SOX6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 6|This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 55553)
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Genes

362 genes differentially expressed following the SOX6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ALKAL1 ALK and LTK ligand 1 3.25358
C18ORF63 chromosome 18 open reading frame 63 3.25358
MORN5 MORN repeat containing 5 3.25358
CLDN14 claudin 14 3.25358
PRR35 proline rich 35 3.25358
CD300LF CD300 molecule-like family member f 3.25358
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 3.25358
SLC25A45 solute carrier family 25, member 45 3.25358
HOPX HOP homeobox 3.25358
DRICH1 aspartate-rich 1 3.25358
NPAS4 neuronal PAS domain protein 4 3.25358
GPR87 G protein-coupled receptor 87 3.25358
LRCOL1 leucine rich colipase-like 1 3.25358
MUC1 mucin 1, cell surface associated 3.25358
LRRC74B leucine rich repeat containing 74B 3.25358
PRG4 proteoglycan 4 3.25358
AMIGO3 adhesion molecule with Ig-like domain 3 3.25358
CFAP97D2 CFAP97 domain containing 2 3.25358
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.25358
HNF1A HNF1 homeobox A 3.25358
WAS Wiskott-Aldrich syndrome 3.25358
MYO16 myosin XVI 3.25358
ACSS1 acyl-CoA synthetase short-chain family member 1 3.25358
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.21902
PCDHA3 protocadherin alpha 3 3.21902
IRF5 interferon regulatory factor 5 3.21902
TEX101 testis expressed 101 3.21902
WDR87 WD repeat domain 87 3.21902
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.21902
NAPSA napsin A aspartic peptidase 3.21902
SBK3 SH3 domain binding kinase family, member 3 3.21902
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.21902
CDH5 cadherin 5, type 2 (vascular endothelium) 3.21902
FOLR1 folate receptor 1 (adult) 3.21902
EQTN equatorin, sperm acrosome associated 3.21902
CFAP74 cilia and flagella associated protein 74 3.21902
BTN3A3 butyrophilin, subfamily 3, member A3 3.21902
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.21902
SIRPB1 signal-regulatory protein beta 1 3.21902
SLC46A2 solute carrier family 46, member 2 3.21902
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.21902
OCM2 oncomodulin 2 3.21902
F2 coagulation factor II (thrombin) 3.21902
C8ORF74 chromosome 8 open reading frame 74 3.21902
OC90 otoconin 90 3.21902
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.21902
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.21902
GNRHR gonadotropin-releasing hormone receptor 3.21902
HBZ hemoglobin, zeta 3.21902
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.21902
RGL4 ral guanine nucleotide dissociation stimulator-like 4 3.21902
TRPV3 transient receptor potential cation channel, subfamily V, member 3 3.21902
SPINK6 serine peptidase inhibitor, Kazal type 6 3.21902
FGL2 fibrinogen-like 2 3.21902
CELA3A chymotrypsin-like elastase family, member 3A 3.21902
HES3 hes family bHLH transcription factor 3 3.21902
NPIPA3 nuclear pore complex interacting protein family, member A3 3.21902
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.21902
GFAP glial fibrillary acidic protein 3.21902
GIMAP4 GTPase, IMAP family member 4 3.21902
HCRTR2 hypocretin (orexin) receptor 2 3.21902
TREML2 triggering receptor expressed on myeloid cells-like 2 3.21902
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.21902
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.21902
PLAAT4 phospholipase A and acyltransferase 4 3.21902
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.21902
SMIM40 small integral membrane protein 40 3.21902
TMEM275 transmembrane protein 275 3.21902
VSIR V-set immunoregulatory receptor 3.21902
RHCE Rh blood group, CcEe antigens 3.21902
SPRR2F small proline-rich protein 2F 3.21902
SMLR1 small leucine-rich protein 1 3.21902
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.21902
ACOD1 aconitate decarboxylase 1 3.21902
TAFA3 TAFA chemokine like family member 3 3.21902
CATSPERH catsper channel auxiliary subunit eta 3.21902
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.21902
SPEGNB SPEG neighbor 3.21902
DPEP2NB DPEP2 neighbor 3.21902
LOC128125822 uncharacterized LOC128125822 3.21902
ZNF593OS ZNF593 opposite strand 3.21902
MYMK myomaker, myoblast fusion factor 3.21902
CLEC20A C-type lectin domain containing 20A 3.21902
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.21902
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.21902
TREX2 three prime repair exonuclease 2 3.21902
TMEM190 transmembrane protein 190 3.21902
GC group-specific component (vitamin D binding protein) 3.21902
RASAL3 RAS protein activator like 3 3.21902
PRR18 proline rich 18 3.21902
SLAMF7 SLAM family member 7 3.21902
BHLHA9 basic helix-loop-helix family, member a9 3.21902
GDF6 growth differentiation factor 6 3.21902
TLR4 toll-like receptor 4 3.21902
OVOL3 ovo-like zinc finger 3 3.21902
CATSPER3 cation channel, sperm associated 3 3.21902
SCN10A sodium channel, voltage gated, type X alpha subunit 3.21902
DAO D-amino-acid oxidase 3.21902
NPFF neuropeptide FF-amide peptide precursor 3.21902
GJD3 gap junction protein, delta 3, 31.9kDa 3.21902
DOK2 docking protein 2, 56kDa 3.21902
RAB36 RAB36, member RAS oncogene family 3.21902
FAM228A family with sequence similarity 228, member A 3.21902
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.21902
DLK2 delta-like 2 homolog (Drosophila) 3.21902
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.21902
FRK fyn-related Src family tyrosine kinase 3.21902
TAS1R1 taste receptor, type 1, member 1 3.21902
FGFBP2 fibroblast growth factor binding protein 2 3.21902
CCR1 chemokine (C-C motif) receptor 1 3.21902
ITK IL2-inducible T-cell kinase 3.21902
CRYGN crystallin, gamma N 3.21902
PRRX1 paired related homeobox 1 3.21902
AKR1B15 aldo-keto reductase family 1, member B15 3.21902
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 3.21902
NIM1K NIM1 serine/threonine protein kinase 3.21902
MRLN myoregulin 3.21902
HHATL hedgehog acyltransferase-like 3.21902
DPRX divergent-paired related homeobox 3.21902
CXCR5 chemokine (C-X-C motif) receptor 5 3.21902
CPSF4L cleavage and polyadenylation specific factor 4-like 3.21902
OR10R2 olfactory receptor, family 10, subfamily R, member 2 3.21902
ADAM2 ADAM metallopeptidase domain 2 3.21902
OAZ3 ornithine decarboxylase antizyme 3 3.21902
CCDC154 coiled-coil domain containing 154 3.21902
PCDHGB2 protocadherin gamma subfamily B, 2 3.21902
PRR15L proline rich 15-like 3.21902
PRAM1 PML-RARA regulated adaptor molecule 1 3.21902
PTGDR prostaglandin D2 receptor (DP) 3.21902
DBX2 developing brain homeobox 2 3.21902
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.21902
AGR2 anterior gradient 2 3.21902
ZNF679 zinc finger protein 679 3.21902
SPRN shadow of prion protein homolog (zebrafish) 3.21902
ERMN ermin, ERM-like protein 3.21902
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.21902
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.21902
C10ORF71 chromosome 10 open reading frame 71 3.21902
SPATA4 spermatogenesis associated 4 3.21902
RGS4 regulator of G-protein signaling 4 3.21902
QRFP pyroglutamylated RFamide peptide 3.21902
DEFB136 defensin, beta 136 3.21902
MYADML2 myeloid-associated differentiation marker-like 2 3.21902
OPTC opticin 3.21902
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.21902
FAM151A family with sequence similarity 151, member A 3.21902
C10ORF105 chromosome 10 open reading frame 105 3.21902
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.21902
CLEC18A C-type lectin domain family 18, member A 3.21902
PLA2G5 phospholipase A2, group V 3.21902
SDS serine dehydratase 3.21902
PRH2 proline-rich protein HaeIII subfamily 2 3.21902
APOC2 apolipoprotein C-II 3.21902
CLEC4C C-type lectin domain family 4, member C 3.21902
TRIM50 tripartite motif containing 50 3.21902
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.21902
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.21902
PRSS50 protease, serine, 50 3.21902
CCDC185 coiled-coil domain containing 185 3.21902
TEX12 testis expressed 12 3.21902
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.21902
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.21902
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.21902
NICN1 nicolin 1 3.21902
CARD9 caspase recruitment domain family, member 9 3.21902
ZNF534 zinc finger protein 534 3.21902
PITX2 paired-like homeodomain 2 3.21902
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.21902
IL33 interleukin 33 3.21902
MSMB microseminoprotein, beta- 3.21902
MAGEC3 melanoma antigen family C3 3.21902
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.21902
APOL3 apolipoprotein L, 3 3.21902
CHAT choline O-acetyltransferase 3.21902
SLC51B solute carrier family 51, beta subunit 3.21902
SNTN sentan, cilia apical structure protein 3.21902
LPA lipoprotein, Lp(a) 3.21902
DMRTC2 DMRT-like family C2 3.21902
PSD2 pleckstrin and Sec7 domain containing 2 3.21902
FXYD3 FXYD domain containing ion transport regulator 3 3.21902
TAS2R41 taste receptor, type 2, member 41 3.21902
TBATA thymus, brain and testes associated 3.21902
ERP27 endoplasmic reticulum protein 27 3.21902
PRDM12 PR domain containing 12 3.21902
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.21902
LDHC lactate dehydrogenase C 3.21902
KRTAP5-2 keratin associated protein 5-2 3.21902
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.21902
EBI3 Epstein-Barr virus induced 3 3.21902
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.21902
SPAG6 sperm associated antigen 6 3.21902
DAND5 DAN domain family member 5, BMP antagonist 3.21902
PF4V1 platelet factor 4 variant 1 3.21902
AOC1 amine oxidase, copper containing 1 3.21902
PADI2 peptidyl arginine deiminase, type II 3.11089
OR52A1 olfactory receptor, family 52, subfamily A, member 1 3.11089
ZNF668 zinc finger protein 668 2.87081
RCL1 RNA terminal phosphate cyclase-like 1 2.86683
ACOT6 acyl-CoA thioesterase 6 2.85325
TMF1 TATA element modulatory factor 1 2.79904
PPCS phosphopantothenoylcysteine synthetase 2.70407
IPCEF1 interaction protein for cytohesin exchange factors 1 2.58122
ZSWIM5 zinc finger, SWIM-type containing 5 2.56264
ITGB5 integrin, beta 5 2.55424
SPAG16 sperm associated antigen 16 2.53771
SLC30A6 solute carrier family 30 (zinc transporter), member 6 2.52868
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.52235
PNPLA8 patatin-like phospholipase domain containing 8 2.47794
HRH1 histamine receptor H1 2.471
ZNF582 zinc finger protein 582 2.45843
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 2.43813
MTMR11 myotubularin related protein 11 2.41329
ESR1 estrogen receptor 1 2.41329
CHD4 chromodomain helicase DNA binding protein 4 2.38719
MACIR macrophage immunometabolism regulator 2.36011
IFT43 intraflagellar transport 43 2.32556
ADRA2A adrenoceptor alpha 2A 2.31724
TMT1B thiol methyltransferase 1B 2.31219
ACAD11 acyl-CoA dehydrogenase family, member 11 2.30497
FBXO5 F-box protein 5 2.26548
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 2.24499
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.22169
ZNF583 zinc finger protein 583 2.19798
EDARADD EDAR-associated death domain 2.18567
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 2.18567
FMNL3 formin-like 3 2.15949
ZFP14 ZFP14 zinc finger protein 2.15748
SHROOM2 shroom family member 2 2.14813
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 2.11934
KATNAL1 katanin p60 subunit A-like 1 2.1169
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 2.11548
HSPA1B heat shock 70kDa protein 1B 2.10928
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.1011
ATF7 activating transcription factor 7 2.1011
EML6 echinoderm microtubule associated protein like 6 2.09802
SIRT4 sirtuin 4 2.08524
MIA melanoma inhibitory activity 2.08524
LRRK2 leucine-rich repeat kinase 2 2.08524
GPS1 G protein pathway suppressor 1 2.08524
SCARF1 scavenger receptor class F, member 1 2.08524
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 2.08524
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 2.08524
KYNU kynureninase 2.08524
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.06841
SEC62 SEC62 homolog (S. cerevisiae) 2.06841
CNOT7 CCR4-NOT transcription complex, subunit 7 2.05904
IKBIP IKBKB interacting protein 2.05883
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.04822
PTPRE protein tyrosine phosphatase, receptor type, E 2.0447
SPRY4 sprouty homolog 4 (Drosophila) 2.0447
CSDE1 cold shock domain containing E1, RNA-binding 2.01908
WDTC1 WD and tetratricopeptide repeats 1 2.00988

decreased expression

Symbol Name Standardized Value
HPD 4-hydroxyphenylpyruvate dioxygenase -3.25358
ZNF404 zinc finger protein 404 -3.25358
ACSL6 acyl-CoA synthetase long-chain family member 6 -3.25358
H4C1 H4 clustered histone 1 -3.25358
GYS2 glycogen synthase 2 (liver) -3.25358
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -3.25358
TRIM17 tripartite motif containing 17 -3.25358
TP73 tumor protein p73 -3.25358
CCDC144A coiled-coil domain containing 144A -3.25358
SIM2 single-minded family bHLH transcription factor 2 -3.21902
PCDHA4 protocadherin alpha 4 -3.21902
PRSS22 protease, serine, 22 -3.21902
VPREB3 pre-B lymphocyte 3 -3.21902
PCDHB12 protocadherin beta 12 -3.21902
C17ORF78 chromosome 17 open reading frame 78 -3.21902
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -3.21902
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -3.21902
FIMP1 fertilization-influencing membrane protein 1 -3.21902
VWC2 von Willebrand factor C domain containing 2 -3.21902
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -3.21902
SLC35D3 solute carrier family 35, member D3 -3.21902
TCP11L2 t-complex 11, testis-specific-like 2 -3.21902
ERAS ES cell expressed Ras -3.21902
TMEM237 transmembrane protein 237 -3.21902
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -3.21902
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -3.21902
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -3.21902
MPL MPL proto-oncogene, thrombopoietin receptor -3.21902
IZUMO2 IZUMO family member 2 -3.21902
ZNF804B zinc finger protein 804B -3.21902
F5 coagulation factor V (proaccelerin, labile factor) -3.21902
C6ORF163 chromosome 6 open reading frame 163 -3.21902
TMEM209 transmembrane protein 209 -3.21902
C19ORF85 chromosome 19 open reading frame 85 -3.21902
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -3.21902
RTBDN retbindin -3.21902
FLRT3 fibronectin leucine rich transmembrane protein 3 -3.21902
MR1 major histocompatibility complex, class I-related -3.21902
TMEM132D transmembrane protein 132D -3.21902
MYORG myogenesis regulating glycosidase (putative) -3.21902
PRSS51 protease, serine, 51 -3.21902
CELA2B chymotrypsin-like elastase family, member 2B -3.21902
RINL Ras and Rab interactor-like -3.21902
PYY peptide YY -3.21902
CLEC4G C-type lectin domain family 4, member G -3.21902
PNPLA7 patatin-like phospholipase domain containing 7 -3.15242
CCDC159 coiled-coil domain containing 159 -3.15242
RGS2 regulator of G-protein signaling 2 -3.14296
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -3.01301
CPA6 carboxypeptidase A6 -2.92995
IFT70A intraflagellar transport 70A -2.76151
ZMPSTE24 zinc metallopeptidase STE24 -2.75324
C4ORF36 chromosome 4 open reading frame 36 -2.65677
SLC25A35 solute carrier family 25, member 35 -2.65677
ALKAL2 ALK and LTK ligand 2 -2.65401
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -2.61803
COL6A6 collagen, type VI, alpha 6 -2.59275
CFAP144 cilia and flagella associated protein 144 -2.59275
H3C1 H3 clustered histone 1 -2.59275
FGF20 fibroblast growth factor 20 -2.59275
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -2.59132
MRPL22 mitochondrial ribosomal protein L22 -2.59132
ZNF682 zinc finger protein 682 -2.58122
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 -2.57801
LPAR1 lysophosphatidic acid receptor 1 -2.52235
TMEM198 transmembrane protein 198 -2.49907
MFSD8 major facilitator superfamily domain containing 8 -2.45843
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.43745
ADAR adenosine deaminase, RNA-specific -2.42156
RAP2A RAP2A, member of RAS oncogene family -2.39349
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.37236
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.33452
PIAS2 protein inhibitor of activated STAT, 2 -2.27463
TTC23 tetratricopeptide repeat domain 23 -2.26883
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.26302
PGAM2 phosphoglycerate mutase 2 (muscle) -2.24781
LAT linker for activation of T cells -2.24781
ZNF880 zinc finger protein 880 -2.22169
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -2.22157
CYB561 cytochrome b561 -2.19798
PEX13 peroxisomal biogenesis factor 13 -2.19266
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -2.18907
VSTM2B V-set and transmembrane domain containing 2B -2.18567
CLDN15 claudin 15 -2.18567
RPL5 ribosomal protein L5 -2.16485
SLC66A3 solute carrier family 66 member 3 -2.16206
MTMR7 myotubularin related protein 7 -2.15949
RASAL1 RAS protein activator like 1 (GAP1 like) -2.15748
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.15748
ZIC1 Zic family member 1 -2.15748
CHIC2 cysteine-rich hydrophobic domain 2 -2.12765
CENPV centromere protein V -2.11912
DPPA4 developmental pluripotency associated 4 -2.11548
ITPKB inositol-trisphosphate 3-kinase B -2.11548
PPAN peter pan homolog (Drosophila) -2.10928
IGSF1 immunoglobulin superfamily, member 1 -2.10254
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -2.1011
IDNK idnK, gluconokinase homolog (E. coli) -2.09746
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.08941
CCDC86 coiled-coil domain containing 86 -2.08524
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 -2.08524
BOLA3 bolA family member 3 -2.08524
RPS20 ribosomal protein S20 -2.06841
TPM1 tropomyosin 1 (alpha) -2.05314
FKBP7 FK506 binding protein 7 -2.03398
MCEE methylmalonyl CoA epimerase -2.02482
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) -2.01751
ERCC6L2 excision repair cross-complementation group 6-like 2 -2.01751
MXRA8 matrix-remodelling associated 8 -2.01299
TBC1D32 TBC1 domain family, member 32 -2.0061