SOX10 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 10|This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6663)
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Genes

315 genes differentially expressed following the SOX10 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMPRSS11E transmembrane protease, serine 11E 3.26238
APLN apelin 3.26238
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.26238
PAX5 paired box 5 3.26238
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.26238
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 3.26238
C19ORF67 chromosome 19 open reading frame 67 3.26238
HCRTR2 hypocretin (orexin) receptor 2 3.26238
OTUD6A OTU deubiquitinase 6A 3.26238
GRXCR2 glutaredoxin, cysteine rich 2 3.26238
CAPNS2 calpain, small subunit 2 3.26238
ADRB2 adrenoceptor beta 2, surface 3.26238
FOLR1 folate receptor 1 (adult) 3.26238
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.26238
GRHL2 grainyhead-like 2 (Drosophila) 3.26238
SCG2 secretogranin II 3.26238
DUXB double homeobox B 3.26238
IGFL2 IGF-like family member 2 3.26238
MC4R melanocortin 4 receptor 3.26238
TRIM15 tripartite motif containing 15 3.26238
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.26238
SFTPB surfactant protein B 3.26238
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.26238
DIO3 deiodinase, iodothyronine, type III 3.26238
BMP5 bone morphogenetic protein 5 3.26238
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.26238
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.26238
TPPP tubulin polymerization promoting protein 3.26238
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.26238
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 3.26238
FGF7 fibroblast growth factor 7 3.26238
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 3.26238
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.26238
NPIPA8 nuclear pore complex interacting protein family, member A8 3.26238
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.26238
TMEM71 transmembrane protein 71 3.26238
RGPD3 RANBP2-like and GRIP domain containing 3 3.26238
PARP16 poly (ADP-ribose) polymerase family, member 16 3.26238
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.26238
ZNF324B zinc finger protein 324B 3.26238
OC90 otoconin 90 3.26238
SHE Src homology 2 domain containing E 3.26238
FAM161B family with sequence similarity 161, member B 3.26238
CIMIP2B ciliary microtubule inner protein 2B 3.26238
PTH1R parathyroid hormone 1 receptor 3.26238
GBP4 guanylate binding protein 4 3.26238
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.26238
ALX3 ALX homeobox 3 3.26238
SPI1 Spi-1 proto-oncogene 3.26238
SPRR2A small proline-rich protein 2A 3.26238
FMO2 flavin containing monooxygenase 2 (non-functional) 3.26238
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.26238
PNMA8B PNMA family member 8B 3.26238
TMEM275 transmembrane protein 275 3.26238
CCN5 cellular communication network factor 5 3.26238
WASL-DT WASL divergent transcript 3.26238
LIPT2-AS1 LIPT2 antisense RNA 1 3.26238
REELD1 reeler domain containing 1 3.26238
H3-7 H3.7 histone (putative) 3.26238
MINDY4B MINDY family member 4B 3.26238
GSG1L2 GSG1 like 2 3.26238
NFILZ NFIL3 like basic leucine zipper 3.26238
CCDC198 coiled-coil domain containing 198 3.26238
DOK2 docking protein 2, 56kDa 3.26238
PCP4L1 Purkinje cell protein 4 like 1 3.26238
ZNF705D zinc finger protein 705D 3.26238
CD79A CD79a molecule, immunoglobulin-associated alpha 3.26238
LRTM3 leucine rich repeat transmembrane protein 3 3.26238
CHRD chordin 3.26238
TEX101 testis expressed 101 3.26238
MAGEB2 melanoma antigen family B2 3.26238
CLDN9 claudin 9 3.26238
CCDC17 coiled-coil domain containing 17 3.26238
SCRG1 stimulator of chondrogenesis 1 3.26238
LDHAL6B lactate dehydrogenase A-like 6B 3.26238
C10ORF67 chromosome 10 open reading frame 67 3.26238
GGACT gamma-glutamylamine cyclotransferase 3.26238
MYO18B myosin XVIIIB 3.26238
BARX2 BARX homeobox 2 3.26238
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.26238
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.26238
S100G S100 calcium binding protein G 3.26238
SPDYC speedy/RINGO cell cycle regulator family member C 3.26238
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.26238
SLAMF6 SLAM family member 6 3.26238
LIPC lipase, hepatic 3.26238
WAS Wiskott-Aldrich syndrome 3.26238
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.26238
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.26238
GOLGA6C golgin A6 family, member C 3.26238
TIGD3 tigger transposable element derived 3 3.26238
ARR3 arrestin 3, retinal (X-arrestin) 3.26238
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.26238
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.26238
PRTN3 proteinase 3 3.26238
APOH apolipoprotein H (beta-2-glycoprotein I) 3.26238
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.26238
ZMYND10 zinc finger, MYND-type containing 10 3.26238
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.26238
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.26238
IER5L immediate early response 5-like 3.26238
MAPK11 mitogen-activated protein kinase 11 3.26238
SHOX short stature homeobox 3.26238
SPINK9 serine peptidase inhibitor, Kazal type 9 3.26238
ATG5 autophagy related 5 3.26238
CFP complement factor properdin 3.26238
LRRC24 leucine rich repeat containing 24 3.26238
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.26238
GOLGA8K golgin A8 family, member K 3.26238
IL25 interleukin 25 3.26238
PLA2G2C phospholipase A2, group IIC 3.26238
C11ORF42 chromosome 11 open reading frame 42 3.26238
CAPSL calcyphosine-like 3.26238
OR8B3 olfactory receptor, family 8, subfamily B, member 3 3.26238
TMEM31 transmembrane protein 31 3.26238
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.26238
IL9R interleukin 9 receptor 3.26238
KLK4 kallikrein-related peptidase 4 3.26238
RGCC regulator of cell cycle 3.26238
CLEC4G C-type lectin domain family 4, member G 3.26238
TBC1D26 TBC1 domain family, member 26 3.26238
NUTM2D NUT family member 2D 3.26238
GRAP2 GRB2-related adaptor protein 2 3.26238
MST1 macrophage stimulating 1 3.26238
POTEA POTE ankyrin domain family, member A 3.26238
CLEC2A C-type lectin domain family 2, member A 3.26238
IRX3 iroquois homeobox 3 3.26238
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.26238
CD101 CD101 molecule 3.26238
ASCL2 achaete-scute family bHLH transcription factor 2 3.26238
AOC1 amine oxidase, copper containing 1 3.26238
CD8A CD8a molecule 3.26238
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.26238
ITPKA inositol-trisphosphate 3-kinase A 3.26238
A1CF APOBEC1 complementation factor 3.26238
SLITRK1 SLIT and NTRK-like family, member 1 3.26238
PITX3 paired-like homeodomain 3 3.26238
RBP4 retinol binding protein 4, plasma 3.26238
SOST sclerostin 3.26238
SCN3A sodium channel, voltage gated, type III alpha subunit 3.26238
LRRC31 leucine rich repeat containing 31 3.26238
PPP1R9B protein phosphatase 1, regulatory subunit 9B 3.26238
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 3.26238
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.26238
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 3.20044
ERVV-2 endogenous retrovirus group V, member 2 3.20044
OBSL1 obscurin-like 1 3.20044
GPR160 G protein-coupled receptor 160 3.1568
DNAI1 dynein, axonemal, intermediate chain 1 3.08429
DPF2 D4, zinc and double PHD fingers family 2 3.08429
ASCC1 activating signal cointegrator 1 complex subunit 1 2.97771
MIXL1 Mix paired-like homeobox 2.96269
MXD3 MAX dimerization protein 3 2.72623
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 2.7088
STPG2 sperm-tail PG-rich repeat containing 2 2.67007
STAC2 SH3 and cysteine rich domain 2 2.65114
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 2.58666
LTA4H leukotriene A4 hydrolase 2.51193
WDR35 WD repeat domain 35 2.44296
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.40922
PDCD2L programmed cell death 2-like 2.40839
TMEM258 transmembrane protein 258 2.38972
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.3803
SH2D6 SH2 domain containing 6 2.3803
CHL1 cell adhesion molecule L1-like 2.3803
PRDM6 PR domain containing 6 2.3803
THAP7 THAP domain containing 7 2.37945
YBEY ybeY metallopeptidase (putative) 2.37917
SMAD7 SMAD family member 7 2.37106
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.37106
PODNL1 podocan-like 1 2.37106
ABHD17B abhydrolase domain containing 17B 2.36288
ALMS1 Alstrom syndrome protein 1 2.36059
RTL6 retrotransposon Gag like 6 2.33918
C6ORF163 chromosome 6 open reading frame 163 2.32881
GAS1 growth arrest-specific 1 2.32881
PCDHGB7 protocadherin gamma subfamily B, 7 2.32881
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.32881
CCDC81 coiled-coil domain containing 81 2.32881
INHBA inhibin, beta A 2.32881
RPS9 ribosomal protein S9 2.32881
STXBP3 syntaxin binding protein 3 2.31034
MMP3 matrix metallopeptidase 3 2.31034
PRUNE2 prune homolog 2 (Drosophila) 2.28827
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.2832
DDB2 damage-specific DNA binding protein 2, 48kDa 2.2832
PTBP2 polypyrimidine tract binding protein 2 2.2832
CACHD1 cache domain containing 1 2.28227
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2.28227
CDHR3 cadherin-related family member 3 2.28227
DCLRE1C DNA cross-link repair 1C 2.27552
CEP41 centrosomal protein 41kDa 2.25735
HELQ helicase, POLQ-like 2.25725
RBM4B RNA binding motif protein 4B 2.25725
MRPL54 mitochondrial ribosomal protein L54 2.23253
AATF apoptosis antagonizing transcription factor 2.21719
SPOP speckle-type POZ protein 2.21522
LIPG lipase, endothelial 2.18291
EIF2D eukaryotic translation initiation factor 2D 2.18073
FAM124B family with sequence similarity 124B 2.16177
IFT20 intraflagellar transport 20 2.1604
KIF7 kinesin family member 7 2.12938
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.12896
ARMC7 armadillo repeat containing 7 2.12896
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.12896
H2AC14 H2A clustered histone 14 2.12859
LRRC45 leucine rich repeat containing 45 2.12477
PKD2L2 polycystic kidney disease 2-like 2 2.12274
PPID peptidylprolyl isomerase D 2.10941
GOLGA4 golgin A4 2.09707
WNT2B wingless-type MMTV integration site family, member 2B 2.09707
STAT5B signal transducer and activator of transcription 5B 2.06335
PURG purine-rich element binding protein G 2.05055
TRHR thyrotropin-releasing hormone receptor 2.02839
ZNF250 zinc finger protein 250 2.02171
LARS2 leucyl-tRNA synthetase 2, mitochondrial 2.01292
PRPF6 pre-mRNA processing factor 6 2.01244
ZNF891 zinc finger protein 891 2.01244

decreased expression

Symbol Name Standardized Value
TRIL TLR4 interactor with leucine-rich repeats -3.26238
PLA2G10 phospholipase A2, group X -3.26238
C1ORF87 chromosome 1 open reading frame 87 -3.26238
ZNF878 zinc finger protein 878 -3.26238
DRC10 dynein regulatory complex subunit 10 -3.26238
CAGE1 cancer antigen 1 -3.26238
PACC1 proton activated chloride channel 1 -3.26238
RAPSN receptor-associated protein of the synapse -3.26238
ATP9A ATPase, class II, type 9A -3.20859
RHBDL2 rhomboid, veinlet-like 2 (Drosophila) -3.09663
PMP2 peripheral myelin protein 2 -3.08429
PPP1R3C protein phosphatase 1, regulatory subunit 3C -3.08429
TSSK6 testis-specific serine kinase 6 -3.08429
NECAB2 N-terminal EF-hand calcium binding protein 2 -3.08429
AKAP14 A kinase (PRKA) anchor protein 14 -3.08429
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.08429
ZBED6 zinc finger, BED-type containing 6 -3.08429
PADI3 peptidyl arginine deiminase, type III -3.08429
BTK Bruton agammaglobulinemia tyrosine kinase -3.08429
CAPN9 calpain 9 -3.08429
SPHK1 sphingosine kinase 1 -3.08429
RSPO1 R-spondin 1 -3.08429
CCNE1 cyclin E1 -3.08429
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -3.08429
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -3.08429
EFNB1 ephrin-B1 -3.08429
RIPK4 receptor-interacting serine-threonine kinase 4 -3.08429
PNLIPRP2 pancreatic lipase-related protein 2 -3.08429
UPK1B uroplakin 1B -3.08429
CTSS cathepsin S -3.08429
HSPB6 heat shock protein, alpha-crystallin-related, B6 -3.08429
LMNTD2 lamin tail domain containing 2 -3.08429
PDE1B phosphodiesterase 1B, calmodulin-dependent -3.08429
CDH10 cadherin 10, type 2 (T2-cadherin) -3.08429
TSLP thymic stromal lymphopoietin -3.08429
CGREF1 cell growth regulator with EF-hand domain 1 -3.0397
DNASE1 deoxyribonuclease I -3.0253
SPRY4 sprouty homolog 4 (Drosophila) -3.02221
STAT4 signal transducer and activator of transcription 4 -3.01776
ARSK arylsulfatase family, member K -2.76579
UCMA upper zone of growth plate and cartilage matrix associated -2.64068
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.61106
DPYSL3 dihydropyrimidinase-like 3 -2.60092
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -2.57244
TULP3 tubby like protein 3 -2.49134
ZCCHC17 zinc finger, CCHC domain containing 17 -2.48254
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.43635
JAGN1 jagunal homolog 1 (Drosophila) -2.43452
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -2.3803
RILPL2 Rab interacting lysosomal protein-like 2 -2.3803
RHCE Rh blood group, CcEe antigens -2.37917
TMEM253 transmembrane protein 253 -2.37917
TXK TXK tyrosine kinase -2.37917
GPR18 G protein-coupled receptor 18 -2.37917
SLC49A3 solute carrier family 49 member 3 -2.37917
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) -2.32881
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.32881
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.32881
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -2.32782
OSBPL3 oxysterol binding protein-like 3 -2.31034
CKMT1A creatine kinase, mitochondrial 1A -2.28227
CRYAB crystallin, alpha B -2.27552
USP16 ubiquitin specific peptidase 16 -2.25735
CCKBR cholecystokinin B receptor -2.25735
NOS3 nitric oxide synthase 3 (endothelial cell) -2.25735
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.25735
ANKRD13D ankyrin repeat domain 13 family, member D -2.25735
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.25725
CSNK1G1 casein kinase 1, gamma 1 -2.23121
CTNNBL1 catenin, beta like 1 -2.22376
KDM2A lysine (K)-specific demethylase 2A -2.21743
QPCTL glutaminyl-peptide cyclotransferase-like -2.20315
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.192
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.18291
CENPO centromere protein O -2.18073
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.14977
H4C9 H4 clustered histone 9 -2.14778
IL17RA interleukin 17 receptor A -2.14778
TDGF1 teratocarcinoma-derived growth factor 1 -2.14753
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.12896
RFK riboflavin kinase -2.12896
UNKL unkempt family zinc finger-like -2.12896
TRIM37 tripartite motif containing 37 -2.10543
SPAG9 sperm associated antigen 9 -2.0902
CAAP1 caspase activity and apoptosis inhibitor 1 -2.08482
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -2.07842
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -2.06335
PCDHGA5 protocadherin gamma subfamily A, 5 -2.06335
MYLK4 myosin light chain kinase family, member 4 -2.06335
PON3 paraoxonase 3 -2.06335
NEU3 sialidase 3 (membrane sialidase) -2.05055
SCAMP1 secretory carrier membrane protein 1 -2.05055
NSL1 NSL1, MIS12 kinetochore complex component -2.04797
CNTN4 contactin 4 -2.03907
PLTP phospholipid transfer protein -2.02839
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.02839
MAGEF1 melanoma antigen family F1 -2.00323