SOCS3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description suppressor of cytokine signaling 3|This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9021)
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Genes

346 genes differentially expressed following the SOCS3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC46A2 solute carrier family 46, member 2 3.09541
BATF basic leucine zipper transcription factor, ATF-like 3.09541
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.09541
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.09541
PBOV1 prostate and breast cancer overexpressed 1 3.09541
TAL2 T-cell acute lymphocytic leukemia 2 3.09541
PECAM1 platelet/endothelial cell adhesion molecule 1 3.09541
RBM6 RNA binding motif protein 6 3.09541
TRIM77 tripartite motif containing 77 3.09541
TCAF2 TRPM8 channel-associated factor 2 3.09541
BIRC3 baculoviral IAP repeat containing 3 3.09541
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 3.09541
SIGLEC9 sialic acid binding Ig-like lectin 9 3.09541
NANOS3 nanos homolog 3 (Drosophila) 3.09541
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 3.09541
ZEB2 zinc finger E-box binding homeobox 2 3.09541
SLC35G5 solute carrier family 35, member G5 3.09541
SOX18 SRY (sex determining region Y)-box 18 3.09541
NCF1 neutrophil cytosolic factor 1 3.09541
SKOR1 SKI family transcriptional corepressor 1 3.09541
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 3.09541
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.09541
FOLR3 folate receptor 3 (gamma) 3.09541
PTGFR prostaglandin F receptor (FP) 3.09541
ADAMTSL5 ADAMTS-like 5 3.09541
BSX brain-specific homeobox 3.09541
CRYGA crystallin, gamma A 3.09541
CRYGN crystallin, gamma N 3.09541
IL2RA interleukin 2 receptor, alpha 3.09541
CORO6 coronin 6 3.09541
MYO16 myosin XVI 3.09541
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.09541
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.09541
C2ORF78 chromosome 2 open reading frame 78 3.09541
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.09541
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.09541
S100A5 S100 calcium binding protein A5 3.09541
ADAT3 adenosine deaminase, tRNA-specific 3 3.09541
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 3.09541
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.09541
TMEM218 transmembrane protein 218 3.09541
ARRDC5 arrestin domain containing 5 3.09541
RGPD3 RANBP2-like and GRIP domain containing 3 3.09541
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.09541
DTNA dystrobrevin, alpha 3.09541
C8ORF74 chromosome 8 open reading frame 74 3.09541
TMEM89 transmembrane protein 89 3.09541
DRGX dorsal root ganglia homeobox 3.09541
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.09541
CDH5 cadherin 5, type 2 (vascular endothelium) 3.09541
HSFX3 heat shock transcription factor family, X-linked member 3 3.09541
SPI1 Spi-1 proto-oncogene 3.09541
HTRA4 HtrA serine peptidase 4 3.09541
RD3 retinal degeneration 3 3.09541
PKD2L1 polycystic kidney disease 2-like 1 3.09541
MYZAP myocardial zonula adherens protein 3.09541
FOXC2 forkhead box C2 3.09541
ZNF705D zinc finger protein 705D 3.09541
C15ORF62 chromosome 15 open reading frame 62 3.09541
GATA3 GATA binding protein 3 3.09541
CNTN6 contactin 6 3.09541
MYH4 myosin, heavy chain 4, skeletal muscle 3.09541
PNLIPRP1 pancreatic lipase-related protein 1 3.09541
DPEP2NB DPEP2 neighbor 3.09541
RPS21-DT RPS21 divergent transcript 3.09541
C1ORF232 chromosome 1 open reading frame 230 3.09541
PRRT1B proline rich transmembrane protein 1B 3.09541
LOC124906010 uncharacterized LOC124906010 3.09541
ELOA2 elongin A2 3.09541
GASK1B golgi associated kinase 1B 3.09541
HTD2 hydroxyacyl-thioester dehydratase type 2 3.09541
SEPTIN14 septin 14 3.09541
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.09541
LTB lymphotoxin beta (TNF superfamily, member 3) 3.09541
IL16 interleukin 16 3.09541
GPR83 G protein-coupled receptor 83 3.09541
GGT5 gamma-glutamyltransferase 5 3.09541
NKX2-2 NK2 homeobox 2 3.09541
PCDHA7 protocadherin alpha 7 3.09541
OR56B2 olfactory receptor family 56 subfamily B member 2 3.09541
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.09541
PDILT protein disulfide isomerase-like, testis expressed 3.09541
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.09541
SIX6 SIX homeobox 6 3.09541
ZNF285 zinc finger protein 285 3.09541
OR11H4 olfactory receptor, family 11, subfamily H, member 4 3.09541
MAG myelin associated glycoprotein 3.09541
ARF1 ADP-ribosylation factor 1 3.09541
IL1R1 interleukin 1 receptor, type I 3.09541
BARX2 BARX homeobox 2 3.09541
MYOG myogenin (myogenic factor 4) 3.09541
MIA melanoma inhibitory activity 3.09541
OVOL3 ovo-like zinc finger 3 3.09541
IL6 interleukin 6 3.09541
SIM2 single-minded family bHLH transcription factor 2 3.09541
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.09541
CATSPER3 cation channel, sperm associated 3 3.09541
SCN10A sodium channel, voltage gated, type X alpha subunit 3.09541
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.09541
MT1A metallothionein 1A 3.09541
NT5DC4 5'-nucleotidase domain containing 4 3.09541
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.09541
CPO carboxypeptidase O 3.09541
KRT13 keratin 13, type I 3.09541
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.09541
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.09541
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.09541
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.09541
EPGN epithelial mitogen 3.09541
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.09541
CTRB1 chymotrypsinogen B1 3.09541
GPBAR1 G protein-coupled bile acid receptor 1 3.09541
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 3.09541
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.09541
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.09541
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.09541
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.09541
VWA7 von Willebrand factor A domain containing 7 3.09541
OCM oncomodulin 3.09541
SPEF1 sperm flagellar 1 3.09541
MAB21L1 mab-21-like 1 (C. elegans) 3.09541
C8ORF89 chromosome 8 open reading frame 89 3.09541
CHURC1 churchill domain containing 1 3.09541
KLHL41 kelch-like family member 41 3.09541
POU1F1 POU class 1 homeobox 1 3.09541
KLK15 kallikrein-related peptidase 15 3.09541
C2ORF66 chromosome 2 open reading frame 66 3.09541
ZMIZ1 zinc finger, MIZ-type containing 1 3.09541
EGR3 early growth response 3 3.09541
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.09541
HBE1 hemoglobin, epsilon 1 3.09541
ZSCAN4 zinc finger and SCAN domain containing 4 3.09541
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.09541
C20ORF144 chromosome 20 open reading frame 144 3.09541
EREG epiregulin 3.09541
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.09541
KRT2 keratin 2, type II 3.09541
GPR150 G protein-coupled receptor 150 3.09541
ADGRF5 adhesion G protein-coupled receptor F5 3.09541
IL26 interleukin 26 3.09541
IL23R interleukin 23 receptor 3.09541
TMEM52B transmembrane protein 52B 3.09541
PGM5 phosphoglucomutase 5 3.09541
MRGPRX3 MAS-related GPR, member X3 3.09541
NLRP13 NLR family, pyrin domain containing 13 3.09541
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.09541
RAB7B RAB7B, member RAS oncogene family 3.09541
ASCL2 achaete-scute family bHLH transcription factor 2 3.09541
OTP orthopedia homeobox 3.09541
SLC38A11 solute carrier family 38, member 11 3.09541
MMP12 matrix metallopeptidase 12 3.09541
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 3.09541
RNASE6 ribonuclease, RNase A family, k6 3.09541
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.09541
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.09541
PPY pancreatic polypeptide 3.09541
SPAG8 sperm associated antigen 8 3.09541
MSLN mesothelin 3.09541
FAM9C family with sequence similarity 9, member C 3.09541
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.09541
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 3.09541
DRC7 dynein regulatory complex subunit 7 3.09541
LOC102724877 uncharacterized LOC102724877 3.09541
BOLA2 bolA family member 2 3.09541
PADI1 peptidyl arginine deiminase, type I 3.09541
CRTAM cytotoxic and regulatory T cell molecule 3.09541
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.09541
S100A2 S100 calcium binding protein A2 3.0452
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.0452
PANO1 proapoptotic nucleolar protein 1 3.0452
PDF peptide deformylase (mitochondrial) 3.0452
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2.92267
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.83112
ARL17B ADP-ribosylation factor-like 17B 2.73508
FUT2 fucosyltransferase 2 (secretor status included) 2.7207
LAMA3 laminin, alpha 3 2.7132
WDR76 WD repeat domain 76 2.67945
ADSL adenylosuccinate lyase 2.59347
ZFP36L1 ZFP36 ring finger protein-like 1 2.58664
TBRG4 transforming growth factor beta regulator 4 2.58464
AP1M1 adaptor-related protein complex 1, mu 1 subunit 2.56928
TMTC1 transmembrane and tetratricopeptide repeat containing 1 2.56789
ST7L suppression of tumorigenicity 7 like 2.54503
AFAP1 actin filament associated protein 1 2.51152
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 2.50985
RTN3 reticulon 3 2.46738
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.44889
ZNF669 zinc finger protein 669 2.44889
FANCG Fanconi anemia, complementation group G 2.44364
LATS2 large tumor suppressor kinase 2 2.44075
ACTG2 actin, gamma 2, smooth muscle, enteric 2.41364
GOLGA8H golgin A8 family, member H 2.41364
GOLT1B golgi transport 1B 2.40782
INPP5J inositol polyphosphate-5-phosphatase J 2.4036
RBM20 RNA binding motif protein 20 2.38902
IRX4 iroquois homeobox 4 2.38267
RO60 Ro60, Y RNA binding protein 2.38267
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.38267
PLCZ1 phospholipase C, zeta 1 2.38267
PLPP4 phospholipid phosphatase 4 2.38267
VAX2 ventral anterior homeobox 2 2.38267
ARHGAP39 Rho GTPase activating protein 39 2.38023
TMED8 transmembrane emp24 protein transport domain containing 8 2.37816
BCL9 B-cell CLL/lymphoma 9 2.34894
RPS17 ribosomal protein S17 2.34469
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 2.3323
ZBED1 zinc finger, BED-type containing 1 2.3267
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.31414
BAIAP3 BAI1-associated protein 3 2.27915
ACTL8 actin-like 8 2.27915
CHAD chondroadherin 2.27915
ENO3 enolase 3 (beta, muscle) 2.27253
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 2.27253
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.26608
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 2.25912
TESMIN testis expressed metallothionein like protein 2.25294
TFDP1 transcription factor Dp-1 2.24746
KIAA1671 KIAA1671 2.20717
ZNF747 zinc finger protein 747 2.20669
MLF1 myeloid leukemia factor 1 2.19959
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2.19811
NAGK N-acetylglucosamine kinase 2.19811
NEMP1 nuclear envelope integral membrane protein 1 2.19613
PTPRT protein tyrosine phosphatase, receptor type, T 2.19389
GRIP2 glutamate receptor interacting protein 2 2.19283
SEC31A SEC31 homolog A (S. cerevisiae) 2.1839
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 2.11916
CCDC59 coiled-coil domain containing 59 2.10677
FHIP2A FHF complex subunit HOOK interacting protein 2A 2.10024
NPIPA5 nuclear pore complex interacting protein family, member A5 2.10024
DRICH1 aspartate-rich 1 2.10024
ALOX15 arachidonate 15-lipoxygenase 2.10024
TMC2 transmembrane channel-like 2 2.10024
RPP21 ribonuclease P/MRP 21kDa subunit 2.10024
CLINT1 clathrin interactor 1 2.10024
RBM19 RNA binding motif protein 19 2.09343
ZNF813 zinc finger protein 813 2.0896
CALB1 calbindin 1, 28kDa 2.07772
KIF1A kinesin family member 1A 2.05619
GSS glutathione synthetase 2.05619
CIMAP3 ciliary microtubule associated protein 3 2.05202
DMAC2L distal membrane arm assembly component 2 like 2.05101
FPGT fucose-1-phosphate guanylyltransferase 2.048
HARS2 histidyl-tRNA synthetase 2, mitochondrial 2.048
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.043
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.02837
GTF2H5 general transcription factor IIH, polypeptide 5 2.02173

decreased expression

Symbol Name Standardized Value
TTC29 tetratricopeptide repeat domain 29 -3.09541
RNF112 ring finger protein 112 -3.09541
ZNF227 zinc finger protein 227 -3.09541
GLIPR1L2 GLI pathogenesis-related 1 like 2 -3.09541
APOH apolipoprotein H (beta-2-glycoprotein I) -3.09541
BMX BMX non-receptor tyrosine kinase -3.09541
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -3.09541
CNGA4 cyclic nucleotide gated channel alpha 4 -3.09541
LVRN laeverin -3.09541
SDSL serine dehydratase-like -3.09541
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 -3.09541
OR14A2 olfactory receptor, family 14, subfamily A, member 2 -3.09541
FRK fyn-related Src family tyrosine kinase -3.09541
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -3.09541
PSCA prostate stem cell antigen -3.09541
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -3.09541
ATP13A4 ATPase type 13A4 -3.09541
TNR tenascin R -3.09541
FGR FGR proto-oncogene, Src family tyrosine kinase -3.09541
HLA-DOB major histocompatibility complex, class II, DO beta -3.09541
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.09541
LRRC15 leucine rich repeat containing 15 -3.09541
FPR2 formyl peptide receptor 2 -3.09541
EVPLL envoplakin-like -3.09541
OLIG1 oligodendrocyte transcription factor 1 -3.09541
QRFP pyroglutamylated RFamide peptide -3.09541
GDNF glial cell derived neurotrophic factor -3.09541
PNLIPRP2 pancreatic lipase-related protein 2 -3.09541
LRRC3 leucine rich repeat containing 3 -3.09541
ZDHHC11 zinc finger, DHHC-type containing 11 -3.0645
ATG7 autophagy related 7 -3.05373
RPP25 ribonuclease P/MRP 25kDa subunit -3.02946
QSER1 glutamine and serine rich 1 -2.86033
RCL1 RNA terminal phosphate cyclase-like 1 -2.78259
YY2 YY2 transcription factor -2.74378
MAP1A microtubule-associated protein 1A -2.74378
SNX18 sorting nexin 18 -2.74086
SLIT1 slit homolog 1 (Drosophila) -2.69887
MTERF4 mitochondrial transcription termination factor 4 -2.69818
SCG5 secretogranin V -2.689
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.66627
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.63893
HPS6 Hermansky-Pudlak syndrome 6 -2.59347
ILDR2 immunoglobulin-like domain containing receptor 2 -2.59347
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -2.59347
JAZF1 JAZF zinc finger 1 -2.54682
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase -2.54531
TPX2 TPX2, microtubule-associated -2.51444
MVB12A multivesicular body subunit 12A -2.49376
AUTS2 autism susceptibility candidate 2 -2.48665
CCSER2 coiled-coil serine-rich protein 2 -2.44889
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.44671
MYO3A myosin IIIA -2.42622
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -2.41382
WDR83 WD repeat domain 83 -2.40782
KIF1B kinesin family member 1B -2.3935
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -2.38902
SIX4 SIX homeobox 4 -2.38267
NOL4L nucleolar protein 4-like -2.35824
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.34894
DTX3L deltex 3 like, E3 ubiquitin ligase -2.2813
RND1 Rho family GTPase 1 -2.27536
ATP10D ATPase, class V, type 10D -2.25433
PTGES prostaglandin E synthase -2.25335
FGFRL1 fibroblast growth factor receptor-like 1 -2.2512
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.21163
LCORL ligand dependent nuclear receptor corepressor-like -2.20918
GIPR gastric inhibitory polypeptide receptor -2.19891
TRIM45 tripartite motif containing 45 -2.19811
NFE2 nuclear factor, erythroid 2 -2.18891
HUS1 HUS1 checkpoint homolog (S. pombe) -2.14682
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.14263
RRBP1 ribosome binding protein 1 -2.13955
WDR73 WD repeat domain 73 -2.12991
SBK1 SH3 domain binding kinase 1 -2.11916
MBNL1 muscleblind-like splicing regulator 1 -2.11916
NLGN3 neuroligin 3 -2.10149
ZBTB16 zinc finger and BTB domain containing 16 -2.10024
TMEM61 transmembrane protein 61 -2.10024
CD300A CD300a molecule -2.10024
ALDOA aldolase A, fructose-bisphosphate -2.10024
TOR1AIP1 torsin A interacting protein 1 -2.10024
CTNS cystinosin, lysosomal cystine transporter -2.09964
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 -2.09964
LRRC59 leucine rich repeat containing 59 -2.0839
BMAL1 basic helix-loop-helix ARNT like 1 -2.08278
CCDC86 coiled-coil domain containing 86 -2.07684
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -2.06913
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -2.06456
LMCD1 LIM and cysteine-rich domains 1 -2.05619
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -2.05438
CSNK1G2 casein kinase 1, gamma 2 -2.05101
FKBP8 FK506 binding protein 8, 38kDa -2.03943
SIRT2 sirtuin 2 -2.01936
GTSE1 G-2 and S-phase expressed 1 -2.01647
TP53I13 tumor protein p53 inducible protein 13 -2.01506
METTL21A methyltransferase like 21A -2.00966
MTOR mechanistic target of rapamycin (serine/threonine kinase) -2.00153
RNF169 ring finger protein 169 -2.00153