SOX2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description SRY (sex determining region Y)-box 2|This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6657)
External Link http://www.ncbi.nlm.nih.gov/gene/6657
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Genes

333 interacting proteins for SOX2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTL6A actin-like 6A
AHCYL1 adenosylhomocysteinase-like 1
AKAP11 A kinase (PRKA) anchor protein 11
ALX4 ALX homeobox 4
AMOTL2 angiomotin like 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGAP1 Rho GTPase activating protein 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMC8 armadillo repeat containing 8
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BMI1 BMI1 proto-oncogene, polycomb ring finger
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRD8 bromodomain containing 8
BRIX1 BRX1, biogenesis of ribosomes
C1QBP complement component 1, q subcomponent binding protein
CALR calreticulin
CAPN2 calpain 2, (m/II) large subunit
CASC5 cancer susceptibility candidate 5
CBX2 chromobox homolog 2
CBX4 chromobox homolog 4
CCNT1 cyclin T1
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC73 cell division cycle 73
CDK1 cyclin-dependent kinase 1
CDK11A cyclin-dependent kinase 11A
CDX1 caudal type homeobox 1
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CHD6 chromodomain helicase DNA binding protein 6
CHD7 chromodomain helicase DNA binding protein 7
CHD8 chromodomain helicase DNA binding protein 8
CHD9 chromodomain helicase DNA binding protein 9
CLOCK clock circadian regulator
CNOT3 CCR4-NOT transcription complex, subunit 3
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COPS3 COP9 signalosome subunit 3
CORO1B coronin, actin binding protein, 1B
CPSF3L cleavage and polyadenylation specific factor 3-like
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CUL7 cullin 7
CUL9 cullin 9
CUX1 cut-like homeobox 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAP3 death associated protein 3
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNM1L dynamin 1-like
DOCK7 dedicator of cytokinesis 7
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EP400 E1A binding protein p400
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ETV3 ets variant 3
ETV6 ets variant 6
FERMT2 fermitin family member 2
FGF4 fibroblast growth factor 4
FOXC1 forkhead box C1
FOXK2 forkhead box K2
FOXP4 forkhead box P4
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GATAD2A GATA zinc finger domain containing 2A
GATAD2B GATA zinc finger domain containing 2B
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GID8 GID complex subunit 8
GLI3 GLI family zinc finger 3
GLIS3 GLIS family zinc finger 3
GPC4 glypican 4
GPN1 GPN-loop GTPase 1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HOXA5 homeobox A5
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPB1 heat shock 27kDa protein 1
ILK integrin-linked kinase
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INTS1 integrator complex subunit 1
INTS2 integrator complex subunit 2
INTS3 integrator complex subunit 3
INTS7 integrator complex subunit 7
INTS9 integrator complex subunit 9
IPO4 importin 4
IPO5 importin 5
IPO7 importin 7
IQGAP3 IQ motif containing GTPase activating protein 3
IRF2BP1 interferon regulatory factor 2 binding protein 1
JUND jun D proto-oncogene
KCMF1 potassium channel modulatory factor 1
KCTD5 potassium channel tetramerization domain containing 5
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KPNA4 karyopherin alpha 4 (importin alpha 3)
LARP1 La ribonucleoprotein domain family, member 1
LAS1L LAS1-like (S. cerevisiae)
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LONP1 lon peptidase 1, mitochondrial
LOX lysyl oxidase
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MACF1 microtubule-actin crosslinking factor 1
MAEA macrophage erythroblast attacher
MAGEC1 melanoma antigen family C1
MAGEC2 melanoma antigen family C2
MAGED2 melanoma antigen family D2
MBD2 methyl-CpG binding domain protein 2
MBD3 methyl-CpG binding domain protein 3
MDN1 MDN1, midasin homolog (yeast)
MECOM MDS1 and EVI1 complex locus
MECP2 methyl CpG binding protein 2
MED22 mediator complex subunit 22
MEIS2 Meis homeobox 2
MEPCE methylphosphate capping enzyme
MFAP1 microfibrillar-associated protein 1
MIER1 mesoderm induction early response 1, transcriptional regulator
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MLF2 myeloid leukemia factor 2
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MRPL1 mitochondrial ribosomal protein L1
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPL39 mitochondrial ribosomal protein L39
MRPL4 mitochondrial ribosomal protein L4
MRPL41 mitochondrial ribosomal protein L41
MRPL9 mitochondrial ribosomal protein L9
MRPS22 mitochondrial ribosomal protein S22
MRPS26 mitochondrial ribosomal protein S26
MRPS35 mitochondrial ribosomal protein S35
MRPS9 mitochondrial ribosomal protein S9
MSI2 musashi RNA-binding protein 2
MSL1 male-specific lethal 1 homolog (Drosophila)
MSL3 male-specific lethal 3 homolog (Drosophila)
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTA3 metastasis associated 1 family, member 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYEF2 myelin expression factor 2
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NAP1L4 nucleosome assembly protein 1-like 4
NCAPD2 non-SMC condensin I complex, subunit D2
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NFIB nuclear factor I/B
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOL9 nucleolar protein 9
NOM1 nucleolar protein with MIF4G domain 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NUP214 nucleoporin 214kDa
NUP93 nucleoporin 93kDa
OLA1 Obg-like ATPase 1
OSBPL11 oxysterol binding protein-like 11
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAPD4 PAP associated domain containing 4
PARVA parvin, alpha
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX6 paired box 6
PBX2 pre-B-cell leukemia homeobox 2
PELP1 proline, glutamate and leucine rich protein 1
PFKP phosphofructokinase, platelet
PHC2 polyhomeotic homolog 2 (Drosophila)
PHC3 polyhomeotic homolog 3 (Drosophila)
PIAS1 protein inhibitor of activated STAT, 1
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POU2F1 POU class 2 homeobox 1
POU5F1 POU class 5 homeobox 1
PPIH peptidylprolyl isomerase H (cyclophilin H)
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP6R1 protein phosphatase 6, regulatory subunit 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PRPF4 pre-mRNA processing factor 4
PWP1 PWP1 homolog (S. cerevisiae)
QSER1 glutamine and serine rich 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAE1 ribonucleic acid export 1
RALY RALY heterogeneous nuclear ribonucleoprotein
RANBP10 RAN binding protein 10
RANBP9 RAN binding protein 9
RANGAP1 Ran GTPase activating protein 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RBM15 RNA binding motif protein 15
RBM4 RNA binding motif protein 4
RBM7 RNA binding motif protein 7
RFX1 regulatory factor X, 1 (influences HLA class II expression)
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RNGTT RNA guanylyltransferase and 5'-phosphatase
RNH1 ribonuclease/angiogenin inhibitor 1
RPP30 ribonuclease P/MRP 30kDa subunit
RUNX1 runt-related transcription factor 1
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SALL1 spalt-like transcription factor 1
SALL2 spalt-like transcription factor 2
SALL3 spalt-like transcription factor 3
SAMD4B sterile alpha motif domain containing 4B
SAP130 Sin3A-associated protein, 130kDa
SART3 squamous cell carcinoma antigen recognized by T cells 3
SCFD1 sec1 family domain containing 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SEC16A SEC16 homolog A (S. cerevisiae)
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
SET SET nuclear proto-oncogene
SETD2 SET domain containing 2
SETD7 SET domain containing (lysine methyltransferase) 7
SGOL2 shugoshin-like 2 (S. pombe)
SHCBP1 SHC SH2-domain binding protein 1
SIN3A SIN3 transcription regulator family member A
SIN3B SIN3 transcription regulator family member B
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLFN11 schlafen family member 11
SLFN5 schlafen family member 5
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMC2 structural maintenance of chromosomes 2
SMC3 structural maintenance of chromosomes 3
SMG6 SMG6 nonsense mediated mRNA decay factor
SOX5 SRY (sex determining region Y)-box 5
SOX6 SRY (sex determining region Y)-box 6
SOX8 SRY (sex determining region Y)-box 8
SP2 Sp2 transcription factor
SPEN spen family transcriptional repressor
SRP54 signal recognition particle 54kDa
SRP68 signal recognition particle 68kDa
SRP72 signal recognition particle 72kDa
SRSF4 serine/arginine-rich splicing factor 4
SSB Sjogren syndrome antigen B (autoantigen La)
SUGP2 SURP and G patch domain containing 2
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBX3 T-box 3
TCF12 transcription factor 12
TCF3 transcription factor 3
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEX10 testis expressed 10
THBS1 thrombospondin 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TNPO1 transportin 1
TNPO3 transportin 3
TNRC18 trinucleotide repeat containing 18
TP73 tumor protein p73
TRERF1 transcriptional regulating factor 1
TRIM26 tripartite motif containing 26
TRIM33 tripartite motif containing 33
TSHZ3 teashirt zinc finger homeobox 3
TSPYL1 TSPY-like 1
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB8 tubulin, beta 8 class VIII
TUBG1 tubulin, gamma 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TWIST1 twist family bHLH transcription factor 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USP15 ubiquitin specific peptidase 15
USP24 ubiquitin specific peptidase 24
USP34 ubiquitin specific peptidase 34
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP9X ubiquitin specific peptidase 9, X-linked
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPRBP Vpr (HIV-1) binding protein
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VWA9 von Willebrand factor A domain containing 9
WDR26 WD repeat domain 26
WDR3 WD repeat domain 3
XPO1 exportin 1
XPO4 exportin 4
XPO5 exportin 5
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YPEL5 yippee-like 5 (Drosophila)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB10 zinc finger and BTB domain containing 10
ZBTB5 zinc finger and BTB domain containing 5
ZBTB7A zinc finger and BTB domain containing 7A
ZCCHC8 zinc finger, CCHC domain containing 8
ZDBF2 zinc finger, DBF-type containing 2
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZFHX4 zinc finger homeobox 4
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF24 zinc finger protein 24
ZNF281 zinc finger protein 281
ZNF384 zinc finger protein 384
ZNF462 zinc finger protein 462
ZNF536 zinc finger protein 536
ZNF609 zinc finger protein 609
ZNF644 zinc finger protein 644
ZNF687 zinc finger protein 687
ZNF787 zinc finger protein 787