SOCS1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description suppressor of cytokine signaling 1|This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8651)
External Link http://www.ncbi.nlm.nih.gov/gene/8651
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143 interacting proteins for SOCS1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ALK anaplastic lymphoma receptor tyrosine kinase
ARHGAP9 Rho GTPase activating protein 9
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AXL AXL receptor tyrosine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDK13 cyclin-dependent kinase 13
CENPF centromere protein F, 350/400kDa
CLEC7A C-type lectin domain family 7, member A
COMMD1 copper metabolism (Murr1) domain containing 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CUL2 cullin 2
CUL5 cullin 5
CXCR4 chemokine (C-X-C motif) receptor 4
CYTIP cytohesin 1 interacting protein
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DGKZ diacylglycerol kinase, zeta
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
EPHA1 EPH receptor A1
EPHB3 EPH receptor B3
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV6 ets variant 6
FGFR3 fibroblast growth factor receptor 3
FLT3 fms-related tyrosine kinase 3
FN3K fructosamine 3 kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
GAK cyclin G associated kinase
GHR growth hormone receptor
GRB2 growth factor receptor-bound protein 2
HRAS Harvey rat sarcoma viral oncogene homolog
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1R insulin-like growth factor 1 receptor
IL13RA1 interleukin 13 receptor, alpha 1
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL4R interleukin 4 receptor
INSL6 insulin-like 6
INSR insulin receptor
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITK IL2-inducible T-cell kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KRT18 keratin 18, type I
KRT74 keratin 74, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LMNB1 lamin B1
LRRC41 leucine rich repeat containing 41
LY96 lymphocyte antigen 96
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARK1 MAP/microtubule affinity-regulating kinase 1
MEP1B meprin A, beta
MET MET proto-oncogene, receptor tyrosine kinase
MPL MPL proto-oncogene, thrombopoietin receptor
MTIF2 mitochondrial translational initiation factor 2
MYD88 myeloid differentiation primary response 88
MYLK myosin light chain kinase
NCK1 NCK adaptor protein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRF1 nuclear respiratory factor 1
PDCD1 programmed cell death 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDLIM5 PDZ and LIM domain 5
PDX1 pancreatic and duodenal homeobox 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB2 phospholipase C, beta 2
PLCG1 phospholipase C, gamma 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRK protein tyrosine phosphatase, receptor type, K
RAB35 RAB35, member RAS oncogene family
RAD17 RAD17 homolog (S. pombe)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SH3GL3 SH3-domain GRB2-like 3
SMC6 structural maintenance of chromosomes 6
SOCS2 suppressor of cytokine signaling 2
SOCS5 suppressor of cytokine signaling 5
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TEC tec protein tyrosine kinase
TEK TEK tyrosine kinase, endothelial
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TP53 tumor protein p53
TRIM8 tripartite motif containing 8
TUBA3C tubulin, alpha 3c
TUBG1 tubulin, gamma 1
TYK2 tyrosine kinase 2
UBASH3A ubiquitin associated and SH3 domain containing A
UBC ubiquitin C
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WSB1 WD repeat and SOCS box containing 1