SOX7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 7|This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 83595)
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Genes

281 genes differentially expressed following the SOX7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CNGB1 cyclic nucleotide gated channel beta 1 2.52509
EFCC1 EF-hand and coiled-coil domain containing 1 2.52509
PRSS54 protease, serine, 54 2.52509
LOXHD1 lipoxygenase homology domains 1 2.52509
BLNK B-cell linker 2.52509
CLEC4G C-type lectin domain family 4, member G 2.52509
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.52509
EPX eosinophil peroxidase 2.52509
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.52509
SLC25A41 solute carrier family 25, member 41 2.52509
BCAN brevican 2.52509
LCNL1 lipocalin-like 1 2.52509
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.52509
PRRX1 paired related homeobox 1 2.52509
ZNF541 zinc finger protein 541 2.52509
MAG myelin associated glycoprotein 2.52509
TMEM184A transmembrane protein 184A 2.52509
KLHL34 kelch-like family member 34 2.5078
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.5078
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.5078
SCGB3A1 secretoglobin, family 3A, member 1 2.5078
PRELP proline/arginine-rich end leucine-rich repeat protein 2.5078
CD274 CD274 molecule 2.5078
SPINK4 serine peptidase inhibitor, Kazal type 4 2.5078
DUXB double homeobox B 2.5078
TMPRSS11A transmembrane protease, serine 11A 2.5078
HLF hepatic leukemia factor 2.5078
CLEC12A C-type lectin domain family 12, member A 2.5078
RASL10A RAS-like, family 10, member A 2.5078
FAM180B family with sequence similarity 180, member B 2.5078
DEGS1 delta(4)-desaturase, sphingolipid 1 2.5078
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.5078
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.5078
AVP arginine vasopressin 2.5078
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.5078
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.5078
FAM216B family with sequence similarity 216, member B 2.5078
RFX6 regulatory factor X, 6 2.5078
CD69 CD69 molecule 2.5078
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.5078
HAS1 hyaluronan synthase 1 2.5078
SLC9C2 solute carrier family 9, member C2 (putative) 2.5078
TAL1 T-cell acute lymphocytic leukemia 1 2.5078
OLFM4 olfactomedin 4 2.5078
TECTB tectorin beta 2.5078
PROB1 proline-rich basic protein 1 2.5078
CCNB3 cyclin B3 2.5078
TMEM132C transmembrane protein 132C 2.5078
ISM2 isthmin 2 2.5078
C15ORF62 chromosome 15 open reading frame 62 2.5078
KHDC1L KH homology domain containing 1-like 2.5078
ASB5 ankyrin repeat and SOCS box containing 5 2.5078
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.5078
LOC124900192 uncharacterized LOC124900192 2.5078
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.5078
MLN motilin 2.5078
SRGN serglycin 2.5078
SPEM1 spermatid maturation 1 2.5078
BNC1 basonuclin 1 2.5078
CLDN16 claudin 16 2.5078
MCHR1 melanin-concentrating hormone receptor 1 2.5078
DERPC DERPC proline and glycine rich nuclear protein 2.5078
CCN3 cellular communication network factor 3 2.5078
C1ORF232 chromosome 1 open reading frame 230 2.5078
TEX53 testis expressed 53 2.5078
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.5078
KL klotho 2.5078
SOAT2 sterol O-acyltransferase 2 2.5078
LIPK lipase, family member K 2.5078
MAGEB3 melanoma antigen family B3 2.5078
CALCA calcitonin-related polypeptide alpha 2.5078
TMEM236 transmembrane protein 236 2.5078
TMCO2 transmembrane and coiled-coil domains 2 2.5078
TLR7 toll-like receptor 7 2.5078
TPTE transmembrane phosphatase with tensin homology 2.5078
PRRT4 proline-rich transmembrane protein 4 2.5078
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.5078
SPDYC speedy/RINGO cell cycle regulator family member C 2.5078
PRR4 proline rich 4 (lacrimal) 2.5078
OSGEP O-sialoglycoprotein endopeptidase 2.5078
FGFBP2 fibroblast growth factor binding protein 2 2.5078
LGSN lengsin, lens protein with glutamine synthetase domain 2.5078
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.5078
PRG4 proteoglycan 4 2.5078
SPMIP9 sperm microtubule inner protein 9 2.5078
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.5078
PRPH peripherin 2.5078
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.5078
TAT tyrosine aminotransferase 2.5078
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.5078
TRIM55 tripartite motif containing 55 2.5078
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.5078
TPSB2 tryptase beta 2 (gene/pseudogene) 2.5078
WFDC8 WAP four-disulfide core domain 8 2.5078
S100Z S100 calcium binding protein Z 2.5078
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.5078
THTPA thiamine triphosphatase 2.5078
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.5078
CST7 cystatin F (leukocystatin) 2.5078
EXTL1 exostosin-like glycosyltransferase 1 2.5078
RGSL1 regulator of G-protein signaling like 1 2.5078
CT55 cancer/testis antigen 55 2.5078
SVOP SV2 related protein homolog (rat) 2.5078
OCM oncomodulin 2.5078
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.5078
BHLHA15 basic helix-loop-helix family, member a15 2.5078
TMEM255A transmembrane protein 255A 2.5078
DRC1 dynein regulatory complex subunit 1 2.5078
ADAM18 ADAM metallopeptidase domain 18 2.5078
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.5078
MYADML2 myeloid-associated differentiation marker-like 2 2.5078
C1ORF105 chromosome 1 open reading frame 105 2.5078
NYX nyctalopin 2.5078
PFN3 profilin 3 2.5078
LHX5 LIM homeobox 5 2.5078
NOBOX NOBOX oogenesis homeobox 2.5078
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.5078
CD200R1 CD200 receptor 1 2.5078
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.5078
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.5078
TMEM132D transmembrane protein 132D 2.5078
NLRP5 NLR family, pyrin domain containing 5 2.5078
ANGPTL5 angiopoietin-like 5 2.5078
SLC7A4 solute carrier family 7, member 4 2.5078
SLITRK4 SLIT and NTRK-like family, member 4 2.5078
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.5078
LRRC31 leucine rich repeat containing 31 2.5078
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.5078
IL17B interleukin 17B 2.5078
TGM6 transglutaminase 6 2.5078
CALML6 calmodulin-like 6 2.5078
CCL27 chemokine (C-C motif) ligand 27 2.5078
ZNF474 zinc finger protein 474 2.5078
KRTAP13-4 keratin associated protein 13-4 2.5078
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 2.5078
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.5078
PCDHGB1 protocadherin gamma subfamily B, 1 2.5078
AASDH aminoadipate-semialdehyde dehydrogenase 2.5078
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.5078
LAMA4 laminin, alpha 4 2.41385
ACKR4 atypical chemokine receptor 4 2.41385
C3ORF49 chromosome 3 open reading frame 49 2.41385
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.41385
IGSF23 immunoglobulin superfamily, member 23 2.41385
MPZL2 myelin protein zero-like 2 2.41385
UTP25 UTP25 small subunit processome component 2.40327
ZNF324B zinc finger protein 324B 2.40227
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.39498
EFCAB14 EF-hand calcium binding domain 14 2.39266
JADE2 jade family PHD finger 2 2.35285
TES testin LIM domain protein 2.34009
CCDC191 coiled-coil domain containing 191 2.32752
SOWAHB sosondowah ankyrin repeat domain family member B 2.28832
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.27117
ZFAND3 zinc finger, AN1-type domain 3 2.26688
STON1 stonin 1 2.26146
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.26089
RPL11 ribosomal protein L11 2.2516
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 2.22679
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 2.20144
CCDC137 coiled-coil domain containing 137 2.19802
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 2.17585
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.16073
FAS Fas cell surface death receptor 2.14582
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 2.14582
RPS23 ribosomal protein S23 2.13547
NTPCR nucleoside-triphosphatase, cancer-related 2.11949
ZNF28 zinc finger protein 28 2.11949
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 2.11185
BTF3 basic transcription factor 3 2.08812
FBXO44 F-box protein 44 2.07218
NICOL1 NELL2 interacting cell ontogeny regulator 1 2.07218
CNBD1 cyclic nucleotide binding domain containing 1 2.07218
TMEM256 transmembrane protein 256 2.07218
SCD5 stearoyl-CoA desaturase 5 2.07218
COMMD2 COMM domain containing 2 2.07218
SLC35D4 solute carrier family 35 member D4 2.07168
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.06037
HMBOX1 homeobox containing 1 2.01259
MRPL58 mitochondrial ribosomal protein L58 2.00087
JSRP1 junctional sarcoplasmic reticulum protein 1 2.00029

decreased expression

Symbol Name Standardized Value
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.52509
B9D2 B9 protein domain 2 -2.52509
HTRA3 HtrA serine peptidase 3 -2.52509
GRIK4 glutamate receptor, ionotropic, kainate 4 -2.5078
GFRA3 GDNF family receptor alpha 3 -2.5078
SOWAHC sosondowah ankyrin repeat domain family member C -2.5078
VSTM2A V-set and transmembrane domain containing 2A -2.5078
OSBPL3 oxysterol binding protein-like 3 -2.5078
APOB apolipoprotein B -2.5078
RPUSD1 RNA pseudouridylate synthase domain containing 1 -2.5078
FZD9 frizzled class receptor 9 -2.5078
AK2 adenylate kinase 2 -2.5078
TRDN triadin -2.5078
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -2.5078
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.5078
FES FES proto-oncogene, tyrosine kinase -2.5078
F11 coagulation factor XI -2.5078
PMP22 peripheral myelin protein 22 -2.5078
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.5078
VASN vasorin -2.5078
KLHL35 kelch-like family member 35 -2.5078
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.5078
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.42422
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.40327
PSD2 pleckstrin and Sec7 domain containing 2 -2.40327
PRRT1B proline rich transmembrane protein 1B -2.40327
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.40327
ZNF492 zinc finger protein 492 -2.40327
PRDM12 PR domain containing 12 -2.40327
BMP8B bone morphogenetic protein 8b -2.40327
GIPR gastric inhibitory polypeptide receptor -2.40327
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.40327
MILR1 mast cell immunoglobulin-like receptor 1 -2.40327
TSGA10IP testis specific, 10 interacting protein -2.40327
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.40327
TRIM17 tripartite motif containing 17 -2.40327
AOC3 amine oxidase, copper containing 3 -2.40327
EBF3 early B-cell factor 3 -2.40327
DYDC1 DPY30 domain containing 1 -2.40327
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.40327
ALAS2 5'-aminolevulinate synthase 2 -2.40327
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.40327
PCDHA13 protocadherin alpha 13 -2.40327
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.40327
TRIM44 tripartite motif containing 44 -2.40227
ZNF331 zinc finger protein 331 -2.39865
SPIN2A spindlin family, member 2A -2.39346
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -2.3883
MIER1 mesoderm induction early response 1, transcriptional regulator -2.3846
KIF19 kinesin family member 19 -2.38357
ARHGAP11A Rho GTPase activating protein 11A -2.38357
LRRC14 leucine rich repeat containing 14 -2.36939
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.35872
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.35285
C1ORF115 chromosome 1 open reading frame 115 -2.35285
FGF16 fibroblast growth factor 16 -2.35285
ARRDC2 arrestin domain containing 2 -2.35285
INIP INTS3 and NABP interacting protein -2.32752
PDHX pyruvate dehydrogenase complex, component X -2.30987
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -2.30987
MON2 MON2 homolog (S. cerevisiae) -2.27117
PARP4 poly (ADP-ribose) polymerase family, member 4 -2.27117
UBALD1 UBA-like domain containing 1 -2.22917
PPARD peroxisome proliferator-activated receptor delta -2.22679
HACL2 2-hydroxyacyl-CoA lyase 2 -2.22679
RINL Ras and Rab interactor-like -2.22679
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -2.20144
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.20018
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.19802
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.19802
TGFBI transforming growth factor, beta-induced, 68kDa -2.16517
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.16517
PTPRD protein tyrosine phosphatase, receptor type, D -2.15825
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -2.15752
CPED1 cadherin-like and PC-esterase domain containing 1 -2.15509
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.14926
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -2.12818
CFAP57 cilia and flagella associated protein 57 -2.12359
VTI1A vesicle transport through interaction with t-SNAREs 1A -2.12341
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.11949
NIBAN1 niban apoptosis regulator 1 -2.08812
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) -2.08812
L3MBTL1 l(3)mbt-like 1 (Drosophila) -2.08207
ANKRD24 ankyrin repeat domain 24 -2.07626
DCHS2 dachsous cadherin-related 2 -2.07626
FOS FBJ murine osteosarcoma viral oncogene homolog -2.07218
PRSS27 protease, serine 27 -2.07218
RHOJ ras homolog family member J -2.07218
FGF19 fibroblast growth factor 19 -2.07218
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -2.07218
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.07218
UBN1 ubinuclein 1 -2.07218
CDK17 cyclin-dependent kinase 17 -2.07195
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 -2.05527
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.04819
XRRA1 X-ray radiation resistance associated 1 -2.03
ZNF623 zinc finger protein 623 -2.01678
GPN2 GPN-loop GTPase 2 -2.01678
CCDC86 coiled-coil domain containing 86 -2.01539
MARVELD3 MARVEL domain containing 3 -2.01259