SOCS3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description suppressor of cytokine signaling 3|This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9021)
External Link http://www.ncbi.nlm.nih.gov/gene/9021
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110 interacting proteins for SOCS3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACADVL acyl-CoA dehydrogenase, very long chain
APP amyloid beta (A4) precursor protein
AR androgen receptor
BCL10 B-cell CLL/lymphoma 10
BIK BCL2-interacting killer (apoptosis-inducing)
CSF1R colony stimulating factor 1 receptor
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSNK1E casein kinase 1, epsilon
CUEDC2 CUE domain containing 2
CUL5 cullin 5
CXCR4 chemokine (C-X-C motif) receptor 4
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
EPOR erythropoietin receptor
ETV6 ets variant 6
FGFR3 fibroblast growth factor receptor 3
GAB1 GRB2-associated binding protein 1
GFRA1 GDNF family receptor alpha 1
GHR growth hormone receptor
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HRAS Harvey rat sarcoma viral oncogene homolog
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1R insulin-like growth factor 1 receptor
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL12RB2 interleukin 12 receptor, beta 2
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
LCK LCK proto-oncogene, Src family tyrosine kinase
LEP leptin
LEPR leptin receptor
MAP1S microtubule-associated protein 1S
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK11 mitogen-activated protein kinase 11
MAPK6 mitogen-activated protein kinase 6
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MET MET proto-oncogene, receptor tyrosine kinase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NONO non-POU domain containing, octamer-binding
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDPK1 3-phosphoinositide dependent protein kinase 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRLR prolactin receptor
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBMX RNA binding motif protein, X-linked
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF31 ring finger protein 31
RNF7 ring finger protein 7
RPL7A ribosomal protein L7a
SH2B3 SH2B adaptor protein 3
SIGLEC7 sialic acid binding Ig-like lectin 7
SOCS2 suppressor of cytokine signaling 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TES testin LIM domain protein
TFDP1 transcription factor Dp-1
TFR2 transferrin receptor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TXNDC11 thioredoxin domain containing 11
TYK2 tyrosine kinase 2
UBC ubiquitin C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase