SOCS6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description suppressor of cytokine signaling 6|The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9306)
External Link http://www.ncbi.nlm.nih.gov/gene/9306
Similar Terms
Downloads & Tools

Genes

35 interacting proteins for SOCS6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTL7A actin-like 7A
ACVR1 activin A receptor, type I
AMOT angiomotin
AR androgen receptor
BMPR1B bone morphogenetic protein receptor, type IB
CUL5 cullin 5
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GAB1 GRB2-associated binding protein 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
INSR insulin receptor
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KDM1A lysine (K)-specific demethylase 1A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MET MET proto-oncogene, receptor tyrosine kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TGFBR1 transforming growth factor, beta receptor 1
TUBA1A tubulin, alpha 1a
TUBB4B tubulin, beta 4B class IVb
TUBD1 tubulin, delta 1
UBC ubiquitin C
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2I ubiquitin-conjugating enzyme E2I
WDR89 WD repeat domain 89
ZMIZ2 zinc finger, MIZ-type containing 2