SOD1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description superoxide dismutase 1, soluble|The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6647)
External Link http://www.ncbi.nlm.nih.gov/gene/6647
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Genes

51 interacting proteins for SOD1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AHCYL1 adenosylhomocysteinase-like 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
CCS copper chaperone for superoxide dismutase
COMMD1 copper metabolism (Murr1) domain containing 1
CRYAB crystallin, alpha B
DCTN1 dynactin 1
DCTN2 dynactin 2 (p50)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
DYNLT1 dynein, light chain, Tctex-type 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
HDAC6 histone deacetylase 6
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXB2 homeobox B2
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
KARS lysyl-tRNA synthetase
LAMP2 lysosomal-associated membrane protein 2
MARCH5 membrane-associated ring finger (C3HC4) 5
MAX MYC associated factor X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBR1 neighbor of BRCA1 gene 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME2 NME/NM23 nucleoside diphosphate kinase 2
OPTN optineurin
PARK7 parkinson protein 7
PLS3 plastin 3
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRDX5 peroxiredoxin 5
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SMAD2 SMAD family member 2
SOD2 superoxide dismutase 2, mitochondrial
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SSR4 signal sequence receptor, delta
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO4 small ubiquitin-like modifier 4
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
UBC ubiquitin C
UBE3A ubiquitin protein ligase E3A