SOX9 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SRY (sex determining region Y)-box 9|The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6662)
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Genes

348 genes differentially expressed following the SOX9 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COL19A1 collagen, type XIX, alpha 1 2.82191
PNOC prepronociceptin 2.82191
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.82191
ZFP92 ZFP92 zinc finger protein 2.82191
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.82191
TBX15 T-box 15 2.82191
CNTN6 contactin 6 2.82191
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.82191
NXPH3 neurexophilin 3 2.82191
CLEC19A C-type lectin domain family 19, member A 2.82191
GPR12 G protein-coupled receptor 12 2.82191
RAD51AP2 RAD51 associated protein 2 2.82191
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.82191
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.82191
CCN5 cellular communication network factor 5 2.82191
NLRP3 NLR family, pyrin domain containing 3 2.82191
PEAK3 PEAK family member 3 2.82191
ESPNL espin-like 2.82191
ACADL acyl-CoA dehydrogenase, long chain 2.82191
NPM2 nucleophosmin/nucleoplasmin 2 2.82191
OVCH1 ovochymase 1 2.82191
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 2.82191
PRCP prolylcarboxypeptidase (angiotensinase C) 2.7995
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.77807
CRELD2 cysteine-rich with EGF-like domains 2 2.76833
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 2.72425
LMO2 LIM domain only 2 (rhombotin-like 1) 2.72425
PEAR1 platelet endothelial aggregation receptor 1 2.72425
MYBPC3 myosin binding protein C, cardiac 2.72425
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.72425
SSX3 synovial sarcoma, X breakpoint 3 2.72425
PGLYRP2 peptidoglycan recognition protein 2 2.72425
IRX4 iroquois homeobox 4 2.72425
IL22RA1 interleukin 22 receptor, alpha 1 2.72425
SCG2 secretogranin II 2.72425
OLIG3 oligodendrocyte transcription factor 3 2.72425
ASB10 ankyrin repeat and SOCS box containing 10 2.72425
LOC107986837 uncharacterized LOC107986837 2.72425
HIC1 hypermethylated in cancer 1 2.72425
SPACA7 sperm acrosome associated 7 2.72425
ERAP2 endoplasmic reticulum aminopeptidase 2 2.72425
MYO16 myosin XVI 2.72425
AMELX amelogenin, X-linked 2.72425
DSPP dentin sialophosphoprotein 2.72425
KRTAP13-4 keratin associated protein 13-4 2.72425
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.72425
ZNF556 zinc finger protein 556 2.72425
STRA8 stimulated by retinoic acid 8 2.72425
GFI1 growth factor independent 1 transcription repressor 2.72425
PBOV1 prostate and breast cancer overexpressed 1 2.72425
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.72425
HLX H2.0-like homeobox 2.72425
TARP TCR gamma alternate reading frame protein 2.72425
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.72425
LOC124901872 uncharacterized LOC124901872 2.72425
FIMP1 fertilization-influencing membrane protein 1 2.72425
ELOVL3 ELOVL fatty acid elongase 3 2.72425
RHCG Rh family, C glycoprotein 2.72425
SCEL sciellin 2.72425
LTB4R2 leukotriene B4 receptor 2 2.72425
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.72425
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.72425
CBY2 chibby family member 2 2.72425
MINDY4B MINDY family member 4B 2.72425
SRARP steroid receptor associated and regulated protein 2.72425
ZNF593OS ZNF593 opposite strand 2.72425
C1ORF232 chromosome 1 open reading frame 230 2.72425
REELD1 reeler domain containing 1 2.72425
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.72425
PNMA6F PNMA family member 6F 2.72425
MYEOV myeloma overexpressed 2.72425
SPATA22 spermatogenesis associated 22 2.72425
OSTN osteocrin 2.72425
TBX21 T-box 21 2.72425
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.72425
FAM168A family with sequence similarity 168, member A 2.72425
C1ORF87 chromosome 1 open reading frame 87 2.72425
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.72425
CCR6 chemokine (C-C motif) receptor 6 2.72425
AKR1D1 aldo-keto reductase family 1, member D1 2.72425
C10ORF67 chromosome 10 open reading frame 67 2.72425
NPIPB9 nuclear pore complex interacting protein family, member B9 2.72425
GOLGA7B golgin A7 family, member B 2.72425
TBX5 T-box 5 2.72425
GJD2 gap junction protein, delta 2, 36kDa 2.72425
PGA3 pepsinogen 3, group I (pepsinogen A) 2.72425
FRK fyn-related Src family tyrosine kinase 2.72425
LRRC71 leucine rich repeat containing 71 2.72425
FOXD4L6 forkhead box D4-like 6 2.72425
NDP Norrie disease (pseudoglioma) 2.72425
SPMIP1 sperm microtubule inner protein 1 2.72425
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.72425
CIDEC cell death-inducing DFFA-like effector c 2.72425
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.72425
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.72425
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.72425
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.72425
CYSLTR1 cysteinyl leukotriene receptor 1 2.72425
UBQLNL ubiquilin-like 2.72425
TCEA3 transcription elongation factor A (SII), 3 2.72425
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.72425
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.72425
LRCOL1 leucine rich colipase-like 1 2.72425
VHLL von Hippel-Lindau tumor suppressor-like 2.72425
MORC1 MORC family CW-type zinc finger 1 2.72425
PYHIN1 pyrin and HIN domain family, member 1 2.72425
MAMLD1 mastermind-like domain containing 1 2.72425
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.72425
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.72425
ACKR2 atypical chemokine receptor 2 2.72425
LMOD2 leiomodin 2 (cardiac) 2.72425
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.72425
GJC2 gap junction protein, gamma 2, 47kDa 2.72425
LMX1A LIM homeobox transcription factor 1, alpha 2.72425
NKX6-1 NK6 homeobox 1 2.72425
RBBP8NL RBBP8 N-terminal like 2.72425
MYLK2 myosin light chain kinase 2 2.72425
PRTN3 proteinase 3 2.72425
PNO1 partner of NOB1 homolog (S. cerevisiae) 2.72425
PDCD1LG2 programmed cell death 1 ligand 2 2.72425
NT5DC4 5'-nucleotidase domain containing 4 2.72425
AMN amnion associated transmembrane protein 2.72425
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.72425
DLX3 distal-less homeobox 3 2.72425
COL6A5 collagen, type VI, alpha 5 2.72425
SLC22A24 solute carrier family 22, member 24 2.72425
ISL2 ISL LIM homeobox 2 2.72425
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.72425
MUC15 mucin 15, cell surface associated 2.72425
PRRX1 paired related homeobox 1 2.72425
MAGEC3 melanoma antigen family C3 2.72425
ZNF648 zinc finger protein 648 2.72425
ANXA1 annexin A1 2.72425
AQP1 aquaporin 1 (Colton blood group) 2.72425
LST1 leukocyte specific transcript 1 2.72425
AOC1 amine oxidase, copper containing 1 2.72425
IL32 interleukin 32 2.72425
CHRM1 cholinergic receptor, muscarinic 1 2.72425
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.72425
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.72425
SP100 SP100 nuclear antigen 2.72425
GCM2 glial cells missing homolog 2 (Drosophila) 2.72425
MAEL maelstrom spermatogenic transposon silencer 2.72425
POU3F3 POU class 3 homeobox 3 2.72425
FLNB filamin B, beta 2.72425
MT1A metallothionein 1A 2.72425
MARCHF1 membrane associated ring-CH-type finger 1 2.71821
CCDC169 coiled-coil domain containing 169 2.70631
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.67915
MBD6 methyl-CpG binding domain protein 6 2.62695
MED9 mediator complex subunit 9 2.57295
FZD8 frizzled class receptor 8 2.55402
CCNT1 cyclin T1 2.54417
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.51161
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.45786
ZNF444 zinc finger protein 444 2.44529
ETV3L ets variant 3-like 2.44529
ASB12 ankyrin repeat and SOCS box containing 12 2.44529
SRSF12 serine/arginine-rich splicing factor 12 2.43003
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 2.42683
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 2.42481
APELA apelin receptor early endogenous ligand 2.41322
C5 complement component 5 2.40296
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.38307
MARK1 MAP/microtubule affinity-regulating kinase 1 2.38307
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 2.38307
VEGFB vascular endothelial growth factor B 2.36452
PKN1 protein kinase N1 2.3516
TSHR thyroid stimulating hormone receptor 2.33409
KTN1 kinectin 1 (kinesin receptor) 2.33249
NOMO1 NODAL modulator 1 2.32739
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 2.31484
RTN4R reticulon 4 receptor 2.31484
GAP43 growth associated protein 43 2.299
TMUB1 transmembrane and ubiquitin-like domain containing 1 2.28577
MCHR1 melanin-concentrating hormone receptor 1 2.28176
TSPYL4 TSPY-like 4 2.27042
APOL6 apolipoprotein L, 6 2.27042
TBC1D21 TBC1 domain family, member 21 2.27042
ABHD16A abhydrolase domain containing 16A 2.27042
EPCAM epithelial cell adhesion molecule 2.26087
RGS17 regulator of G-protein signaling 17 2.25341
CDHR3 cadherin-related family member 3 2.24767
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.2364
ADCK5 aarF domain containing kinase 5 2.23626
MTMR12 myotubularin related protein 12 2.21962
IL4I1 interleukin 4 induced 1 2.21913
FMO3 flavin containing monooxygenase 3 2.21913
PARL presenilin associated, rhomboid-like 2.19247
CCPG1 cell cycle progression 1 2.19208
PURG purine-rich element binding protein G 2.18519
UBE2M ubiquitin-conjugating enzyme E2M 2.18235
LCT lactase 2.16871
BCCIP BRCA2 and CDKN1A interacting protein 2.16871
ITGA11 integrin, alpha 11 2.16871
C20ORF203 chromosome 20 open reading frame 203 2.15557
RFXAP regulatory factor X-associated protein 2.14731
TSEN34 TSEN34 tRNA splicing endonuclease subunit 2.14627
FGF22 fibroblast growth factor 22 2.13567
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.13536
ARMH4 armadillo like helical domain containing 4 2.13277
SPPL3 signal peptide peptidase like 3 2.12906
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.10618
UBR4 ubiquitin protein ligase E3 component n-recognin 4 2.08674
TEFM transcription elongation factor, mitochondrial 2.08674
VWA5B1 von Willebrand factor A domain containing 5B1 2.07882
ACAT2 acetyl-CoA acetyltransferase 2 2.07882
PALS1 protein associated with LIN7 1, MAGUK p55 family member 2.0752
DSCC1 DNA replication and sister chromatid cohesion 1 2.0752
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.04717
OXR1 oxidation resistance 1 2.03536
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.0295
OXLD1 oxidoreductase-like domain containing 1 2.0268
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 2.0268
ZNF671 zinc finger protein 671 2.0266
ZNF486 zinc finger protein 486 2.02539
SNTG1 syntrophin, gamma 1 2.00939
LINS1 lines homolog 1 2.00939
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 2.0023

decreased expression

Symbol Name Standardized Value
RHCE Rh blood group, CcEe antigens -2.82191
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.82191
MXRA5 matrix-remodelling associated 5 -2.82191
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.82191
C1QTNF7 C1q and tumor necrosis factor related protein 7 -2.82191
RAG1 recombination activating gene 1 -2.82191
C4ORF46 chromosome 4 open reading frame 46 -2.82191
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -2.82191
SCN2B sodium channel, voltage gated, type II beta subunit -2.72425
DUSP26 dual specificity phosphatase 26 (putative) -2.72425
SH2D7 SH2 domain containing 7 -2.72425
APLN apelin -2.72425
NGB neuroglobin -2.72425
HGD homogentisate 1,2-dioxygenase -2.72425
MAGEB17 melanoma antigen family B17 -2.72425
STAB1 stabilin 1 -2.72425
DUSP10 dual specificity phosphatase 10 -2.72425
PDE7B phosphodiesterase 7B -2.72425
ZC2HC1B zinc finger, C2HC-type containing 1B -2.72425
MYRIP myosin VIIA and Rab interacting protein -2.72425
DCST1 DC-STAMP domain containing 1 -2.72425
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.72425
KIF19 kinesin family member 19 -2.72425
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -2.72425
MEIKIN meiotic kinetochore factor -2.72425
TMEM215 transmembrane protein 215 -2.72425
GNRHR gonadotropin-releasing hormone receptor -2.72425
TGM1 transglutaminase 1 -2.72425
GYPB glycophorin B (MNS blood group) -2.72425
LDLRAP1 low density lipoprotein receptor adaptor protein 1 -2.72425
GRHL3 grainyhead-like 3 (Drosophila) -2.72425
FOLR1 folate receptor 1 (adult) -2.72425
HRH4 histamine receptor H4 -2.72425
AGXT2 alanine--glyoxylate aminotransferase 2 -2.72425
LY6G6C lymphocyte antigen 6 complex, locus G6C -2.72425
TMEM31 transmembrane protein 31 -2.72425
INSM1 insulinoma-associated 1 -2.72425
GLUL glutamate-ammonia ligase -2.72425
CLUL1 clusterin-like 1 (retinal) -2.72425
SPACA9 sperm acrosome associated 9 -2.72425
CFAP206 cilia and flagella associated protein 206 -2.72425
TMEM40 transmembrane protein 40 -2.72425
C4ORF50 chromosome 4 open reading frame 50 -2.72425
TMPRSS11D transmembrane protease, serine 11D -2.72425
PRRT4 proline-rich transmembrane protein 4 -2.72425
LHFPL4 lipoma HMGIC fusion partner-like 4 -2.72425
SGSM3 small G protein signaling modulator 3 -2.72425
ITM2A integral membrane protein 2A -2.72425
RASA1 RAS p21 protein activator (GTPase activating protein) 1 -2.70714
ZSCAN30 zinc finger and SCAN domain containing 30 -2.67428
PPP1R12B protein phosphatase 1, regulatory subunit 12B -2.62228
CALCA calcitonin-related polypeptide alpha -2.61344
ERLEC1 endoplasmic reticulum lectin 1 -2.59843
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.58214
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -2.57583
INTS15 integrator complex subunit 15 -2.54976
SYNPO2 synaptopodin 2 -2.48947
SAXO5 stabilizer of axonemal microtubules 5 -2.43973
LTC4S leukotriene C4 synthase -2.43973
SNX27 sorting nexin family member 27 -2.42999
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -2.42546
AIRIM AFG2 interacting ribosome maturation factor -2.40296
ZNF846 zinc finger protein 846 -2.38533
PMEL premelanosome protein -2.38533
GEMIN8 gem (nuclear organelle) associated protein 8 -2.38533
SIPA1L3 signal-induced proliferation-associated 1 like 3 -2.38533
ZFAND4 zinc finger, AN1-type domain 4 -2.38533
ERLIN1 ER lipid raft associated 1 -2.38169
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -2.37972
IVD isovaleryl-CoA dehydrogenase -2.34262
JAKMIP2 janus kinase and microtubule interacting protein 2 -2.33975
SNAPIN SNAP-associated protein -2.33252
H2AC13 H2A clustered histone 13 -2.33057
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -2.32555
DOCK11 dedicator of cytokinesis 11 -2.32555
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -2.31484
HP1BP3 heterochromatin protein 1, binding protein 3 -2.31484
NKX3-1 NK3 homeobox 1 -2.31339
LOC124902694 uncharacterized LOC124902694 -2.31339
ZNF681 zinc finger protein 681 -2.30522
PHIP pleckstrin homology domain interacting protein -2.30249
FKBP6 FK506 binding protein 6, 36kDa -2.30005
MBLAC1 metallo-beta-lactamase domain containing 1 -2.30005
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -2.28577
TTC39B tetratricopeptide repeat domain 39B -2.28577
NUTM1 NUT midline carcinoma, family member 1 -2.2733
PAIP1 poly(A) binding protein interacting protein 1 -2.27052
EFHC1 EF-hand domain (C-terminal) containing 1 -2.2552
TMEM267 transmembrane protein 267 -2.23936
PRORP protein only RNase P catalytic subunit -2.23626
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.22882
TAFA1 TAFA chemokine like family member 1 -2.21962
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.21534
GLOD4 glyoxalase domain containing 4 -2.21108
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase -2.19779
SGMS2 sphingomyelin synthase 2 -2.19163
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -2.18519
MIGA1 mitoguardin 1 -2.17337
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -2.17058
PTBP1 polypyrimidine tract binding protein 1 -2.16871
ZNF615 zinc finger protein 615 -2.16871
PIAS4 protein inhibitor of activated STAT, 4 -2.16871
RECK reversion-inducing-cysteine-rich protein with kazal motifs -2.15557
MMP24 matrix metallopeptidase 24 (membrane-inserted) -2.15226
CHMP2B charged multivesicular body protein 2B -2.15008
INVS inversin -2.13536
FAM169A family with sequence similarity 169, member A -2.13536
TMEM106C transmembrane protein 106C -2.13426
PHF3 PHD finger protein 3 -2.13399
ASRGL1 asparaginase like 1 -2.13277
CDH24 cadherin 24, type 2 -2.13189
CEP295 centrosomal protein 295kDa -2.1147
EXOSC9 exosome component 9 -2.09276
ARHGAP1 Rho GTPase activating protein 1 -2.0888
CTSL cathepsin L -2.08348
ATF7IP activating transcription factor 7 interacting protein -2.08081
CDHR1 cadherin-related family member 1 -2.07697
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.07697
KLF4 Kruppel-like factor 4 (gut) -2.07697
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -2.0752
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 -2.07403
MEST mesoderm specific transcript -2.04717
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.041
CAMK1D calcium/calmodulin-dependent protein kinase ID -2.03924
SNX33 sorting nexin 33 -2.02997
IQSEC3 IQ motif and Sec7 domain 3 -2.0295
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.00939
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 -2.00547
CDC25B cell division cycle 25B -2.00547