SOX4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 4|This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6659)
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Genes

323 genes differentially expressed following the SOX4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GRXCR1 glutaredoxin, cysteine rich 1 3.5679
OR10A4 olfactory receptor, family 10, subfamily A, member 4 3.5679
PDZD9 PDZ domain containing 9 3.5679
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.5679
CSTL1 cystatin-like 1 3.5679
DSG3 desmoglein 3 3.5679
PDE7B phosphodiesterase 7B 3.5679
CEP295NL CEP295 N-terminal like 3.5679
GPR22 G protein-coupled receptor 22 3.5679
ADAD2 adenosine deaminase domain containing 2 3.5679
SIRPB1 signal-regulatory protein beta 1 3.5679
HYAL4 hyaluronoglucosaminidase 4 3.5679
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.5679
NCBP2L nuclear cap binding protein subunit 2-like 3.5679
GPR75 G protein-coupled receptor 75 3.5679
TMPRSS11F transmembrane protease, serine 11F 3.5679
TREM2 triggering receptor expressed on myeloid cells 2 3.5679
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.5679
ADGRE3 adhesion G protein-coupled receptor E3 3.5679
SCN2B sodium channel, voltage gated, type II beta subunit 3.5679
SOX18 SRY (sex determining region Y)-box 18 3.5679
LYNX1 Ly6/neurotoxin 1 3.5679
ARSF arylsulfatase F 3.5679
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.5679
ASGR2 asialoglycoprotein receptor 2 3.5679
KLLN killin, p53-regulated DNA replication inhibitor 3.5679
C2ORF78 chromosome 2 open reading frame 78 3.5679
ACY3 aminoacylase 3 3.5679
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.5679
HES2 hes family bHLH transcription factor 2 3.5679
ERAP2 endoplasmic reticulum aminopeptidase 2 3.5679
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.5679
ACOT12 acyl-CoA thioesterase 12 3.5679
BFSP2 beaded filament structural protein 2, phakinin 3.5679
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.5679
BSX brain-specific homeobox 3.5679
SMIM5 small integral membrane protein 5 3.5679
ZNF229 zinc finger protein 229 3.5679
KIF2B kinesin family member 2B 3.5679
LGI1 leucine-rich, glioma inactivated 1 3.5679
S100A1 S100 calcium binding protein A1 3.5679
LRRC66 leucine rich repeat containing 66 3.5679
CRYGA crystallin, gamma A 3.5679
CYSRT1 cysteine-rich tail protein 1 3.5679
LOC107986837 uncharacterized LOC107986837 3.5679
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.5679
CCDC9B coiled-coil domain containing 9B 3.5679
HAO2 hydroxyacid oxidase 2 (long chain) 3.5679
GBP2 guanylate binding protein 2, interferon-inducible 3.5679
ZAR1 zygote arrest 1 3.5679
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.5679
HBG2 hemoglobin, gamma G 3.5679
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.5679
SPEM1 spermatid maturation 1 3.5679
SPACDR sperm acrosome developmental regulator 3.5679
H2BC3 H2B clustered histone 3 3.5679
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.5679
SPMAP1 sperm microtubule associated protein 1 3.5679
SMIM47 small integral membrane protein 47 3.5679
STRIT1 small transmembrane regulator of ion transport 1 3.5679
SRARP steroid receptor associated and regulated protein 3.5679
C20ORF204 chromosome 20 open reading frame 204 3.5679
TEX13C TEX13 family member C 3.5679
GARIN5B golgi associated RAB2 interactor family member 5B 3.5679
CHCT1 CHD1 helical C-terminal domain containing 1 3.5679
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.5679
SPRR2A small proline-rich protein 2A 3.5679
TAS1R3 taste receptor, type 1, member 3 3.5679
IL6 interleukin 6 3.5679
SCN10A sodium channel, voltage gated, type X alpha subunit 3.5679
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.5679
TEX101 testis expressed 101 3.5679
GGT5 gamma-glutamyltransferase 5 3.5679
RHOXF2 Rhox homeobox family, member 2 3.5679
CAPN11 calpain 11 3.5679
HDC histidine decarboxylase 3.5679
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.5679
HAL histidine ammonia-lyase 3.5679
SPRR2F small proline-rich protein 2F 3.5679
FAM220A family with sequence similarity 220, member A 3.5679
ZNF705D zinc finger protein 705D 3.5679
PRDM7 PR domain containing 7 3.5679
CSAG1 chondrosarcoma associated gene 1 3.5679
PRG4 proteoglycan 4 3.5679
ASIC4 acid sensing (proton gated) ion channel family member 4 3.5679
GDF6 growth differentiation factor 6 3.5679
GPR88 G protein-coupled receptor 88 3.5679
RS1 retinoschisin 1 3.5679
KRTAP13-4 keratin associated protein 13-4 3.5679
CFP complement factor properdin 3.5679
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.5679
KISS1 KiSS-1 metastasis-suppressor 3.5679
IL1B interleukin 1, beta 3.5679
TRIM55 tripartite motif containing 55 3.5679
MAB21L1 mab-21-like 1 (C. elegans) 3.5679
TRADD TNFRSF1A-associated via death domain 3.5679
ADAM7 ADAM metallopeptidase domain 7 3.5679
GOLGA6B golgin A6 family, member B 3.5679
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.5679
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.5679
SCML4 sex comb on midleg-like 4 (Drosophila) 3.5679
CXCR6 chemokine (C-X-C motif) receptor 6 3.5679
EFCAB9 EF-hand calcium binding domain 9 3.5679
LCT lactase 3.5679
TCEA3 transcription elongation factor A (SII), 3 3.5679
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.5679
ECM1 extracellular matrix protein 1 3.5679
FBXO47 F-box protein 47 3.5679
SIRPG signal-regulatory protein gamma 3.5679
LRRC24 leucine rich repeat containing 24 3.5679
GOLGA8R golgin A8 family, member R 3.5679
TEX26 testis expressed 26 3.5679
NPY2R neuropeptide Y receptor Y2 3.5679
GJB6 gap junction protein, beta 6, 30kDa 3.5679
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.5679
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 3.5679
TSPAN19 tetraspanin 19 3.5679
MSMP microseminoprotein, prostate associated 3.5679
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 3.5679
RBBP8NL RBBP8 N-terminal like 3.5679
TAGAP T-cell activation RhoGTPase activating protein 3.5679
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.5679
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.5679
EBF2 early B-cell factor 2 3.5679
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.5679
FSHR follicle stimulating hormone receptor 3.5679
FZD1 frizzled class receptor 1 3.5679
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.5679
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.5679
BOD1L2 biorientation of chromosomes in cell division 1-like 2 3.5679
GLTPD2 glycolipid transfer protein domain containing 2 3.5679
TUBAL3 tubulin, alpha-like 3 3.5679
FCAR Fc fragment of IgA receptor 3.5679
CLCNKA chloride channel, voltage-sensitive Ka 3.5679
C4BPA complement component 4 binding protein, alpha 3.5679
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.5679
TGM3 transglutaminase 3 3.5679
MMEL1 membrane metallo-endopeptidase-like 1 3.5679
C17ORF78 chromosome 17 open reading frame 78 3.5679
MST1 macrophage stimulating 1 3.5679
NUTM2D NUT family member 2D 3.5679
FABP12 fatty acid binding protein 12 3.5679
SLITRK6 SLIT and NTRK-like family, member 6 3.5679
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.5679
CD22 CD22 molecule 3.5679
R3HDML R3H domain containing-like 3.5679
PRR15L proline rich 15-like 3.5679
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 3.49299
EXTL1 exostosin-like glycosyltransferase 1 3.49299
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 3.40679
RYR2 ryanodine receptor 2 (cardiac) 3.27761
HTRA1 HtrA serine peptidase 1 2.99974
GAL galanin/GMAP prepropeptide 2.86092
BRMS1L breast cancer metastasis-suppressor 1-like 2.83865
CHRM3 cholinergic receptor, muscarinic 3 2.83835
TMEM127 transmembrane protein 127 2.81992
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.79356
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.77664
ZNF408 zinc finger protein 408 2.75027
SNX25 sorting nexin 25 2.74578
PGAM5 phosphoglycerate mutase family member 5 2.72359
NHSL3 NHS like 3 2.72359
SYT17 synaptotagmin XVII 2.72328
TMEM165 transmembrane protein 165 2.72328
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 2.69969
GET1 guided entry of tail-anchored proteins factor 1 2.69212
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.67207
CELF2 CUGBP, Elav-like family member 2 2.65212
NRP1 neuropilin 1 2.60821
LRRC55 leucine rich repeat containing 55 2.58067
TLR3 toll-like receptor 3 2.58067
ZEB2 zinc finger E-box binding homeobox 2 2.58067
SYT15B synaptotagmin 15B 2.58067
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.58067
LCN2 lipocalin 2 2.58067
UBE2A ubiquitin-conjugating enzyme E2A 2.58067
TP63 tumor protein p63 2.58067
CCNI2 cyclin I family, member 2 2.58067
CD226 CD226 molecule 2.58067
WDR43 WD repeat domain 43 2.55609
ZMYM2 zinc finger, MYM-type 2 2.51779
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.49907
CTSZ cathepsin Z 2.48781
PES1 pescadillo ribosomal biogenesis factor 1 2.45303
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 2.43173
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 2.40747
DAP3 death associated protein 3 2.3874
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 2.37588
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 2.36652
MTFR1L mitochondrial fission regulator 1-like 2.35388
PLD1 phospholipase D1, phosphatidylcholine-specific 2.35173
TMEM106C transmembrane protein 106C 2.34421
WFDC3 WAP four-disulfide core domain 3 2.32311
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 2.32044
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.31108
MYO9A myosin IXA 2.28622
C5ORF34 chromosome 5 open reading frame 34 2.28355
ZNF391 zinc finger protein 391 2.2768
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.27391
TRPC5OS TRPC5 opposite strand 2.27391
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 2.27391
MTMR6 myotubularin related protein 6 2.25814
PRXL2C peroxiredoxin like 2C 2.23825
GRB10 growth factor receptor-bound protein 10 2.21323
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 2.21323
SCO2 SCO2 cytochrome c oxidase assembly protein 2.20572
FER fer (fps/fes related) tyrosine kinase 2.19669
ALK anaplastic lymphoma receptor tyrosine kinase 2.19543
KBTBD6 kelch repeat and BTB (POZ) domain containing 6 2.16815
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 2.16815
PF4 platelet factor 4 2.15499
RBM10 RNA binding motif protein 10 2.13134
PCNX3 pecanex 3 2.11495
ZNF185 zinc finger protein 185 (LIM domain) 2.10854
AVPI1 arginine vasopressin-induced 1 2.10854
USP8 ubiquitin specific peptidase 8 2.09562
FCF1 FCF1 rRNA-processing protein 2.08612
DKC1 dyskeratosis congenita 1, dyskerin 2.051
SHROOM4 shroom family member 4 2.0336
SOX10 SRY (sex determining region Y)-box 10 2.03146
FZD5 frizzled class receptor 5 2.03123
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III 2.02
NT5C2 5'-nucleotidase, cytosolic II 2.01975
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.01048
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 2.0084
NSF N-ethylmaleimide-sensitive factor 2.00657

decreased expression

Symbol Name Standardized Value
SPATS2L spermatogenesis associated, serine-rich 2-like -3.5679
PLA2G10 phospholipase A2, group X -3.5679
STXBP3 syntaxin binding protein 3 -3.5679
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -3.5679
CD164L2 CD164 sialomucin-like 2 -3.5679
MSX1 msh homeobox 1 -3.49299
OR8D4 olfactory receptor, family 8, subfamily D, member 4 -3.49299
LPAR5 lysophosphatidic acid receptor 5 -3.49299
PRB2 proline-rich protein BstNI subfamily 2 -3.49299
FAM131C family with sequence similarity 131, member C -3.49299
WFDC6 WAP four-disulfide core domain 6 -3.49299
HKDC1 hexokinase domain containing 1 -3.49299
RBM44 RNA binding motif protein 44 -3.49299
WNT4 wingless-type MMTV integration site family, member 4 -3.49299
EGR2 early growth response 2 -3.49299
BHLHE40 basic helix-loop-helix family, member e40 -3.49299
MTTP microsomal triglyceride transfer protein -3.49299
ENKUR enkurin, TRPC channel interacting protein -3.49299
GYS2 glycogen synthase 2 (liver) -3.49299
FBXO48 F-box protein 48 -3.38025
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 -3.23327
TMSB15A thymosin beta 15a -3.22769
TEX10 testis expressed 10 -3.05081
P3H3 prolyl 3-hydroxylase 3 -3.03464
FANCA Fanconi anemia, complementation group A -2.96246
TEDC1 tubulin epsilon and delta complex 1 -2.87115
ERGIC3 ERGIC and golgi 3 -2.86092
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.85918
PIKFYVE phosphoinositide kinase, FYVE finger containing -2.7709
ALG11 ALG11, alpha-1,2-mannosyltransferase -2.75257
ZNF350 zinc finger protein 350 -2.62762
SOX4 SRY (sex determining region Y)-box 4 -2.61438
TRERF1 transcriptional regulating factor 1 -2.58067
NKD1 naked cuticle homolog 1 (Drosophila) -2.58067
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -2.55609
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -2.53446
MARCKS myristoylated alanine-rich protein kinase C substrate -2.497
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -2.49402
CEP295 centrosomal protein 295kDa -2.49113
ZNF836 zinc finger protein 836 -2.44361
GPS1 G protein pathway suppressor 1 -2.44271
SNCAIP synuclein, alpha interacting protein -2.44271
ELK1 ELK1, member of ETS oncogene family -2.41488
CENPV centromere protein V -2.3974
ZBTB22 zinc finger and BTB domain containing 22 -2.39263
ERICH1 glutamate-rich 1 -2.36731
ZNF488 zinc finger protein 488 -2.36652
TMEM17 transmembrane protein 17 -2.3541
DENND2D DENN/MADD domain containing 2D -2.3541
SPATA32 spermatogenesis associated 32 -2.3541
CCDC159 coiled-coil domain containing 159 -2.3541
PTGFRN prostaglandin F2 receptor inhibitor -2.35318
CCNI cyclin I -2.34331
CADPS Ca++-dependent secretion activator -2.34011
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.32282
SEPTIN3 septin 3 -2.31983
VCF1 VCP nuclear cofactor family member 1 -2.31936
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.31936
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.30983
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa -2.30939
ARV1 ARV1 homolog (S. cerevisiae) -2.30053
CCDC191 coiled-coil domain containing 191 -2.29652
ACSF3 acyl-CoA synthetase family member 3 -2.27391
B9D2 B9 protein domain 2 -2.27391
PSIP1 PC4 and SFRS1 interacting protein 1 -2.26431
CSDE1 cold shock domain containing E1, RNA-binding -2.26366
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.25814
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -2.25552
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.25552
H3C1 H3 clustered histone 1 -2.21323
IDNK idnK, gluconokinase homolog (E. coli) -2.19669
OLFM2 olfactomedin 2 -2.18219
SLC26A11 solute carrier family 26 (anion exchanger), member 11 -2.16862
AGBL5 ATP/GTP binding protein-like 5 -2.16815
KLF10 Kruppel-like factor 10 -2.16496
PARP4 poly (ADP-ribose) polymerase family, member 4 -2.16481
ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog -2.16268
USP15 ubiquitin specific peptidase 15 -2.14847
NAIP NLR family, apoptosis inhibitory protein -2.14321
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -2.14132
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.1394
GSTP1 glutathione S-transferase pi 1 -2.1328
TMSB10 thymosin beta 10 -2.1328
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -2.12423
CAPG capping protein (actin filament), gelsolin-like -2.12409
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -2.12409
RSBN1 round spermatid basic protein 1 -2.12145
SLF2 SMC5-SMC6 complex localization factor 2 -2.12145
STAT5B signal transducer and activator of transcription 5B -2.11028
ZNF554 zinc finger protein 554 -2.09562
DDAH2 dimethylarginine dimethylaminohydrolase 2 -2.0951
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) -2.09473
CCDC126 coiled-coil domain containing 126 -2.07428
KIF4A kinesin family member 4A -2.0625
TMEM63B transmembrane protein 63B -2.04631
TOGARAM1 TOG array regulator of axonemal microtubules 1 -2.03123
KLHL24 kelch-like family member 24 -2.03123