SOX8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 8|This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 30812)
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Genes

360 genes differentially expressed following the SOX8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
C1QL3 complement component 1, q subcomponent-like 3 3.94505
GJA3 gap junction protein, alpha 3, 46kDa 3.94505
SIX1 SIX homeobox 1 3.94505
FMNL2 formin-like 2 3.94505
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.94505
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.94505
SCGN secretagogin, EF-hand calcium binding protein 3.94505
SIGLECL1 SIGLEC family like 1 3.94505
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.94505
NANOS2 nanos homolog 2 (Drosophila) 3.94505
TMEM176B transmembrane protein 176B 3.94505
PCDHB6 protocadherin beta 6 3.94505
ABHD16B abhydrolase domain containing 16B 3.94505
RNF151 ring finger protein 151 3.94505
FAM3D family with sequence similarity 3, member D 3.94505
ERAS ES cell expressed Ras 3.94505
CFAP45 cilia and flagella associated protein 45 3.94505
RNF113B ring finger protein 113B 3.94505
MIA melanoma inhibitory activity 3.94505
SLC45A2 solute carrier family 45, member 2 3.94505
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 3.94505
TLR1 toll-like receptor 1 3.94505
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.94505
C4ORF17 chromosome 4 open reading frame 17 3.94505
OASL 2'-5'-oligoadenylate synthetase-like 3.94505
SLFN14 schlafen family member 14 3.94505
ATP13A4 ATPase type 13A4 3.94505
ACTRT1 actin-related protein T1 3.94505
PNMA5 paraneoplastic Ma antigen family member 5 3.94505
RIMBP2 RIMS binding protein 2 3.94505
LBX2 ladybird homeobox 2 3.94505
FAM216B family with sequence similarity 216, member B 3.94505
ATOH8 atonal homolog 8 (Drosophila) 3.94505
PRDM12 PR domain containing 12 3.94505
ASGR2 asialoglycoprotein receptor 2 3.94505
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.94505
CRYAA crystallin, alpha A 3.94505
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.94505
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.94505
RNF39 ring finger protein 39 3.94505
LOC105378220 macrophage receptor MARCO-like 3.94505
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.94505
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.94505
RFX6 regulatory factor X, 6 3.94505
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.94505
TKTL1 transketolase-like 1 3.94505
PTH2 parathyroid hormone 2 3.94505
CEP295NL CEP295 N-terminal like 3.94505
XCL1 chemokine (C motif) ligand 1 3.94505
TUBB8 tubulin, beta 8 class VIII 3.94505
NEU4 sialidase 4 3.94505
MFAP5 microfibrillar associated protein 5 3.94505
TGFB3 transforming growth factor, beta 3 3.94505
FHL5 four and a half LIM domains 5 3.94505
LRRC10B leucine rich repeat containing 10B 3.94505
TTLL2 tubulin tyrosine ligase-like family member 2 3.94505
YY2 YY2 transcription factor 3.94505
OR56A5 olfactory receptor, family 56, subfamily A, member 5 3.94505
SPATA31G1 SPATA31 subfamily G member 1 3.94505
ITPRID1 ITPR interacting domain containing 1 3.94505
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.94505
RNF227 ring finger protein 227 3.94505
CCDC187 coiled-coil domain containing 187 3.94505
CRACDL CRACD like 3.94505
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.94505
PYDC5 pyrin domain containing 5 3.94505
ALPG alkaline phosphatase, germ cell 3.94505
PHF24 PHD finger protein 24 3.94505
GOLGA6L7 golgin A6 family like 7 3.94505
ALDOB aldolase B, fructose-bisphosphate 3.94505
CLDN14 claudin 14 3.94505
CHCT1 CHD1 helical C-terminal domain containing 1 3.94505
H1-8 H1.8 linker histone 3.94505
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 3.94505
OR1R1 olfactory receptor family 1 subfamily R member 1 3.94505
SMIM32 small integral membrane protein 32 3.94505
TBC1D3I TBC1 domain family member 3I 3.94505
FAM240C family with sequence similarity 240 member C 3.94505
FAM240A family with sequence similarity 240 member A 3.94505
DAAM2-AS1 DAAM2 antisense RNA 1 3.94505
CIMAP1B ciliary microtubule associated protein 1B 3.94505
H3C3 H3 clustered histone 3 3.94505
CIBAR2 CBY1 interacting BAR domain containing 2 3.94505
ACP4 acid phosphatase 4 3.94505
DNAAF6 dynein axonemal assembly factor 6 3.94505
H2BW2 H2B.W histone 2 3.94505
CD300LF CD300 molecule-like family member f 3.94505
PNLIPRP3 pancreatic lipase-related protein 3 3.94505
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.94505
SOAT2 sterol O-acyltransferase 2 3.94505
WNT9B wingless-type MMTV integration site family, member 9B 3.94505
BLNK B-cell linker 3.94505
VCX3A variable charge, X-linked 3A 3.94505
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.94505
C7ORF57 chromosome 7 open reading frame 57 3.94505
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.94505
S100G S100 calcium binding protein G 3.94505
CCR3 chemokine (C-C motif) receptor 3 3.94505
SPDYC speedy/RINGO cell cycle regulator family member C 3.94505
LECT2 leukocyte cell-derived chemotaxin 2 3.94505
ZNF705A zinc finger protein 705A 3.94505
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.94505
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.94505
VN1R2 vomeronasal 1 receptor 2 3.94505
MGAT4D MGAT4 family, member D 3.94505
STMN4 stathmin-like 4 3.94505
STX11 syntaxin 11 3.94505
MLN motilin 3.94505
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.94505
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.94505
TMPRSS4 transmembrane protease, serine 4 3.94505
IQCF1 IQ motif containing F1 3.94505
SRPK3 SRSF protein kinase 3 3.94505
WNT16 wingless-type MMTV integration site family, member 16 3.94505
TSPAN8 tetraspanin 8 3.94505
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.94505
NUTM2F NUT family member 2F 3.94505
EDN1 endothelin 1 3.94505
LCNL1 lipocalin-like 1 3.94505
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.94505
CDC20B cell division cycle 20B 3.94505
SPANXN3 SPANX family, member N3 3.94505
ANKRD63 ankyrin repeat domain 63 3.94505
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.94505
CYSLTR1 cysteinyl leukotriene receptor 1 3.94505
IGFALS insulin-like growth factor binding protein, acid labile subunit 3.94505
ADAM7 ADAM metallopeptidase domain 7 3.94505
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 3.94505
TRIM50 tripartite motif containing 50 3.94505
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.94505
CNTF ciliary neurotrophic factor 3.94505
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.94505
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.94505
CALML6 calmodulin-like 6 3.94505
SMYD1 SET and MYND domain containing 1 3.94505
FEZF2 FEZ family zinc finger 2 3.94505
APOD apolipoprotein D 3.94505
APOF apolipoprotein F 3.94505
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.94505
ENDOU endonuclease, polyU-specific 3.94505
ARR3 arrestin 3, retinal (X-arrestin) 3.94505
EBF2 early B-cell factor 2 3.94505
NIM1K NIM1 serine/threonine protein kinase 3.94505
AGXT2 alanine--glyoxylate aminotransferase 2 3.94505
COX7B2 cytochrome c oxidase subunit VIIb2 3.94505
TEKT5 tektin 5 3.94505
ERVV-1 endogenous retrovirus group V, member 1 3.94505
PLA2G2C phospholipase A2, group IIC 3.94505
MEIS1 Meis homeobox 1 3.94505
CPN2 carboxypeptidase N, polypeptide 2 3.94505
LMX1B LIM homeobox transcription factor 1, beta 3.94505
LMX1A LIM homeobox transcription factor 1, alpha 3.94505
CNGB1 cyclic nucleotide gated channel beta 1 3.94505
TTC24 tetratricopeptide repeat domain 24 3.94505
ADRA2A adrenoceptor alpha 2A 3.94505
GJC2 gap junction protein, gamma 2, 47kDa 3.94505
LRRC24 leucine rich repeat containing 24 3.94505
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.94505
LRRC25 leucine rich repeat containing 25 3.94505
CA5A carbonic anhydrase VA, mitochondrial 3.94505
ZCCHC12 zinc finger, CCHC domain containing 12 3.94505
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.94505
EPGN epithelial mitogen 3.94505
BSPH1 binder of sperm protein homolog 1 3.94505
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.94505
MAGED4B melanoma antigen family D4B 3.94505
LYZ lysozyme 3.94505
PNLIP pancreatic lipase 3.94505
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.94505
GPR62 G protein-coupled receptor 62 3.94505
ZIM2 zinc finger, imprinted 2 3.94505
CTSO cathepsin O 3.94505
SIDT1 SID1 transmembrane family, member 1 3.94505
DEFB134 defensin, beta 134 3.94505
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.94505
SLC38A11 solute carrier family 38, member 11 3.94505
RNF222 ring finger protein 222 3.94505
RNF224 ring finger protein 224 3.94505
PADI1 peptidyl arginine deiminase, type I 3.94505
AMDHD1 amidohydrolase domain containing 1 3.94505
PTCRA pre T-cell antigen receptor alpha 3.94505
TGM2 transglutaminase 2 3.94505
IFNE interferon, epsilon 3.94505
IFNK interferon, kappa 3.94505
A1CF APOBEC1 complementation factor 3.94505
ALLC allantoicase 3.94505
ANGPTL6 angiopoietin-like 6 3.94505
AHSG alpha-2-HS-glycoprotein 3.94505
GPR55 G protein-coupled receptor 55 3.94505
NNMT nicotinamide N-methyltransferase 3.94505
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.94505
NUTM2B NUT family member 2B 3.94505
FGF3 fibroblast growth factor 3 3.94505
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.94505
BIN2 bridging integrator 2 3.94505
PITX3 paired-like homeodomain 3 3.94505
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.94505
NLRP11 NLR family, pyrin domain containing 11 3.94505
MMP3 matrix metallopeptidase 3 3.94505
ZNF396 zinc finger protein 396 3.94505
LPO lactoperoxidase 3.94505
BGN biglycan 3.84479
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 3.84479
TGFB2 transforming growth factor, beta 2 3.84479
SCARF1 scavenger receptor class F, member 1 3.84479
ENKUR enkurin, TRPC channel interacting protein 3.84479
FLACC1 flagellum associated containing coiled-coil domains 1 3.84479
NFE2L1 nuclear factor, erythroid 2-like 1 3.60061
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 3.31358
HIST1H2BI histone cluster 1, H2bi 3.29471
TGFBI transforming growth factor, beta-induced, 68kDa 3.27301
RILP Rab interacting lysosomal protein 3.13291
ZNF805 zinc finger protein 805 3.00972
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.0007
CEP63 centrosomal protein 63kDa 2.99335
ZNF285 zinc finger protein 285 2.89982
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 2.89982
LAG3 lymphocyte-activation gene 3 2.87393
TMEM191C transmembrane protein 191C 2.87393
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.76502
UPK3A uroplakin 3A 2.73484
SERTM1 serine-rich and transmembrane domain containing 1 2.73484
STRIT1 small transmembrane regulator of ion transport 1 2.73484
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.73484
ARHGAP25 Rho GTPase activating protein 25 2.66262
HSPB11 heat shock protein family B (small), member 11 2.63709
CCNL2 cyclin L2 2.59879
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.58538
NPAS2 neuronal PAS domain protein 2 2.54316
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.53919
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 2.52596
NXT2 nuclear transport factor 2-like export factor 2 2.52596
LGALS7B lectin, galactoside-binding, soluble, 7B 2.47271
ANOS1 anosmin 1 2.47271
PWWP2B PWWP domain containing 2B 2.40535
GPR108 G protein-coupled receptor 108 2.39695
CDK7 cyclin-dependent kinase 7 2.36817
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.33519
GREM1 gremlin 1, DAN family BMP antagonist 2.33519
OTOF otoferlin 2.31313
CD8B CD8b molecule 2.31313
RASGRP4 RAS guanyl releasing protein 4 2.30074
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 2.30074
CENPN centromere protein N 2.29188
SRRM4 serine/arginine repetitive matrix 4 2.26881
TJAP1 tight junction associated protein 1 (peripheral) 2.26494
LPAR5 lysophosphatidic acid receptor 5 2.23942
FBXO5 F-box protein 5 2.23942
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.23942
MAPK6 mitogen-activated protein kinase 6 2.23942
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.23942
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.23942
SF3B2 splicing factor 3b, subunit 2, 145kDa 2.23746
ZNF608 zinc finger protein 608 2.23436
UBE3A ubiquitin protein ligase E3A 2.23218
UBE2H ubiquitin-conjugating enzyme E2H 2.22778
BOD1L1 biorientation of chromosomes in cell division 1-like 1 2.22006
SLC26A11 solute carrier family 26 (anion exchanger), member 11 2.20781
AHDC1 AT hook, DNA binding motif, containing 1 2.19029
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 2.16249
SAMD4B sterile alpha motif domain containing 4B 2.15178
PIPOX pipecolic acid oxidase 2.11675
RNF207 ring finger protein 207 2.11298
OTX1 orthodenticle homeobox 1 2.11298
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.11298
C2CD2L C2CD2-like 2.11298
FAM114A2 family with sequence similarity 114, member A2 2.10876
PITPNA phosphatidylinositol transfer protein, alpha 2.09251
ZNF383 zinc finger protein 383 2.09251
TMEM50A transmembrane protein 50A 2.08578
CUL4A cullin 4A 2.07766
APMAP adipocyte plasma membrane associated protein 2.0735
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.06094
FAM162B family with sequence similarity 162, member B 2.06094
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.059
SPACA6 sperm acrosome associated 6 2.00617

decreased expression

Symbol Name Standardized Value
AKNAD1 AKNA domain containing 1 -3.94505
CCER2 coiled-coil glutamate-rich protein 2 -3.94505
CCDC57 coiled-coil domain containing 57 -3.94505
WSCD2 WSC domain containing 2 -3.94505
TMPRSS11F transmembrane protease, serine 11F -3.94505
PPP1R3A protein phosphatase 1, regulatory subunit 3A -3.94505
FBXO8 F-box protein 8 -3.94505
IL17C interleukin 17C -3.94505
GADL1 glutamate decarboxylase-like 1 -3.94505
EPSTI1 epithelial stromal interaction 1 (breast) -3.94505
IFI27 interferon, alpha-inducible protein 27 -3.94505
HEPHL1 hephaestin-like 1 -3.94505
OIT3 oncoprotein induced transcript 3 -3.94505
ACOX2 acyl-CoA oxidase 2, branched chain -3.94505
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) -3.94505
SPATA45 spermatogenesis associated 45 -3.94505
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -3.94505
MOV10L1 Mov10 RISC complex RNA helicase like 1 -3.94505
SPACA9 sperm acrosome associated 9 -3.94505
HCK HCK proto-oncogene, Src family tyrosine kinase -3.94505
CCDC163 CCDC163 homolog -3.94505
GUCY2F guanylate cyclase 2F, retinal -3.94505
SCN7A sodium channel, voltage gated, type VII alpha subunit -3.94505
PHF13 PHD finger protein 13 -3.94505
ORM2 orosomucoid 2 -3.94505
POPDC3 popeye domain containing 3 -3.85343
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) -3.67718
AKIRIN1 akirin 1 -3.43829
LDOC1 leucine zipper, down-regulated in cancer 1 -3.34144
FAM199X family with sequence similarity 199, X-linked -3.29793
RBM8A RNA binding motif protein 8A -3.15701
REXO5 RNA exonuclease 5 -3.13588
AK8 adenylate kinase 8 -3.11989
BTLA B and T lymphocyte associated -3.04978
H4C11 H4 clustered histone 11 -3.04978
BBC3 BCL2 binding component 3 -3.04978
TSSK6 testis-specific serine kinase 6 -3.04978
S1PR5 sphingosine-1-phosphate receptor 5 -3.04978
MDFI MyoD family inhibitor -3.04978
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 -3.04978
AOC3 amine oxidase, copper containing 3 -3.04978
VWC2 von Willebrand factor C domain containing 2 -3.04978
ARL11 ADP-ribosylation factor-like 11 -3.00772
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.97923
STX12 syntaxin 12 -2.91573
ELOC elongin C -2.89698
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.8068
SIAH1 siah E3 ubiquitin protein ligase 1 -2.78478
CDC26 cell division cycle 26 -2.76502
TMEM237 transmembrane protein 237 -2.67922
GCC2 GRIP and coiled-coil domain containing 2 -2.56807
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.51221
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.51173
TRIR telomerase RNA component interacting RNase -2.47271
CYTIP cytohesin 1 interacting protein -2.42029
BEAN1 brain expressed, associated with NEDD4, 1 -2.39695
UPK1B uroplakin 1B -2.39695
PSD4 pleckstrin and Sec7 domain containing 4 -2.38783
G0S2 G0/G1 switch 2 -2.38783
ELOVL2 ELOVL fatty acid elongase 2 -2.37559
SH2B1 SH2B adaptor protein 1 -2.35641
ABHD18 abhydrolase domain containing 18 -2.33178
TMEM107 transmembrane protein 107 -2.30707
TMEM52 transmembrane protein 52 -2.29456
HPCAL4 hippocalcin like 4 -2.26299
WDFY3 WD repeat and FYVE domain containing 3 -2.26299
CFAP73 cilia and flagella associated protein 73 -2.26299
NOMO3 NODAL modulator 3 -2.23942
MTMR7 myotubularin related protein 7 -2.23942
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -2.23942
RTKN rhotekin -2.23729
RBM23 RNA binding motif protein 23 -2.23378
SNX12 sorting nexin 12 -2.22621
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 -2.1574
MEF2B myocyte enhancer factor 2B -2.15579
MIIP migration and invasion inhibitory protein -2.15245
C6ORF62 chromosome 6 open reading frame 62 -2.14697
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.11253
TMEM140 transmembrane protein 140 -2.08829
VWCE von Willebrand factor C and EGF domains -2.07862
SELENOP selenoprotein P -2.0735
BIRC5 baculoviral IAP repeat containing 5 -2.0186
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -2.0158
SKIC3 SKI3 subunit of superkiller complex -2.01106