 3 3.11132
ASB15 ankyrin repeat and SOCS box containing 15 3.11132
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.11132
DRD2 dopamine receptor D2 3.11132
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.11132
BTNL3 butyrophilin-like 3 3.11132
MUCL1 mucin-like 1 3.11132
MR1 major histocompatibility complex, class I-related 3.11132
AKR1B15 aldo-keto reductase family 1, member B15 3.11132
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.11132
GPR68 G protein-coupled receptor 68 3.11132
ENDOU endonuclease, polyU-specific 3.11132
PCDHGB1 protocadherin gamma subfamily B, 1 3.11132
PLCD4 phospholipase C, delta 4 3.11132
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 3.11132
KIF4B kinesin family member 4B 3.11132
TMPPE transmembrane protein with metallophosphoesterase domain 3.11132
C11ORF97 chromosome 11 open reading frame 97 3.11132
AQP7 aquaporin 7 3.11132
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 3.11132
MAB21L2 mab-21-like 2 (C. elegans) 3.11132
PSKH2 protein serine kinase H2 3.11132
PAGE4 P antigen family, member 4 (prostate associated) 3.11132
C2CD4A C2 calcium-dependent domain containing 4A 3.11132
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.11132
GLT1D1 glycosyltransferase 1 domain containing 1 3.11132
CCL19 chemokine (C-C motif) ligand 19 3.11132
SCML4 sex comb on midleg-like 4 (Drosophila) 3.11132
GLOD5 glyoxalase domain containing 5 3.11132
IL1B interleukin 1, beta 3.11132
CXCR6 chemokine (C-X-C motif) receptor 6 3.11132
CRYBB2 crystallin, beta B2 3.11132
CER1 cerberus 1, DAN family BMP antagonist 3.11132
DBX1 developing brain homeobox 1 3.11132
SUN3 Sad1 and UNC84 domain containing 3 3.11132
EPO erythropoietin 3.11132
SLC10A4 solute carrier family 10, member 4 3.11132
C22ORF31 chromosome 22 open reading frame 31 3.11132
NPC1L1 NPC1-like 1 3.11132
IL10RA interleukin 10 receptor, alpha 3.11132
ABLIM3 actin binding LIM protein family, member 3 3.11132
SYTL4 synaptotagmin-like 4 3.11132
DMRTC1 DMRT-like family C1 3.11132
NEUROD1 neuronal differentiation 1 3.11132
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.11132
MMP12 matrix metallopeptidase 12 3.11132
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.11132
FAIM2 Fas apoptotic inhibitory molecule 2 3.11132
LRRN4 leucine rich repeat neuronal 4 3.11132
LOC105378220 macrophage receptor MARCO-like 3.11132
RXRG retinoid X receptor, gamma 3.11132
DLX3 distal-less homeobox 3 3.11132
FAM9C family with sequence similarity 9, member C 3.11132
PATE2 prostate and testis expressed 2 3.11132
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.11132
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.11132
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.11132
IGIP IgA-inducing protein 3.11132
OR52N5 olfactory receptor, family 52, subfamily N, member 5 3.11132
RAB33A RAB33A, member RAS oncogene family 2.97267
PCDH19 protocadherin 19 2.95701
DMAC2 distal membrane arm assembly component 2 2.89235
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 2.8487
FAAP100 FA core complex associated protein 100 2.8459
PGRMC1 progesterone receptor membrane component 1 2.71657
MYL12B myosin, light chain 12B, regulatory 2.71452
FXYD6 FXYD domain containing ion transport regulator 6 2.58126
PTBP2 polypyrimidine tract binding protein 2 2.5516
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 2.52945
THOC2 THO complex 2 2.52347
BHMT betaine--homocysteine S-methyltransferase 2.49463
NDE1 nudE neurodevelopment protein 1 2.43629
CRACD capping protein inhibiting regulator of actin dynamics 2.43301
PRUNE1 prune exopolyphosphatase 1 2.43301
GLI2 GLI family zinc finger 2 2.43221
PKM pyruvate kinase, muscle 2.42821
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.38878
ARSF arylsulfatase F 2.38878
TMCO1 transmembrane and coiled-coil domains 1 2.38878
PLAAT4 phospholipase A and acyltransferase 4 2.38182
RABGAP1L RAB GTPase activating protein 1-like 2.35997
PPP1R10 protein phosphatase 1, regulatory subunit 10 2.35997
ROM1 retinal outer segment membrane protein 1 2.356
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.356
LECT2 leukocyte cell-derived chemotaxin 2 2.356
FYN FYN proto-oncogene, Src family tyrosine kinase 2.33601
SAXO2 stabilizer of axonemal microtubules 2 2.33256
MYO6 myosin VI 2.3126
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.30362
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 2.30325
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 2.30017
TCHP trichoplein, keratin filament binding 2.30017
ZFYVE27 zinc finger, FYVE domain containing 27 2.29803
PELP1 proline, glutamate and leucine rich protein 1 2.26742
SDHAF4 succinate dehydrogenase complex assembly factor 4 2.24073
RAP1GAP2 RAP1 GTPase activating protein 2 2.23878
SND1 staphylococcal nuclease and tudor domain containing 1 2.2277
CPLX1 complexin 1 2.20861
ALX4 ALX homeobox 4 2.20861
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.20861
MARCHF10 membrane associated ring-CH-type finger 10 2.20861
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.20861
CFAP74 cilia and flagella associated protein 74 2.20861
NELFCD negative elongation factor complex member C/D 2.18535
BYSL bystin-like 2.15273
LOC728743 zinc finger protein pseudogene 2.15184
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 2.15184
MAPK8 mitogen-activated protein kinase 8 2.15068
ABHD5 abhydrolase domain containing 5 2.13873
RAB23 RAB23, member RAS oncogene family 2.13547
TRIL TLR4 interactor with leucine-rich repeats 2.13547
HSPA4 heat shock 70kDa protein 4 2.12647
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.12069
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 2.12069
STK17B serine/threonine kinase 17b 2.11697
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.10553
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2.10553
CALY calcyon neuron-specific vesicular protein 2.10089
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.10089
CHN1 chimerin 1 2.098
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.07874
PHOSPHO2 phosphatase, orphan 2 2.07874
PRMT3 protein arginine methyltransferase 3 2.07874
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) 2.06893
IRGM immunity-related GTPase family, M 2.06809
ARHGAP29 Rho GTPase activating protein 29 2.06809
DAAM1 dishevelled associated activator of morphogenesis 1 2.06365
ZNF362 zinc finger protein 362 2.06365
ZNF888 zinc finger protein 888 2.06005
PYCR3 pyrroline-5-carboxylate reductase 3 2.05713
ABHD18 abhydrolase domain containing 18 2.05447
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 2.05241
TBC1D10A TBC1 domain family, member 10A 2.04144
MTMR11 myotubularin related protein 11 2.03455
TCEAL9 transcription elongation factor A like 9 2.03455
PRELID3A PRELI domain containing 3A 2.02296
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.01506

decreased expression

Symbol Name Standardized Value
OAF OAF homolog (Drosophila) -3.11132
SNX31 sorting nexin 31 -3.11132
LRRC51 leucine rich repeat containing 51 -3.11132
PTX3 pentraxin 3, long -3.11132
SGSH N-sulfoglucosamine sulfohydrolase -3.11132
HES4 hes family bHLH transcription factor 4 -3.11132
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.11132
ALX3 ALX homeobox 3 -3.05878
ARHGAP12 Rho GTPase activating protein 12 -3.03628
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -3.00277
TBC1D26 TBC1 domain family, member 26 -3.00277
SAMD11 sterile alpha motif domain containing 11 -3.00277
LOX lysyl oxidase -3.00277
SLA2 Src-like-adaptor 2 -3.00277
FCMR Fc fragment of IgM receptor -3.00277
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -3.00277
SFTPD surfactant protein D -3.00277
BSX brain-specific homeobox -3.00277
AKR1C2 aldo-keto reductase family 1, member C2 -3.00277
ZNF404 zinc finger protein 404 -3.00277
GMNC geminin coiled-coil domain containing -3.00277
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -3.00277
THSD1 thrombospondin, type I, domain containing 1 -3.00277
NWD2 NACHT and WD repeat domain containing 2 -3.00277
AHSG alpha-2-HS-glycoprotein -3.00277
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -3.00277
BRDT bromodomain, testis-specific -3.00277
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -3.00277
OLFML1 olfactomedin-like 1 -3.00277
PHF24 PHD finger protein 24 -3.00277
IL1A interleukin 1, alpha -3.00277
LYG2 lysozyme G-like 2 -3.00277
CALR3 calreticulin 3 -3.00277
DNAI7 dynein axonemal intermediate chain 7 -3.00277
TBC1D3L TBC1 domain family, member 3L -3.00277
NT5C1B 5'-nucleotidase, cytosolic IB -3.00277
PRTN3 proteinase 3 -3.00277
ERVV-2 endogenous retrovirus group V, member 2 -3.00277
NME9 NME/NM23 family member 9 -2.97267
HMGB1 high mobility group box 1 -2.97267
TLCD3B TLC domain containing 3B -2.95701
ALX1 ALX homeobox 1 -2.89235
CARD14 caspase recruitment domain family, member 14 -2.89235
TFF3 trefoil factor 3 (intestinal) -2.89235
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -2.82333
IQCK IQ motif containing K -2.82333
IL13RA1 interleukin 13 receptor, alpha 1 -2.76957
WDR88 WD repeat domain 88 -2.73049
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -2.65743
TCTN2 tectonic family member 2 -2.64162
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.59831
ABHD17B abhydrolase domain containing 17B -2.59831
GGNBP2 gametogenetin binding protein 2 -2.5516
STUM stum, mechanosensory transduction mediator homolog -2.51406
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -2.50088
FGF22 fibroblast growth factor 22 -2.49463
NLRP1 NLR family, pyrin domain containing 1 -2.49463
DUSP14 dual specificity phosphatase 14 -2.49463
PCDHA10 protocadherin alpha 10 -2.41695
ADM5 adrenomedullin 5 (putative) -2.41216
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -2.41216
ABHD15 abhydrolase domain containing 15 -2.41216
ATP2A3 ATPase, Ca++ transporting, ubiquitous -2.38944
MMD monocyte to macrophage differentiation-associated -2.38878
ZNF33A zinc finger protein 33A -2.35997
CTC1 CTS telomere maintenance complex component 1 -2.33658
ZNF345 zinc finger protein 345 -2.29476
JPH3 junctophilin 3 -2.25703
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.24775
COMMD4 COMM domain containing 4 -2.24131
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.23028
SLC25A39 solute carrier family 25, member 39 -2.22728
TP63 tumor protein p63 -2.20861
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.18535
CYRIB CYFIP related Rac1 interactor B -2.18535
FAM241B family with sequence similarity 241 member B -2.16821
SUSD6 sushi domain containing 6 -2.16045
SPATA32 spermatogenesis associated 32 -2.15273
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -2.15273
USPL1 ubiquitin specific peptidase like 1 -2.15273
SPIRE1 spire-type actin nucleation factor 1 -2.15273
ERCC6 excision repair cross-complementation group 6 -2.15184
LASP1NB LASP1 neighbor -2.15184
QTGAL queuosine-tRNA galactosyltransferase -2.15184
PTBP3 polypyrimidine tract binding protein 3 -2.15068
COL16A1 collagen, type XVI, alpha 1 -2.14343
PON3 paraoxonase 3 -2.14343
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.13547
LY75 lymphocyte antigen 75 -2.13547
HDAC2 histone deacetylase 2 -2.12647
VTI1A vesicle transport through interaction with t-SNAREs 1A -2.12314
USP11 ubiquitin specific peptidase 11 -2.11519
SENP6 SUMO1/sentrin specific peptidase 6 -2.11519
UBXN2A UBX domain protein 2A -2.11042
TNNC1 troponin C type 1 (slow) -2.10553
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.10089
TMEM154 transmembrane protein 154 -2.10089
CSPG4 chondroitin sulfate proteoglycan 4 -2.10089
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.098
PTN pleiotrophin -2.098
FAM174B family with sequence similarity 174, member B -2.08548
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 -2.06893
YTHDC1 YTH domain containing 1 -2.06809
SH3BP5L SH3-binding domain protein 5-like -2.06809
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -2.06469
KIAA1549 KIAA1549 -2.06365
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.05447
SNX9 sorting nexin 9 -2.05282
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.05241
GGACT gamma-glutamylamine cyclotransferase -2.05241
BRIX1 BRX1, biogenesis of ribosomes -2.04049
PPP1R42 protein phosphatase 1, regulatory subunit 42 -2.01992
HAPLN3 hyaluronan and proteoglycan link protein 3 -2.01506
ZFX zinc finger protein, X-linked -2.01332