SOX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 1|This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6656)
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Genes

317 genes differentially expressed following the SOX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPMIP3 sperm microtubule inner protein 3 3.14203
GMFG glia maturation factor, gamma 3.14203
ANXA1 annexin A1 3.14203
SGPP2 sphingosine-1-phosphate phosphatase 2 3.14203
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.14203
BIRC3 baculoviral IAP repeat containing 3 3.14203
F5 coagulation factor V (proaccelerin, labile factor) 3.14203
SCG2 secretogranin II 3.14203
MYH15 myosin, heavy chain 15 3.14203
C1QTNF7 C1q and tumor necrosis factor related protein 7 3.14203
CDH10 cadherin 10, type 2 (T2-cadherin) 3.14203
SUN3 Sad1 and UNC84 domain containing 3 3.14203
LCN12 lipocalin 12 3.14203
NXPH4 neurexophilin 4 3.14203
C7ORF57 chromosome 7 open reading frame 57 3.14203
RSAD2 radical S-adenosyl methionine domain containing 2 3.14203
LAMB4 laminin, beta 4 3.14203
FGF9 fibroblast growth factor 9 3.14203
EVPL envoplakin 3.14203
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.14203
NLRP3 NLR family, pyrin domain containing 3 3.14203
SLC31A2 solute carrier family 31 (copper transporter), member 2 3.14203
ZNF285 zinc finger protein 285 3.13963
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 3.13963
PTH2 parathyroid hormone 2 3.13963
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 3.13963
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.13963
USP26 ubiquitin specific peptidase 26 3.13963
PNMA5 paraneoplastic Ma antigen family member 5 3.13963
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.13963
PGBDF plakoglobin binding and degradation factor 3.13963
AADACL4 arylacetamide deacetylase-like 4 3.13963
KNG1 kininogen 1 3.13963
PAX4 paired box 4 3.13963
CD300A CD300a molecule 3.13963
XCL2 chemokine (C motif) ligand 2 3.13963
GLRA3 glycine receptor, alpha 3 3.13963
CPB1 carboxypeptidase B1 (tissue) 3.13963
CRYGC crystallin, gamma C 3.13963
BMP5 bone morphogenetic protein 5 3.13963
AIRE autoimmune regulator 3.13963
TMC2 transmembrane channel-like 2 3.13963
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.13963
TDRD6 tudor domain containing 6 3.13963
GUCY2F guanylate cyclase 2F, retinal 3.13963
DMRTC1B DMRT-like family C1B 3.13963
TUBB8 tubulin, beta 8 class VIII 3.13963
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 3.13963
TMEM132C transmembrane protein 132C 3.13963
GPR21 G protein-coupled receptor 21 3.13963
CA6 carbonic anhydrase VI 3.13963
UNC45B unc-45 homolog B (C. elegans) 3.13963
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.13963
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.13963
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.13963
CBLIF cobalamin binding intrinsic factor 3.13963
MARCHF2 membrane associated ring-CH-type finger 2 3.13963
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.13963
CCN3 cellular communication network factor 3 3.13963
RCVRN recoverin 3.13963
FMOD fibromodulin 3.13963
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.13963
GATA3 GATA binding protein 3 3.13963
SYT15 synaptotagmin XV 3.13963
MSANTD5 Myb/SANT DNA binding domain containing 5 3.13963
CIROP ciliated left-right organizer metallopeptidase 3.13963
SPMIP11 sperm microtubule inner protein 11 3.13963
SPMIP9 sperm microtubule inner protein 9 3.13963
TEX53 testis expressed 53 3.13963
NHERF4 NHERF family PDZ scaffold protein 4 3.13963
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.13963
EZHIP EZH inhibitory protein 3.13963
TEX13C TEX13 family member C 3.13963
TERB1 telomere repeat binding bouquet formation protein 1 3.13963
DUSP29 dual specificity phosphatase 29 3.13963
CCDC42 coiled-coil domain containing 42 3.13963
HNF1B HNF1 homeobox B 3.13963
WNT11 wingless-type MMTV integration site family, member 11 3.13963
IRF8 interferon regulatory factor 8 3.13963
GGT5 gamma-glutamyltransferase 5 3.13963
ZNF436 zinc finger protein 436 3.13963
RS1 retinoschisin 1 3.13963
GRXCR1 glutaredoxin, cysteine rich 1 3.13963
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.13963
NRN1 neuritin 1 3.13963
HNF4A hepatocyte nuclear factor 4, alpha 3.13963
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.13963
ANXA13 annexin A13 3.13963
PRG3 proteoglycan 3 3.13963
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.13963
COX8C cytochrome c oxidase subunit VIIIC 3.13963
LRRC70 leucine rich repeat containing 70 3.13963
PLD4 phospholipase D family, member 4 3.13963
FOXI2 forkhead box I2 3.13963
NPFF neuropeptide FF-amide peptide precursor 3.13963
C1QTNF1 C1q and tumor necrosis factor related protein 1 3.13963
GOLGA7B golgin A7 family, member B 3.13963
NHP2 NHP2 ribonucleoprotein 3.13963
CYSLTR1 cysteinyl leukotriene receptor 1 3.13963
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.13963
PRSS55 protease, serine, 55 3.13963
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.13963
CALML6 calmodulin-like 6 3.13963
IER5L immediate early response 5-like 3.13963
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.13963
LPAR5 lysophosphatidic acid receptor 5 3.13963
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.13963
NUTM2A NUT family member 2A 3.13963
TEX12 testis expressed 12 3.13963
PAGE2B P antigen family, member 2B 3.13963
LST1 leukocyte specific transcript 1 3.13963
FGF10 fibroblast growth factor 10 3.13963
WFDC10A WAP four-disulfide core domain 10A 3.13963
HELT helt bHLH transcription factor 3.13963
CYBB cytochrome b-245, beta polypeptide 3.13963
MUC17 mucin 17, cell surface associated 3.13963
CTAGE9 CTAGE family, member 9 3.13963
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 3.13963
CXCR5 chemokine (C-X-C motif) receptor 5 3.13963
KLHL41 kelch-like family member 41 3.13963
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.13963
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 3.13963
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.13963
CDH19 cadherin 19, type 2 3.13963
CCDC154 coiled-coil domain containing 154 3.13963
PCDHGB5 protocadherin gamma subfamily B, 5 3.13963
FBXO39 F-box protein 39 3.13963
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 3.13963
PCDHGA2 protocadherin gamma subfamily A, 2 3.13963
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 3.13963
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.13963
SAMD5 sterile alpha motif domain containing 5 3.13963
CRTAM cytotoxic and regulatory T cell molecule 3.13963
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.13963
RGS4 regulator of G-protein signaling 4 3.13963
LYPD5 LY6/PLAUR domain containing 5 3.13963
LGALS14 lectin, galactoside-binding, soluble, 14 3.13963
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 3.13963
LDLRAD1 low density lipoprotein receptor class A domain containing 1 3.13963
IRX4 iroquois homeobox 4 3.13963
GPR62 G protein-coupled receptor 62 3.13963
GOLGA8J golgin A8 family, member J 3.13963
GOLGA8M golgin A8 family, member M 3.13963
GOLGA8R golgin A8 family, member R 3.13963
NLRP14 NLR family, pyrin domain containing 14 3.13963
PRSS22 protease, serine, 22 3.13963
ACRBP acrosin binding protein 3.13963
IZUMO1R IZUMO1 receptor, JUNO 3.13963
NT5C1B 5'-nucleotidase, cytosolic IB 3.13963
PRSS38 protease, serine, 38 3.13963
ISX intestine-specific homeobox 3.13963
ADRA1B adrenoceptor alpha 1B 3.13963
XCR1 chemokine (C motif) receptor 1 3.13963
FCRLB Fc receptor-like B 3.13963
AGBL4 ATP/GTP binding protein-like 4 3.13963
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 3.13963
PADI6 peptidyl arginine deiminase, type VI 3.13963
SSX3 synovial sarcoma, X breakpoint 3 3.13963
LY9 lymphocyte antigen 9 3.13963
LIN7A lin-7 homolog A (C. elegans) 2.74585
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.72194
MYO10 myosin X 2.71481
KIRREL1 kirre like nephrin family adhesion molecule 1 2.69814
KIF21B kinesin family member 21B 2.69465
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2.69465
BLTP3B bridge-like lipid transfer protein family member 3B 2.68362
ZNF397 zinc finger protein 397 2.5635
UGDH UDP-glucose 6-dehydrogenase 2.50513
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.50352
MYO1F myosin IF 2.46149
C6ORF132 chromosome 6 open reading frame 132 2.43568
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 2.43163
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 2.39867
YY1 YY1 transcription factor 2.38374
TNNI3 troponin I type 3 (cardiac) 2.34274
IL17RE interleukin 17 receptor E 2.33637
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 2.32958
UNKL unkempt family zinc finger-like 2.30603
MRPL15 mitochondrial ribosomal protein L15 2.30603
MAGED2 melanoma antigen family D2 2.30603
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.28186
ZNF703 zinc finger protein 703 2.28179
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.26
KLC1 kinesin light chain 1 2.24421
RAB26 RAB26, member RAS oncogene family 2.24066
CEP170B centrosomal protein 170B 2.22206
HSDL2 hydroxysteroid dehydrogenase like 2 2.22078
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.21735
DCLK3 doublecortin-like kinase 3 2.21735
ADH6 alcohol dehydrogenase 6 (class V) 2.21735
FLNC filamin C, gamma 2.21735
OVCH2 ovochymase 2 (gene/pseudogene) 2.21735
DCST1 DC-STAMP domain containing 1 2.21735
SALL2 spalt-like transcription factor 2 2.21061
COMT catechol-O-methyltransferase 2.21061
RTEL1 regulator of telomere elongation helicase 1 2.21061
CUTA cutA divalent cation tolerance homolog (E. coli) 2.20508
NECTIN3 nectin cell adhesion molecule 3 2.1837
ZIC3 Zic family member 3 2.17891
DCTD dCMP deaminase 2.15922
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.14383
RANBP10 RAN binding protein 10 2.14358
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 2.13666
ARHGAP12 Rho GTPase activating protein 12 2.13097
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 2.12047
SCAMP2 secretory carrier membrane protein 2 2.10891
TBL3 transducin (beta)-like 3 2.10608
NONO non-POU domain containing, octamer-binding 2.09881
MPV17L MPV17 mitochondrial membrane protein-like 2.09639
LMLN leishmanolysin-like (metallopeptidase M8 family) 2.07973
TMEM50B transmembrane protein 50B 2.07275
ANKRD16 ankyrin repeat domain 16 2.07275
BCAP31 B-cell receptor-associated protein 31 2.07275
NEK11 NIMA-related kinase 11 2.07275
PCNX2 pecanex 2 2.0688
ADAM15 ADAM metallopeptidase domain 15 2.06793
LDOC1 leucine zipper, down-regulated in cancer 1 2.06793
TFRC transferrin receptor 2.06474
MBLAC2 metallo-beta-lactamase domain containing 2 2.05867
SETDB1 SET domain, bifurcated 1 2.05165
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.04453
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 2.04039
FBXL18 F-box and leucine-rich repeat protein 18 2.02176
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 2.02176
IGF2R insulin-like growth factor 2 receptor 2.01583
FBH1 F-box DNA helicase 1 2.01583
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.01191
LIN9 lin-9 DREAM MuvB core complex component 2.01191
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.00044
SPRED3 sprouty-related, EVH1 domain containing 3 2.00044

decreased expression

Symbol Name Standardized Value
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -3.14203
PCED1B PC-esterase domain containing 1B -3.13963
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -3.13963
INHBE inhibin, beta E -3.13963
DOC2B double C2-like domains, beta -3.13963
SEPTIN4 septin 4 -3.13963
RTL10 retrotransposon Gag like 10 -3.13963
CSDC2 cold shock domain containing C2, RNA binding -3.13963
NPIPA7 nuclear pore complex interacting protein family, member A7 -3.13963
TMEM81 transmembrane protein 81 -3.04807
DIS3L DIS3 like exosome 3'-5' exoribonuclease -2.99792
RPRD1B regulation of nuclear pre-mRNA domain containing 1B -2.9549
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -2.93629
PTX3 pentraxin 3, long -2.93629
CD1D CD1d molecule -2.93629
SP100 SP100 nuclear antigen -2.93629
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.93629
ASB14 ankyrin repeat and SOCS box containing 14 -2.93629
NAT16 N-acetyltransferase 16 (GCN5-related, putative) -2.93629
ETV2 ets variant 2 -2.93629
PSCA prostate stem cell antigen -2.93629
GGN gametogenetin -2.93629
LRRC61 leucine rich repeat containing 61 -2.93629
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.93629
TLE6 transducin-like enhancer of split 6 -2.93629
MZB1 marginal zone B and B1 cell-specific protein -2.93629
ACSS1 acyl-CoA synthetase short-chain family member 1 -2.93629
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.93629
DAPL1 death associated protein-like 1 -2.93629
CATSPERT catsper channel auxiliary subunit tau -2.93629
AVPR1B arginine vasopressin receptor 1B -2.93629
CAPN9 calpain 9 -2.93629
CFAP45 cilia and flagella associated protein 45 -2.93629
GCOM1 GRINL1A complex locus 1 -2.93629
KHDC1L KH homology domain containing 1-like -2.93629
STARD6 StAR-related lipid transfer (START) domain containing 6 -2.93629
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.84544
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.81056
SCYL1 SCY1-like 1 (S. cerevisiae) -2.78449
KLHL13 kelch-like family member 13 -2.77719
TMEM203 transmembrane protein 203 -2.75284
RAE1 ribonucleic acid export 1 -2.75194
NKTR natural killer cell triggering receptor -2.73531
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.71481
KCTD7 potassium channel tetramerization domain containing 7 -2.70121
OSER1 oxidative stress responsive serine-rich 1 -2.70074
ETV6 ets variant 6 -2.69918
WDR72 WD repeat domain 72 -2.69465
CAMTA2 calmodulin binding transcription activator 2 -2.65202
ZNF730 zinc finger protein 730 -2.56911
TOB1 transducer of ERBB2, 1 -2.54277
MRPL33 mitochondrial ribosomal protein L33 -2.42082
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.41569
NLRP10 NLR family, pyrin domain containing 10 -2.41569
CCDC183 coiled-coil domain containing 183 -2.41569
PCDHA13 protocadherin alpha 13 -2.41569
ZMAT4 zinc finger, matrin-type 4 -2.37958
PCDHA6 protocadherin alpha 6 -2.35306
JAG2 jagged 2 -2.35306
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 -2.30525
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.30117
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.25335
ZNF791 zinc finger protein 791 -2.22078
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.21735
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.21735
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.21061
PI4K2B phosphatidylinositol 4-kinase type 2 beta -2.18662
CHN2 chimerin 2 -2.18633
CDCA8 cell division cycle associated 8 -2.18035
ACVR2A activin A receptor, type IIA -2.17912
TMEM233 transmembrane protein 233 -2.15674
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.14016
CRB2 crumbs family member 2 -2.14016
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific -2.13587
AHNAK2 AHNAK nucleoprotein 2 -2.12425
WDR41 WD repeat domain 41 -2.09896
F2R coagulation factor II (thrombin) receptor -2.08151
ZNF451 zinc finger protein 451 -2.07973
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -2.07275
KIF20A kinesin family member 20A -2.04336
TDG thymine-DNA glycosylase -2.0329
NKX1-2 NK1 homeobox 2 -2.02996
C6ORF136 chromosome 6 open reading frame 136 -2.02996
GPRC5B G protein-coupled receptor, class C, group 5, member B -2.02523
PHACTR4 phosphatase and actin regulator 4 -2.01797
BABAM2 BRISC and BRCA1 A complex member 2 -2.01191
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.01037