SOD1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description superoxide dismutase 1, soluble|The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6647)
External Link https://ncbi.nlm.nih.gov/gene/6647
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Genes

499 genes differentially expressed following the SOD1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
XIC X chromosome inactivation center 0.0113332
TFPI2 tissue factor pathway inhibitor 2 0.00995832
CA2 carbonic anhydrase II 0.00858157
BAG3 BCL2-associated athanogene 3 0.0083525
S100P S100 calcium binding protein P 0.00821083
ODC1 ornithine decarboxylase 1 0.00810958
SCGB1D2 secretoglobin, family 1D, member 2 0.00784263
HMOX1 heme oxygenase 1 0.00745983
STK10 serine/threonine kinase 10 0.00736396
KRT7 keratin 7, type II 0.00731549
HSPH1 heat shock 105kDa/110kDa protein 1 0.00729147
ARID4A AT rich interactive domain 4A (RBP1-like) 0.00727351
GOLGA8A golgin A8 family, member A 0.00705338
EIF5A eukaryotic translation initiation factor 5A 0.00694148
SCGB2A2 secretoglobin, family 2A, member 2 0.00675672
NNMT nicotinamide N-methyltransferase 0.00646643
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.00632238
ISG20 interferon stimulated exonuclease gene 20kDa 0.00630635
MFAP2 microfibrillar-associated protein 2 0.0062604
FGG fibrinogen gamma chain 0.00625211
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00625196
RGS4 regulator of G-protein signaling 4 0.00604319
PON2 paraoxonase 2 0.00591033
EPCAM epithelial cell adhesion molecule 0.00590573
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.00589766
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.00557856
FGB fibrinogen beta chain 0.00551741
ADI1 acireductone dioxygenase 1 0.00549441
MDK midkine (neurite growth-promoting factor 2) 0.00545572
SCG5 secretogranin V 0.00532576
SPEN spen family transcriptional repressor 0.00530346
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 0.00527082
SCGB2A1 secretoglobin, family 2A, member 1 0.00524357
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0052304
IL6 interleukin 6 0.00512848
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.00512304
CYBA cytochrome b-245, alpha polypeptide 0.0050839
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.0050694
TLE4 transducin-like enhancer of split 4 0.00502225
IFRD1 interferon-related developmental regulator 1 0.00493159
HES1 hes family bHLH transcription factor 1 0.00491959
TPD52L1 tumor protein D52-like 1 0.00491454
HGD homogentisate 1,2-dioxygenase 0.0048961
TRIP6 thyroid hormone receptor interactor 6 0.00487753
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 0.00487335
MT1M metallothionein 1M 0.00486566
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.00485279
CXCL2 chemokine (C-X-C motif) ligand 2 0.00483259
ACD adrenocortical dysplasia homolog (mouse) 0.00480003
MMP11 matrix metallopeptidase 11 0.00478306
ARID4B AT rich interactive domain 4B (RBP1-like) 0.00477504
PAWR PRKC, apoptosis, WT1, regulator 0.00474983
FKBP11 FK506 binding protein 11, 19 kDa 0.00472699
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.00472189
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.00470404
GNLY granulysin 0.00469013
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.00467742
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.00467292
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0046646
LAMP5 lysosomal-associated membrane protein family, member 5 0.00465632
FXYD3 FXYD domain containing ion transport regulator 3 0.0046485
CPB1 carboxypeptidase B1 (tissue) 0.0046452
SLC38A1 solute carrier family 38, member 1 0.00464148
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0046395
NKX3-1 NK3 homeobox 1 0.00454943
TUBA4A tubulin, alpha 4a 0.00454779
POMZP3 POM121 and ZP3 fusion 0.00454737
CKS2 CDC28 protein kinase regulatory subunit 2 0.00452695
HSPE1 heat shock 10kDa protein 1 0.00447184
PRAME preferentially expressed antigen in melanoma 0.00446941
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.00444679
TM4SF1 transmembrane 4 L six family member 1 0.00443829
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.00442513
CTSZ cathepsin Z 0.00440296
GPX1 glutathione peroxidase 1 0.00438783
TMEM243 transmembrane protein 243, mitochondrial 0.00436324
VCAN versican 0.00433487
PENK proenkephalin 0.00431241
TMEM14A transmembrane protein 14A 0.00430294
CLDN1 claudin 1 0.00430141
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 0.00426866
AKR1C2 aldo-keto reductase family 1, member C2 0.00426122
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 0.00425507
PEG3 paternally expressed 3 0.00425506
ZBTB35 zinc finger and BTB domain containing 35 0.00423525
PMEPA1 prostate transmembrane protein, androgen induced 1 0.00421367
SGCE sarcoglycan, epsilon 0.00420885
GLRX glutaredoxin (thioltransferase) 0.00420766
RGCC regulator of cell cycle 0.00418595
SQOR sulfide quinone oxidoreductase 0.00414786
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 0.00411558
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00411234
THBS2 thrombospondin 2 0.00409737
PDZK1IP1 PDZK1 interacting protein 1 0.00408856
PDLIM4 PDZ and LIM domain 4 0.00404907
PAEP progestagen-associated endometrial protein 0.00403993
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.00402871
CRIP1 cysteine-rich protein 1 (intestinal) 0.00401159
MOB4 MOB family member 4, phocein 0.00400561
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.0039711
DUSP3 dual specificity phosphatase 3 0.00395463
KRT17 keratin 17, type I 0.00393294
CCL20 chemokine (C-C motif) ligand 20 0.00392471
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 0.00392113
ZC3H12A zinc finger CCCH-type containing 12A 0.00391568
MYO1B myosin IB 0.00391423
MT1F metallothionein 1F 0.00390444
POSTN periostin, osteoblast specific factor 0.00389966
RB1 retinoblastoma 1 0.00389132
TLK2 tousled-like kinase 2 0.00386468
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.00385258
TMEM41B transmembrane protein 41B 0.00383164
LUM lumican 0.00382491
FGA fibrinogen alpha chain 0.00381751
ADAM12 ADAM metallopeptidase domain 12 0.00381512
INHBA inhibin, beta A 0.00380825
ETNK1 ethanolamine kinase 1 0.00380822
MGMT O-6-methylguanine-DNA methyltransferase 0.00380635
GOLT1B golgi transport 1B 0.00379455
LEF1 lymphoid enhancer-binding factor 1 0.00378316
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.00377716
SPP1 secreted phosphoprotein 1 0.0037733
GSTP1 glutathione S-transferase pi 1 0.00377145
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.00376556
ITPKB inositol-trisphosphate 3-kinase B 0.00373973
MLF1 myeloid leukemia factor 1 0.00373318
UPP1 uridine phosphorylase 1 0.00372837
AKR1C1 aldo-keto reductase family 1, member C1 0.00372733
TESC tescalcin 0.00371151
NXT1 nuclear transport factor 2-like export factor 1 0.00370555
MMP7 matrix metallopeptidase 7 0.00369643
PTPRK protein tyrosine phosphatase, receptor type, K 0.00369241
TAC1 tachykinin, precursor 1 0.00368986
GOLM1 golgi membrane protein 1 0.00368399
CFB complement factor B 0.00367431
TKTL1 transketolase-like 1 0.00366804
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.00366486
MRPS30 mitochondrial ribosomal protein S30 0.00365074
KRT19 keratin 19, type I 0.00364858
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.0036444
SDS serine dehydratase 0.00364195
ALG8 ALG8, alpha-1,3-glucosyltransferase 0.00362543
RND1 Rho family GTPase 1 0.00360447
SLPI secretory leukocyte peptidase inhibitor 0.00360191
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.00359854
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.00358894
TGIF1 TGFB-induced factor homeobox 1 0.00358084
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.00357815
AQP3 aquaporin 3 (Gill blood group) 0.00357152
HOMER1 homer scaffolding protein 1 0.00356809
NOSIP nitric oxide synthase interacting protein 0.00356346
WIF1 WNT inhibitory factor 1 0.00354973
BCAS1 breast carcinoma amplified sequence 1 0.00353834
SARAF store-operated calcium entry-associated regulatory factor 0.00353675
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 0.00353414
AKR1C3 aldo-keto reductase family 1, member C3 0.00351008
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.00349704
MYRF myelin regulatory factor 0.00349005
FAM162A family with sequence similarity 162, member A 0.00348898
ITM2C integral membrane protein 2C 0.00348868
MRPL18 mitochondrial ribosomal protein L18 0.0034813
ADCY7 adenylate cyclase 7 0.00347552
RAB21 RAB21, member RAS oncogene family 0.00346629
CD79A CD79a molecule, immunoglobulin-associated alpha 0.00344286
TXNDC9 thioredoxin domain containing 9 0.00343675
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.00343452
ITGB6 integrin, beta 6 0.00343421
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 0.00343187
OCRL oculocerebrorenal syndrome of Lowe 0.00343086
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.00342733
TMEM134 transmembrane protein 134 0.00342718
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.00342194
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 0.00341571
FZD10 frizzled class receptor 10 0.00341259
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 0.00341045
ALCAM activated leukocyte cell adhesion molecule 0.00340852
TSPAN13 tetraspanin 13 0.00339747
NEFM neurofilament, medium polypeptide 0.00339375
NDUFA4 NDUFA4, mitochondrial complex associated 0.00338672
PDPN podoplanin 0.00338393
ATP5MJ ATP synthase membrane subunit j 0.00337839
DCTPP1 dCTP pyrophosphatase 1 0.00336346
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 0.00336148
ZFC3H1 zinc finger, C3H1-type containing 0.0033584
BCAS4 breast carcinoma amplified sequence 4 0.00335005
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.00334125
TOM1L1 target of myb1 (chicken)-like 1 0.00334076
CEMIP cell migration inducing protein, hyaluronan binding 0.00333185
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 0.00332537
COX5B cytochrome c oxidase subunit Vb 0.00332186
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.00331959
GCH1 GTP cyclohydrolase 1 0.0033162
KDM7A lysine (K)-specific demethylase 7A 0.00331164
STMN2 stathmin 2 0.00331147
PDCD10 programmed cell death 10 0.00330859
ZHX2 zinc fingers and homeoboxes 2 0.00329811
MZT2A mitotic spindle organizing protein 2A 0.00329517
ZNHIT1 zinc finger, HIT-type containing 1 0.00328808
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.00328514
PLXNC1 plexin C1 0.00328073
PPIH peptidylprolyl isomerase H (cyclophilin H) 0.00327189
GNG11 guanine nucleotide binding protein (G protein), gamma 11 0.00325769
COMMD3 COMM domain containing 3 0.00325144
EMC7 ER membrane protein complex subunit 7 0.00325015
HTRA1 HtrA serine peptidase 1 0.00324175
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0032318
ANKRD10 ankyrin repeat domain 10 0.00323179
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.00323171
NSF N-ethylmaleimide-sensitive factor 0.00321407
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 0.00321243
FGFR2 fibroblast growth factor receptor 2 0.00320991
TYMP thymidine phosphorylase 0.00320766
FOXE1 forkhead box E1 0.0032042
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.00320172
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.00319372
CTTN cortactin 0.00319147
IGF1R insulin-like growth factor 1 receptor 0.00318588
FKBP4 FK506 binding protein 4, 59kDa 0.00318498
TMEM70 transmembrane protein 70 0.00318181
FASTKD1 FAST kinase domains 1 0.00317466
ASRGL1 asparaginase like 1 0.00317389
TXNDC15 thioredoxin domain containing 15 0.00317336
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.00315523
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.0031534
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 0.00314608
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.00314549
ARFIP2 ADP-ribosylation factor interacting protein 2 0.00314436
ABHD4 abhydrolase domain containing 4 0.00313718
HLA-DMB major histocompatibility complex, class II, DM beta 0.0031339
PLK1 polo-like kinase 1 0.00312953
C8ORF4 chromosome 8 open reading frame 4 0.00311867
REEP5 receptor accessory protein 5 0.00311672
RNF103 ring finger protein 103 0.0031159
MRC2 mannose receptor, C type 2 0.00310617
LRRN3 leucine rich repeat neuronal 3 0.00310536
SEPTIN8 septin 8 0.00309687
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 0.0030953
TFRC transferrin receptor 0.00309486
EZR ezrin 0.00308334
WIPF1 WAS/WASL interacting protein family, member 1 0.00307727
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.00307419
CPT1A carnitine palmitoyltransferase 1A (liver) 0.00306657
GJA1 gap junction protein, alpha 1, 43kDa 0.00305788
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.00305737
PTPRE protein tyrosine phosphatase, receptor type, E 0.00305233
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 0.00305054
ZDHHC17 zinc finger, DHHC-type containing 17 0.0030441
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.00304043
EVI2A ecotropic viral integration site 2A 0.00303974
HLA-DMA major histocompatibility complex, class II, DM alpha 0.00303457

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0112727
BAMBI BMP and activin membrane-bound inhibitor -0.00988964
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.00905808
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00884358
KDM5D lysine (K)-specific demethylase 5D -0.00801215
OLFM4 olfactomedin 4 -0.00770358
CD99 CD99 molecule -0.00739363
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide -0.00721732
PROM1 prominin 1 -0.00674899
CFD complement factor D (adipsin) -0.00662094
MYH11 myosin, heavy chain 11, smooth muscle -0.00660794
S100A9 S100 calcium binding protein A9 -0.00655703
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -0.00654651
DAAM1 dishevelled associated activator of morphogenesis 1 -0.00636633
MATN2 matrilin 2 -0.00633302
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -0.00624917
CRYBG1 crystallin beta-gamma domain containing 1 -0.00623408
PLN phospholamban -0.00613525
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.00612955
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.00612391
TYRP1 tyrosinase-related protein 1 -0.00611673
TGFBR3 transforming growth factor, beta receptor III -0.00608229
FAM13A family with sequence similarity 13, member A -0.00603289
S100A8 S100 calcium binding protein A8 -0.00595915
G0S2 G0/G1 switch 2 -0.00587506
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.00584732
MTF2 metal response element binding transcription factor 2 -0.00583512
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.00578397
PTGER4 prostaglandin E receptor 4 (subtype EP4) -0.00572922
HNMT histamine N-methyltransferase -0.00572574
PFKL phosphofructokinase, liver -0.00569643
TLR4 toll-like receptor 4 -0.00557916
MCOLN1 mucolipin 1 -0.00552903
F13A1 coagulation factor XIII, A1 polypeptide -0.00550205
PITX3 paired-like homeodomain 3 -0.00550127
GLUL glutamate-ammonia ligase -0.00542179
ABHD6 abhydrolase domain containing 6 -0.00537744
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.0053318
MMP9 matrix metallopeptidase 9 -0.00523575
SAP30 Sin3A-associated protein, 30kDa -0.00522746
FAR2 fatty acyl CoA reductase 2 -0.00519016
APOD apolipoprotein D -0.00517639
INSM1 insulinoma-associated 1 -0.00517401
CHRDL1 chordin-like 1 -0.00517391
PALLD palladin, cytoskeletal associated protein -0.00515939
ITSN1 intersectin 1 (SH3 domain protein) -0.00514407
KCTD12 potassium channel tetramerization domain containing 12 -0.00510549
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.00507011
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.00503363
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -0.00502945
MYB v-myb avian myeloblastosis viral oncogene homolog -0.00499771
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.00498849
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -0.00498095
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -0.00490345
PODXL podocalyxin-like -0.00487505
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -0.00482771
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -0.00482717
TIMP3 TIMP metallopeptidase inhibitor 3 -0.00482557
C7 complement component 7 -0.0048047
TUBA1A tubulin, alpha 1a -0.00479398
ZEB2 zinc finger E-box binding homeobox 2 -0.0047151
SEPP1 selenoprotein P, plasma, 1 -0.00470426
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.00467067
CSDE1 cold shock domain containing E1, RNA-binding -0.00460081
ASPH aspartate beta-hydroxylase -0.0045952
PLTP phospholipid transfer protein -0.00456853
PNMA8A PNMA family member 8A -0.00456169
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.00455318
CD209 CD209 molecule -0.00455171
TLCD3A TLC domain containing 3A -0.00454606
RAD23B RAD23 homolog B (S. cerevisiae) -0.00453664
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00453295
PPP1R3C protein phosphatase 1, regulatory subunit 3C -0.00447816
TACC1 transforming, acidic coiled-coil containing protein 1 -0.00445974
NRN1 neuritin 1 -0.00444221
ASCL1 achaete-scute family bHLH transcription factor 1 -0.00440396
PPL periplakin -0.00440133
ADIPOQ adiponectin, C1Q and collagen domain containing -0.00435653
PMM2 phosphomannomutase 2 -0.00435384
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00435166
BMP4 bone morphogenetic protein 4 -0.00435016
CCNF cyclin F -0.00431659
DPYD dihydropyrimidine dehydrogenase -0.00429631
FZD4 frizzled class receptor 4 -0.00428507
HMG20B high mobility group 20B -0.00426767
NELL1 NEL-like 1 (chicken) -0.00426349
LOXL1 lysyl oxidase-like 1 -0.00426319
CAV2 caveolin 2 -0.0042381
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.00422111
FXYD6 FXYD domain containing ion transport regulator 6 -0.00420888
MYLK myosin light chain kinase -0.00420867
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0042063
PRELP proline/arginine-rich end leucine-rich repeat protein -0.00420114
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.00418597
NOTCH1 notch 1 -0.00417601
MGP matrix Gla protein -0.00416489
OBSL1 obscurin-like 1 -0.00416104
NFE2L3 nuclear factor, erythroid 2-like 3 -0.00416066
AZU1 azurocidin 1 -0.00415134
LYZ lysozyme -0.004145
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.00414143
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 -0.00413494
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -0.00413395
CCL13 chemokine (C-C motif) ligand 13 -0.00412551
ELANE elastase, neutrophil expressed -0.00411485
ALOX15B arachidonate 15-lipoxygenase, type B -0.00410354
ARMCX1 armadillo repeat containing, X-linked 1 -0.00410161
PLVAP plasmalemma vesicle associated protein -0.00409659
CYB5A cytochrome b5 type A (microsomal) -0.00408749
WLS wntless Wnt ligand secretion mediator -0.00406539
C5AR1 complement component 5a receptor 1 -0.00406483
EPAS1 endothelial PAS domain protein 1 -0.00406478
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00406419
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -0.00405805
AOC3 amine oxidase, copper containing 3 -0.00405634
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.00405358
EMP2 epithelial membrane protein 2 -0.00404776
CREG1 cellular repressor of E1A-stimulated genes 1 -0.0040374
NIBAN1 niban apoptosis regulator 1 -0.0040357
FLNA filamin A, alpha -0.004033
REG1B regenerating islet-derived 1 beta -0.00403058
KANK2 KN motif and ankyrin repeat domains 2 -0.00402753
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) -0.00402203
MARCKSL1 MARCKS-like 1 -0.00400004
CPM carboxypeptidase M -0.00398294
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -0.00397615
CAV1 caveolin 1, caveolae protein, 22kDa -0.00396073
PMEL premelanosome protein -0.00395487
PCOLCE2 procollagen C-endopeptidase enhancer 2 -0.00394914
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -0.00394411
MFSD10 major facilitator superfamily domain containing 10 -0.00394402
OLFM1 olfactomedin 1 -0.00393224
ANXA3 annexin A3 -0.00391484
CAPZB capping protein (actin filament) muscle Z-line, beta -0.00390144
MACROH2A1 macroH2A.1 histone -0.00388926
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.00388216
SEPTIN11 septin 11 -0.00386719
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -0.0038573
SDC4 syndecan 4 -0.00385139
SRPX sushi-repeat containing protein, X-linked -0.00384428
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.00384093
FILIP1L filamin A interacting protein 1-like -0.00383948
LTBP1 latent transforming growth factor beta binding protein 1 -0.00383759
STEAP3 STEAP family member 3, metalloreductase -0.00383427
TNC tenascin C -0.00383127
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene -0.00382294
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.00382184
HMGB1 high mobility group box 1 -0.00378975
RRAGD Ras-related GTP binding D -0.00378821
CLEC3B C-type lectin domain family 3, member B -0.00378309
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.00378036
CDA cytidine deaminase -0.00377764
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -0.00374461
ARHGAP29 Rho GTPase activating protein 29 -0.00372872
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.00371691
DPYSL3 dihydropyrimidinase-like 3 -0.0037161
CR2 complement component (3d/Epstein Barr virus) receptor 2 -0.00371336
DMXL2 Dmx-like 2 -0.00371324
HILPDA hypoxia inducible lipid droplet-associated -0.00370278
GSTA4 glutathione S-transferase alpha 4 -0.00369705
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial -0.00369479
CLGN calmegin -0.00369468
IGFBP5 insulin-like growth factor binding protein 5 -0.00368076
MME membrane metallo-endopeptidase -0.00367272
NSDHL NAD(P) dependent steroid dehydrogenase-like -0.00367048
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -0.00366246
RGL1 ral guanine nucleotide dissociation stimulator-like 1 -0.00365992
YBX1 Y box binding protein 1 -0.00365325
DMD dystrophin -0.00365208
H1-2 H1.2 linker histone, cluster member -0.00365131
GIPC2 GIPC PDZ domain containing family, member 2 -0.00363982
OLFML2A olfactomedin-like 2A -0.00363888
SNCAIP synuclein, alpha interacting protein -0.00362525
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.00361985
RSL1D1 ribosomal L1 domain containing 1 -0.00360696
CA9 carbonic anhydrase IX -0.00360621
COLEC12 collectin sub-family member 12 -0.00360602
HIST1H2BD histone cluster 1, H2bd -0.00359405
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.00358931
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00358863
GNS glucosamine (N-acetyl)-6-sulfatase -0.00358773
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -0.00357894
PLIN1 perilipin 1 -0.00357638
FBP1 fructose-1,6-bisphosphatase 1 -0.00357474
CES1 carboxylesterase 1 -0.00357438
C14ORF132 chromosome 14 open reading frame 132 -0.0035671
NCF2 neutrophil cytosolic factor 2 -0.00356535
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.00356145
XAF1 XIAP associated factor 1 -0.00355919
MSRA methionine sulfoxide reductase A -0.00355752
MARCO macrophage receptor with collagenous structure -0.00355616
PRKD3 protein kinase D3 -0.0035523
TBXA2R thromboxane A2 receptor -0.00354582
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.003527
SPRY2 sprouty homolog 2 (Drosophila) -0.00351473
PRTN3 proteinase 3 -0.00351175
FGFR1 fibroblast growth factor receptor 1 -0.00350812
GYG2 glycogenin 2 -0.0034779
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.00347698
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -0.00347128
BHLHE41 basic helix-loop-helix family, member e41 -0.00346893
TNS2 tensin 2 -0.00346455
TSPAN4 tetraspanin 4 -0.00346002
FABP7 fatty acid binding protein 7, brain -0.00343708
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -0.00343533
CD14 CD14 molecule -0.003435
PMP22 peripheral myelin protein 22 -0.00342628
CALML3 calmodulin-like 3 -0.00342163
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.00341711
CETN2 centrin, EF-hand protein, 2 -0.0034171
ACAD8 acyl-CoA dehydrogenase family, member 8 -0.00341407
LHFP lipoma HMGIC fusion partner -0.00341155
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.00341073
THOC2 THO complex 2 -0.00340872
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -0.00340275
TENT5A terminal nucleotidyltransferase 5A -0.00339569
ZW10 zw10 kinetochore protein -0.00338875
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.00338792
MNDA myeloid cell nuclear differentiation antigen -0.00338493
PALMD palmdelphin -0.00337812
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -0.00337523
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.00337261
F8 coagulation factor VIII, procoagulant component -0.00337237
GPX3 glutathione peroxidase 3 -0.00336832
PFN1 profilin 1 -0.00336643
TMEM100 transmembrane protein 100 -0.00336116
USP9Y ubiquitin specific peptidase 9, Y-linked -0.00336014
RHOBTB3 Rho-related BTB domain containing 3 -0.00335642
CYBB cytochrome b-245, beta polypeptide -0.00334704
TPPP3 tubulin polymerization-promoting protein family member 3 -0.00334142
SCPEP1 serine carboxypeptidase 1 -0.00334088
F2R coagulation factor II (thrombin) receptor -0.0033277
TBC1D16 TBC1 domain family, member 16 -0.00331729
NES nestin -0.00331613
FSCN1 fascin actin-bundling protein 1 -0.00331267
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.00330633
ST18 suppression of tumorigenicity 18, zinc finger -0.00330361
TMEM164 transmembrane protein 164 -0.00329823
U2AF1 U2 small nuclear RNA auxiliary factor 1 -0.00329318
AREG amphiregulin -0.00328657
TSC2 tuberous sclerosis 2 -0.00327434
BCL2A1 BCL2-related protein A1 -0.00327044
ANXA6 annexin A6 -0.00326728
TJP2 tight junction protein 2 -0.00325919
VANGL1 VANGL planar cell polarity protein 1 -0.00325751
MEIS2 Meis homeobox 2 -0.00325721
REG1A regenerating islet-derived 1 alpha -0.0032523
CCDC170 coiled-coil domain containing 170 -0.00325162
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -0.00325142