SOX18 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 18|This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 54345)
Similar Terms
Downloads & Tools

Genes

323 genes differentially expressed following the SOX18 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HPCAL4 hippocalcin like 4 2.71726
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.71726
RGCC regulator of cell cycle 2.71726
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.71726
NPNT nephronectin 2.71726
MYBPC3 myosin binding protein C, cardiac 2.71726
ASCL2 achaete-scute family bHLH transcription factor 2 2.71726
PRR11 proline rich 11 2.71726
NOX3 NADPH oxidase 3 2.71726
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.71726
CST1 cystatin SN 2.71726
ANXA8 annexin A8 2.71726
ZMYND12 zinc finger, MYND-type containing 12 2.71726
ZNF597 zinc finger protein 597 2.71726
MEP1B meprin A, beta 2.71726
KLHL34 kelch-like family member 34 2.71726
BSX brain-specific homeobox 2.71726
TMC3 transmembrane channel-like 3 2.71726
MYO1A myosin IA 2.71726
LOXHD1 lipoxygenase homology domains 1 2.71726
SPEGNB SPEG neighbor 2.71726
DNAAF6 dynein axonemal assembly factor 6 2.71726
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.71726
ORM2 orosomucoid 2 2.71726
TNS4 tensin 4 2.71726
NWD1 NACHT and WD repeat domain containing 1 2.71726
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.71726
RGPD5 RANBP2-like and GRIP domain containing 5 2.59793
TRIM15 tripartite motif containing 15 2.59313
MUC6 mucin 6, oligomeric mucus/gel-forming 2.59313
PRICKLE4 prickle homolog 4 (Drosophila) 2.59313
PLIN1 perilipin 1 2.59313
CD68 CD68 molecule 2.59313
NPPB natriuretic peptide B 2.59313
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.59313
CRX cone-rod homeobox 2.59313
DUXA double homeobox A 2.59313
UROC1 urocanate hydratase 1 2.59313
DLX4 distal-less homeobox 4 2.59313
SCGN secretagogin, EF-hand calcium binding protein 2.59313
PDIA2 protein disulfide isomerase family A, member 2 2.59313
CELA1 chymotrypsin-like elastase family, member 1 2.59313
SUSD2 sushi domain containing 2 2.59313
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.59313
MFAP4 microfibrillar-associated protein 4 2.59313
SSTR5 somatostatin receptor 5 2.59313
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.59313
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.59313
SGPP2 sphingosine-1-phosphate phosphatase 2 2.59313
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.59313
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.59313
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.59313
RRAD Ras-related associated with diabetes 2.59313
TNNI1 troponin I type 1 (skeletal, slow) 2.59313
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.59313
MAGED4 melanoma antigen family D4 2.59313
RAX retina and anterior neural fold homeobox 2.59313
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.59313
LRRD1 leucine-rich repeats and death domain containing 1 2.59313
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.59313
SPRR2F small proline-rich protein 2F 2.59313
TMPRSS7 transmembrane protease, serine 7 2.59313
TMPRSS4 transmembrane protease, serine 4 2.59313
TTR transthyretin 2.59313
FCMR Fc fragment of IgM receptor 2.59313
GRAP GRB2-related adaptor protein 2.59313
TBX10 T-box 10 2.59313
F5 coagulation factor V (proaccelerin, labile factor) 2.59313
HBG2 hemoglobin, gamma G 2.59313
SQOR sulfide quinone oxidoreductase 2.59313
PLAAT4 phospholipase A and acyltransferase 4 2.59313
TEKTL1 tektin like 1 2.59313
LOC124902436 talanin 2.59313
CTXND1 cortexin domain containing 1 2.59313
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.59313
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.59313
CFAP97D1 CFAP97 domain containing 1 2.59313
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.59313
CCDC187 coiled-coil domain containing 187 2.59313
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.59313
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.59313
MTNR1B melatonin receptor 1B 2.59313
DTHD1 death domain containing 1 2.59313
NKX2-5 NK2 homeobox 5 2.59313
PCDHA8 protocadherin alpha 8 2.59313
AZI2 5-azacytidine induced 2 2.59313
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.59313
GJA9 gap junction protein, alpha 9, 59kDa 2.59313
CST11 cystatin 11 2.59313
VIT vitrin 2.59313
IRF5 interferon regulatory factor 5 2.59313
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.59313
COX8C cytochrome c oxidase subunit VIIIC 2.59313
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.59313
IL1R2 interleukin 1 receptor, type II 2.59313
OR10K2 olfactory receptor, family 10, subfamily K, member 2 2.59313
CNTFR ciliary neurotrophic factor receptor 2.59313
ZNF257 zinc finger protein 257 2.59313
ULBP1 UL16 binding protein 1 2.59313
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.59313
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.59313
TEX38 testis expressed 38 2.59313
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.59313
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.59313
PHOSPHO1 phosphatase, orphan 1 2.59313
NGB neuroglobin 2.59313
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 2.59313
GP5 glycoprotein V (platelet) 2.59313
EHF ets homologous factor 2.59313
FATE1 fetal and adult testis expressed 1 2.59313
PRSS55 protease, serine, 55 2.59313
MAPK11 mitogen-activated protein kinase 11 2.59313
TMEM45B transmembrane protein 45B 2.59313
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.59313
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.59313
LAMP5 lysosomal-associated membrane protein family, member 5 2.59313
NOS2 nitric oxide synthase 2, inducible 2.59313
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.59313
GLT6D1 glycosyltransferase 6 domain containing 1 2.59313
POTEJ POTE ankyrin domain family, member J 2.59313
POU1F1 POU class 1 homeobox 1 2.59313
TDRD10 tudor domain containing 10 2.59313
NPFFR1 neuropeptide FF receptor 1 2.59313
ZC3H11D zinc finger CCCH-type containing 11D 2.59313
FGB fibrinogen beta chain 2.59313
ARL13A ADP-ribosylation factor-like 13A 2.59313
DMRT1 doublesex and mab-3 related transcription factor 1 2.59313
POU4F2 POU class 4 homeobox 2 2.59313
ETV3L ets variant 3-like 2.59313
CNGB1 cyclic nucleotide gated channel beta 1 2.59313
DRC7 dynein regulatory complex subunit 7 2.59313
CDCA2 cell division cycle associated 2 2.59313
TEX12 testis expressed 12 2.59313
FIBIN fin bud initiation factor homolog (zebrafish) 2.59313
TTC9B tetratricopeptide repeat domain 9B 2.59313
C22ORF42 chromosome 22 open reading frame 42 2.59313
ALOXE3 arachidonate lipoxygenase 3 2.59313
BCO1 beta-carotene oxygenase 1 2.59313
ISL1 ISL LIM homeobox 1 2.59313
IL1A interleukin 1, alpha 2.59313
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.59313
PHACTR3 phosphatase and actin regulator 3 2.59313
CALR3 calreticulin 3 2.59313
LPA lipoprotein, Lp(a) 2.59313
MUC22 mucin 22 2.59313
TREML1 triggering receptor expressed on myeloid cells-like 1 2.59313
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.59313
IRX4 iroquois homeobox 4 2.59313
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.59313
CD3G CD3g molecule, gamma (CD3-TCR complex) 2.59313
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.59313
C5ORF46 chromosome 5 open reading frame 46 2.59313
RBP4 retinol binding protein 4, plasma 2.59313
GRM6 glutamate receptor, metabotropic 6 2.59313
TLDC2 TBC/LysM-associated domain containing 2 2.59313
LPO lactoperoxidase 2.59313
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.59313
TRAF3IP3 TRAF3 interacting protein 3 2.59313
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.59313
SPHK1 sphingosine kinase 1 2.59313
TGM5 transglutaminase 5 2.59313
PLA2G1B phospholipase A2, group IB (pancreas) 2.59313
SETSIP SET-like protein 2.59313
VENTX VENT homeobox 2.49156
LDB1 LIM domain binding 1 2.49156
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.49066
LTB4R2 leukotriene B4 receptor 2 2.42979
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 2.42883
GALNS galactosamine (N-acetyl)-6-sulfatase 2.39325
SMAD7 SMAD family member 7 2.39325
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 2.39198
MOSPD3 motile sperm domain containing 3 2.39198
ZNF816 zinc finger protein 816 2.385
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 2.358
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 2.35607
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.34134
HACD4 3-hydroxyacyl-CoA dehydratase 4 2.31363
SON SON DNA binding protein 2.30402
ISG20 interferon stimulated exonuclease gene 20kDa 2.30387
MAP2K5-DT MAP2K5 divergent transcript 2.28995
MPC2 mitochondrial pyruvate carrier 2 2.28995
ETFB electron-transfer-flavoprotein, beta polypeptide 2.28053
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.2676
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.2676
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 2.2676
TMEM87A transmembrane protein 87A 2.26196
PRMT5 protein arginine methyltransferase 5 2.23535
CDK7 cyclin-dependent kinase 7 2.23169
GSN gelsolin 2.23169
SIRT3 sirtuin 3 2.20972
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 2.20428
RAP2A RAP2A, member of RAS oncogene family 2.20204
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 2.20204
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 2.19582
FBXO25 F-box protein 25 2.18533
SREK1 splicing regulatory glutamine/lysine-rich protein 1 2.18192
GGT7 gamma-glutamyltransferase 7 2.1776
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 2.16541
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 2.15885
CTIF CBP80/20-dependent translation initiation factor 2.15195
NOL7 nucleolar protein 7, 27kDa 2.13678
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.13455
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.12693
KIF20B kinesin family member 20B 2.12069
GOLGA7 golgin A7 2.11966
UVSSA UV-stimulated scaffold protein A 2.10539
STAT2 signal transducer and activator of transcription 2, 113kDa 2.07161
TRIM59 tripartite motif containing 59 2.07161
SMIM24 small integral membrane protein 24 2.05486
ABHD18 abhydrolase domain containing 18 2.04176
P3H2 prolyl 3-hydroxylase 2 2.03722
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 2.02538
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.01388
PEX19 peroxisomal biogenesis factor 19 2.01255
CXXC4 CXXC finger protein 4 2.01231

decreased expression

Symbol Name Standardized Value
EOLA2 endothelium and lymphocyte associated ASCH domain 2 -2.71726
ETV1 ets variant 1 -2.71726
EFNA1 ephrin-A1 -2.59793
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.59793
UPK3B uroplakin 3B -2.59793
ATF4 activating transcription factor 4 -2.59313
NRG1 neuregulin 1 -2.59313
GRM1 glutamate receptor, metabotropic 1 -2.59313
TUBA8 tubulin, alpha 8 -2.59313
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.59313
SLC25A35 solute carrier family 25, member 35 -2.59313
ACTL6B actin-like 6B -2.59313
PMPCA peptidase (mitochondrial processing) alpha -2.5667
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.55571
DGCR6 DiGeorge syndrome critical region gene 6 -2.49156
TMEM86B transmembrane protein 86B -2.49156
C9ORF152 chromosome 9 open reading frame 152 -2.49156
GMFG glia maturation factor, gamma -2.49156
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.49156
NELL1 NEL-like 1 (chicken) -2.49156
GPR179 G protein-coupled receptor 179 -2.49156
C2CD2L C2CD2-like -2.49156
HCST hematopoietic cell signal transducer -2.49156
SLC39A5 solute carrier family 39 (zinc transporter), member 5 -2.49156
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.49156
IL6ST-DT IL6ST divergent transcript -2.49156
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -2.49156
GOLGA6L10 golgin A6 family-like 10 -2.49156
C1ORF87 chromosome 1 open reading frame 87 -2.49156
ATP13A4 ATPase type 13A4 -2.49156
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.49156
SMOC1 SPARC related modular calcium binding 1 -2.49156
CFHR3 complement factor H-related 3 -2.49156
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.49156
NXPH3 neurexophilin 3 -2.49156
CYB561D1 cytochrome b561 family, member D1 -2.49156
NCF2 neutrophil cytosolic factor 2 -2.49156
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.49156
C6ORF58 chromosome 6 open reading frame 58 -2.49156
SPMIP10 sperm microtubule inner protein 10 -2.49156
LY6G6C lymphocyte antigen 6 complex, locus G6C -2.49156
SV2B synaptic vesicle glycoprotein 2B -2.49156
WFDC8 WAP four-disulfide core domain 8 -2.49156
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -2.49156
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.49156
KLK14 kallikrein-related peptidase 14 -2.49156
OCM oncomodulin -2.49156
ZNHIT1 zinc finger, HIT-type containing 1 -2.49156
RANBP3L RAN binding protein 3-like -2.49156
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -2.49156
ADCY4 adenylate cyclase 4 -2.49156
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.49156
PLA2G2C phospholipase A2, group IIC -2.49156
MTCH2 mitochondrial carrier 2 -2.49156
HAPLN4 hyaluronan and proteoglycan link protein 4 -2.45858
FGF11 fibroblast growth factor 11 -2.43655
CUL4A cullin 4A -2.43526
ANKRD35 ankyrin repeat domain 35 -2.38107
KLRG2 killer cell lectin-like receptor subfamily G, member 2 -2.36797
THUMPD1 THUMP domain containing 1 -2.34134
ZFP36L1 ZFP36 ring finger protein-like 1 -2.34134
NUDCD1 NudC domain containing 1 -2.32945
INTS15 integrator complex subunit 15 -2.32384
ZBBX zinc finger, B-box domain containing -2.32319
TMEM132D transmembrane protein 132D -2.32319
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B -2.31707
RPL3 ribosomal protein L3 -2.31363
COX19 COX19 cytochrome c oxidase assembly factor -2.3072
ZFP90 ZFP90 zinc finger protein -2.30095
PPME1 protein phosphatase methylesterase 1 -2.2967
RGS17 regulator of G-protein signaling 17 -2.2967
GPER1 G protein-coupled estrogen receptor 1 -2.29253
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -2.28769
CHST10 carbohydrate sulfotransferase 10 -2.28594
TLL1 tolloid-like 1 -2.27558
CGGBP1 CGG triplet repeat binding protein 1 -2.27558
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.27558
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) -2.24453
NRXN3 neurexin 3 -2.23535
DNAH6 dynein, axonemal, heavy chain 6 -2.22078
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -2.21414
RBM12B RNA binding motif protein 12B -2.19582
HLA-A major histocompatibility complex, class I, A -2.1776
CHID1 chitinase domain containing 1 -2.16993
MTM1 myotubularin 1 -2.16928
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.15885
CPNE5 copine V -2.15885
ECSIT ECSIT signalling integrator -2.13678
C1ORF202 chromosome 1 open reading frame 202 -2.12782
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.12693
RALBP1 ralA binding protein 1 -2.11998
RBP1 retinol binding protein 1, cellular -2.1119
FERMT1 fermitin family member 1 -2.10914
EXOSC4 exosome component 4 -2.10539
SPMIP4 sperm microtubule inner protein 4 -2.10539
SGO1 shugoshin 1 -2.09697
POLM polymerase (DNA directed), mu -2.08281
GTF2IRD2B GTF2I repeat domain containing 2B -2.03535
GPX1 glutathione peroxidase 1 -2.03275
MSMP microseminoprotein, prostate associated -2.03139
CDC37 cell division cycle 37 -2.03139
ZNF510 zinc finger protein 510 -2.02979
HINFP histone H4 transcription factor -2.02756
MOB4 MOB family member 4, phocein -2.02538
NSD1 nuclear receptor binding SET domain protein 1 -2.02538
BMP2K BMP2 inducible kinase -2.02428
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like -2.00781
ENOSF1 enolase superfamily member 1 -2.00464