SOCS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description suppressor of cytokine signaling 1|This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8651)
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Genes

330 genes differentially expressed following the SOCS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.20545
CLDN14 claudin 14 3.20545
FRG2C FSHD region gene 2 family, member C 3.20545
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.20545
MAP6 microtubule-associated protein 6 3.20545
PTGFR prostaglandin F receptor (FP) 3.20545
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 3.20545
RNF183 ring finger protein 183 3.20545
FGF16 fibroblast growth factor 16 3.20545
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.20545
ECM1 extracellular matrix protein 1 3.20545
SPDYC speedy/RINGO cell cycle regulator family member C 3.20545
ANKRD62 ankyrin repeat domain 62 3.20545
CYSLTR1 cysteinyl leukotriene receptor 1 3.20545
EFCAB9 EF-hand calcium binding domain 9 3.20545
SLC35D3 solute carrier family 35, member D3 3.20545
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.20545
PTK6 protein tyrosine kinase 6 3.20545
BMP5 bone morphogenetic protein 5 3.20545
ETV3L ets variant 3-like 3.20545
SLC10A5 solute carrier family 10, member 5 3.20545
ATOH7 atonal homolog 7 (Drosophila) 3.20545
BFSP2 beaded filament structural protein 2, phakinin 3.20545
CCR6 chemokine (C-C motif) receptor 6 3.20545
TRIM7 tripartite motif containing 7 3.20545
CXXC1 CXXC finger protein 1 3.13741
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.13741
VCX variable charge, X-linked 3.13741
OIT3 oncoprotein induced transcript 3 3.13741
PRR29 proline rich 29 3.13741
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.13741
IL5RA interleukin 5 receptor, alpha 3.13741
ZNF662 zinc finger protein 662 3.13741
PRSS41 protease, serine, 41 3.13741
UCN urocortin 3.13741
RXFP3 relaxin/insulin-like family peptide receptor 3 3.13741
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.13741
GIMAP4 GTPase, IMAP family member 4 3.13741
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.13741
TREML1 triggering receptor expressed on myeloid cells-like 1 3.13741
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.13741
PAX2 paired box 2 3.13741
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.13741
C8ORF74 chromosome 8 open reading frame 74 3.13741
CRYGC crystallin, gamma C 3.13741
CRYGA crystallin, gamma A 3.13741
IL17B interleukin 17B 3.13741
CXCL2 chemokine (C-X-C motif) ligand 2 3.13741
NRROS negative regulator of reactive oxygen species 3.13741
CYSTM1 cysteine-rich transmembrane module containing 1 3.13741
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.13741
SSTR3 somatostatin receptor 3 3.13741
TLX3 T-cell leukemia homeobox 3 3.13741
BMP3 bone morphogenetic protein 3 3.13741
XCL2 chemokine (C motif) ligand 2 3.13741
FOLR2 folate receptor 2 (fetal) 3.13741
PAX6 paired box 6 3.13741
TSGA13 testis specific, 13 3.13741
CATSPERH catsper channel auxiliary subunit eta 3.13741
ZNF726 zinc finger protein 726 3.13741
C3AR1 complement component 3a receptor 1 3.13741
OR10H1 olfactory receptor, family 10, subfamily H, member 1 3.13741
YIPF7 Yip1 domain family, member 7 3.13741
PROP1 PROP paired-like homeobox 1 3.13741
TYROBP TYRO protein tyrosine kinase binding protein 3.13741
FMOD fibromodulin 3.13741
TRIM31 tripartite motif containing 31 3.13741
MYL10 myosin, light chain 10, regulatory 3.13741
PLG plasminogen 3.13741
PLAAT4 phospholipase A and acyltransferase 4 3.13741
PLAAT2 phospholipase A and acyltransferase 2 3.13741
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.13741
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.13741
SPMIP11 sperm microtubule inner protein 11 3.13741
TEKTL1 tektin like 1 3.13741
ERLN endoregulin 3.13741
DEFB109B defensin beta 109B 3.13741
H4C15 H4 clustered histone 15 3.13741
GNG5B G protein subunit gamma 5B 3.13741
DIPK1C divergent protein kinase domain 1C 3.13741
TSPAN1 tetraspanin 1 3.13741
OR52E4 olfactory receptor, family 52, subfamily E, member 4 3.13741
TBX5 T-box 5 3.13741
IL5 interleukin 5 3.13741
TMEM235 transmembrane protein 235 3.13741
CATSPER3 cation channel, sperm associated 3 3.13741
CD79A CD79a molecule, immunoglobulin-associated alpha 3.13741
KRABD1 KRAB domain containing 1 3.13741
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.13741
SYCP2 synaptonemal complex protein 2 3.13741
GPR75 G protein-coupled receptor 75 3.13741
AMY2A amylase, alpha 2A (pancreatic) 3.13741
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.13741
EXOC3L4 exocyst complex component 3-like 4 3.13741
SELL selectin L 3.13741
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.13741
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.13741
SOAT2 sterol O-acyltransferase 2 3.13741
ZNF683 zinc finger protein 683 3.13741
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.13741
GDF7 growth differentiation factor 7 3.13741
SAA2 serum amyloid A2 3.13741
SBSN suprabasin 3.13741
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.13741
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.13741
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.13741
ERICH6 glutamate-rich 6 3.13741
GPR12 G protein-coupled receptor 12 3.13741
AQP4 aquaporin 4 3.13741
CTAGE4 CTAGE family, member 4 3.13741
BPIFB4 BPI fold containing family B, member 4 3.13741
TBC1D10C TBC1 domain family, member 10C 3.13741
GOLGA6D golgin A6 family, member D 3.13741
NPFFR1 neuropeptide FF receptor 1 3.13741
SERINC4 serine incorporator 4 3.13741
RFX2 regulatory factor X, 2 (influences HLA class II expression) 3.13741
RSAD2 radical S-adenosyl methionine domain containing 2 3.13741
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.13741
KRT15 keratin 15, type I 3.13741
KRT17 keratin 17, type I 3.13741
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.13741
CLEC7A C-type lectin domain family 7, member A 3.13741
SKAP1 src kinase associated phosphoprotein 1 3.13741
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.13741
PRF1 perforin 1 (pore forming protein) 3.13741
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.13741
PAGE4 P antigen family, member 4 (prostate associated) 3.13741
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.13741
LHX5 LIM homeobox 5 3.13741
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.13741
CTRB1 chymotrypsinogen B1 3.13741
LRRC25 leucine rich repeat containing 25 3.13741
SLC25A34 solute carrier family 25, member 34 3.13741
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.13741
DRC7 dynein regulatory complex subunit 7 3.13741
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.13741
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.13741
IGLL1 immunoglobulin lambda-like polypeptide 1 3.13741
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.13741
IL1B interleukin 1, beta 3.13741
COL17A1 collagen, type XVII, alpha 1 3.13741
RGCC regulator of cell cycle 3.13741
CATIP ciliogenesis associated TTC17 interacting protein 3.13741
SPRR2A small proline-rich protein 2A 3.13741
ITGA10 integrin, alpha 10 3.13741
ITGB7 integrin, beta 7 3.13741
ZC3H12D zinc finger CCCH-type containing 12D 3.13741
GSTA2 glutathione S-transferase alpha 2 3.13741
CRTAM cytotoxic and regulatory T cell molecule 3.13741
ADAM29 ADAM metallopeptidase domain 29 3.13741
GH1 growth hormone 1 3.13741
NPAS4 neuronal PAS domain protein 4 3.13741
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 3.13741
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.13741
RBP4 retinol binding protein 4, plasma 3.13741
GRAPL GRB2-related adaptor protein-like 3.13741
FXYD3 FXYD domain containing ion transport regulator 3 3.13741
CIB3 calcium and integrin binding family member 3 3.13741
PITX1 paired-like homeodomain 1 3.13741
TEX35 testis expressed 35 3.13741
TTC36 tetratricopeptide repeat domain 36 3.13741
TGM6 transglutaminase 6 3.13741
ASCL2 achaete-scute family bHLH transcription factor 2 3.13741
TAS2R40 taste receptor, type 2, member 40 3.13741
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 3.13741
PRSS21 protease, serine, 21 (testisin) 3.13741
RGR retinal G protein coupled receptor 3.13741
HCAR1 hydroxycarboxylic acid receptor 1 3.13741
CCDC83 coiled-coil domain containing 83 3.13741
CCDC89 coiled-coil domain containing 89 3.13741
EPO erythropoietin 3.13741
GPR17 G protein-coupled receptor 17 3.13741
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 3.13741
ACRBP acrosin binding protein 3.13741
APOL3 apolipoprotein L, 3 3.13741
KRTAP12-2 keratin associated protein 12-2 3.13741
FGF8 fibroblast growth factor 8 (androgen-induced) 3.13741
SYCE2 synaptonemal complex central element protein 2 3.09378
ZNF324 zinc finger protein 324 3.04484
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 3.04484
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.04484
DEPDC1 DEP domain containing 1 2.93282
HAX1 HCLS1 associated protein X-1 2.93104
TBX10 T-box 10 2.87503
GPR22 G protein-coupled receptor 22 2.87503
ZNF837 zinc finger protein 837 2.83413
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.8248
NFE2L1 nuclear factor, erythroid 2-like 1 2.78141
CEP70 centrosomal protein 70kDa 2.73207
MACROH2A1 macroH2A.1 histone 2.69599
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 2.64588
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) 2.63267
PSME3IP1 proteasome activator subunit 3 interacting protein 1 2.52671
LECT2 leukocyte cell-derived chemotaxin 2 2.51791
KIAA0586 KIAA0586 2.49747
MYO5B myosin VB 2.4747
FNBP1 formin binding protein 1 2.42732
HSF5 heat shock transcription factor family member 5 2.41603
CLDN6 claudin 6 2.39695
CARNMT1 carnosine N-methyltransferase 1 2.39254
CASKIN2 CASK interacting protein 2 2.36919
GLG1 golgi glycoprotein 1 2.3216
MRPL14 mitochondrial ribosomal protein L14 2.31779
APOL6 apolipoprotein L, 6 2.31498
ZNF516 zinc finger protein 516 2.29908
CARM1 coactivator-associated arginine methyltransferase 1 2.28806
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.28443
CAPN6 calpain 6 2.28443
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.27637
EPHB3 EPH receptor B3 2.27581
VCX3A variable charge, X-linked 3A 2.27565
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.27565
IQCJ IQ motif containing J 2.24905
GPR63 G protein-coupled receptor 63 2.23029
RNF25 ring finger protein 25 2.21004
SAT2 spermidine/spermine N1-acetyltransferase family member 2 2.20812
KLC3 kinesin light chain 3 2.20704
FN3K fructosamine 3 kinase 2.17985
ZNF749 zinc finger protein 749 2.17044
EMILIN3 elastin microfibril interfacer 3 2.16357
MYL9 myosin, light chain 9, regulatory 2.13232
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 2.1102
ISYNA1 inositol-3-phosphate synthase 1 2.10633
ZNF469 zinc finger protein 469 2.09223
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 2.09223
LETMD1 LETM1 domain containing 1 2.08339
GFM1 G elongation factor, mitochondrial 1 2.07852
BRD9 bromodomain containing 9 2.07832
TYW5 tRNA-yW synthesizing protein 5 2.07125
PRICKLE3 prickle homolog 3 (Drosophila) 2.05755
ZNF526 zinc finger protein 526 2.0556
TMEM161A transmembrane protein 161A 2.0556
CCDC170 coiled-coil domain containing 170 2.03839
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.0301
PCDHAC1 protocadherin alpha subfamily C, 1 2.0301
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.0301
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2.0025

decreased expression

Symbol Name Standardized Value
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -3.20545
IL6ST-DT IL6ST divergent transcript -3.20545
OTOA otoancorin -3.20545
CLCN1 chloride channel, voltage-sensitive 1 -3.20545
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -3.13741
SCRT2 scratch family zinc finger 2 -3.13741
FOXP3 forkhead box P3 -3.13741
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -3.13741
TMPRSS11A transmembrane protease, serine 11A -3.13741
IRX4 iroquois homeobox 4 -3.13741
PCDHA8 protocadherin alpha 8 -3.13741
PAX7 paired box 7 -3.13741
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -3.13741
SYCP1 synaptonemal complex protein 1 -3.13741
S100A1 S100 calcium binding protein A1 -3.13741
LGI2 leucine-rich repeat LGI family, member 2 -3.13741
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -3.13741
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 -3.13741
FNDC1 fibronectin type III domain containing 1 -3.13741
MROH5 maestro heat-like repeat family member 5 -3.13741
PAQR5 progestin and adipoQ receptor family member V -3.13741
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -3.13741
PRRT1B proline rich transmembrane protein 1B -3.13741
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.13741
FCHO1 FCH domain only 1 -3.13741
VXN vexin -3.13741
SIAH3 siah E3 ubiquitin protein ligase family member 3 -3.13741
TAMALIN trafficking regulator and scaffold protein tamalin -3.13741
NASP nuclear autoantigenic sperm protein (histone-binding) -3.13741
ASB12 ankyrin repeat and SOCS box containing 12 -3.13741
CAMK2D calcium/calmodulin-dependent protein kinase II delta -3.13741
ERICH6B glutamate-rich 6B -3.13741
PINK1 PTEN induced putative kinase 1 -3.13741
CFAP65 cilia and flagella associated protein 65 -3.13741
TMEM198 transmembrane protein 198 -3.07438
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -2.99717
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.99717
NPTN neuroplastin -2.93089
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -2.92995
ERI1 exoribonuclease 1 -2.84504
RNF32 ring finger protein 32 -2.83413
DOCK1 dedicator of cytokinesis 1 -2.83413
CNBP CCHC-type zinc finger, nucleic acid binding protein -2.77022
MFAP3 microfibrillar-associated protein 3 -2.72741
FAAP100 FA core complex associated protein 100 -2.6851
SLC75A1 solute carrier family 75 member 1 -2.67398
IDS iduronate 2-sulfatase -2.59339
ANOS1 anosmin 1 -2.53829
PRB3 proline-rich protein BstNI subfamily 3 -2.50257
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.50035
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.49747
MSR1 macrophage scavenger receptor 1 -2.47913
ZNF771 zinc finger protein 771 -2.47257
FHDC1 FH2 domain containing 1 -2.43763
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -2.42894
LINC02762 long intergenic non-protein coding RNA 2762 -2.42894
H2AC25 H2A clustered histone 25 -2.37081
MAGEL2 melanoma antigen family L2 -2.34856
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -2.32352
FADS2 fatty acid desaturase 2 -2.3216
CISD2 CDGSH iron sulfur domain 2 -2.31993
SIVA1 SIVA1, apoptosis-inducing factor -2.30231
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.29544
NME7 NME/NM23 family member 7 -2.25054
SH2D4B SH2 domain containing 4B -2.24886
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.24886
ZNF543 zinc finger protein 543 -2.234
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.21419
MDC1 mediator of DNA-damage checkpoint 1 -2.21419
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.21004
CLDN11 claudin 11 -2.21004
ADGRB2 adhesion G protein-coupled receptor B2 -2.20812
VRK1 vaccinia related kinase 1 -2.17641
HEPH hephaestin -2.1662
H1-4 H1.4 linker histone, cluster member -2.16593
OFD1 oral-facial-digital syndrome 1 -2.1519
NALF1 NALCN channel auxiliary factor 1 -2.13066
EFNA5 ephrin-A5 -2.13066
AFAP1L2 actin filament associated protein 1-like 2 -2.10996
CNOT7 CCR4-NOT transcription complex, subunit 7 -2.08813
IER5 immediate early response 5 -2.0842
MRPS2 mitochondrial ribosomal protein S2 -2.0842
ANGPT4 angiopoietin 4 -2.08148
RGN regucalcin -2.08148
HARBI1 harbinger transposase derived 1 -2.08049
CREB3L2 cAMP responsive element binding protein 3-like 2 -2.06335
ADAM22 ADAM metallopeptidase domain 22 -2.0446
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.03186
ZCCHC9 zinc finger, CCHC domain containing 9 -2.0301
SOCS1 suppressor of cytokine signaling 1 -2.02835
SLC39A11 solute carrier family 39, member 11 -2.02193
PNPLA4 patatin-like phospholipase domain containing 4 -2.01819
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa -2.00684