SOX3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 3|This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6658)
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Genes

349 genes differentially expressed following the SOX3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COL20A1 collagen, type XX, alpha 1 3.10088
SH2D6 SH2 domain containing 6 3.10088
PAX5 paired box 5 3.10088
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.10088
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.10088
GIMAP4 GTPase, IMAP family member 4 3.10088
SLC23A3 solute carrier family 23, member 3 3.10088
TRIM73 tripartite motif containing 73 3.10088
UNC45B unc-45 homolog B (C. elegans) 3.10088
CXCL2 chemokine (C-X-C motif) ligand 2 3.10088
SFTPB surfactant protein B 3.10088
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 3.10088
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.10088
MYBPC3 myosin binding protein C, cardiac 3.10088
AGTR1 angiotensin II receptor, type 1 3.10088
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.10088
DUXB double homeobox B 3.10088
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.10088
SPINK6 serine peptidase inhibitor, Kazal type 6 3.10088
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.10088
TRIM10 tripartite motif containing 10 3.10088
OR2A42 olfactory receptor, family 2, subfamily A, member 42 3.10088
PKP1 plakophilin 1 3.10088
PNMA5 paraneoplastic Ma antigen family member 5 3.10088
CCNB3 cyclin B3 3.10088
C9ORF152 chromosome 9 open reading frame 152 3.10088
SPNS2 spinster homolog 2 (Drosophila) 3.10088
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.10088
KRTAP5-7 keratin associated protein 5-7 3.10088
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.10088
BTBD16 BTB (POZ) domain containing 16 3.10088
BTBD19 BTB (POZ) domain containing 19 3.10088
SPDEF SAM pointed domain containing ETS transcription factor 3.10088
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.10088
RHOJ ras homolog family member J 3.10088
CD22 CD22 molecule 3.10088
MMRN1 multimerin 1 3.10088
DNAH8 dynein, axonemal, heavy chain 8 3.10088
STEAP4 STEAP family member 4 3.10088
CFAP54 cilia and flagella associated 54 3.10088
SREBF2 sterol regulatory element binding transcription factor 2 3.10088
UMODL1 uromodulin-like 1 3.10088
SYCE3 synaptonemal complex central element protein 3 3.10088
KIF2B kinesin family member 2B 3.10088
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.10088
VSX1 visual system homeobox 1 3.10088
TRPC5OS TRPC5 opposite strand 3.10088
LGALS9 lectin, galactoside-binding, soluble, 9 3.10088
SP5 Sp5 transcription factor 3.10088
LOC105378220 macrophage receptor MARCO-like 3.10088
THEMIS thymocyte selection associated 3.10088
AHSG alpha-2-HS-glycoprotein 3.10088
SPEGNB SPEG neighbor 3.10088
UNC93A unc-93 homolog A (C. elegans) 3.10088
YIPF7 Yip1 domain family, member 7 3.10088
MGAM maltase-glucoamylase 3.10088
SPI1 Spi-1 proto-oncogene 3.10088
HTRA4 HtrA serine peptidase 4 3.10088
FMO2 flavin containing monooxygenase 2 (non-functional) 3.10088
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.10088
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 3.10088
ACSL5 acyl-CoA synthetase long-chain family member 5 3.10088
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 3.10088
BDKRB2 bradykinin receptor B2 3.10088
RAG1 recombination activating gene 1 3.10088
SPATS1 spermatogenesis associated, serine-rich 1 3.10088
LITAFD LITAF domain containing 3.10088
LY6S-AS1 LY6S antisense RNA 1 3.10088
H4C15 H4 clustered histone 15 3.10088
RSKR ribosomal protein S6 kinase related 3.10088
H2AC19 H2A clustered histone 19 3.10088
LHFPL7 LHFPL tetraspan subfamily member 7 3.10088
TEX55 testis expressed 55 3.10088
CFAP206 cilia and flagella associated protein 206 3.10088
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.10088
TMEM275 transmembrane protein 275 3.10088
RAB6D RAB6D, member RAS oncogene family 3.10088
DYNLRB2 dynein, light chain, roadblock-type 2 3.10088
ASIC3 acid sensing (proton gated) ion channel 3 3.10088
WNT11 wingless-type MMTV integration site family, member 11 3.10088
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.10088
LTBP2 latent transforming growth factor beta binding protein 2 3.10088
CFAP99 cilia and flagella associated protein 99 3.10088
PCDHB11 protocadherin beta 11 3.10088
RHOXF2 Rhox homeobox family, member 2 3.10088
CCIN calicin 3.10088
FPR3 formyl peptide receptor 3 3.10088
USH1G Usher syndrome 1G (autosomal recessive) 3.10088
HNF4A hepatocyte nuclear factor 4, alpha 3.10088
TMEM212 transmembrane protein 212 3.10088
DAO D-amino-acid oxidase 3.10088
TLR6 toll-like receptor 6 3.10088
FGFBP1 fibroblast growth factor binding protein 1 3.10088
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.10088
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.10088
RGS21 regulator of G-protein signaling 21 3.10088
TSPO2 translocator protein 2 3.10088
TACR2 tachykinin receptor 2 3.10088
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.10088
FAM186A family with sequence similarity 186, member A 3.10088
PRR18 proline rich 18 3.10088
MIP major intrinsic protein of lens fiber 3.10088
MYH13 myosin, heavy chain 13, skeletal muscle 3.10088
HRH1 histamine receptor H1 3.10088
APOB apolipoprotein B 3.10088
KLHL41 kelch-like family member 41 3.10088
WFDC6 WAP four-disulfide core domain 6 3.10088
HPX hemopexin 3.10088
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.10088
SERINC4 serine incorporator 4 3.10088
SPINK9 serine peptidase inhibitor, Kazal type 9 3.10088
CD5L CD5 molecule-like 3.10088
APOC4 apolipoprotein C-IV 3.10088
OR52K1 olfactory receptor, family 52, subfamily K, member 1 3.10088
CD28 CD28 molecule 3.10088
VNN2 vanin 2 3.10088
ADORA3 adenosine A3 receptor 3.10088
PCDHGB2 protocadherin gamma subfamily B, 2 3.10088
CCL24 chemokine (C-C motif) ligand 24 3.10088
GLOD5 glyoxalase domain containing 5 3.10088
EXTL1 exostosin-like glycosyltransferase 1 3.10088
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.10088
POF1B premature ovarian failure, 1B 3.10088
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.10088
ADGRA1 adhesion G protein-coupled receptor A1 3.10088
THTPA thiamine triphosphatase 3.10088
IL19 interleukin 19 3.10088
PCDH12 protocadherin 12 3.10088
CRHBP corticotropin releasing hormone binding protein 3.10088
OTOP2 otopetrin 2 3.10088
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.10088
CLEC1A C-type lectin domain family 1, member A 3.10088
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.10088
MEPE matrix extracellular phosphoglycoprotein 3.10088
WNT2 wingless-type MMTV integration site family member 2 3.10088
ZNF831 zinc finger protein 831 3.10088
BTG4 B-cell translocation gene 4 3.10088
NT5DC4 5'-nucleotidase domain containing 4 3.10088
TH tyrosine hydroxylase 3.10088
TG thyroglobulin 3.10088
KLK11 kallikrein-related peptidase 11 3.10088
KIAA1210 KIAA1210 3.10088
ZFP92 ZFP92 zinc finger protein 3.10088
TEX12 testis expressed 12 3.10088
SIRPG signal-regulatory protein gamma 3.10088
SAMD9 sterile alpha motif domain containing 9 3.10088
SAMD7 sterile alpha motif domain containing 7 3.10088
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.10088
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.10088
PHACTR3 phosphatase and actin regulator 3 3.10088
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 3.10088
FGF16 fibroblast growth factor 16 3.10088
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.10088
RUFY4 RUN and FYVE domain containing 4 3.10088
OR10G4 olfactory receptor, family 10, subfamily G, member 4 3.10088
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.10088
RHAG Rh-associated glycoprotein 3.10088
NUTM2A NUT family member 2A 3.10088
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.10088
BIN2 bridging integrator 2 3.10088
TBC1D21 TBC1 domain family, member 21 3.10088
C9ORF57 chromosome 9 open reading frame 57 3.10088
CD80 CD80 molecule 3.10088
APOL1 apolipoprotein L, 1 3.10088
APOL6 apolipoprotein L, 6 3.10088
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.10088
CLEC7A C-type lectin domain family 7, member A 3.10088
KCTD4 potassium channel tetramerization domain containing 4 3.10088
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.10088
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.10088
SPRN shadow of prion protein homolog (zebrafish) 3.10088
TGM6 transglutaminase 6 3.10088
ZMYND15 zinc finger, MYND-type containing 15 3.10088
TTC36 tetratricopeptide repeat domain 36 3.10088
AMER2 APC membrane recruitment protein 2 3.10088
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.10088
FIGNL1 fidgetin-like 1 3.06585
CD164L2 CD164 sialomucin-like 2 3.01958
HLA-DMB major histocompatibility complex, class II, DM beta 3.01958
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 3.01958
FBLN7 fibulin 7 3.01958
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 2.98247
AMMECR1L AMMECR1-like 2.98247
CCDC81 coiled-coil domain containing 81 2.87896
C18ORF32 chromosome 18 open reading frame 32 2.79799
PFDN5 prefoldin subunit 5 2.73111
RGPD6 RANBP2-like and GRIP domain containing 6 2.65891
PROKR1 prokineticin receptor 1 2.65891
BCAM basal cell adhesion molecule (Lutheran blood group) 2.63968
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.63552
SSC5D scavenger receptor cysteine rich family, 5 domains 2.63552
KIAA1549 KIAA1549 2.63533
PARP12 poly (ADP-ribose) polymerase family, member 12 2.53536
LRRC26 leucine rich repeat containing 26 2.50264
ZNF146 zinc finger protein 146 2.42969
STMN3 stathmin-like 3 2.40772
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.40545
WFDC1 WAP four-disulfide core domain 1 2.40545
SYCP2 synaptonemal complex protein 2 2.40545
TMTC1 transmembrane and tetratricopeptide repeat containing 1 2.39955
CCNK cyclin K 2.37349
TMEM79 transmembrane protein 79 2.36049
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 2.30566
CDK7 cyclin-dependent kinase 7 2.29597
REX1BD required for excision 1-B domain containing 2.29245
TMEM222 transmembrane protein 222 2.28114
EHD3 EH-domain containing 3 2.26887
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.26352
CEP162 centrosomal protein 162kDa 2.2467
TCEAL5 transcription elongation factor A (SII)-like 5 2.24483
MAT2A methionine adenosyltransferase II, alpha 2.23921
ZNF267 zinc finger protein 267 2.22278
EXTL3 exostosin-like glycosyltransferase 3 2.21996
OPTN optineurin 2.21935
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.20732
ANKRD50 ankyrin repeat domain 50 2.20644
MMP21 matrix metallopeptidase 21 2.20644
SPAG1 sperm associated antigen 1 2.19735
DLK1 delta-like 1 homolog (Drosophila) 2.17206
LRRC38 leucine rich repeat containing 38 2.1688
SAPCD1 suppressor APC domain containing 1 2.1688
SLA2 Src-like-adaptor 2 2.1688
GOLGA6L10 golgin A6 family-like 10 2.1688
UNC13C unc-13 homolog C (C. elegans) 2.1688
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.1688
TLR3 toll-like receptor 3 2.1688
ZNF750 zinc finger protein 750 2.1688
SP100 SP100 nuclear antigen 2.1688
TMEM47 transmembrane protein 47 2.1688
FCF1 FCF1 rRNA-processing protein 2.16772
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.16767
UBB ubiquitin B 2.16738
HACL2 2-hydroxyacyl-CoA lyase 2 2.16002
UGT8 UDP glycosyltransferase 8 2.15916
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 2.13507
SLC30A7 solute carrier family 30 (zinc transporter), member 7 2.13507
ZNF3 zinc finger protein 3 2.13299
CNIH3 cornichon family AMPA receptor auxiliary protein 3 2.12114
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 2.12114
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.07208
HAUS6 HAUS augmin-like complex, subunit 6 2.04806
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.04806
FBXO17 F-box protein 17 2.04358
FMO4 flavin containing monooxygenase 4 2.04271
UFD1 ubiquitin recognition factor in ER associated degradation 1 2.04024
FIZ1 FLT3-interacting zinc finger 1 2.03545
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2.02545
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.02263
GON7 GON7 subunit of KEOPS complex 2.02041
WNT5A wingless-type MMTV integration site family, member 5A 2.01677
SAXO2 stabilizer of axonemal microtubules 2 2.01464
COPS2 COP9 signalosome subunit 2 2.00906

decreased expression

Symbol Name Standardized Value
LIMS2 LIM and senescent cell antigen-like domains 2 -3.10088
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -3.10088
GP1BA glycoprotein Ib (platelet), alpha polypeptide -3.10088
GPRIN3 GPRIN family member 3 -3.10088
NQO2 NAD(P)H dehydrogenase, quinone 2 -3.10088
ZFPM1 zinc finger protein, FOG family member 1 -3.10088
AKR1C1 aldo-keto reductase family 1, member C1 -3.10088
IL17RC interleukin 17 receptor C -3.10088
INKA1 inka box actin regulator 1 -3.10088
H4C11 H4 clustered histone 11 -3.10088
CLCN1 chloride channel, voltage-sensitive 1 -2.98247
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.98247
TMEM184A transmembrane protein 184A -2.98247
MNX1 motor neuron and pancreas homeobox 1 -2.98247
ATP5MGL ATP synthase membrane subunit g like -2.98247
TMEM213 transmembrane protein 213 -2.98247
ANGPTL7 angiopoietin-like 7 -2.98247
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled -2.98247
CHAD chondroadherin -2.98247
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.98247
CFAP45 cilia and flagella associated protein 45 -2.98247
PRDM6 PR domain containing 6 -2.98247
SLC45A2 solute carrier family 45, member 2 -2.98247
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.98247
CCDC17 coiled-coil domain containing 17 -2.98247
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.98247
ALOX15 arachidonate 15-lipoxygenase -2.98247
ZEB2 zinc finger E-box binding homeobox 2 -2.98247
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.98247
CNTFR ciliary neurotrophic factor receptor -2.98247
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -2.98247
PLEK2 pleckstrin 2 -2.98247
FAM240C family with sequence similarity 240 member C -2.98247
HCRT hypocretin (orexin) neuropeptide precursor -2.98247
SLC25A34 solute carrier family 25, member 34 -2.98247
IL21R interleukin 21 receptor -2.98247
CLIC2 chloride intracellular channel 2 -2.98247
INSM1 insulinoma-associated 1 -2.98247
NGB neuroglobin -2.98247
PHOSPHO1 phosphatase, orphan 1 -2.98247
CREG2 cellular repressor of E1A-stimulated genes 2 -2.98247
CCNA1 cyclin A1 -2.98247
PAGE4 P antigen family, member 4 (prostate associated) -2.98247
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.98247
UPK1B uroplakin 1B -2.98247
CDC20B cell division cycle 20B -2.98247
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa -2.92393
PTPRG protein tyrosine phosphatase, receptor type, G -2.90135
DNAH1 dynein, axonemal, heavy chain 1 -2.87896
IRF7 interferon regulatory factor 7 -2.87896
WNK2 WNK lysine deficient protein kinase 2 -2.87128
H4C2 H4 clustered histone 2 -2.83651
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.82089
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.74238
BGLAP bone gamma-carboxyglutamate (gla) protein -2.58953
LOC122539214 Zinc finger protein LOC122539214 -2.56349
LOC124902694 uncharacterized LOC124902694 -2.56349
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.51762
SCRN3 secernin 3 -2.50939
XYLB xylulokinase homolog (H. influenzae) -2.49954
IFT46 intraflagellar transport 46 -2.46106
ZSWIM9 zinc finger SWIM-type containing 9 -2.42908
GLRA1 glycine receptor, alpha 1 -2.41376
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -2.41376
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') -2.41063
DNA2 DNA replication helicase/nuclease 2 -2.36396
ZFHX4 zinc finger homeobox 4 -2.32215
TSPAN14 tetraspanin 14 -2.30706
ZC3H10 zinc finger CCCH-type containing 10 -2.29597
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.29597
KLHDC7A kelch domain containing 7A -2.28388
PLAC8 placenta-specific 8 -2.23921
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -2.23921
PCP4 Purkinje cell protein 4 -2.23921
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.21527
PLPPR1 phospholipid phosphatase related 1 -2.20644
TADA1 transcriptional adaptor 1 -2.19015
SAMD8 sterile alpha motif domain containing 8 -2.19015
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.18071
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.18071
CATSPERQ catsper channel auxiliary subunit theta -2.18071
FSIP1 fibrous sheath interacting protein 1 -2.1688
FEM1B fem-1 homolog b (C. elegans) -2.1688
CLHC1 clathrin heavy chain linker domain containing 1 -2.1688
SPN sialophorin -2.16738
ZNF891 zinc finger protein 891 -2.16738
TMEM61 transmembrane protein 61 -2.16738
MRAP melanocortin 2 receptor accessory protein -2.16738
INO80 INO80 complex subunit -2.14523
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -2.11797
CRYGD crystallin, gamma D -2.10951
TESMIN testis expressed metallothionein like protein -2.09501
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 -2.08319
EHBP1L1 EH domain binding protein 1-like 1 -2.07747
ACTL6A actin-like 6A -2.0631
ELK1 ELK1, member of ETS oncogene family -2.04956
HSPA4L heat shock 70kDa protein 4-like -2.00547