SOX30 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 30|This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Apr 2015] (NCBI Entrez Gene Database, 11063)
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Genes

331 genes differentially expressed following the SOX30 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
BARX1 BARX homeobox 1 3.06752
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.06752
PCDHB13 protocadherin beta 13 3.06752
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.06752
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.06752
LRRC70 leucine rich repeat containing 70 3.06752
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.06752
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.06752
CD200R1L CD200 receptor 1-like 3.06752
ADRA1B adrenoceptor alpha 1B 3.06752
CDKN2A cyclin-dependent kinase inhibitor 2A 3.06752
LY6G5C lymphocyte antigen 6 complex, locus G5C 3.06752
PARP15 poly (ADP-ribose) polymerase family, member 15 3.06752
MTTP microsomal triglyceride transfer protein 3.06752
VWA3A von Willebrand factor A domain containing 3A 3.06752
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.06752
C1ORF146 chromosome 1 open reading frame 146 3.06752
BMX BMX non-receptor tyrosine kinase 3.06752
FNDC11 fibronectin type III domain containing 11 3.06752
CFAP157 cilia and flagella associated protein 157 3.06752
CARD9 caspase recruitment domain family, member 9 3.06752
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.06752
GLYATL1B glycine-N-acyltransferase like 1B 3.06752
TPH1 tryptophan hydroxylase 1 3.06752
FAM229A family with sequence similarity 229, member A 3.06752
SPMAP2L sperm microtubule associated protein 2 like 3.06752
PCDHAC1 protocadherin alpha subfamily C, 1 3.06752
ACOX2 acyl-CoA oxidase 2, branched chain 3.06752
R3HDML R3H domain containing-like 3.06752
PCDHB4 protocadherin beta 4 2.92922
GUCA1C guanylate cyclase activator 1C 2.92922
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.92922
NXPH3 neurexophilin 3 2.92922
NDRG1 N-myc downstream regulated 1 2.92922
SPINK4 serine peptidase inhibitor, Kazal type 4 2.92922
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.92922
TMEM212 transmembrane protein 212 2.92922
SCG2 secretogranin II 2.92922
ZSCAN5B zinc finger and SCAN domain containing 5B 2.92922
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.92922
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.92922
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.92922
RPL3L ribosomal protein L3-like 2.92922
FSCN2 fascin actin-bundling protein 2, retinal 2.92922
CRX cone-rod homeobox 2.92922
FABP12 fatty acid binding protein 12 2.92922
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.92922
S100A5 S100 calcium binding protein A5 2.92922
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.92922
SETSIP SET-like protein 2.92922
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.92922
TPSD1 tryptase delta 1 2.92922
SUSD2 sushi domain containing 2 2.92922
SH2D6 SH2 domain containing 6 2.92922
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.92922
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.92922
PAX6 paired box 6 2.92922
FAM156B family with sequence similarity 156, member B 2.92922
OLIG1 oligodendrocyte transcription factor 1 2.92922
MEI1 meiosis inhibitor 1 2.92922
CIITA class II, major histocompatibility complex, transactivator 2.92922
TRPC5OS TRPC5 opposite strand 2.92922
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.92922
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.92922
SPI1 Spi-1 proto-oncogene 2.92922
TMPRSS3 transmembrane protease, serine 3 2.92922
FOXC1 forkhead box C1 2.92922
WNT16 wingless-type MMTV integration site family, member 16 2.92922
DOK7 docking protein 7 2.92922
SPATA25 spermatogenesis associated 25 2.92922
IMPG2 interphotoreceptor matrix proteoglycan 2 2.92922
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.92922
VN1R1 vomeronasal 1 receptor 1 2.92922
PNLIPRP3 pancreatic lipase-related protein 3 2.92922
GPX5 glutathione peroxidase 5 2.92922
LOC124904542 uncharacterized LOC124904542 2.92922
H4C14 H4 clustered histone 14 2.92922
DEFB131B defensin beta 131B 2.92922
RTL9 retrotransposon Gag like 9 2.92922
GK3 glycerol kinase 3 2.92922
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.92922
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.92922
OTOF otoferlin 2.92922
YPEL4 yippee-like 4 (Drosophila) 2.92922
INSIG2 insulin induced gene 2 2.92922
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.92922
SLC22A25 solute carrier family 22, member 25 2.92922
IL31RA interleukin 31 receptor A 2.92922
MAG myelin associated glycoprotein 2.92922
MAGEB3 melanoma antigen family B3 2.92922
CDX2 caudal type homeobox 2 2.92922
ACTL10 actin-like 10 2.92922
RS1 retinoschisin 1 2.92922
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.92922
FPR2 formyl peptide receptor 2 2.92922
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.92922
GSC goosecoid homeobox 2.92922
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.92922
GATA6 GATA binding protein 6 2.92922
CNGA3 cyclic nucleotide gated channel alpha 3 2.92922
PRG4 proteoglycan 4 2.92922
ZAR1L zygote arrest 1-like 2.92922
LRRC72 leucine rich repeat containing 72 2.92922
OR2D2 olfactory receptor, family 2, subfamily D, member 2 2.92922
SAMD11 sterile alpha motif domain containing 11 2.92922
PGA4 pepsinogen 4, group I (pepsinogen A) 2.92922
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.92922
TBX20 T-box 20 2.92922
CPLX3 complexin 3 2.92922
CLRN1 clarin 1 2.92922
BLID BH3-like motif containing, cell death inducer 2.92922
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.92922
TG thyroglobulin 2.92922
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.92922
CCL22 chemokine (C-C motif) ligand 22 2.92922
LST1 leukocyte specific transcript 1 2.92922
MT1M metallothionein 1M 2.92922
TPPP2 tubulin polymerization-promoting protein family member 2 2.92922
HHIPL2 HHIP-like 2 2.92922
PTHLH parathyroid hormone-like hormone 2.92922
CLEC9A C-type lectin domain family 9, member A 2.92922
RNF224 ring finger protein 224 2.92922
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.92922
LRRC74B leucine rich repeat containing 74B 2.92922
KLK7 kallikrein-related peptidase 7 2.92922
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.92922
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.92922
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.92922
CRYBB3 crystallin, beta B3 2.92922
ADORA3 adenosine A3 receptor 2.92922
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.92922
GPR12 G protein-coupled receptor 12 2.92922
EFCAB9 EF-hand calcium binding domain 9 2.92922
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.92922
IRGC immunity-related GTPase family, cinema 2.92922
CCL27 chemokine (C-C motif) ligand 27 2.92922
EBF3 early B-cell factor 3 2.92922
SLC25A52 solute carrier family 25, member 52 2.92922
DGCR6 DiGeorge syndrome critical region gene 6 2.92922
BAHCC1 BAH domain and coiled-coil containing 1 2.92922
C17ORF99 chromosome 17 open reading frame 99 2.92922
DMRT1 doublesex and mab-3 related transcription factor 1 2.92922
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.92922
STOML3 stomatin (EPB72)-like 3 2.92922
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.92922
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.92922
STAP1 signal transducing adaptor family member 1 2.92922
ANKRD30A ankyrin repeat domain 30A 2.92922
SYT5 synaptotagmin V 2.92922
BHLHA15 basic helix-loop-helix family, member a15 2.92922
GOLGA8H golgin A8 family, member H 2.92922
SLC36A3 solute carrier family 36, member 3 2.92922
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.92922
PODN podocan 2.92922
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.92922
CCNA1 cyclin A1 2.92922
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.92922
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.92922
BCL2L15 BCL2-like 15 2.92922
CTRB1 chymotrypsinogen B1 2.92922
MAGEC3 melanoma antigen family C3 2.92922
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.92922
IL20 interleukin 20 2.92922
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.92922
TDO2 tryptophan 2,3-dioxygenase 2.92922
TGM4 transglutaminase 4 2.92922
ANGPTL3 angiopoietin-like 3 2.92922
CRTAM cytotoxic and regulatory T cell molecule 2.92922
GMPR guanosine monophosphate reductase 2.85988
ANGPTL1 angiopoietin-like 1 2.80055
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.79098
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 2.76216
DYNLT5 dynein light chain Tctex-type family member 5 2.7621
GLB1L2 galactosidase, beta 1-like 2 2.7621
STBD1 starch binding domain 1 2.70188
GCFC2 GC-rich sequence DNA-binding factor 2 2.69627
MARVELD1 MARVEL domain containing 1 2.63071
SF3A2 splicing factor 3a, subunit 2, 66kDa 2.62446
ZNF410 zinc finger protein 410 2.59827
RAD51 RAD51 recombinase 2.57116
FMC1 formation of mitochondrial complex V assembly factor 1 homolog 2.55672
DCAKD dephospho-CoA kinase domain containing 2.52608
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.49638
FAM89B family with sequence similarity 89, member B 2.49474
METTL2B methyltransferase like 2B 2.48222
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.48222
DPH1 diphthamide biosynthesis 1 2.43597
SPHKAP SPHK1 interactor, AKAP domain containing 2.43597
ASTN2 astrotactin 2 2.43597
LIF leukemia inhibitory factor 2.43597
ZHX3 zinc fingers and homeoboxes 3 2.43516
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.42477
CD37 CD37 molecule 2.40305
REPS2 RALBP1 associated Eps domain containing 2 2.39967
PAQR4 progestin and adipoQ receptor family member IV 2.39026
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 2.35766
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.34591
HILPDA hypoxia inducible lipid droplet-associated 2.33637
LBHD1 LBH domain containing 1 2.30444
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.28838
WDR88 WD repeat domain 88 2.26385
CDRT4 CMT1A duplicated region transcript 4 2.26271
TATDN1 TatD DNase domain containing 1 2.25166
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 2.24468
DNAL1 dynein, axonemal, light chain 1 2.23573
CHMP6 charged multivesicular body protein 6 2.21117
SLC35G2 solute carrier family 35, member G2 2.19237
NR2C1 nuclear receptor subfamily 2, group C, member 1 2.19237
TMEM51 transmembrane protein 51 2.17175
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.17129
RP9 retinitis pigmentosa 9 (autosomal dominant) 2.16931
SLC60A1 solute carrier family 60 member 1 2.16887
HIPK2 homeodomain interacting protein kinase 2 2.12918
MAST3 microtubule associated serine/threonine kinase 3 2.12834
USP28 ubiquitin specific peptidase 28 2.12565
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.12565
ZFP41 ZFP41 zinc finger protein 2.09448
PTGES2 prostaglandin E synthase 2 2.05729
SNRPF small nuclear ribonucleoprotein polypeptide F 2.0537
TSC1 tuberous sclerosis 1 2.04911
PURB purine-rich element binding protein B 2.03675
TMT1A thiol methyltransferase 1A 2.03675
DIAPH1 diaphanous-related formin 1 2.03263
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 2.03263
LSAMP limbic system-associated membrane protein 2.01547

decreased expression

Symbol Name Standardized Value
JOSD2 Josephin domain containing 2 -3.06752
TRIL TLR4 interactor with leucine-rich repeats -3.06752
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -3.06752
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -3.06752
SERF1A small EDRK-rich factor 1A (telomeric) -2.92922
AMDHD1 amidohydrolase domain containing 1 -2.92922
THEM6 thioesterase superfamily member 6 -2.92922
GDA guanine deaminase -2.92922
CD48 CD48 molecule -2.92922
ROM1 retinal outer segment membrane protein 1 -2.92922
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -2.92922
PSORS1C1 psoriasis susceptibility 1 candidate 1 -2.92922
MAPK11 mitogen-activated protein kinase 11 -2.92922
TMEM179 transmembrane protein 179 -2.92922
CORIN corin, serine peptidase -2.92922
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -2.92922
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.92922
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -2.92922
TDRD1 tudor domain containing 1 -2.92922
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.92922
DPPA3 developmental pluripotency associated 3 -2.92922
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.92922
AVP arginine vasopressin -2.92922
LRRC8E leucine rich repeat containing 8 family, member E -2.92922
COL19A1 collagen, type XIX, alpha 1 -2.92922
CD79B CD79b molecule, immunoglobulin-associated beta -2.92922
TEKT5 tektin 5 -2.92922
SMIM35 small integral membrane protein 35 -2.92922
DEUP1 deuterosome assembly protein 1 -2.92922
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.92922
TLNRD1 talin rod domain containing 1 -2.92922
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.92922
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.92922
HLA-DOB major histocompatibility complex, class II, DO beta -2.92922
RASD2 RASD family, member 2 -2.92922
MRAP melanocortin 2 receptor accessory protein -2.92922
MRPS16 mitochondrial ribosomal protein S16 -2.92922
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -2.92922
IL21R interleukin 21 receptor -2.92922
MAGEB17 melanoma antigen family B17 -2.92922
ZNF365 zinc finger protein 365 -2.92922
GIPR gastric inhibitory polypeptide receptor -2.92922
BBS12 Bardet-Biedl syndrome 12 -2.92922
TRAPPC12 trafficking protein particle complex 12 -2.92922
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -2.87732
GMDS GDP-mannose 4,6-dehydratase -2.84566
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.77694
ACSF3 acyl-CoA synthetase family member 3 -2.73156
IL6ST-DT IL6ST divergent transcript -2.69155
CRIP2 cysteine-rich protein 2 -2.69155
LBP lipopolysaccharide binding protein -2.69155
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -2.65101
ZNF10 zinc finger protein 10 -2.64286
BLZF1 basic leucine zipper nuclear factor 1 -2.62977
TSPAN18 tetraspanin 18 -2.59827
EIF1B eukaryotic translation initiation factor 1B -2.58738
TMEM53 transmembrane protein 53 -2.49638
WIF1 WNT inhibitory factor 1 -2.49474
METTL16 methyltransferase like 16 -2.48397
TMSB15A thymosin beta 15a -2.43646
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) -2.4307
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -2.42719
MRPL35 mitochondrial ribosomal protein L35 -2.41573
FAM111A family with sequence similarity 111, member A -2.39259
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.35838
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -2.34591
ZBED3 zinc finger, BED-type containing 3 -2.34591
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 -2.34591
AFF2 AF4/FMR2 family, member 2 -2.3124
RBM34 RNA binding motif protein 34 -2.30826
AHCTF1 AT hook containing transcription factor 1 -2.28054
CCDC186 coiled-coil domain containing 186 -2.27197
ALK anaplastic lymphoma receptor tyrosine kinase -2.27044
ZSCAN31 zinc finger and SCAN domain containing 31 -2.26385
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.26385
PNPLA2 patatin-like phospholipase domain containing 2 -2.26271
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -2.22393
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.17175
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.16487
TM6SF2 transmembrane 6 superfamily member 2 -2.16487
TXNDC9 thioredoxin domain containing 9 -2.15053
UIMC1 ubiquitin interaction motif containing 1 -2.14601
GKAP1 G kinase anchoring protein 1 -2.14249
HECA headcase homolog (Drosophila) -2.13873
USP21 ubiquitin specific peptidase 21 -2.12565
SPATA18 spermatogenesis associated 18 -2.12565
MRS2 MRS2 magnesium transporter -2.12565
IL18 interleukin 18 -2.12565
LOC124902694 uncharacterized LOC124902694 -2.12565
CYB5R2 cytochrome b5 reductase 2 -2.11394
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -2.11394
NELFA negative elongation factor complex member A -2.09256
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -2.08017
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.0743
TRAPPC2B trafficking protein particle complex 2B -2.06919
PRPF6 pre-mRNA processing factor 6 -2.0577
DAP death-associated protein -2.05729
RNF145 ring finger protein 145 -2.05394
STOML2 stomatin (EPB72)-like 2 -2.0537
DGKH diacylglycerol kinase, eta -2.0537
SOX11 SRY (sex determining region Y)-box 11 -2.04172
DZIP3 DAZ interacting zinc finger protein 3 -2.03263
CCDC86 coiled-coil domain containing 86 -2.01912
TCTN1 tectonic family member 1 -2.01912
ABHD8 abhydrolase domain containing 8 -2.01669
ZNF697 zinc finger protein 697 -2.01669