SOCS5 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description suppressor of cytokine signaling 5|The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9655)
External Link http://www.ncbi.nlm.nih.gov/gene/9655
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Genes

57 interacting proteins for SOCS5 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALK anaplastic lymphoma receptor tyrosine kinase
APP amyloid beta (A4) precursor protein
ARHGAP9 Rho GTPase activating protein 9
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDK13 cyclin-dependent kinase 13
CENPF centromere protein F, 350/400kDa
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DGKZ diacylglycerol kinase, zeta
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
EPHA1 EPH receptor A1
EPHB3 EPH receptor B3
FN3K fructosamine 3 kinase
GAK cyclin G associated kinase
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL4R interleukin 4 receptor
INSL6 insulin-like 6
IRF7 interferon regulatory factor 7
IRS4 insulin receptor substrate 4
ITK IL2-inducible T-cell kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT74 keratin 74, type II
LMNB1 lamin B1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARK1 MAP/microtubule affinity-regulating kinase 1
MEP1B meprin A, beta
MET MET proto-oncogene, receptor tyrosine kinase
MTIF2 mitochondrial translational initiation factor 2
MYLK myosin light chain kinase
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PDLIM5 PDZ and LIM domain 5
PDX1 pancreatic and duodenal homeobox 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCB2 phospholipase C, beta 2
PLCG1 phospholipase C, gamma 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTPRK protein tyrosine phosphatase, receptor type, K
RAB35 RAB35, member RAS oncogene family
RAD17 RAD17 homolog (S. pombe)
SH3GL3 SH3-domain GRB2-like 3
SMC6 structural maintenance of chromosomes 6
SOCS1 suppressor of cytokine signaling 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TMBIM1 transmembrane BAX inhibitor motif containing 1
UBASH3A ubiquitin associated and SH3 domain containing A
UBC ubiquitin C