SOCS6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description suppressor of cytokine signaling 6|The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9306)
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Genes

355 genes differentially expressed following the SOCS6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FPGT fucose-1-phosphate guanylyltransferase 3.07799
FAM3B family with sequence similarity 3, member B 3.07799
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 3.07799
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 3.07799
ACTA2 actin, alpha 2, smooth muscle, aorta 3.07799
FOXD1 forkhead box D1 3.07799
LRRTM2 leucine rich repeat transmembrane neuronal 2 3.07799
HSPA1L heat shock 70kDa protein 1-like 3.07799
PIWIL2 piwi-like RNA-mediated gene silencing 2 3.07799
C6ORF118 chromosome 6 open reading frame 118 3.07799
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 3.07799
ASB16 ankyrin repeat and SOCS box containing 16 3.07799
RRH retinal pigment epithelium-derived rhodopsin homolog 3.07799
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 3.07799
MIXL1 Mix paired-like homeobox 3.07799
ADAM32 ADAM metallopeptidase domain 32 3.07799
SLC22A25 solute carrier family 22, member 25 3.07799
PLA2G10 phospholipase A2, group X 3.07799
BHMT betaine--homocysteine S-methyltransferase 3.07799
BTN3A3 butyrophilin, subfamily 3, member A3 3.07799
TTC29 tetratricopeptide repeat domain 29 3.07799
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.07799
CD96 CD96 molecule 3.07799
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.07799
ACP7 acid phosphatase 7, tartrate resistant (putative) 3.07799
ADAP2 ArfGAP with dual PH domains 2 3.07799
KCTD19 potassium channel tetramerization domain containing 19 3.07799
SP140 SP140 nuclear body protein 3.07799
CFAP299 cilia and flagella associated protein 299 3.07799
NR4A2 nuclear receptor subfamily 4, group A, member 2 3.07799
PCDHB4 protocadherin beta 4 3.00165
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.00165
CCNB3 cyclin B3 3.00165
GNLY granulysin 3.00165
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 3.00165
ZNF560 zinc finger protein 560 3.00165
GLYAT glycine-N-acyltransferase 3.00165
IRF7 interferon regulatory factor 7 3.00165
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 3.00165
TMEM176B transmembrane protein 176B 3.00165
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 3.00165
PTX3 pentraxin 3, long 3.00165
FOXA2 forkhead box A2 3.00165
RFPL2 ret finger protein-like 2 3.00165
TMEM71 transmembrane protein 71 3.00165
MLNR motilin receptor 3.00165
S100A1 S100 calcium binding protein A1 3.00165
TMEM121 transmembrane protein 121 3.00165
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.00165
LGALS4 lectin, galactoside-binding, soluble, 4 3.00165
BRICD5 BRICHOS domain containing 5 3.00165
HYPK huntingtin interacting protein K 3.00165
IL2RB interleukin 2 receptor, beta 3.00165
ACOT12 acyl-CoA thioesterase 12 3.00165
CAPS calcyphosine 3.00165
FETUB fetuin B 3.00165
TDRD9 tudor domain containing 9 3.00165
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.00165
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 3.00165
C6ORF58 chromosome 6 open reading frame 58 3.00165
MEI1 meiosis inhibitor 1 3.00165
GDNF glial cell derived neurotrophic factor 3.00165
GPR26 G protein-coupled receptor 26 3.00165
C19ORF38 chromosome 19 open reading frame 38 3.00165
FBLN7 fibulin 7 3.00165
SUSD2 sushi domain containing 2 3.00165
AVPR2 arginine vasopressin receptor 2 3.00165
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.00165
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.00165
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.00165
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.00165
GPR32 G protein-coupled receptor 32 3.00165
PHF11 PHD finger protein 11 3.00165
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.00165
MGAT4D MGAT4 family, member D 3.00165
KLB klotho beta 3.00165
PROC protein C (inactivator of coagulation factors Va and VIIIa) 3.00165
RAB36 RAB36, member RAS oncogene family 3.00165
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.00165
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.00165
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.00165
HAO2 hydroxyacid oxidase 2 (long chain) 3.00165
TMEM275 transmembrane protein 275 3.00165
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.00165
WHR1 winged helix repair factor 1 3.00165
SPEGNB SPEG neighbor 3.00165
C19ORF85 chromosome 19 open reading frame 85 3.00165
RAMACL RNA guanine-7 methyltransferase activating subunit like 3.00165
H4C12 H4 clustered histone 12 3.00165
FYB2 FYN binding protein 2 3.00165
H3C3 H3 clustered histone 3 3.00165
CLEC20A C-type lectin domain containing 20A 3.00165
ATP5MGL ATP synthase membrane subunit g like 3.00165
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.00165
BARHL1 BarH-like homeobox 1 3.00165
CCDC81 coiled-coil domain containing 81 3.00165
ACTL8 actin-like 8 3.00165
OR2A2 olfactory receptor, family 2, subfamily A, member 2 3.00165
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.00165
MEP1B meprin A, beta 3.00165
FABP9 fatty acid binding protein 9, testis 3.00165
CST11 cystatin 11 3.00165
COL20A1 collagen, type XX, alpha 1 3.00165
NAPSA napsin A aspartic peptidase 3.00165
FGF23 fibroblast growth factor 23 3.00165
GGT5 gamma-glutamyltransferase 5 3.00165
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.00165
MOB3A MOB kinase activator 3A 3.00165
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.00165
LEF1 lymphoid enhancer-binding factor 1 3.00165
STYK1 serine/threonine/tyrosine kinase 1 3.00165
MSX2 msh homeobox 2 3.00165
CATSPER3 cation channel, sperm associated 3 3.00165
JAGN1 jagunal homolog 1 (Drosophila) 3.00165
LTBP2 latent transforming growth factor beta binding protein 2 3.00165
CFAP99 cilia and flagella associated protein 99 3.00165
C5ORF58 chromosome 5 open reading frame 58 3.00165
KNG1 kininogen 1 3.00165
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.00165
C11ORF96 chromosome 11 open reading frame 96 3.00165
FAM222A family with sequence similarity 222, member A 3.00165
FAM163A family with sequence similarity 163, member A 3.00165
EMX2 empty spiracles homeobox 2 3.00165
PRM1 protamine 1 3.00165
ERICH6B glutamate-rich 6B 3.00165
SCT secretin 3.00165
TDRD10 tudor domain containing 10 3.00165
F2RL2 coagulation factor II (thrombin) receptor-like 2 3.00165
SPINK9 serine peptidase inhibitor, Kazal type 9 3.00165
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 3.00165
DNAH10 dynein, axonemal, heavy chain 10 3.00165
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.00165
PHOSPHO1 phosphatase, orphan 1 3.00165
BMX BMX non-receptor tyrosine kinase 3.00165
FBXO39 F-box protein 39 3.00165
A3GALT2 alpha 1,3-galactosyltransferase 2 3.00165
EBF4 early B-cell factor 4 3.00165
FNDC8 fibronectin type III domain containing 8 3.00165
KRTAP5-11 keratin associated protein 5-11 3.00165
CLIC2 chloride intracellular channel 2 3.00165
CLIC5 chloride intracellular channel 5 3.00165
HAMP hepcidin antimicrobial peptide 3.00165
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 3.00165
DHH desert hedgehog 3.00165
SDS serine dehydratase 3.00165
TMPPE transmembrane protein with metallophosphoesterase domain 3.00165
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.00165
GPR150 G protein-coupled receptor 150 3.00165
FAM151A family with sequence similarity 151, member A 3.00165
LMX1B LIM homeobox transcription factor 1, beta 3.00165
WNT4 wingless-type MMTV integration site family, member 4 3.00165
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 3.00165
UPK1B uroplakin 1B 3.00165
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.00165
SPHKAP SPHK1 interactor, AKAP domain containing 3.00165
LRRC3 leucine rich repeat containing 3 3.00165
ANKRD55 ankyrin repeat domain 55 3.00165
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.00165
ALS2CL ALS2 C-terminal like 3.00165
PATE4 prostate and testis expressed 4 3.00165
PROK2 prokineticin 2 3.00165
ZFP92 ZFP92 zinc finger protein 3.00165
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.00165
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 3.00165
TF transferrin 3.00165
CD200R1 CD200 receptor 1 3.00165
RBM24 RNA binding motif protein 24 3.00165
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.00165
KISS1R KISS1 receptor 3.00165
LHX6 LIM homeobox 6 3.00165
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 3.00165
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.00165
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.00165
CCDC83 coiled-coil domain containing 83 3.00165
PF4V1 platelet factor 4 variant 1 3.00165
PGM5 phosphoglucomutase 5 3.00165
PRSS27 protease, serine 27 3.00165
NPR3 natriuretic peptide receptor 3 3.00165
KRTAP13-4 keratin associated protein 13-4 3.00165
IL23A interleukin 23, alpha subunit p19 3.00165
MMP12 matrix metallopeptidase 12 3.00165
AMIGO3 adhesion molecule with Ig-like domain 3 3.00165
CD36 CD36 molecule (thrombospondin receptor) 3.00165
NLRP1 NLR family, pyrin domain containing 1 3.00165
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.00165
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.00165
KLLN killin, p53-regulated DNA replication inhibitor 3.00165
SMYD1 SET and MYND domain containing 1 3.00165
SP6 Sp6 transcription factor 3.00165
CYBB cytochrome b-245, beta polypeptide 3.00165
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.00165
CELA2B chymotrypsin-like elastase family, member 2B 3.00165
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.00165
PRSS55 protease, serine, 55 3.00165
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.00165
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.00165
RAMP3 receptor (G protein-coupled) activity modifying protein 3 3.00165
NTSR1 neurotensin receptor 1 (high affinity) 3.00165
CLCN1 chloride channel, voltage-sensitive 1 3.00165
TDO2 tryptophan 2,3-dioxygenase 3.00165
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.00165
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.00165
NPY1R neuropeptide Y receptor Y1 2.96433
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase 2.78309
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.7701
AACS acetoacetyl-CoA synthetase 2.7701
NBPF10 neuroblastoma breakpoint family, member 10 2.7701
RPL4 ribosomal protein L4 2.70563
MRPS15 mitochondrial ribosomal protein S15 2.67948
MAPK12 mitogen-activated protein kinase 12 2.64682
NIN ninein (GSK3B interacting protein) 2.6194
CFAP95 cilia and flagella associated protein 95 2.58579
SCD5 stearoyl-CoA desaturase 5 2.58579
RHBDD1 rhomboid domain containing 1 2.5831
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 2.57742
GLTP glycolipid transfer protein 2.55879
NT5DC3 5'-nucleotidase domain containing 3 2.54639
AFF2 AF4/FMR2 family, member 2 2.53211
MSH4 mutS homolog 4 2.53006
ZNF793 zinc finger protein 793 2.49932
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 2.47516
MINDY2 MINDY lysine 48 deubiquitinase 2 2.47011
GOT1 glutamic-oxaloacetic transaminase 1, soluble 2.41437
MACROH2A2 macroH2A.2 histone 2.41325
SP4 Sp4 transcription factor 2.38111
ZNG1B Zn regulated GTPase metalloprotein activator 1B 2.36029
STEAP2 STEAP family member 2, metalloreductase 2.34505
SMYD5 SMYD family member 5 2.29749
ZNF20 zinc finger protein 20 2.26231
STX6 syntaxin 6 2.25336
CALB2 calbindin 2 2.20302
SYT13 synaptotagmin XIII 2.16865
CHM choroideremia (Rab escort protein 1) 2.16356
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.12898
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 2.1268
IMPACT impact RWD domain protein 2.12294
SRCAP Snf2-related CREBBP activator protein 2.11984
LYRM4 LYR motif containing 4 2.11562
PHF7 PHD finger protein 7 2.11524
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.07399
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 2.03976
ZFYVE19 zinc finger, FYVE domain containing 19 2.0365
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 2.02548
SLC38A10 solute carrier family 38, member 10 2.01303
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 2.00661

decreased expression

Symbol Name Standardized Value
PTCHD4 patched domain containing 4 -3.07799
KLK13 kallikrein-related peptidase 13 -3.07799
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -3.07799
TTPAL tocopherol (alpha) transfer protein-like -3.07799
TMEM223 transmembrane protein 223 -3.07799
COL16A1 collagen, type XVI, alpha 1 -3.00165
CORT cortistatin -3.00165
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -3.00165
DUSP10 dual specificity phosphatase 10 -3.00165
NAGS N-acetylglutamate synthase -3.00165
GSG1 germ cell associated 1 -3.00165
TMEM140 transmembrane protein 140 -3.00165
CRYGB crystallin, gamma B -3.00165
TMT1B thiol methyltransferase 1B -3.00165
PRELID2 PRELI domain containing 2 -3.00165
NPB neuropeptide B -3.00165
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -3.00165
EIF3F eukaryotic translation initiation factor 3, subunit F -3.00165
PKD1L3 polycystic kidney disease 1-like 3 -3.00165
LRRC8E leucine rich repeat containing 8 family, member E -3.00165
ITPRID1 ITPR interacting domain containing 1 -3.00165
TMPRSS5 transmembrane protease, serine 5 -3.00165
NEURL1 neuralized E3 ubiquitin protein ligase 1 -3.00165
STAC3 SH3 and cysteine rich domain 3 -3.00165
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -3.00165
CASKIN1 CASK interacting protein 1 -3.00165
S1PR1 sphingosine-1-phosphate receptor 1 -3.00165
LDHAL6A lactate dehydrogenase A-like 6A -3.00165
ANKRD42-DT ANKRD42 divergent transcript -3.00165
PCDHB14 protocadherin beta 14 -3.00165
TM6SF2 transmembrane 6 superfamily member 2 -3.00165
MALSU1 mitochondrial assembly of ribosomal large subunit 1 -3.00165
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -3.00165
LHCGR luteinizing hormone/choriogonadotropin receptor -3.00165
INHBE inhibin, beta E -3.00165
KIRREL2 kin of IRRE like 2 (Drosophila) -3.00165
NOS3 nitric oxide synthase 3 (endothelial cell) -3.00165
SIRPA signal-regulatory protein alpha -3.00165
CFAP36 cilia and flagella associated protein 36 -3.00165
LRRC36 leucine rich repeat containing 36 -3.00165
NBPF8 neuroblastoma breakpoint family, member 8 -3.00165
IGFBP7 insulin-like growth factor binding protein 7 -3.00165
SV2C synaptic vesicle glycoprotein 2C -3.00165
ITGA11 integrin, alpha 11 -3.00165
CLUL1 clusterin-like 1 (retinal) -3.00165
PRSS3 protease, serine, 3 -3.00165
DPH1 diphthamide biosynthesis 1 -3.00165
MUC19 mucin 19, oligomeric -3.00165
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 -3.00165
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.90681
ENDOD1 endonuclease domain containing 1 -2.86019
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.83262
TMEM198 transmembrane protein 198 -2.83262
TSN translin -2.71605
RHOBTB2 Rho-related BTB domain containing 2 -2.66915
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.65029
DCDC1 doublecortin domain containing 1 -2.62404
KIAA1217 KIAA1217 -2.58997
POLR3GL polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like -2.56686
KLHL2 kelch-like family member 2 -2.55879
NIT1 nitrilase 1 -2.55879
SLC16A12 solute carrier family 16, member 12 -2.54691
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -2.5228
ZNG1A Zn regulated GTPase metalloprotein activator 1A -2.51694
CRTAC1 cartilage acidic protein 1 -2.51374
TEP1 telomerase-associated protein 1 -2.51374
SGK1 serum/glucocorticoid regulated kinase 1 -2.50281
KLHL5 kelch-like family member 5 -2.48537
RPS7 ribosomal protein S7 -2.47516
GCLC glutamate-cysteine ligase, catalytic subunit -2.45956
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.41766
RBM12 RNA binding motif protein 12 -2.41325
PHGDH phosphoglycerate dehydrogenase -2.32685
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.30868
SMOX spermine oxidase -2.30868
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -2.30868
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -2.29805
NRBP1 nuclear receptor binding protein 1 -2.29668
RALYL RALY RNA binding protein-like -2.26475
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -2.26231
IKBIP IKBKB interacting protein -2.24792
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.2424
PABPC5 poly(A) binding protein, cytoplasmic 5 -2.2424
ZNF177 zinc finger protein 177 -2.2424
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 -2.24142
PHYHD1 phytanoyl-CoA dioxygenase domain containing 1 -2.22667
H2AC14 H2A clustered histone 14 -2.21067
H1-2 H1.2 linker histone, cluster member -2.20415
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -2.197
LPIN2 lipin 2 -2.17857
RPS27L ribosomal protein S27-like -2.14379
PHF5A PHD finger protein 5A -2.13672
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -2.12822
RPTOR regulatory associated protein of MTOR, complex 1 -2.09024
ZMAT5 zinc finger, matrin-type 5 -2.08777
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.08321
UBXN11 UBX domain protein 11 -2.08262
SEC14L5 SEC14-like 5 (S. cerevisiae) -2.08262
DNALI1 dynein, axonemal, light intermediate chain 1 -2.08262
PTMA prothymosin, alpha -2.07712
TLE3 transducin-like enhancer of split 3 -2.07301
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B -2.07197
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -2.07135
PTPRJ protein tyrosine phosphatase, receptor type, J -2.05693
HSPB11 heat shock protein family B (small), member 11 -2.05062
DST dystonin -2.05062
MIB2 mindbomb E3 ubiquitin protein ligase 2 -2.02548
CDRT4 CMT1A duplicated region transcript 4 -2.01805
MIS18BP1 MIS18 binding protein 1 -2.01303
LINS1 lines homolog 1 -2.00074