| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | suppressor of cytokine signaling 1|This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8651) |
| External Link | https://ncbi.nlm.nih.gov/gene/8651 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the SOCS1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GNAS | GNAS complex locus | 0.0216168 |
| AMDHD2 | amidohydrolase domain containing 2 | 0.0165714 |
| PEG10 | paternally expressed 10 | 0.0152107 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.0150395 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0145558 |
| NVL | nuclear VCP-like | 0.0144593 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.0142107 |
| KLK5 | kallikrein-related peptidase 5 | 0.0123888 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0123373 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0120973 |
| NID2 | nidogen 2 (osteonidogen) | 0.0118651 |
| PLK2 | polo-like kinase 2 | 0.0118321 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | 0.0116442 |
| CALD1 | caldesmon 1 | 0.0113553 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.0113537 |
| GOLGA8A | golgin A8 family, member A | 0.0110695 |
| SC5D | sterol-C5-desaturase | 0.0110613 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.0109114 |
| CFB | complement factor B | 0.0108471 |
| PDGFC | platelet derived growth factor C | 0.0103373 |
| KLK7 | kallikrein-related peptidase 7 | 0.0102974 |
| SCG5 | secretogranin V | 0.0102879 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | 0.0102419 |
| NXN | nucleoredoxin | 0.0101661 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0100999 |
| MXRA5 | matrix-remodelling associated 5 | 0.00989822 |
| HTRA1 | HtrA serine peptidase 1 | 0.00980841 |
| RPS27L | ribosomal protein S27-like | 0.00970486 |
| NPY | neuropeptide Y | 0.00959496 |
| CTBP2 | C-terminal binding protein 2 | 0.00949718 |
| DPP4 | dipeptidyl-peptidase 4 | 0.00944954 |
| DEFB1 | defensin, beta 1 | 0.00944914 |
| WT1 | Wilms tumor 1 | 0.00938169 |
| TNS3 | tensin 3 | 0.00933169 |
| IPO13 | importin 13 | 0.00922418 |
| GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | 0.00910196 |
| ABAT | 4-aminobutyrate aminotransferase | 0.00909077 |
| STK10 | serine/threonine kinase 10 | 0.00906922 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.00904525 |
| CLGN | calmegin | 0.00899432 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00896416 |
| METTL7A | methyltransferase like 7A | 0.00896413 |
| GPX3 | glutathione peroxidase 3 | 0.00894314 |
| CFI | complement factor I | 0.00878729 |
| ASPN | asporin | 0.00874081 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 0.00862764 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | 0.00861618 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00858651 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | 0.00857565 |
| EXOSC4 | exosome component 4 | 0.00857489 |
| REC8 | REC8 meiotic recombination protein | 0.00854961 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.00853811 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0084694 |
| CAPN1 | calpain 1, (mu/I) large subunit | 0.00846052 |
| MXRA8 | matrix-remodelling associated 8 | 0.00845201 |
| PILRB | paired immunoglobin-like type 2 receptor beta | 0.00841944 |
| RHOD | ras homolog family member D | 0.00841103 |
| LRRC15 | leucine rich repeat containing 15 | 0.00839345 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00836861 |
| COL6A2 | collagen, type VI, alpha 2 | 0.00836684 |
| CTSV | cathepsin V | 0.00832772 |
| ANXA4 | annexin A4 | 0.00830945 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00830037 |
| TSPAN13 | tetraspanin 13 | 0.00825626 |
| TMPRSS4 | transmembrane protease, serine 4 | 0.00822138 |
| FASN | fatty acid synthase | 0.00821864 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.00821028 |
| CP | ceruloplasmin (ferroxidase) | 0.00809584 |
| CTSA | cathepsin A | 0.00809071 |
| IL1R1 | interleukin 1 receptor, type I | 0.00808123 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00806623 |
| PRRC2A | proline-rich coiled-coil 2A | 0.00805452 |
| LAMA5 | laminin, alpha 5 | 0.00799342 |
| PLXNC1 | plexin C1 | 0.0079917 |
| CHN2 | chimerin 2 | 0.00788571 |
| LCN2 | lipocalin 2 | 0.00788372 |
| REG1A | regenerating islet-derived 1 alpha | 0.00786777 |
| XIC | X chromosome inactivation center | 0.00785641 |
| SGCE | sarcoglycan, epsilon | 0.00784134 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.00783512 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00781817 |
| CTSD | cathepsin D | 0.007809 |
| NOTCH1 | notch 1 | 0.00778814 |
| SPON2 | spondin 2, extracellular matrix protein | 0.00776946 |
| MAMLD1 | mastermind-like domain containing 1 | 0.00774012 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00767977 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.00765698 |
| COL9A3 | collagen, type IX, alpha 3 | 0.00764016 |
| EPCAM | epithelial cell adhesion molecule | 0.00763012 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 0.00757956 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 0.00754688 |
| SNAI2 | snail family zinc finger 2 | 0.00752619 |
| ANGPTL2 | angiopoietin-like 2 | 0.00751738 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00751533 |
| FRZB | frizzled-related protein | 0.00751522 |
| WASF1 | WAS protein family, member 1 | 0.00751515 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00746752 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00744474 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.00741857 |
| EML3 | echinoderm microtubule associated protein like 3 | 0.00740567 |
| C2 | complement component 2 | 0.00738151 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00731185 |
| NPIPA1 | nuclear pore complex interacting protein family, member A1 | 0.00730265 |
| HOXC6 | homeobox C6 | 0.00727379 |
| WBP5 | WW domain binding protein 5 | 0.00725977 |
| CLDN3 | claudin 3 | 0.00725795 |
| GAS1 | growth arrest-specific 1 | 0.0072537 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | 0.00724252 |
| PCLAF | PCNA clamp associated factor | 0.00723208 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.0072297 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | 0.00722344 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | 0.00721722 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.00718628 |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.00710355 |
| PTK2B | protein tyrosine kinase 2 beta | 0.00708311 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | 0.00706873 |
| PLXNB2 | plexin B2 | 0.00704686 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 0.00703262 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.00703249 |
| VEGFB | vascular endothelial growth factor B | 0.00702509 |
| ASRGL1 | asparaginase like 1 | 0.00701625 |
| COMP | cartilage oligomeric matrix protein | 0.00701346 |
| MEIS1 | Meis homeobox 1 | 0.00697757 |
| PFKL | phosphofructokinase, liver | 0.00694768 |
| COL10A1 | collagen, type X, alpha 1 | 0.0069442 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.00694347 |
| TRIB2 | tribbles pseudokinase 2 | 0.00693209 |
| KRT8 | keratin 8, type II | 0.00692899 |
| WDR26 | WD repeat domain 26 | 0.0069159 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.00689637 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00688104 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.00686997 |
| PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | 0.00686668 |
| H1-2 | H1.2 linker histone, cluster member | 0.00686145 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 0.00679457 |
| MFSD10 | major facilitator superfamily domain containing 10 | 0.00678491 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.00677929 |
| EFNB2 | ephrin-B2 | 0.00676381 |
| CHKA | choline kinase alpha | 0.00674646 |
| LAMB1 | laminin, beta 1 | 0.00674135 |
| THY1 | Thy-1 cell surface antigen | 0.00674052 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.00669866 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 0.00668942 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.00667936 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | 0.0066787 |
| GLOD4 | glyoxalase domain containing 4 | 0.00666705 |
| CHGA | chromogranin A | 0.00663492 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.0066092 |
| GOLGA8H | golgin A8 family, member H | 0.00659672 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.00658772 |
| TYMS | thymidylate synthetase | 0.00658691 |
| PNN | pinin, desmosome associated protein | 0.006581 |
| SLBP | stem-loop binding protein | 0.00657765 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00657379 |
| QPRT | quinolinate phosphoribosyltransferase | 0.0065471 |
| KLK8 | kallikrein-related peptidase 8 | 0.00654084 |
| PFKM | phosphofructokinase, muscle | 0.00651557 |
| JMJD6 | jumonji domain containing 6 | 0.0065115 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00649325 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.00648168 |
| MUC16 | mucin 16, cell surface associated | 0.00647941 |
| CAPN15 | calpain 15 | 0.00646768 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.00644884 |
| ATP6V1B1 | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 | 0.00644854 |
| KLK10 | kallikrein-related peptidase 10 | 0.0064478 |
| CLDN4 | claudin 4 | 0.00643912 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.0064381 |
| GRK2 | G protein-coupled receptor kinase 2 | 0.00641266 |
| NCDN | neurochondrin | 0.00638649 |
| CPSF1 | cleavage and polyadenylation specific factor 1, 160kDa | 0.00637099 |
| SH3GLB2 | SH3-domain GRB2-like endophilin B2 | 0.00632876 |
| RGL1 | ral guanine nucleotide dissociation stimulator-like 1 | 0.0063229 |
| NELL1 | NEL-like 1 (chicken) | 0.00632288 |
| DGKZ | diacylglycerol kinase, zeta | 0.00631029 |
| ADD3 | adducin 3 (gamma) | 0.00629857 |
| G0S2 | G0/G1 switch 2 | 0.00628404 |
| ATG2A | autophagy related 2A | 0.00624584 |
| INTS1 | integrator complex subunit 1 | 0.0062458 |
| FRMD4B | FERM domain containing 4B | 0.00623471 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.00623258 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.00621393 |
| ALB | albumin | 0.00620477 |
| TDO2 | tryptophan 2,3-dioxygenase | 0.00619546 |
| BBX | bobby sox homolog (Drosophila) | 0.00618449 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.00617801 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.00616225 |
| MEIS2 | Meis homeobox 2 | 0.0061618 |
| HSPB11 | heat shock protein family B (small), member 11 | 0.00615306 |
| NUP210 | nucleoporin 210kDa | 0.00615078 |
| PRDX3 | peroxiredoxin 3 | 0.00614293 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.00613968 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00613204 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.00612688 |
| CRIP2 | cysteine-rich protein 2 | 0.00611463 |
| NINJ2 | ninjurin 2 | 0.00610968 |
| LXN | latexin | 0.00610792 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.00609759 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00609385 |
| COL16A1 | collagen, type XVI, alpha 1 | 0.00608617 |
| SBF1 | SET binding factor 1 | 0.00607319 |
| CDR2L | cerebellar degeneration-related protein 2-like | 0.00606782 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00606344 |
| CCNL2 | cyclin L2 | 0.00605926 |
| C5ORF15 | chromosome 5 open reading frame 15 | 0.00605372 |
| PGF | placental growth factor | 0.00605041 |
| AEBP1 | AE binding protein 1 | 0.00602885 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.00601484 |
| MSLN | mesothelin | 0.00600672 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00599827 |
| LDB1 | LIM domain binding 1 | 0.00599689 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.00599357 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | 0.00598613 |
| SLC35E2B | solute carrier family 35, member E2B | 0.00596257 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 0.00594164 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.00592107 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00591952 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.00589757 |
| NPY1R | neuropeptide Y receptor Y1 | 0.00589275 |
| PBLD | phenazine biosynthesis-like protein domain containing | 0.00587844 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.00587556 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.00587271 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00585952 |
| MGLL | monoglyceride lipase | 0.00585106 |
| TNFRSF25 | tumor necrosis factor receptor superfamily, member 25 | 0.00585102 |
| NDUFAF3 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 | 0.00584544 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.00583987 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | 0.00583513 |
| ASS1 | argininosuccinate synthase 1 | 0.00582821 |
| SCAMP4 | secretory carrier membrane protein 4 | 0.00582659 |
| REEP1 | receptor accessory protein 1 | 0.00582016 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.00581987 |
| KLK6 | kallikrein-related peptidase 6 | 0.00581863 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00580676 |
| THBS1 | thrombospondin 1 | 0.0058027 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.00579901 |
| RGS5 | regulator of G-protein signaling 5 | 0.00579442 |
| FADS1 | fatty acid desaturase 1 | 0.00579402 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.00578661 |
| ESR1 | estrogen receptor 1 | 0.00578006 |
| SGSM2 | small G protein signaling modulator 2 | 0.00577384 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | 0.00577322 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | 0.0057664 |
| LIMD2 | LIM domain containing 2 | 0.00576402 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.00576381 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | 0.00576323 |
| CLCN7 | chloride channel, voltage-sensitive 7 | 0.00575674 |
| PHF1 | PHD finger protein 1 | 0.00573791 |
| HOXC4 | homeobox C4 | 0.00573003 |
| E4F1 | E4F transcription factor 1 | 0.00571819 |
| RFX5 | regulatory factor X, 5 (influences HLA class II expression) | 0.00571676 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.0156571 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0152361 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0145032 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.0143535 |
| MMP12 | matrix metallopeptidase 12 | -0.0139054 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.0134531 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0133647 |
| MYBPC1 | myosin binding protein C, slow type | -0.0128771 |
| HBB | hemoglobin, beta | -0.0125718 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0122393 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.0122294 |
| CSTA | cystatin A (stefin A) | -0.012033 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0119139 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.011858 |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | -0.0118507 |
| KRT13 | keratin 13, type I | -0.0114204 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.0113769 |
| MAGEA3 | melanoma antigen family A3 | -0.0110653 |
| TUBB2A | tubulin, beta 2A class IIa | -0.0110146 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | -0.0108354 |
| LY6D | lymphocyte antigen 6 complex, locus D | -0.0107154 |
| NEBL | nebulette | -0.0106815 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.0106558 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | -0.0104519 |
| SPRR3 | small proline-rich protein 3 | -0.0104292 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.010375 |
| ANO10 | anoctamin 10 | -0.0103216 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.0102569 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.0101882 |
| NRIP3 | nuclear receptor interacting protein 3 | -0.0101506 |
| GPX2 | glutathione peroxidase 2 | -0.010142 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00997186 |
| S100P | S100 calcium binding protein P | -0.00990801 |
| TNNC1 | troponin C type 1 (slow) | -0.00988485 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00988287 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.0098596 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | -0.0097779 |
| FABP7 | fatty acid binding protein 7, brain | -0.0097741 |
| PIP | prolactin-induced protein | -0.00966237 |
| GPM6B | glycoprotein M6B | -0.0096611 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00963662 |
| FAR2 | fatty acyl CoA reductase 2 | -0.0096324 |
| CFD | complement factor D (adipsin) | -0.00955588 |
| TP63 | tumor protein p63 | -0.00949705 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.00941988 |
| CD59 | CD59 molecule, complement regulatory protein | -0.00927549 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00925701 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00910706 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | -0.00909337 |
| EGR2 | early growth response 2 | -0.00907729 |
| SPRR1B | small proline-rich protein 1B | -0.00903738 |
| IL32 | interleukin 32 | -0.00893994 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | -0.0088688 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -0.00886835 |
| FERMT1 | fermitin family member 1 | -0.00885398 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00875282 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00870068 |
| RGCC | regulator of cell cycle | -0.00869091 |
| CLCA4 | chloride channel accessory 4 | -0.00866778 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00863384 |
| GUCY2C | guanylate cyclase 2C | -0.00859754 |
| CHI3L2 | chitinase 3-like 2 | -0.00859719 |
| HOPX | HOP homeobox | -0.00856185 |
| CTSS | cathepsin S | -0.00852681 |
| TTN | titin | -0.00850112 |
| KRT20 | keratin 20, type I | -0.00849904 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.00843604 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00841709 |
| LMOD1 | leiomodin 1 (smooth muscle) | -0.0083249 |
| KRT1 | keratin 1, type II | -0.00826438 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00826378 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00826331 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | -0.0081618 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.00815805 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00815158 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00812879 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00810897 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.00808837 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.00805931 |
| CD52 | CD52 molecule | -0.00805291 |
| ANXA2 | annexin A2 | -0.00803126 |
| PSAP | prosaposin | -0.0080106 |
| CH25H | cholesterol 25-hydroxylase | -0.0079785 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00790277 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00788491 |
| SYNGR3 | synaptogyrin 3 | -0.00787321 |
| MAGEA12 | melanoma antigen family A12 | -0.00779646 |
| C8ORF33 | chromosome 8 open reading frame 33 | -0.00778173 |
| AQP4 | aquaporin 4 | -0.00777608 |
| CD1B | CD1b molecule | -0.00771874 |
| MOCOS | molybdenum cofactor sulfurase | -0.00771628 |
| GLUL | glutamate-ammonia ligase | -0.00769011 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00767989 |
| SIRT3 | sirtuin 3 | -0.00763312 |
| COL1A2 | collagen, type I, alpha 2 | -0.00762484 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -0.00761591 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.00760254 |
| SNX11 | sorting nexin 11 | -0.00757269 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | -0.00754936 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.00754449 |
| FZD5 | frizzled class receptor 5 | -0.00748258 |
| MB | myoglobin | -0.00746407 |
| PLIN3 | perilipin 3 | -0.00744733 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00742309 |
| VWF | von Willebrand factor | -0.00735812 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.00734501 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00733214 |
| ANXA2P2 | annexin A2 pseudogene 2 | -0.00729271 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00728717 |
| PRAME | preferentially expressed antigen in melanoma | -0.00724146 |
| S100A10 | S100 calcium binding protein A10 | -0.00722528 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00722334 |
| PLCB4 | phospholipase C, beta 4 | -0.00721095 |
| S100A7 | S100 calcium binding protein A7 | -0.00720999 |
| NTS | neurotensin | -0.00717574 |
| NCF2 | neutrophil cytosolic factor 2 | -0.0071723 |
| S100A9 | S100 calcium binding protein A9 | -0.00715073 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00713864 |
| STAC | SH3 and cysteine rich domain | -0.00713158 |
| LTF | lactotransferrin | -0.0071245 |
| IRF6 | interferon regulatory factor 6 | -0.00710813 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | -0.00710587 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.00710156 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00709838 |
| BDNF | brain-derived neurotrophic factor | -0.00709073 |
| ANOS1 | anosmin 1 | -0.00705797 |
| AK4 | adenylate kinase 4 | -0.0070355 |
| KAT7 | K(lysine) acetyltransferase 7 | -0.00703025 |
| DIXDC1 | DIX domain containing 1 | -0.00694818 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | -0.00693332 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.00693144 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | -0.00692168 |
| SLN | sarcolipin | -0.00691805 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | -0.00690319 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.00688954 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.00686572 |
| RNF125 | ring finger protein 125, E3 ubiquitin protein ligase | -0.00686023 |
| HEPH | hephaestin | -0.00684877 |
| SYT1 | synaptotagmin I | -0.00684206 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.00683892 |
| MAL | mal, T-cell differentiation protein | -0.00683627 |
| EDNRB | endothelin receptor type B | -0.00682274 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | -0.00682233 |
| PLEK2 | pleckstrin 2 | -0.00680606 |
| AGR2 | anterior gradient 2 | -0.00679334 |
| ABHD17B | abhydrolase domain containing 17B | -0.00678378 |
| TSPAN31 | tetraspanin 31 | -0.00677299 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | -0.00674185 |
| COPA | coatomer protein complex, subunit alpha | -0.0067228 |
| ITK | IL2-inducible T-cell kinase | -0.00671934 |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | -0.00671022 |
| ADORA2B | adenosine A2b receptor | -0.00670958 |
| PGD | phosphogluconate dehydrogenase | -0.00669265 |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | -0.00667896 |
| CLDN8 | claudin 8 | -0.00666972 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00666324 |
| PHB2 | prohibitin 2 | -0.00666092 |
| APOBEC3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | -0.0066334 |
| RGS13 | regulator of G-protein signaling 13 | -0.00662998 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0066291 |
| FZD10 | frizzled class receptor 10 | -0.00662469 |
| CD2 | CD2 molecule | -0.00662305 |
| WFDC1 | WAP four-disulfide core domain 1 | -0.00661835 |
| KRT6A | keratin 6A, type II | -0.00661655 |
| KCNMB1 | potassium channel subfamily M regulatory beta subunit 1 | -0.00660444 |
| CNN1 | calponin 1, basic, smooth muscle | -0.00660259 |
| NOD2 | nucleotide-binding oligomerization domain containing 2 | -0.00659934 |
| ATP10B | ATPase, class V, type 10B | -0.00659528 |
| CD8A | CD8a molecule | -0.00658561 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00657714 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0065496 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.00654693 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.00652614 |
| TPM2 | tropomyosin 2 (beta) | -0.00651722 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00651515 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | -0.00644349 |
| TEAD4 | TEA domain family member 4 | -0.00643828 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.00643807 |
| CD247 | CD247 molecule | -0.00641966 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | -0.00639943 |
| RTCB | RNA 2',3'-cyclic phosphate and 5'-OH ligase | -0.0063948 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.00639081 |
| MED6 | mediator complex subunit 6 | -0.00637282 |
| IL33R | interleukin 33 receptor | -0.00635902 |
| PKP1 | plakophilin 1 | -0.00634412 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00633147 |
| PTHLH | parathyroid hormone-like hormone | -0.00632763 |
| LRRC59 | leucine rich repeat containing 59 | -0.00631832 |
| CCL14 | chemokine (C-C motif) ligand 14 | -0.00630251 |
| RIOK3 | RIO kinase 3 | -0.00629897 |
| FOXO1 | forkhead box O1 | -0.00629629 |
| GSTA4 | glutathione S-transferase alpha 4 | -0.00629357 |
| TAGLN2 | transgelin 2 | -0.00628774 |
| SET | SET nuclear proto-oncogene | -0.00628662 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | -0.00624572 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.00622955 |
| CD1D | CD1d molecule | -0.00622918 |
| ETHE1 | ethylmalonic encephalopathy 1 | -0.00621988 |
| STEAP3 | STEAP family member 3, metalloreductase | -0.00620216 |
| TM6SF1 | transmembrane 6 superfamily member 1 | -0.0061966 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.00618789 |
| ACP6 | acid phosphatase 6, lysophosphatidic | -0.00617864 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -0.00617773 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.00616936 |
| KRT5 | keratin 5, type II | -0.00616371 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | -0.00615855 |
| WIF1 | WNT inhibitory factor 1 | -0.00615017 |
| SULT1B1 | sulfotransferase family, cytosolic, 1B, member 1 | -0.00614751 |
| S100A8 | S100 calcium binding protein A8 | -0.00612166 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.00611378 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | -0.00611254 |
| TPI1 | triosephosphate isomerase 1 | -0.00610746 |
| IL1RN | interleukin 1 receptor antagonist | -0.0060989 |
| TRIM38 | tripartite motif containing 38 | -0.00609099 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | -0.00608913 |
| TBX3 | T-box 3 | -0.00608656 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.00607644 |
| GM2A | GM2 ganglioside activator | -0.0060578 |
| CHGB | chromogranin B | -0.0060341 |
| CD8B | CD8b molecule | -0.00602863 |
| LY86 | lymphocyte antigen 86 | -0.00601598 |
| BCL2L14 | BCL2-like 14 (apoptosis facilitator) | -0.0060125 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00599999 |
| C12ORF49 | chromosome 12 open reading frame 49 | -0.0059925 |
| SYNM | synemin, intermediate filament protein | -0.00599227 |
| TAGLN | transgelin | -0.00599125 |
| CPQ | carboxypeptidase Q | -0.00598849 |
| RHOA | ras homolog family member A | -0.0059799 |
| TRH | thyrotropin-releasing hormone | -0.0059783 |
| PLP1 | proteolipid protein 1 | -0.00597422 |
| OXTR | oxytocin receptor | -0.00596799 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00596647 |
| GIMAP4 | GTPase, IMAP family member 4 | -0.00595427 |
| NMT2 | N-myristoyltransferase 2 | -0.0059505 |
| CD1E | CD1e molecule | -0.00594162 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.00593642 |
| NDP | Norrie disease (pseudoglioma) | -0.00593494 |
| PRSS16 | protease, serine, 16 (thymus) | -0.00593422 |
| CHEK2 | checkpoint kinase 2 | -0.00592639 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00592477 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.00591933 |
| IER2 | immediate early response 2 | -0.00591213 |
| TLR4 | toll-like receptor 4 | -0.00590661 |
| STATH | statherin | -0.00589614 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.00589342 |
| ABHD5 | abhydrolase domain containing 5 | -0.00587001 |
| SSX1 | synovial sarcoma, X breakpoint 1 | -0.00586808 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00586558 |
| ATG5 | autophagy related 5 | -0.00586505 |
