SOX17 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 17|This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 64321)
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Genes

338 genes differentially expressed following the SOX17 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SON SON DNA binding protein 2.7601
ACTA2 actin, alpha 2, smooth muscle, aorta 2.7601
KRT86 keratin 86, type II 2.7601
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 2.7601
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.7601
LOXL4 lysyl oxidase-like 4 2.7601
ASB17 ankyrin repeat and SOCS box containing 17 2.7601
SCG2 secretogranin II 2.7601
TMEM215 transmembrane protein 215 2.7601
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.7601
SAMD5 sterile alpha motif domain containing 5 2.7601
CRHR1 corticotropin releasing hormone receptor 1 2.7601
SPATA9 spermatogenesis associated 9 2.7601
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.7601
TACR2 tachykinin receptor 2 2.7601
SAMD11 sterile alpha motif domain containing 11 2.7601
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.7601
C19ORF67 chromosome 19 open reading frame 67 2.7601
SHE Src homology 2 domain containing E 2.7601
DEPP1 DEPP autophagy regulator 1 2.7601
SIX2 SIX homeobox 2 2.7601
HEPHL1 hephaestin-like 1 2.7601
SMIM38 small integral membrane protein 38 2.7601
ACRBP acrosin binding protein 2.7601
LRRC63 leucine rich repeat containing 63 2.7601
NIM1K NIM1 serine/threonine protein kinase 2.7601
RASL10A RAS-like, family 10, member A 2.7601
OTOF otoferlin 2.7601
KLHL10 kelch-like family member 10 2.7601
BHLHE40 basic helix-loop-helix family, member e40 2.7601
TRAT1 T cell receptor associated transmembrane adaptor 1 2.7601
PCNA proliferating cell nuclear antigen 2.68426
TPBGL trophoblast glycoprotein-like 2.63008
PPARD peroxisome proliferator-activated receptor delta 2.63008
IL22RA1 interleukin 22 receptor, alpha 1 2.63008
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.63008
SLC46A2 solute carrier family 46, member 2 2.63008
GPR55 G protein-coupled receptor 55 2.63008
FOXQ1 forkhead box Q1 2.63008
COLEC10 collectin sub-family member 10 (C-type lectin) 2.63008
CARD18 caspase recruitment domain family, member 18 2.63008
CBLN3 cerebellin 3 precursor 2.63008
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.63008
CARD16 caspase recruitment domain family, member 16 2.63008
LIPN lipase, family member N 2.63008
EPS8L3 EPS8-like 3 2.63008
PCDHB8 protocadherin beta 8 2.63008
RFX6 regulatory factor X, 6 2.63008
RLN3 relaxin 3 2.63008
FABP1 fatty acid binding protein 1, liver 2.63008
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.63008
ADAMTSL1 ADAMTS-like 1 2.63008
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.63008
ARSF arylsulfatase F 2.63008
ASPA aspartoacylase 2.63008
GDNF glial cell derived neurotrophic factor 2.63008
FETUB fetuin B 2.63008
PAX2 paired box 2 2.63008
WT1 Wilms tumor 1 2.63008
LRRC14B leucine rich repeat containing 14B 2.63008
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.63008
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.63008
SLC35G5 solute carrier family 35, member G5 2.63008
MUC22 mucin 22 2.63008
SBK3 SH3 domain binding kinase family, member 3 2.63008
LHFPL7 LHFPL tetraspan subfamily member 7 2.63008
SCEL sciellin 2.63008
CXCL13 chemokine (C-X-C motif) ligand 13 2.63008
SPEM1 spermatid maturation 1 2.63008
KRT80 keratin 80, type II 2.63008
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.63008
SMLR1 small leucine-rich protein 1 2.63008
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.63008
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.63008
TMPRSS3 transmembrane protease, serine 3 2.63008
CLDN16 claudin 16 2.63008
GBP2 guanylate binding protein 2, interferon-inducible 2.63008
CIBAR2 CBY1 interacting BAR domain containing 2 2.63008
EZHIP EZH inhibitory protein 2.63008
PEAK3 PEAK family member 3 2.63008
H4C2 H4 clustered histone 2 2.63008
TMEM271 transmembrane protein 271 2.63008
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.63008
SQOR sulfide quinone oxidoreductase 2.63008
MT3 metallothionein 3 2.63008
GBP6 guanylate binding protein family, member 6 2.63008
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.63008
DOK7 docking protein 7 2.63008
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.63008
ZIC4 Zic family member 4 2.63008
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.63008
WASL-DT WASL divergent transcript 2.63008
CLDN9 claudin 9 2.63008
PTPRH protein tyrosine phosphatase, receptor type, H 2.63008
KLF17 Kruppel-like factor 17 2.63008
FAM3D family with sequence similarity 3, member D 2.63008
USH1G Usher syndrome 1G (autosomal recessive) 2.63008
SCARA5 scavenger receptor class A, member 5 2.63008
TACSTD2 tumor-associated calcium signal transducer 2 2.63008
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.63008
GATA2 GATA binding protein 2 2.63008
GDF5 growth differentiation factor 5 2.63008
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.63008
FMR1NB fragile X mental retardation 1 neighbor 2.63008
OR10K2 olfactory receptor, family 10, subfamily K, member 2 2.63008
TSPO2 translocator protein 2 2.63008
S100G S100 calcium binding protein G 2.63008
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.63008
C1QL2 complement component 1, q subcomponent-like 2 2.63008
SRL sarcalumenin 2.63008
CRYGA crystallin, gamma A 2.63008
TSLP thymic stromal lymphopoietin 2.63008
CABP5 calcium binding protein 5 2.63008
FBXO39 F-box protein 39 2.63008
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.63008
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.63008
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.63008
MAEL maelstrom spermatogenic transposon silencer 2.63008
AOC3 amine oxidase, copper containing 3 2.63008
EPX eosinophil peroxidase 2.63008
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.63008
ZC3H11D zinc finger CCCH-type containing 11D 2.63008
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.63008
CHRM4 cholinergic receptor, muscarinic 4 2.63008
NPAS4 neuronal PAS domain protein 4 2.63008
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2.63008
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.63008
ITPKA inositol-trisphosphate 3-kinase A 2.63008
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.63008
RSAD2 radical S-adenosyl methionine domain containing 2 2.63008
RFPL1 ret finger protein-like 1 2.63008
AQP6 aquaporin 6, kidney specific 2.63008
SMIM23 small integral membrane protein 23 2.63008
AQP7 aquaporin 7 2.63008
ZFPM1 zinc finger protein, FOG family member 1 2.63008
TDRD10 tudor domain containing 10 2.63008
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.63008
LCNL1 lipocalin-like 1 2.63008
APOC4 apolipoprotein C-IV 2.63008
FOXE3 forkhead box E3 2.63008
SHISA8 shisa family member 8 2.63008
EDN3 endothelin 3 2.63008
BCO1 beta-carotene oxygenase 1 2.63008
THBD thrombomodulin 2.63008
TCEA3 transcription elongation factor A (SII), 3 2.63008
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.63008
SHOX2 short stature homeobox 2 2.63008
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.63008
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.63008
GRAP2 GRB2-related adaptor protein 2 2.63008
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.63008
MNX1 motor neuron and pancreas homeobox 1 2.63008
TSPAN19 tetraspanin 19 2.63008
DRC1 dynein regulatory complex subunit 1 2.63008
ZPBP zona pellucida binding protein 2.63008
GALP galanin-like peptide 2.63008
TPRX1 tetra-peptide repeat homeobox 1 2.63008
ZNF831 zinc finger protein 831 2.63008
CCDC89 coiled-coil domain containing 89 2.63008
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.63008
GJC2 gap junction protein, gamma 2, 47kDa 2.63008
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.63008
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.63008
UPK1A uroplakin 1A 2.63008
CRYAA crystallin, alpha A 2.63008
SP6 Sp6 transcription factor 2.63008
NLRP14 NLR family, pyrin domain containing 14 2.63008
GHRH growth hormone releasing hormone 2.63008
CLEC18B C-type lectin domain family 18, member B 2.63008
PRH2 proline-rich protein HaeIII subfamily 2 2.63008
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.63008
TGM4 transglutaminase 4 2.63008
OTOP3 otopetrin 3 2.63008
LYPD5 LY6/PLAUR domain containing 5 2.63008
CDH24 cadherin 24, type 2 2.63008
CCNI2 cyclin I family, member 2 2.63008
ANGPTL6 angiopoietin-like 6 2.63008
GPR149 G protein-coupled receptor 149 2.63008
ANGPTL5 angiopoietin-like 5 2.63008
CNR2 cannabinoid receptor 2 (macrophage) 2.63008
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.63008
GCSAML germinal center-associated, signaling and motility-like 2.63008
CHRDL2 chordin-like 2 2.63008
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.63008
LMX1B LIM homeobox transcription factor 1, beta 2.63008
MMP20 matrix metallopeptidase 20 2.63008
SFRP4 secreted frizzled-related protein 4 2.59076
WFDC1 WAP four-disulfide core domain 1 2.59076
LINC02983 long intergenic non-protein coding RNA 2983 2.56916
AMIGO2 adhesion molecule with Ig-like domain 2 2.56664
ASRGL1 asparaginase like 1 2.5391
NRBP1 nuclear receptor binding protein 1 2.51576
RPUSD4 RNA pseudouridylate synthase domain containing 4 2.51021
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.46813
POTEJ POTE ankyrin domain family, member J 2.43616
NBPF19 neuroblastoma breakpoint family, member 19 2.42921
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 2.37676
ADCY10 adenylate cyclase 10 (soluble) 2.36834
PNO1 partner of NOB1 homolog (S. cerevisiae) 2.33365
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.31171
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.29661
PET100 PET100 homolog (S. cerevisiae) 2.29661
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.29093
CCBE1 collagen and calcium binding EGF domains 1 2.28242
H2AJ H2A.J histone 2.27116
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.24146
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.24146
AP5B1 adaptor-related protein complex 5, beta 1 subunit 2.2187
DPY19L2 dpy-19-like 2 (C. elegans) 2.19172
RALY RALY heterogeneous nuclear ribonucleoprotein 2.18989
TMEM178B transmembrane protein 178B 2.17878
CUEDC1 CUE domain containing 1 2.17372
ANXA5 annexin A5 2.15102
ESRRG estrogen-related receptor gamma 2.15102
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.1507
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 2.1507
PNRC1 proline-rich nuclear receptor coactivator 1 2.1507
H4C3 H4 clustered histone 3 2.14721
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.14421
DNAI1 dynein, axonemal, intermediate chain 1 2.13388
SNX21 sorting nexin family member 21 2.12754
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.1141
ITGB4 integrin, beta 4 2.11361
DYNLT2B dynein light chain Tctex-type 2B 2.10929
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.10618
UBE2T ubiquitin-conjugating enzyme E2T 2.10365
NPIPA5 nuclear pore complex interacting protein family, member A5 2.08743
DYM dymeclin 2.08743
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.08743
ANKRD6 ankyrin repeat domain 6 2.07933
EIF4H eukaryotic translation initiation factor 4H 2.07366
FRAS1 Fraser extracellular matrix complex subunit 1 2.05939
TGFBR1 transforming growth factor, beta receptor 1 2.05464
ZNF805 zinc finger protein 805 2.03201
NFE2L2 nuclear factor, erythroid 2-like 2 2.0287
ZNF234 zinc finger protein 234 2.0148
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.00867
RILPL2 Rab interacting lysosomal protein-like 2 2.00101

decreased expression

Symbol Name Standardized Value
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -2.7319
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -2.7319
STAB2 stabilin 2 -2.7319
TMPRSS5 transmembrane protease, serine 5 -2.7319
ANPEP alanyl (membrane) aminopeptidase -2.7319
BCL2L12 BCL2-like 12 (proline rich) -2.71436
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -2.63008
SH2D6 SH2 domain containing 6 -2.63008
CCDC59 coiled-coil domain containing 59 -2.63008
ATF2 activating transcription factor 2 -2.63008
USP50 ubiquitin specific peptidase 50 -2.63008
ELOVL3 ELOVL fatty acid elongase 3 -2.63008
FGF18 fibroblast growth factor 18 -2.63008
C1ORF146 chromosome 1 open reading frame 146 -2.63008
RBP2 retinol binding protein 2, cellular -2.63008
RBP4 retinol binding protein 4, plasma -2.63008
TMPRSS9 transmembrane protease, serine 9 -2.63008
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.63008
UGCG UDP-glucose ceramide glucosyltransferase -2.63008
MYO16 myosin XVI -2.63008
TTLL2 tubulin tyrosine ligase-like family member 2 -2.63008
SDSL serine dehydratase-like -2.63008
RGS11 regulator of G-protein signaling 11 -2.63008
DNAH10 dynein, axonemal, heavy chain 10 -2.63008
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.63008
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -2.63008
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.63008
CFAP126 cilia and flagella associated protein 126 -2.63008
EFCC1 EF-hand and coiled-coil domain containing 1 -2.63008
SPDYE18 speedy/RINGO cell cycle regulator family member E18 -2.63008
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime -2.63008
CAPN14 calpain 14 -2.63008
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -2.63008
SVOP SV2 related protein homolog (rat) -2.63008
OXTR oxytocin receptor -2.63008
CXCR2 chemokine (C-X-C motif) receptor 2 -2.63008
ADAMTSL4 ADAMTS-like 4 -2.63008
SLC9C2 solute carrier family 9, member C2 (putative) -2.63008
ARG1 arginase 1 -2.63008
SCRT2 scratch family zinc finger 2 -2.63008
GFRA3 GDNF family receptor alpha 3 -2.63008
LOC114841035 uncharacterized LOC114841035 -2.63008
GOLGA6B golgin A6 family, member B -2.63008
PCDHGB6 protocadherin gamma subfamily B, 6 -2.59261
SHLD3 shieldin complex subunit 3 -2.59261
ZNF76 zinc finger protein 76 -2.59076
CBX1 chromobox homolog 1 -2.52328
ZBTB12 zinc finger and BTB domain containing 12 -2.5133
ADAP2 ArfGAP with dual PH domains 2 -2.51021
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.51021
SMIM10 small integral membrane protein 10 -2.51021
ZNF776 zinc finger protein 776 -2.47035
BHLHE41 basic helix-loop-helix family, member e41 -2.43616
IL34 interleukin 34 -2.42921
PLCE1 phospholipase C, epsilon 1 -2.41894
EIF3M eukaryotic translation initiation factor 3, subunit M -2.40256
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 -2.3812
TIFA TRAF-interacting protein with forkhead-associated domain -2.35423
HSPH1 heat shock 105kDa/110kDa protein 1 -2.35423
JCAD junctional cadherin 5 associated -2.35423
KAT6B K(lysine) acetyltransferase 6B -2.3283
RXRA retinoid X receptor, alpha -2.32044
NMRK1 nicotinamide riboside kinase 1 -2.3077
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.26058
APCDD1 adenomatosis polyposis coli down-regulated 1 -2.2177
B3GLCT beta 3-glucosyltransferase -2.21744
TRUB1 TruB pseudouridine (psi) synthase family member 1 -2.19172
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta -2.19172
TIGD6 tigger transposable element derived 6 -2.18989
FAS Fas cell surface death receptor -2.18971
TTYH1 tweety family member 1 -2.18971
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -2.15824
DCK deoxycytidine kinase -2.1507
OAT ornithine aminotransferase -2.1507
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -2.14237
FSTL5 follistatin-like 5 -2.12771
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.12771
FGD3 FYVE, RhoGEF and PH domain containing 3 -2.12765
SPRED2 sprouty-related, EVH1 domain containing 2 -2.1141
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.1141
C1ORF116 chromosome 1 open reading frame 116 -2.1141
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.1141
PRSS8 protease, serine, 8 -2.11013
ZNF329 zinc finger protein 329 -2.10929
SAXO4 stabilizer of axonemal microtubules 4 -2.10633
DENND1A DENN/MADD domain containing 1A -2.10618
DMAP1 DNA methyltransferase 1 associated protein 1 -2.10618
INTS11 integrator complex subunit 11 -2.10618
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -2.08743
PZP pregnancy-zone protein -2.07933
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.07933
RAB39A RAB39A, member RAS oncogene family -2.07451
ZNF18 zinc finger protein 18 -2.05706
CCDC69 coiled-coil domain containing 69 -2.05516
MEX3C mex-3 RNA binding family member C -2.05404
EXD3 exonuclease 3'-5' domain containing 3 -2.05244
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -2.04728
ASMTL acetylserotonin O-methyltransferase-like -2.0354
FHOD1 formin homology 2 domain containing 1 -2.03467
SLC38A4 solute carrier family 38, member 4 -2.0287