SOX11 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 11|This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6664)
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Genes

327 genes differentially expressed following the SOX11 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.4362
PAX7 paired box 7 3.4362
ARHGAP36 Rho GTPase activating protein 36 3.4362
OLIG1 oligodendrocyte transcription factor 1 3.4362
OLIG2 oligodendrocyte lineage transcription factor 2 3.4362
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.4362
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 3.4362
SLC9C2 solute carrier family 9, member C2 (putative) 3.4362
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.4362
BSX brain-specific homeobox 3.4362
FFAR4 free fatty acid receptor 4 3.4362
CCL5 chemokine (C-C motif) ligand 5 3.4362
SKOR2 SKI family transcriptional corepressor 2 3.4362
CTRC chymotrypsin C (caldecrin) 3.4362
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.4362
MAGEA6 melanoma antigen family A6 3.4362
ADRB2 adrenoceptor beta 2, surface 3.4362
PDIA2 protein disulfide isomerase family A, member 2 3.4362
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.4362
FOXA2 forkhead box A2 3.4362
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.4362
OR10A4 olfactory receptor, family 10, subfamily A, member 4 3.4362
TDRD6 tudor domain containing 6 3.4362
NLRP10 NLR family, pyrin domain containing 10 3.4362
GMFG glia maturation factor, gamma 3.4362
PRSS21 protease, serine, 21 (testisin) 3.4362
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 3.4362
FXYD3 FXYD domain containing ion transport regulator 3 3.4362
ZC2HC1B zinc finger, C2HC-type containing 1B 3.4362
CD3E CD3e molecule, epsilon (CD3-TCR complex) 3.4362
CD33 CD33 molecule 3.4362
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.4362
NEUROD1 neuronal differentiation 1 3.4362
MAGEC3 melanoma antigen family C3 3.4362
EPHB3 EPH receptor B3 3.4362
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.4362
RNF39 ring finger protein 39 3.4362
CRH corticotropin releasing hormone 3.4362
RLN1 relaxin 1 3.4362
APOBR apolipoprotein B receptor 3.4362
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.4362
PNOC prepronociceptin 3.4362
WNT8B wingless-type MMTV integration site family, member 8B 3.4362
LGALS2 lectin, galactoside-binding, soluble, 2 3.4362
GYS2 glycogen synthase 2 (liver) 3.4362
TPPP tubulin polymerization promoting protein 3.4362
GLB1L galactosidase, beta 1-like 3.4362
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.4362
LOC122526780 uncharacterized LOC122526780 3.4362
ASB4 ankyrin repeat and SOCS box containing 4 3.4362
SPATA31H1 SPATA31 subfamily H member 1 3.4362
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 3.4362
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 3.4362
HNF1B HNF1 homeobox B 3.4362
DLK2 delta-like 2 homolog (Drosophila) 3.4362
NPIPB8 nuclear pore complex interacting protein family, member B8 3.4362
C9 complement component 9 3.4362
PLB1 phospholipase B1 3.4362
ASB5 ankyrin repeat and SOCS box containing 5 3.4362
LMNTD1 lamin tail domain containing 1 3.4362
STX11 syntaxin 11 3.4362
H3C13 H3 clustered histone 13 3.4362
SMIM45 small integral membrane protein 45 3.4362
CFAP107 cilia and flagella associated protein 107 3.4362
AJM1 apical junction component 1 homolog 3.4362
ERVW-1 endogenous retrovirus group W, member 1 3.4362
AVPR1B arginine vasopressin receptor 1B 3.4362
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.4362
HEYL hes-related family bHLH transcription factor with YRPW motif-like 3.4362
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.4362
NPFF neuropeptide FF-amide peptide precursor 3.4362
C1QL4 complement component 1, q subcomponent-like 4 3.4362
C1QL2 complement component 1, q subcomponent-like 2 3.4362
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.4362
FPR2 formyl peptide receptor 2 3.4362
OR5P3 olfactory receptor, family 5, subfamily P, member 3 3.4362
TMPRSS11D transmembrane protease, serine 11D 3.4362
HLF hepatic leukemia factor 3.4362
HRH1 histamine receptor H1 3.4362
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.4362
LY86 lymphocyte antigen 86 3.4362
NOTO notochord homeobox 3.4362
GRXCR1 glutaredoxin, cysteine rich 1 3.4362
LOC390937 Ets2 repressor factor-like 3.4362
NKX2-2 NK2 homeobox 2 3.4362
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 3.4362
GDF10 growth differentiation factor 10 3.4362
TPTE transmembrane phosphatase with tensin homology 3.4362
IL4 interleukin 4 3.4362
SCRT1 scratch family zinc finger 1 3.4362
CALCA calcitonin-related polypeptide alpha 3.4362
SCN10A sodium channel, voltage gated, type X alpha subunit 3.4362
CRLF2 cytokine receptor-like factor 2 3.4362
C1ORF87 chromosome 1 open reading frame 87 3.4362
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.4362
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.4362
PLET1 placenta expressed transcript 1 3.4362
KLF4 Kruppel-like factor 4 (gut) 3.4362
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.4362
HHLA2 HERV-H LTR-associating 2 3.4362
HMGB4 high mobility group box 4 3.4362
LGALS14 lectin, galactoside-binding, soluble, 14 3.4362
ACTC1 actin, alpha, cardiac muscle 1 3.4362
EFCAB12 EF-hand calcium binding domain 12 3.4362
SLC35F2 solute carrier family 35, member F2 3.4362
FAIM2 Fas apoptotic inhibitory molecule 2 3.4362
AMIGO1 adhesion molecule with Ig-like domain 1 3.4362
EDN1 endothelin 1 3.4362
SHOX2 short stature homeobox 2 3.4362
PALMD palmdelphin 3.4362
DACT3 dishevelled-binding antagonist of beta-catenin 3 3.4362
MORC1 MORC family CW-type zinc finger 1 3.4362
HAVCR1 hepatitis A virus cellular receptor 1 3.4362
NPFFR1 neuropeptide FF receptor 1 3.4362
KLK11 kallikrein-related peptidase 11 3.4362
IL1B interleukin 1, beta 3.4362
IL18 interleukin 18 3.4362
ILDR2 immunoglobulin-like domain containing receptor 2 3.4362
TAPBPL TAP binding protein-like 3.4362
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.4362
VWA3B von Willebrand factor A domain containing 3B 3.4362
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.4362
EVPLL envoplakin-like 3.4362
NTN3 netrin 3 3.4362
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 3.4362
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 3.4362
LY9 lymphocyte antigen 9 3.4362
BCL2L15 BCL2-like 15 3.4362
CD27 CD27 molecule 3.4362
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.4362
PLA2G2C phospholipase A2, group IIC 3.4362
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 3.4362
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.4362
APOL1 apolipoprotein L, 1 3.4362
GCM1 glial cells missing homolog 1 (Drosophila) 3.4362
RHAG Rh-associated glycoprotein 3.4362
TMEM86B transmembrane protein 86B 3.4362
TTC24 tetratricopeptide repeat domain 24 3.4362
GOLGA8M golgin A8 family, member M 3.4362
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.4362
CIB3 calcium and integrin binding family member 3 3.4362
GSDMC gasdermin C 3.4362
ADAM20 ADAM metallopeptidase domain 20 3.4362
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.4362
ALLC allantoicase 3.4362
ST18 suppression of tumorigenicity 18, zinc finger 3.4362
CFB complement factor B 3.4362
CRTAM cytotoxic and regulatory T cell molecule 3.4362
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.4362
SHISA3 shisa family member 3 3.4362
AQP1 aquaporin 1 (Colton blood group) 3.4362
IL12A interleukin 12A 3.4362
CALML5 calmodulin-like 5 3.4362
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.4362
IL26 interleukin 26 3.4362
POTEE POTE ankyrin domain family, member E 3.4362
OR8H1 olfactory receptor, family 8, subfamily H, member 1 3.4362
IL25 interleukin 25 3.4362
LAMB3 laminin, beta 3 3.4362
ERMN ermin, ERM-like protein 3.4362
NPY2R neuropeptide Y receptor Y2 3.4362
CNGB1 cyclic nucleotide gated channel beta 1 3.4362
DES desmin 3.4362
GMPR guanosine monophosphate reductase 3.31316
OR1F1 olfactory receptor, family 1, subfamily F, member 1 3.31316
RYR2 ryanodine receptor 2 (cardiac) 3.25682
HRH4 histamine receptor H4 3.1788
CMKLR1 chemerin chemokine-like receptor 1 3.13664
TADA2B transcriptional adaptor 2B 3.12401
CCDC160 coiled-coil domain containing 160 3.09484
DOCK9 dedicator of cytokinesis 9 3.04358
KIAA0319L KIAA0319-like 2.95438
RORA RAR-related orphan receptor A 2.87834
TPST1 tyrosylprotein sulfotransferase 1 2.77631
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.74273
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 2.65487
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like 2.64989
TRIM21 tripartite motif containing 21 2.59882
FBXL14 F-box and leucine-rich repeat protein 14 2.5946
DNAH2 dynein, axonemal, heavy chain 2 2.58919
APP-DT APP divergent transcript 2.58219
MEGF6 multiple EGF-like-domains 6 2.57069
TMEM106C transmembrane protein 106C 2.55427
NCAPH non-SMC condensin I complex, subunit H 2.55083
CTSL cathepsin L 2.53718
ADD2 adducin 2 (beta) 2.50525
FGF18 fibroblast growth factor 18 2.49566
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.49566
RIN2 Ras and Rab interactor 2 2.48656
SPATS1 spermatogenesis associated, serine-rich 1 2.47053
VGLL3 vestigial-like family member 3 2.47038
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.44793
SAE1 SUMO1 activating enzyme subunit 1 2.44319
H2AC11 H2A clustered histone 11 2.43135
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.34334
MRO maestro 2.34334
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.34334
PTAFR platelet-activating factor receptor 2.34334
C5ORF58 chromosome 5 open reading frame 58 2.34334
COL17A1 collagen, type XVII, alpha 1 2.34334
RASGRP4 RAS guanyl releasing protein 4 2.34334
ERC1 ELKS/RAB6-interacting/CAST family member 1 2.33822
RBM10 RNA binding motif protein 10 2.33011
CREB3L2 cAMP responsive element binding protein 3-like 2 2.32973
SRPK2 SRSF protein kinase 2 2.31856
FHIP1A FHF complex subunit HOOK interacting protein 1A 2.31361
MBD2 methyl-CpG binding domain protein 2 2.31262
BICRAL BICRA like chromatin remodeling complex associated protein 2.28309
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.25979
MRPL40 mitochondrial ribosomal protein L40 2.25295
HARS1 histidyl-tRNA synthetase 1 2.24248
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.21779
CIAPIN1 cytokine induced apoptosis inhibitor 1 2.21468
ACER3 alkaline ceramidase 3 2.20867
PCYOX1 prenylcysteine oxidase 1 2.20867
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 2.20867
BTBD8 BTB (POZ) domain containing 8 2.17593
RPL22L1 ribosomal protein L22-like 1 2.14173
HDAC3 histone deacetylase 3 2.14173
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.13808
NUP155 nucleoporin 155kDa 2.13808
ZCCHC7 zinc finger, CCHC domain containing 7 2.13808
NUTM1 NUT midline carcinoma, family member 1 2.13651
GRID1 glutamate receptor, ionotropic, delta 1 2.126
SLC38A10 solute carrier family 38, member 10 2.10174
FAM216A family with sequence similarity 216, member A 2.09468
RPS29 ribosomal protein S29 2.07908
NIPAL1 NIPA-like domain containing 1 2.05158
KLHL29 kelch-like family member 29 2.05143
NOP10 NOP10 ribonucleoprotein 2.02439

decreased expression

Symbol Name Standardized Value
NFAM1 NFAT activating protein with ITAM motif 1 -3.4362
LRTM3 leucine rich repeat transmembrane protein 3 -3.4362
WSCD2 WSC domain containing 2 -3.4362
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -3.4362
TNS2 tensin 2 -3.4362
HHEX hematopoietically expressed homeobox -3.4362
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 -3.4362
EXOC1 exocyst complex component 1 -3.4362
BTK Bruton agammaglobulinemia tyrosine kinase -3.4362
TCP11L2 t-complex 11, testis-specific-like 2 -3.4362
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -3.4362
VCX variable charge, X-linked -3.4362
CEP68 centrosomal protein 68kDa -3.4362
SOX11 SRY (sex determining region Y)-box 11 -3.4362
CPB2 carboxypeptidase B2 (plasma) -3.4362
TMEM217 transmembrane protein 217 -3.4362
IQCJ IQ motif containing J -3.4362
ZNF792 zinc finger protein 792 -3.4362
CATSPERD catsper channel auxiliary subunit delta -3.4362
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.4362
EFHC2 EF-hand domain (C-terminal) containing 2 -3.4362
ACP7 acid phosphatase 7, tartrate resistant (putative) -3.4362
UNC13C unc-13 homolog C (C. elegans) -3.4362
AMH anti-Mullerian hormone -3.4362
CD200R1 CD200 receptor 1 -3.4362
PARVG parvin, gamma -3.4362
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -3.4362
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -3.4362
ODC1 ornithine decarboxylase 1 -3.04558
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 -2.98035
RGS16 regulator of G-protein signaling 16 -2.94794
NASP nuclear autoantigenic sperm protein (histone-binding) -2.94794
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein -2.93921
STYK1 serine/threonine/tyrosine kinase 1 -2.86779
BCL3 B-cell CLL/lymphoma 3 -2.80767
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.80688
TRIM3 tripartite motif containing 3 -2.72205
DTD1 D-tyrosyl-tRNA deacylase 1 -2.7147
DMTF1 cyclin D binding myb-like transcription factor 1 -2.70838
HTATSF1 HIV-1 Tat specific factor 1 -2.61887
CFAP36 cilia and flagella associated protein 36 -2.61168
JPH4 junctophilin 4 -2.59882
RUFY2 RUN and FYVE domain containing 2 -2.59882
PPP2R5D protein phosphatase 2, regulatory subunit B', delta -2.58919
DDR2 discoidin domain receptor tyrosine kinase 2 -2.58061
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -2.57918
POGLUT1 protein O-glucosyltransferase 1 -2.52449
C8ORF76 chromosome 8 open reading frame 76 -2.51861
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -2.50558
CENPV centromere protein V -2.50558
ZNF784 zinc finger protein 784 -2.47053
ALPL alkaline phosphatase, liver/bone/kidney -2.44793
H1-0 H1.0 linker histone -2.43475
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.4053
NCS1 neuronal calcium sensor 1 -2.40435
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.39192
MAP6 microtubule-associated protein 6 -2.39192
C5ORF63 chromosome 5 open reading frame 63 -2.39147
DNAH14 dynein, axonemal, heavy chain 14 -2.38014
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -2.37744
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.37744
H3C14 H3 clustered histone 14 -2.37744
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.37744
PPP1R9B protein phosphatase 1, regulatory subunit 9B -2.37744
NOXO1 NADPH oxidase organizer 1 -2.37744
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 -2.3764
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.35569
CBS cystathionine-beta-synthase -2.3531
H3C6 H3 clustered histone 6 -2.34334
EFNA1 ephrin-A1 -2.33011
PDE7A phosphodiesterase 7A -2.32289
FUCA2 fucosidase, alpha-L- 2, plasma -2.31527
TMEM201 transmembrane protein 201 -2.31066
GRB2 growth factor receptor-bound protein 2 -2.26597
GPR183 G protein-coupled receptor 183 -2.26535
TSLIG3B tRNA splicing ligase complex subunit 3B -2.26535
UBE2F ubiquitin-conjugating enzyme E2F (putative) -2.26535
TTLL7 tubulin tyrosine ligase-like family member 7 -2.21522
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.21522
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -2.21468
ZRANB2 zinc finger, RAN-binding domain containing 2 -2.20566
RPL13 ribosomal protein L13 -2.1571
COMT catechol-O-methyltransferase -2.15699
RANBP1 RAN binding protein 1 -2.14173
ABRACL ABRA C-terminal like -2.14173
ZNF107 zinc finger protein 107 -2.13808
OCIAD1 OCIA domain containing 1 -2.13651
COPS7B COP9 signalosome subunit 7B -2.13651
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.09702
POGK pogo transposable element with KRAB domain -2.09683
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 -2.0878
FAM111B family with sequence similarity 111, member B -2.0878
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -2.0878
RIT1 Ras-like without CAAX 1 -2.0878
PDE9A phosphodiesterase 9A -2.03417
LTBP4 latent transforming growth factor beta binding protein 4 -2.03417
ADORA1 adenosine A1 receptor -2.01096