SOCS2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description suppressor of cytokine signaling 2|This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] (NCBI Entrez Gene Database, 8835)
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Genes

297 genes differentially expressed following the SOCS2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TSSK4 testis-specific serine kinase 4 2.38532
MIIP migration and invasion inhibitory protein 2.38532
ADGRG4 adhesion G protein-coupled receptor G4 2.38532
MAP7D1 MAP7 domain containing 1 2.38532
PGBDF plakoglobin binding and degradation factor 2.38532
UNC13C unc-13 homolog C (C. elegans) 2.38532
IL5RA interleukin 5 receptor, alpha 2.38532
C8ORF48 chromosome 8 open reading frame 48 2.38532
TMEM100 transmembrane protein 100 2.38532
CORT cortistatin 2.38532
CD163 CD163 molecule 2.38532
CD209 CD209 molecule 2.38532
SPINK6 serine peptidase inhibitor, Kazal type 6 2.38532
GJA4 gap junction protein, alpha 4, 37kDa 2.38532
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.38532
CFAP74 cilia and flagella associated protein 74 2.38532
INHBB inhibin, beta B 2.38532
GOT1L1 glutamic-oxaloacetic transaminase 1-like 1 2.38532
CDH5 cadherin 5, type 2 (vascular endothelium) 2.38532
USP26 ubiquitin specific peptidase 26 2.38532
SCGN secretagogin, EF-hand calcium binding protein 2.38532
IL22RA1 interleukin 22 receptor, alpha 1 2.38532
HBA1 hemoglobin, alpha 1 2.38532
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.38532
BMP5 bone morphogenetic protein 5 2.38532
LGALS4 lectin, galactoside-binding, soluble, 4 2.38532
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.38532
GALR3 galanin receptor 3 2.38532
TMC2 transmembrane channel-like 2 2.38532
SP5 Sp5 transcription factor 2.38532
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.38532
HES2 hes family bHLH transcription factor 2 2.38532
TMEM132C transmembrane protein 132C 2.38532
BIRC2 baculoviral IAP repeat containing 2 2.38532
CBY3 chibby homolog 3 (Drosophila) 2.38532
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.38532
FOLR3 folate receptor 3 (gamma) 2.38532
TLX2 T-cell leukemia homeobox 2 2.38532
FABP2 fatty acid binding protein 2, intestinal 2.38532
TAL2 T-cell acute lymphocytic leukemia 2 2.38532
ANKRD34A ankyrin repeat domain 34A 2.38532
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.38532
PRAMEF20 PRAME family member 20 2.38532
C2ORF80 chromosome 2 open reading frame 80 2.38532
OR1L6 olfactory receptor, family 1, subfamily L, member 6 2.38532
SENP7 SUMO1/sentrin specific peptidase 7 2.38532
SPMAP2L sperm microtubule associated protein 2 like 2.38532
CIROP ciliated left-right organizer metallopeptidase 2.38532
ANKRD40CL ANKRD40 C-terminal like 2.38532
SELENOP selenoprotein P 2.38532
TMEM275 transmembrane protein 275 2.38532
SQOR sulfide quinone oxidoreductase 2.38532
ROPN1L rhophilin associated tail protein 1-like 2.38532
POM121L2 POM121 transmembrane nucleoporin-like 2 2.38532
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.38532
LOC124900192 uncharacterized LOC124900192 2.38532
DNAI3 dynein axonemal intermediate chain 3 2.38532
H2BW2 H2B.W histone 2 2.38532
H3-7 H3.7 histone (putative) 2.38532
CIMIP2B ciliary microtubule inner protein 2B 2.38532
SPMIP10 sperm microtubule inner protein 10 2.38532
DRC9 dynein regulatory complex subunit 9 2.38532
CIMIP2C ciliary microtubule inner protein 2C 2.38532
CIMIP7 ciliary microtubule inner protein 7 2.38532
WASL-DT WASL divergent transcript 2.38532
CFAP97D2 CFAP97 domain containing 2 2.38532
SPAAR small regulatory polypeptide of amino acid response 2.38532
C20ORF204 chromosome 20 open reading frame 204 2.38532
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.38532
IQCF1 IQ motif containing F1 2.38532
TBX3 T-box 3 2.38532
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.38532
MIA melanoma inhibitory activity 2.38532
PRADC1 protease-associated domain containing 1 2.38532
PANX3 pannexin 3 2.38532
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.38532
LIPC lipase, hepatic 2.38532
IZUMO4 IZUMO family member 4 2.38532
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2.38532
TBX5 T-box 5 2.38532
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.38532
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.38532
SELL selectin L 2.38532
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.38532
MLANA melan-A 2.38532
PCDHGC4 protocadherin gamma subfamily C, 4 2.38532
GDF6 growth differentiation factor 6 2.38532
FMR1NB fragile X mental retardation 1 neighbor 2.38532
VCX3B variable charge, X-linked 3B 2.38532
TACR2 tachykinin receptor 2 2.38532
CLDN23 claudin 23 2.38532
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.38532
KRTAP5-9 keratin associated protein 5-9 2.38532
CLIC2 chloride intracellular channel 2 2.38532
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.38532
CKS2 CDC28 protein kinase regulatory subunit 2 2.38532
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.38532
C22ORF42 chromosome 22 open reading frame 42 2.38532
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.38532
COL17A1 collagen, type XVII, alpha 1 2.38532
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 2.38532
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.38532
GML glycosylphosphatidylinositol anchored molecule like 2.38532
PRM1 protamine 1 2.38532
TBC1D10C TBC1 domain family, member 10C 2.38532
MRLN myoregulin 2.38532
RAD21L1 RAD21-like 1 (S. pombe) 2.38532
EXTL1 exostosin-like glycosyltransferase 1 2.38532
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.38532
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.38532
CTAGE4 CTAGE family, member 4 2.38532
KRT222 keratin 222, type II 2.38532
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.38532
TEX12 testis expressed 12 2.38532
FAM135B family with sequence similarity 135, member B 2.38532
RAB6C RAB6C, member RAS oncogene family 2.38532
GPR142 G protein-coupled receptor 142 2.38532
SPATA19 spermatogenesis associated 19 2.38532
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.38532
FKBP1C FK506 binding protein 1C 2.38532
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.38532
RAD9B RAD9 homolog B (S. pombe) 2.38532
SLC36A3 solute carrier family 36, member 3 2.38532
GSC2 goosecoid homeobox 2 2.38532
HMGB4 high mobility group box 4 2.38532
CD27 CD27 molecule 2.38532
MUC7 mucin 7, secreted 2.38532
GFRAL GDNF family receptor alpha like 2.38532
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.38532
DMRT1 doublesex and mab-3 related transcription factor 1 2.38532
ZIM2 zinc finger, imprinted 2 2.38532
PLCD4 phospholipase C, delta 4 2.38532
PSG9 pregnancy specific beta-1-glycoprotein 9 2.38532
PSG8 pregnancy specific beta-1-glycoprotein 8 2.38532
ITGA8 integrin, alpha 8 2.38532
EBF2 early B-cell factor 2 2.38532
FOXG1 forkhead box G1 2.38532
ACSM2B acyl-CoA synthetase medium-chain family member 2B 2.38532
FOXO1 forkhead box O1 2.38532
TYR tyrosinase 2.38532
TAS2R46 taste receptor, type 2, member 46 2.38532
TGM2 transglutaminase 2 2.38532
ADRA1B adrenoceptor alpha 1B 2.38532
WDFY4 WDFY family member 4 2.38532
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.38532
FADS6 fatty acid desaturase 6 2.38532
RNF222 ring finger protein 222 2.38532
URGCP upregulator of cell proliferation 2.38532
MYOZ2 myozenin 2 2.38532
NLRP9 NLR family, pyrin domain containing 9 2.38532
IFITM10 interferon induced transmembrane protein 10 2.38532
AKR1B15 aldo-keto reductase family 1, member B15 2.38532
LKAAEAR1 LKAAEAR motif containing 1 2.38532
ASCL1 achaete-scute family bHLH transcription factor 1 2.38532
ISL1 ISL LIM homeobox 1 2.38532
ASCL2 achaete-scute family bHLH transcription factor 2 2.38532
IRX1 iroquois homeobox 1 2.38532
RPA4 replication protein A4, 30kDa 2.38532
FBXO39 F-box protein 39 2.38532
MORC1 MORC family CW-type zinc finger 1 2.38532
SMIM22 small integral membrane protein 22 2.38532
CLPS colipase, pancreatic 2.38532
RERGL RERG/RAS-like 2.38532
OCRL oculocerebrorenal syndrome of Lowe 2.37595
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 2.3725
SPACA7 sperm acrosome associated 7 2.3725
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.3725
VPS13B vacuolar protein sorting 13 homolog B (yeast) 2.3725
MR1 major histocompatibility complex, class I-related 2.3725
ADGRL4 adhesion G protein-coupled receptor L4 2.3627
CLDN10 claudin 10 2.33014
SMKR1 small lysine-rich protein 1 2.30819
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.29727
FAM186B family with sequence similarity 186, member B 2.29727
TSGA10IP testis specific, 10 interacting protein 2.29727
EYA4 EYA transcriptional coactivator and phosphatase 4 2.29727
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.23607
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.22258
PACRGL PARK2 co-regulated-like 2.21774
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2.15577
SQSTM1 sequestosome 1 2.13539
CPVL carboxypeptidase, vitellogenic-like 2.12512
IGSF9 immunoglobulin superfamily, member 9 2.1195
FAM120C family with sequence similarity 120C 2.11778
DAZL deleted in azoospermia-like 2.11578
TMEM91 transmembrane protein 91 2.10994
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.10958
NCOA5 nuclear receptor coactivator 5 2.10914
NBN nibrin 2.1047
PDE11A phosphodiesterase 11A 2.07862
FAM161A family with sequence similarity 161, member A 2.07757
RNPC3 RNA-binding region (RNP1, RRM) containing 3 2.0702
GRIP2 glutamate receptor interacting protein 2 2.05201
TMEM126A transmembrane protein 126A 2.03924
MOB4 MOB family member 4, phocein 2.02771
SPAG1 sperm associated antigen 1 2.02493
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 2.02493
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 2.01912

decreased expression

Symbol Name Standardized Value
INSYN1 inhibitory synaptic factor 1 -2.38532
BMP8B bone morphogenetic protein 8b -2.38532
EP300 E1A binding protein p300 -2.38532
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.38532
NLRP10 NLR family, pyrin domain containing 10 -2.38532
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.38532
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.38532
CRX cone-rod homeobox -2.38532
TFRC transferrin receptor -2.38532
CARM1 coactivator-associated arginine methyltransferase 1 -2.38532
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 -2.38532
MMP21 matrix metallopeptidase 21 -2.38532
TAS2R19 taste receptor, type 2, member 19 -2.38532
MYO1H myosin IH -2.38532
ETV2 ets variant 2 -2.38532
SMCO3 single-pass membrane protein with coiled-coil domains 3 -2.38532
NLRP7 NLR family, pyrin domain containing 7 -2.38532
OSGIN1 oxidative stress induced growth inhibitor 1 -2.38532
HEATR9 HEAT repeat containing 9 -2.38532
SLC66A1 solute carrier family 66 member 1 -2.38532
DUSP9 dual specificity phosphatase 9 -2.38532
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -2.38532
ARHGAP10 Rho GTPase activating protein 10 -2.38532
EID2 EP300 interacting inhibitor of differentiation 2 -2.38532
TEK TEK tyrosine kinase, endothelial -2.38532
HEMK1 HemK methyltransferase family member 1 -2.38532
ZFP28 ZFP28 zinc finger protein -2.38532
PRB2 proline-rich protein BstNI subfamily 2 -2.38532
TMEM229B transmembrane protein 229B -2.38532
ZNF90 zinc finger protein 90 -2.38532
HRH1 histamine receptor H1 -2.38532
GOLGA2 golgin A2 -2.38532
MMS22L MMS22-like, DNA repair protein -2.38532
ALK anaplastic lymphoma receptor tyrosine kinase -2.38532
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.38532
PXDN peroxidasin -2.38532
POU5F2 POU domain class 5, transcription factor 2 -2.38532
SUN1 Sad1 and UNC84 domain containing 1 -2.38532
NUTM1 NUT midline carcinoma, family member 1 -2.38532
SDF2L1 stromal cell-derived factor 2-like 1 -2.38532
MRAP melanocortin 2 receptor accessory protein -2.38532
SNCB synuclein, beta -2.38532
MOG myelin oligodendrocyte glycoprotein -2.38532
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.38532
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -2.38532
ARL9 ADP-ribosylation factor-like 9 -2.38532
ZC3H12D zinc finger CCCH-type containing 12D -2.38532
LRRK2 leucine-rich repeat kinase 2 -2.38532
S100A13 S100 calcium binding protein A13 -2.38532
CFP complement factor properdin -2.38532
CCDC78 coiled-coil domain containing 78 -2.38532
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.38532
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.38532
FOXP3 forkhead box P3 -2.38532
NSUN3 NOP2/Sun domain family, member 3 -2.38532
ADAM20 ADAM metallopeptidase domain 20 -2.38532
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -2.3725
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 -2.3725
KCNG3 potassium channel, voltage gated modifier subfamily G, member 3 -2.34972
PRPF6 pre-mRNA processing factor 6 -2.30358
F13A1 coagulation factor XIII, A1 polypeptide -2.29727
DIAPH3 diaphanous-related formin 3 -2.29727
NES nestin -2.29727
CYTH2 cytohesin 2 -2.29601
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.27529
MAGIX MAGI family member, X-linked -2.26143
DMAC2L distal membrane arm assembly component 2 like -2.24911
ZNF654 zinc finger protein 654 -2.24911
LARS1 leucyl-tRNA synthetase 1 -2.22907
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -2.22241
STX18 syntaxin 18 -2.21865
TMEM163 transmembrane protein 163 -2.21836
ST7 suppression of tumorigenicity 7 -2.21774
TMEM132B transmembrane protein 132B -2.1919
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.18654
NEFL neurofilament, light polypeptide -2.16997
TASOR2 transcription activation suppressor family member 2 -2.1195
DNAL1 dynein, axonemal, light chain 1 -2.11578
ITPRID2 ITPR interacting domain containing 2 -2.11578
C12ORF56 chromosome 12 open reading frame 56 -2.10958
ESRP1 epithelial splicing regulatory protein 1 -2.1047
ZNF18 zinc finger protein 18 -2.09726
TSPAN9 tetraspanin 9 -2.09726
STPG2 sperm-tail PG-rich repeat containing 2 -2.09726
PRCC papillary renal cell carcinoma (translocation-associated) -2.09261
OXR1 oxidation resistance 1 -2.08547
SMIM24 small integral membrane protein 24 -2.0807
IFNAR1 interferon (alpha, beta and omega) receptor 1 -2.06615
RPL21 ribosomal protein L21 -2.06318
VGLL4 vestigial-like family member 4 -2.05733
COG3 component of oligomeric golgi complex 3 -2.05081
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 -2.03046
TUG1 taurine up-regulated 1 (non-protein coding) -2.03046
CD48 CD48 molecule -2.02493
HCK HCK proto-oncogene, Src family tyrosine kinase -2.02493
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.02493
DTNBP1 dystrobrevin binding protein 1 -2.02493
MAMDC4 MAM domain containing 4 -2.02493
NPY5R neuropeptide Y receptor Y5 -2.01912