SOX21 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 21|SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004] (NCBI Entrez Gene Database, 11166)
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Genes

367 genes differentially expressed following the SOX21 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HLX H2.0-like homeobox 3.27088
SOX14 SRY (sex determining region Y)-box 14 3.27088
SOX18 SRY (sex determining region Y)-box 18 3.27088
PGBDF plakoglobin binding and degradation factor 3.27088
CNTNAP4 contactin associated protein-like 4 3.27088
TM4SF20 transmembrane 4 L six family member 20 3.27088
AMTN amelotin 3.27088
SKOR2 SKI family transcriptional corepressor 2 3.27088
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.27088
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 3.27088
DSG4 desmoglein 4 3.27088
HES7 hes family bHLH transcription factor 7 3.27088
OR1A1 olfactory receptor, family 1, subfamily A, member 1 3.27088
MGAM2 maltase-glucoamylase 2 (putative) 3.27088
HRH1 histamine receptor H1 3.27088
AIP aryl hydrocarbon receptor interacting protein 3.27088
CD5 CD5 molecule 3.27088
LURAP1L leucine rich adaptor protein 1-like 3.27088
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 3.27088
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.27088
IGFL2 IGF-like family member 2 3.27088
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.27088
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.27088
CD163 CD163 molecule 3.27088
TBR1 T-box, brain, 1 3.27088
C6ORF58 chromosome 6 open reading frame 58 3.27088
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 3.27088
CRYGA crystallin, gamma A 3.27088
FAM216B family with sequence similarity 216, member B 3.27088
IL2RA interleukin 2 receptor, alpha 3.27088
CAPS calcyphosine 3.27088
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.27088
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.27088
CLEC14A C-type lectin domain family 14, member A 3.27088
C2ORF78 chromosome 2 open reading frame 78 3.27088
TPPP tubulin polymerization promoting protein 3.27088
PRR29 proline rich 29 3.27088
OR7A17 olfactory receptor, family 7, subfamily A, member 17 3.27088
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.27088
GPHB5 glycoprotein hormone beta 5 3.27088
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.27088
SHCBP1L SHC SH2-domain binding protein 1-like 3.27088
GPR20 G protein-coupled receptor 20 3.27088
ADAMTSL5 ADAMTS-like 5 3.27088
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.27088
BSX brain-specific homeobox 3.27088
TDRD9 tudor domain containing 9 3.27088
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.27088
LRRC10B leucine rich repeat containing 10B 3.27088
TMEM217 transmembrane protein 217 3.27088
KIAA1755 KIAA1755 3.27088
ACKR5 atypical chemokine receptor 5 3.27088
HBG2 hemoglobin, gamma G 3.27088
SPI1 Spi-1 proto-oncogene 3.27088
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.27088
SPRR2A small proline-rich protein 2A 3.27088
FOXN4 forkhead box N4 3.27088
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.27088
TMPRSS6 transmembrane protease, serine 6 3.27088
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.27088
ADRB1 adrenoceptor beta 1 3.27088
MYEOV myeloma overexpressed 3.27088
TAS2R60 taste receptor, type 2, member 60 3.27088
H2BC1 H2B clustered histone 1 3.27088
SQOR sulfide quinone oxidoreductase 3.27088
TEKTL1 tektin like 1 3.27088
ZC3H11C zinc finger CCCH-type containing 11C 3.27088
LY6S lymphocyte antigen 6 family member S 3.27088
TEX53 testis expressed 53 3.27088
PCARE photoreceptor cilium actin regulator 3.27088
CCDC187 coiled-coil domain containing 187 3.27088
DIPK2B divergent protein kinase domain 2B 3.27088
HTD2 hydroxyacyl-thioester dehydratase type 2 3.27088
ALPG alkaline phosphatase, germ cell 3.27088
STYXL2 serine/threonine/tyrosine interacting like 2 3.27088
DYNLRB2 dynein, light chain, roadblock-type 2 3.27088
F5 coagulation factor V (proaccelerin, labile factor) 3.27088
PRDM7 PR domain containing 7 3.27088
VSX2 visual system homeobox 2 3.27088
PCDHB11 protocadherin beta 11 3.27088
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.27088
NKX2-6 NK2 homeobox 6 3.27088
CAPN14 calpain 14 3.27088
RAB41 RAB41, member RAS oncogene family 3.27088
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.27088
CPNE6 copine VI (neuronal) 3.27088
FPR3 formyl peptide receptor 3 3.27088
TBX22 T-box 22 3.27088
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.27088
CBLN3 cerebellin 3 precursor 3.27088
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.27088
LRRC72 leucine rich repeat containing 72 3.27088
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.27088
PTH parathyroid hormone 3.27088
BARX2 BARX homeobox 2 3.27088
TCF23 transcription factor 23 3.27088
C6ORF118 chromosome 6 open reading frame 118 3.27088
TBX3 T-box 3 3.27088
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.27088
RNF113B ring finger protein 113B 3.27088
OVOL3 ovo-like zinc finger 3 3.27088
HBA2 hemoglobin, alpha 2 3.27088
GCOM1 GRINL1A complex locus 1 3.27088
IL19 interleukin 19 3.27088
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.27088
ZNF366 zinc finger protein 366 3.27088
TEKT5 tektin 5 3.27088
KISS1 KiSS-1 metastasis-suppressor 3.27088
KRT15 keratin 15, type I 3.27088
CYBB cytochrome b-245, beta polypeptide 3.27088
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 3.27088
ZMYND15 zinc finger, MYND-type containing 15 3.27088
ZMYND10 zinc finger, MYND-type containing 10 3.27088
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 3.27088
CALML5 calmodulin-like 5 3.27088
IGF2 insulin-like growth factor 2 3.27088
RGSL1 regulator of G-protein signaling like 1 3.27088
CARD9 caspase recruitment domain family, member 9 3.27088
UTS2B urotensin 2B 3.27088
ISL1 ISL LIM homeobox 1 3.27088
FNDC8 fibronectin type III domain containing 8 3.27088
MYF6 myogenic factor 6 (herculin) 3.27088
CYSLTR1 cysteinyl leukotriene receptor 1 3.27088
SPATA31A1 SPATA31 subfamily A, member 1 3.27088
AQP8 aquaporin 8 3.27088
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.27088
C2ORF66 chromosome 2 open reading frame 66 3.27088
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.27088
TDRD10 tudor domain containing 10 3.27088
SPATA4 spermatogenesis associated 4 3.27088
CPA5 carboxypeptidase A5 3.27088
TLR10 toll-like receptor 10 3.27088
CLDN34 claudin 34 3.27088
C2CD4B C2 calcium-dependent domain containing 4B 3.27088
LMOD2 leiomodin 2 (cardiac) 3.27088
LCT lactase 3.27088
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.27088
RGS13 regulator of G-protein signaling 13 3.27088
TECRL trans-2,3-enoyl-CoA reductase-like 3.27088
ZC3H12D zinc finger CCCH-type containing 12D 3.27088
CTAGE9 CTAGE family, member 9 3.27088
PLA2G1B phospholipase A2, group IB (pancreas) 3.27088
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.27088
TM4SF19 transmembrane 4 L six family member 19 3.27088
CNR2 cannabinoid receptor 2 (macrophage) 3.27088
ETV3L ets variant 3-like 3.27088
C5ORF46 chromosome 5 open reading frame 46 3.27088
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.27088
PITX2 paired-like homeodomain 2 3.27088
CD34 CD34 molecule 3.27088
CLEC18B C-type lectin domain family 18, member B 3.27088
PLA2G5 phospholipase A2, group V 3.27088
AMIGO3 adhesion molecule with Ig-like domain 3 3.27088
OR51A4 olfactory receptor, family 51, subfamily A, member 4 3.27088
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.27088
POU4F1 POU class 4 homeobox 1 3.27088
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.27088
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.27088
PRSS33 protease, serine, 33 3.27088
NT5C1B 5'-nucleotidase, cytosolic IB 3.27088
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 3.27088
GLT6D1 glycosyltransferase 6 domain containing 1 3.27088
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.27088
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.27088
UBXN10 UBX domain protein 10 3.27088
NCR3 natural cytotoxicity triggering receptor 3 3.27088
TMPRSS15 transmembrane protease, serine 15 3.27088
CLEC1A C-type lectin domain family 1, member A 3.27088
IFITM10 interferon induced transmembrane protein 10 3.27088
BPIFC BPI fold containing family C 3.27088
TTC36 tetratricopeptide repeat domain 36 3.27088
CLEC4A C-type lectin domain family 4, member A 3.27088
POU3F2 POU class 3 homeobox 2 3.27088
SMNDC1 survival motor neuron domain containing 1 3.16875
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.13682
NCBP2AS2 NCBP2 antisense 2 (head to head) 3.1215
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.04273
MTCP1 mature T-cell proliferation 1 3.00009
HMCN2 hemicentin 2 2.98611
RBM4B RNA binding motif protein 4B 2.92506
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.91711
C9ORF153 chromosome 9 open reading frame 153 2.90863
AGTR1 angiotensin II receptor, type 1 2.84933
TPM4 tropomyosin 4 2.81657
AKAP1 A kinase (PRKA) anchor protein 1 2.80266
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.79706
ZNF35 zinc finger protein 35 2.73144
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.7303
AFF2 AF4/FMR2 family, member 2 2.6836
LPXN leupaxin 2.64358
TTC9C tetratricopeptide repeat domain 9C 2.61695
KIF6 kinesin family member 6 2.59291
THOC1 THO complex 1 2.57629
DPPA4 developmental pluripotency associated 4 2.56972
SYTL2 synaptotagmin-like 2 2.4968
ZBBX zinc finger, B-box domain containing 2.46826
CMC4 C-x(9)-C motif containing 4 2.43885
IARS1 isoleucyl-tRNA synthetase 1 2.43885
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.42312
VMP1 vacuole membrane protein 1 2.42291
HSPA1L heat shock 70kDa protein 1-like 2.38905
IRGM immunity-related GTPase family, M 2.38905
COMMD5 COMM domain containing 5 2.38421
GPR161 G protein-coupled receptor 161 2.37244
SPATS2 spermatogenesis associated, serine-rich 2 2.36877
OXSR1 oxidative stress responsive 1 2.36645
SMAD4 SMAD family member 4 2.34159
DPH6 diphthamine biosynthesis 6 2.33656
SLC25A34 solute carrier family 25, member 34 2.33451
COL6A5 collagen, type VI, alpha 5 2.33239
EMC1 ER membrane protein complex subunit 1 2.32981
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 2.32981
ACIN1 apoptotic chromatin condensation inducer 1 2.31776
MEIS3 Meis homeobox 3 2.29698
GAN gigaxonin 2.29698
MAP7D2 MAP7 domain containing 2 2.29214
GALNS galactosamine (N-acetyl)-6-sulfatase 2.29065
C8ORF34 chromosome 8 open reading frame 34 2.28627
NEMP2 nuclear envelope integral membrane protein 2 2.28436
CA1 carbonic anhydrase I 2.21365
HNMT histamine N-methyltransferase 2.21281
AOX1 aldehyde oxidase 1 2.20678
SATL1 spermidine/spermine N1-acetyl transferase-like 1 2.19889
GPRC5C G protein-coupled receptor, class C, group 5, member C 2.19495
ENSA endosulfine alpha 2.19409
LIMD1 LIM domains containing 1 2.1887
NOL8 nucleolar protein 8 2.1887
MRPL43 mitochondrial ribosomal protein L43 2.1887
VWA3A von Willebrand factor A domain containing 3A 2.18169
KLC2 kinesin light chain 2 2.14014
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.13397
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 2.1304
RAB22A RAB22A, member RAS oncogene family 2.12717
NPHP4 nephronophthisis 4 2.11739
R3HDM2 R3H domain containing 2 2.11558
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.10029
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 2.08557
CRMP1 collapsin response mediator protein 1 2.08007
PRPF4 pre-mRNA processing factor 4 2.077
LTBP2 latent transforming growth factor beta binding protein 2 2.06114
SPEF1 sperm flagellar 1 2.06114
NXPH4 neurexophilin 4 2.06114
MID1 midline 1 2.06114
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.06114
CAPN9 calpain 9 2.06114
TMEM11 transmembrane protein 11 2.04478
TXNDC9 thioredoxin domain containing 9 2.02455
INTS5 integrator complex subunit 5 2.02288
ARF4 ADP-ribosylation factor 4 2.00769
LIPI lipase, member I 2.00761
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.00761
DIS3L DIS3 like exosome 3'-5' exoribonuclease 2.00448

decreased expression

Symbol Name Standardized Value
UBE2S ubiquitin-conjugating enzyme E2S -3.27088
ECT2 epithelial cell transforming 2 -3.27088
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -3.27088
TRPM8 transient receptor potential cation channel, subfamily M, member 8 -3.27088
TMEM86B transmembrane protein 86B -3.27088
MT1M metallothionein 1M -3.27088
CD96 CD96 molecule -3.27088
GJA9 gap junction protein, alpha 9, 59kDa -3.27088
C4ORF51 chromosome 4 open reading frame 51 -3.27088
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -3.27088
LEF1 lymphoid enhancer-binding factor 1 -3.27088
ADGRE3 adhesion G protein-coupled receptor E3 -3.27088
SPINK1 serine peptidase inhibitor, Kazal type 1 -3.27088
GYPB glycophorin B (MNS blood group) -3.27088
ETV7 ets variant 7 -3.27088
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -3.27088
CSTL1 cystatin-like 1 -3.27088
SPDEF SAM pointed domain containing ETS transcription factor -3.27088
NRSN1 neurensin 1 -3.27088
RUNDC3B RUN domain containing 3B -3.27088
BTLA B and T lymphocyte associated -3.27088
TNNI1 troponin I type 1 (skeletal, slow) -3.27088
TMC3 transmembrane channel-like 3 -3.27088
BRDT bromodomain, testis-specific -3.27088
LGSN lengsin, lens protein with glutamine synthetase domain -3.27088
PROC protein C (inactivator of coagulation factors Va and VIIIa) -3.27088
MAP6 microtubule-associated protein 6 -3.27088
VSTM1 V-set and transmembrane domain containing 1 -3.27088
LMNTD1 lamin tail domain containing 1 -3.27088
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -3.27088
KLB klotho beta -3.27088
CXCL13 chemokine (C-X-C motif) ligand 13 -3.27088
H3-5 H3.5 histone -3.27088
IGIP IgA-inducing protein -3.27088
NIBAN3 niban apoptosis regulator 3 -3.27088
SMIM41 small integral membrane protein 41 -3.27088
MLANA melan-A -3.27088
LOC124902436 talanin -3.27088
THTPA thiamine triphosphatase -3.27088
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -3.27088
TUBA4B tubulin, alpha 4b -3.27088
AKNAD1 AKNA domain containing 1 -3.27088
AFAP1L1 actin filament associated protein 1-like 1 -3.27088
TSPAN10 tetraspanin 10 -3.17747
RBP2 retinol binding protein 2, cellular -3.12649
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -3.08038
FUT2 fucosyltransferase 2 (secretor status included) -3.08014
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -3.06815
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.96679
KRT10 keratin 10, type I -2.94035
ZFP62 ZFP62 zinc finger protein -2.90863
TALDO1 transaldolase 1 -2.87226
FSTL5 follistatin-like 5 -2.78077
HDAC9 histone deacetylase 9 -2.73197
KLC3 kinesin light chain 3 -2.6938
HSPA12B heat shock 70kD protein 12B -2.66778
SAMD14 sterile alpha motif domain containing 14 -2.63504
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -2.63504
ZBTB45 zinc finger and BTB domain containing 45 -2.63504
RDH16 retinol dehydrogenase 16 (all-trans) -2.63504
ZCCHC18 zinc finger, CCHC domain containing 18 -2.63504
IL17C interleukin 17C -2.63504
SLC25A40 solute carrier family 25, member 40 -2.61785
RCN2 reticulocalbin 2, EF-hand calcium binding domain -2.56699
TM4SF18 transmembrane 4 L six family member 18 -2.53665
PROKR1 prokineticin receptor 1 -2.49074
PLAC8 placenta-specific 8 -2.49074
ZNF506 zinc finger protein 506 -2.4824
AK4 adenylate kinase 4 -2.45885
FAM167B family with sequence similarity 167, member B -2.44009
IDUA iduronidase, alpha-L- -2.44009
CLUH clustered mitochondria (cluA/CLU1) homolog -2.43574
BCL6B B-cell CLL/lymphoma 6, member B -2.43574
DOCK10 dedicator of cytokinesis 10 -2.43574
AKT2 v-akt murine thymoma viral oncogene homolog 2 -2.42337
GPR87 G protein-coupled receptor 87 -2.42312
CARMIL2 capping protein regulator and myosin 1 linker 2 -2.41502
ALDOA aldolase A, fructose-bisphosphate -2.40239
ARID5B AT rich interactive domain 5B (MRF1-like) -2.38317
GOLT1B golgi transport 1B -2.37244
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.37244
DCP1A decapping mRNA 1A -2.33674
EFNA3 ephrin-A3 -2.32981
CFL2 cofilin 2 (muscle) -2.32634
ATP5F1A ATP synthase F1 subunit alpha -2.31722
SELENBP1 selenium binding protein 1 -2.29698
SACK1A scaffolding CK1 anchoring protein A -2.29065
KISS1R KISS1 receptor -2.29065
GEMIN2 gem (nuclear organelle) associated protein 2 -2.2833
JOSD1 Josephin domain containing 1 -2.27278
H2AC25 H2A clustered histone 25 -2.25918
POMT2 protein-O-mannosyltransferase 2 -2.24792
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.21327
RASL12 RAS-like, family 12 -2.21168
RASA1 RAS p21 protein activator (GTPase activating protein) 1 -2.20868
TARDBP TAR DNA binding protein -2.19889
ZNF721 zinc finger protein 721 -2.19495
SACS sacsin molecular chaperone -2.18924
NOXRED1 NADP-dependent oxidoreductase domain containing 1 -2.1887
SOX7 SRY (sex determining region Y)-box 7 -2.1887
H2BC4 H2B clustered histone 4 -2.18477
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.18299
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.18185
PTCH1 patched 1 -2.15518
IPO5 importin 5 -2.09834
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -2.07142
HAUS6 HAUS augmin-like complex, subunit 6 -2.06616
RBM33 RNA binding motif protein 33 -2.05803
CALHM2 calcium homeostasis modulator 2 -2.05803
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -2.05803
DGKE diacylglycerol kinase, epsilon 64kDa -2.02044
PCDH11X protocadherin 11 X-linked -2.01446
CLK3 CDC-like kinase 3 -2.01401
EPHA7 EPH receptor A7 -2.01321
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -2.00448