SP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Sp1 transcription factor|The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 6667)
Similar Terms
Downloads & Tools

Genes

348 genes differentially expressed following the SP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.107
AVPR1B arginine vasopressin receptor 1B 3.107
CD300LF CD300 molecule-like family member f 3.107
SCEL sciellin 3.107
DUSP9 dual specificity phosphatase 9 3.107
RPL3L ribosomal protein L3-like 3.107
THBD thrombomodulin 3.107
TMEM156 transmembrane protein 156 3.107
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.107
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.107
ADAM21 ADAM metallopeptidase domain 21 3.107
TACR2 tachykinin receptor 2 3.107
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.107
MUC6 mucin 6, oligomeric mucus/gel-forming 3.107
HAO2 hydroxyacid oxidase 2 (long chain) 3.107
IRX4 iroquois homeobox 4 3.107
C8ORF74 chromosome 8 open reading frame 74 3.107
DRC1 dynein regulatory complex subunit 1 3.107
DEPP1 DEPP autophagy regulator 1 3.107
TTLL13 tubulin tyrosine ligase like 13 3.107
ZNF593OS ZNF593 opposite strand 3.107
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.07916
SPDYE4 speedy/RINGO cell cycle regulator family member E4 3.07916
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 3.07916
FGF4 fibroblast growth factor 4 3.07916
SH2D6 SH2 domain containing 6 3.07916
KLRC1 killer cell lectin-like receptor subfamily C, member 1 3.07916
DDN dendrin 3.07916
NCF4 neutrophil cytosolic factor 4, 40kDa 3.07916
CNTNAP4 contactin associated protein-like 4 3.07916
FGF9 fibroblast growth factor 9 3.07916
SCN2B sodium channel, voltage gated, type II beta subunit 3.07916
SIGLECL1 SIGLEC family like 1 3.07916
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.07916
PARP3 poly (ADP-ribose) polymerase family, member 3 3.07916
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.07916
CES5A carboxylesterase 5A 3.07916
LRRC55 leucine rich repeat containing 55 3.07916
PAX5 paired box 5 3.07916
LGI1 leucine-rich, glioma inactivated 1 3.07916
PRSS36 protease, serine, 36 3.07916
ARHGAP36 Rho GTPase activating protein 36 3.07916
WNT8B wingless-type MMTV integration site family, member 8B 3.07916
CELA1 chymotrypsin-like elastase family, member 1 3.07916
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.07916
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.07916
ADGB androglobin 3.07916
FMN2 formin 2 3.07916
OR8S1 olfactory receptor, family 8, subfamily S, member 1 3.07916
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 3.07916
MYOM2 myomesin 2 3.07916
SPACA3 sperm acrosome associated 3 3.07916
RSPO3 R-spondin 3 3.07916
FAM90A1 family with sequence similarity 90, member A1 3.07916
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 3.07916
MEIKIN meiotic kinetochore factor 3.07916
KLRC2 killer cell lectin-like receptor subfamily C, member 2 3.07916
TEKTL1 tektin like 1 3.07916
ADGRG3 adhesion G protein-coupled receptor G3 3.07916
FRG2C FSHD region gene 2 family, member C 3.07916
KRT86 keratin 86, type II 3.07916
FMO1 flavin containing monooxygenase 1 3.07916
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 3.07916
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.07916
GC group-specific component (vitamin D binding protein) 3.07916
C10ORF53 chromosome 10 open reading frame 53 3.07916
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.07916
SQOR sulfide quinone oxidoreductase 3.07916
ALPG alkaline phosphatase, germ cell 3.07916
SPATA31H1 SPATA31 subfamily H member 1 3.07916
SPAAR small regulatory polypeptide of amino acid response 3.07916
TRIM75 tripartite motif containing 75 3.07916
TMEM225B transmembrane protein 225B 3.07916
MEIOSIN meiosis initiator 3.07916
TMEM270 transmembrane protein 270 3.07916
CCN5 cellular communication network factor 5 3.07916
LRTM3 leucine rich repeat transmembrane protein 3 3.07916
GRAP GRB2-related adaptor protein 3.07916
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.07916
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.07916
TEX101 testis expressed 101 3.07916
SNX20 sorting nexin 20 3.07916
TUBA3E tubulin, alpha 3e 3.07916
PCDHA2 protocadherin alpha 2 3.07916
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.07916
SLC22A10 solute carrier family 22, member 10 3.07916
ACR acrosin 3.07916
SIX6 SIX homeobox 6 3.07916
TMEM236 transmembrane protein 236 3.07916
NPNT nephronectin 3.07916
DMBX1 diencephalon/mesencephalon homeobox 1 3.07916
FGFBP2 fibroblast growth factor binding protein 2 3.07916
IL7R interleukin 7 receptor 3.07916
OOSP1 oocyte secreted protein 1, pseudogene 3.07916
BLNK B-cell linker 3.07916
VCX3B variable charge, X-linked 3B 3.07916
SPDYC speedy/RINGO cell cycle regulator family member C 3.07916
SH3TC1 SH3 domain and tetratricopeptide repeats 1 3.07916
IL4 interleukin 4 3.07916
TMPRSS11D transmembrane protease, serine 11D 3.07916
DBX2 developing brain homeobox 2 3.07916
CLDN34 claudin 34 3.07916
CDC20B cell division cycle 20B 3.07916
CSTA cystatin A (stefin A) 3.07916
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 3.07916
AQP6 aquaporin 6, kidney specific 3.07916
ARR3 arrestin 3, retinal (X-arrestin) 3.07916
C2ORF66 chromosome 2 open reading frame 66 3.07916
SEBOX SEBOX homeobox 3.07916
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 3.07916
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.07916
MYF6 myogenic factor 6 (herculin) 3.07916
KIF4B kinesin family member 4B 3.07916
SLFN12L schlafen family member 12-like 3.07916
TSPAN32 tetraspanin 32 3.07916
KLF2 Kruppel-like factor 2 3.07916
HSF4 heat shock transcription factor 4 3.07916
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.07916
HP haptoglobin 3.07916
VAX2 ventral anterior homeobox 2 3.07916
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.07916
SPATA4 spermatogenesis associated 4 3.07916
CPA4 carboxypeptidase A4 3.07916
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.07916
CD28 CD28 molecule 3.07916
ORM1 orosomucoid 1 3.07916
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 3.07916
NMBR neuromedin B receptor 3.07916
POU4F1 POU class 4 homeobox 1 3.07916
GAS2L2 growth arrest-specific 2 like 2 3.07916
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.07916
TEX26 testis expressed 26 3.07916
NTN5 netrin 5 3.07916
DMRT1 doublesex and mab-3 related transcription factor 1 3.07916
POU2AF1 POU class 2 associating factor 1 3.07916
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.07916
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.07916
TEX19 testis expressed 19 3.07916
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.07916
KLK11 kallikrein-related peptidase 11 3.07916
SLC31A2 solute carrier family 31 (copper transporter), member 2 3.07916
TBX1 T-box 1 3.07916
EPHA5 EPH receptor A5 3.07916
TMEM255A transmembrane protein 255A 3.07916
IRX1 iroquois homeobox 1 3.07916
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.07916
EPO erythropoietin 3.07916
CLCA1 chloride channel accessory 1 3.07916
CHRDL2 chordin-like 2 3.07916
PRAP1 proline-rich acidic protein 1 3.07916
FOXG1 forkhead box G1 3.07916
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.07916
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.07916
GH2 growth hormone 2 3.07916
SHISA3 shisa family member 3 3.07916
ANXA8 annexin A8 3.07916
LHB luteinizing hormone beta polypeptide 3.07916
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.07916
LAMP5 lysosomal-associated membrane protein family, member 5 3.07916
ADGRF5 adhesion G protein-coupled receptor F5 3.07916
TBC1D21 TBC1 domain family, member 21 3.07916
MAEL maelstrom spermatogenic transposon silencer 3.07916
PLGLB2 plasminogen-like B2 3.07916
NUTM2A NUT family member 2A 3.07916
WFDC11 WAP four-disulfide core domain 11 3.07916
GRAP2 GRB2-related adaptor protein 2 3.07916
TEX35 testis expressed 35 3.07916
EPX eosinophil peroxidase 3.07916
GPR12 G protein-coupled receptor 12 2.95462
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.95462
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.95462
CD86 CD86 molecule 2.95462
TTPA tocopherol (alpha) transfer protein 2.95462
ANXA11 annexin A11 2.88504
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.77637
TMEM178A transmembrane protein 178A 2.70969
LRRC4C leucine rich repeat containing 4C 2.70969
ZNF800 zinc finger protein 800 2.69447
ZIC1 Zic family member 1 2.56819
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 2.56819
PYCR1 pyrroline-5-carboxylate reductase 1 2.51047
FLRT2 fibronectin leucine rich transmembrane protein 2 2.50482
SIX1 SIX homeobox 1 2.48771
PRELID2 PRELI domain containing 2 2.45547
SPATA6 spermatogenesis associated 6 2.41693
MSH6 mutS homolog 6 2.40806
ZNF124 zinc finger protein 124 2.40781
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 2.40585
MYSM1 Myb-like, SWIRM and MPN domains 1 2.4058
HMMR hyaluronan-mediated motility receptor (RHAMM) 2.40463
ATP5MG ATP synthase membrane subunit g 2.40463
NEBL nebulette 2.3882
PTPRB protein tyrosine phosphatase, receptor type, B 2.3882
SOGA1 suppressor of glucose, autophagy associated 1 2.3702
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.35082
PXDC1 PX domain containing 1 2.33118
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.31413
RNF14 ring finger protein 14 2.30535
HEXD hexosaminidase D 2.30472
APAF1 apoptotic peptidase activating factor 1 2.30376
ZNF76 zinc finger protein 76 2.28605
EIF5B eukaryotic translation initiation factor 5B 2.24457
REEP3 receptor accessory protein 3 2.22909
CHN1 chimerin 1 2.21402
CLDND2 claudin domain containing 2 2.21402
GAPVD1 GTPase activating protein and VPS9 domains 1 2.20759
HLA-B major histocompatibility complex, class I, B 2.18518
CIRBP cold inducible RNA binding protein 2.1733
OAZ2 ornithine decarboxylase antizyme 2 2.14826
IQCH IQ motif containing H 2.14737
RAE1 ribonucleic acid export 1 2.14552
ZNF398 zinc finger protein 398 2.13218
NTS neurotensin 2.13218
ZC3H3 zinc finger CCCH-type containing 3 2.10563
EXOC4 exocyst complex component 4 2.10092
ELAVL1 ELAV like RNA binding protein 1 2.08161
SEZ6 seizure related 6 homolog (mouse) 2.07648
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.07648
SARNP SAP domain containing ribonucleoprotein 2.07417
EMD emerin 2.07255
ZBED8 zinc finger, BED-type containing 8 2.06801
OSBPL1A oxysterol binding protein-like 1A 2.06697
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 2.06271
NBN nibrin 2.05166
FAR1 fatty acyl CoA reductase 1 2.04808
ZW10 zw10 kinetochore protein 2.04225
UPK3BL1 uroplakin 3B like 1 2.03867
CENPA centromere protein A 2.036
TXNDC9 thioredoxin domain containing 9 2.03208
RIOX1 ribosomal oxygenase 1 2.03208
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 2.02597
RND3 Rho family GTPase 3 2.0204
ADAL adenosine deaminase-like 2.01864
HAUS7 HAUS augmin-like complex, subunit 7 2.0148
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.01052
RWDD2A RWD domain containing 2A 2.00046

decreased expression

Symbol Name Standardized Value
IFI35 interferon-induced protein 35 -3.107
ESYT3 extended synaptotagmin-like protein 3 -3.107
TNN tenascin N -3.107
TMEM81 transmembrane protein 81 -3.107
REM2 RAS (RAD and GEM)-like GTP binding 2 -3.107
SHTN1 shootin 1 -3.07916
AKT1 v-akt murine thymoma viral oncogene homolog 1 -3.07916
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -3.07916
RORC RAR-related orphan receptor C -3.07916
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -3.07916
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -3.07916
RNF112 ring finger protein 112 -3.07916
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -3.07916
CRX cone-rod homeobox -3.07916
OR10A2 olfactory receptor, family 10, subfamily A, member 2 -3.07916
RHAG Rh-associated glycoprotein -3.07916
IL32 interleukin 32 -3.07916
MOGAT3 monoacylglycerol O-acyltransferase 3 -3.07916
ARHGAP30 Rho GTPase activating protein 30 -3.07916
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -3.07916
DHRS2 dehydrogenase/reductase (SDR family) member 2 -3.07916
TMEM184A transmembrane protein 184A -3.07916
PTAFR platelet-activating factor receptor -3.07916
NRGN neurogranin (protein kinase C substrate, RC3) -3.07916
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 -3.07916
KLHL1 kelch-like family member 1 -3.07916
CXCR5 chemokine (C-X-C motif) receptor 5 -3.07916
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -3.07916
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -3.07916
CNR2 cannabinoid receptor 2 (macrophage) -3.07916
CCDC121 coiled-coil domain containing 121 -3.07916
ADGRG1 adhesion G protein-coupled receptor G1 -3.07916
BEAN1 brain expressed, associated with NEDD4, 1 -3.07916
RIPPLY2 ripply transcriptional repressor 2 -3.07916
LY6H lymphocyte antigen 6 complex, locus H -3.07916
CATIP ciliogenesis associated TTC17 interacting protein -3.07916
FMO3 flavin containing monooxygenase 3 -3.07916
PTPRQ protein tyrosine phosphatase, receptor type, Q -3.07916
DCLK2 doublecortin-like kinase 2 -3.07916
CCN3 cellular communication network factor 3 -3.07916
PANO1 proapoptotic nucleolar protein 1 -2.913
IPO13 importin 13 -2.8915
MMP21 matrix metallopeptidase 21 -2.8888
DAAM1 dishevelled associated activator of morphogenesis 1 -2.86594
MFF mitochondrial fission factor -2.85965
ALPK3 alpha-kinase 3 -2.71043
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.70969
PCDHA12 protocadherin alpha 12 -2.69519
EPN1 epsin 1 -2.68915
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 -2.66711
ADGRB1 adhesion G protein-coupled receptor B1 -2.66691
TNK1 tyrosine kinase, non-receptor, 1 -2.61801
XPC xeroderma pigmentosum, complementation group C -2.61242
PDZK1 PDZ domain containing 1 -2.5921
ENTREP3 endosomal transmembrane epsin interactor 3 -2.55675
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough -2.54702
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.54263
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.53018
MTMR3 myotubularin related protein 3 -2.52945
ANXA1 annexin A1 -2.5268
THBS3 thrombospondin 3 -2.52175
DPCD deleted in primary ciliary dyskinesia homolog (mouse) -2.52175
SRBD1 S1 RNA binding domain 1 -2.48347
SPRY3 sprouty homolog 3 (Drosophila) -2.47171
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -2.4372
TYSND1 trypsin domain containing 1 -2.40463
TIMM23B translocase of inner mitochondrial membrane 23 homolog B (yeast) -2.40463
NCOR2 nuclear receptor corepressor 2 -2.39863
TFG TRK-fused gene -2.39772
TCP10L t-complex 10-like -2.39574
BTBD6 BTB (POZ) domain containing 6 -2.35454
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.31834
ZSCAN22 zinc finger and SCAN domain containing 22 -2.30258
MUC1 mucin 1, cell surface associated -2.30258
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.26843
CXCL17 chemokine (C-X-C motif) ligand 17 -2.26843
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.26843
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -2.26843
RCSD1 RCSD domain containing 1 -2.26843
SCX scleraxis basic helix-loop-helix transcription factor -2.26078
RAB33B RAB33B, member RAS oncogene family -2.26078
CCDC175 coiled-coil domain containing 175 -2.25139
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.24656
ZNF136 zinc finger protein 136 -2.24582
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.23751
RRBP1 ribosome binding protein 1 -2.23624
RIMS4 regulating synaptic membrane exocytosis 4 -2.23327
RPS3A ribosomal protein S3A -2.20759
SUN1 Sad1 and UNC84 domain containing 1 -2.20221
C4ORF51 chromosome 4 open reading frame 51 -2.19732
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 -2.19212
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -2.1733
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.1733
UQCC6 ubiquinol-cytochrome c reductase complex assembly factor 6 -2.17277
FKBP6 FK506 binding protein 6, 36kDa -2.16973
STRA6 stimulated by retinoic acid 6 -2.15666
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 -2.15577
NBPF1 neuroblastoma breakpoint family, member 1 -2.14737
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -2.13859
DHCR24 24-dehydrocholesterol reductase -2.0785
MT2A metallothionein 2A -2.07705
PNPO pyridoxamine 5'-phosphate oxidase -2.07417
OAF OAF homolog (Drosophila) -2.07414
SUSD3 sushi domain containing 3 -2.06801
LARS2 leucyl-tRNA synthetase 2, mitochondrial -2.06271
NPIPB6 nuclear pore complex interacting protein family, member B6 -2.06271
SNAP23 synaptosomal-associated protein, 23kDa -2.05531
KANSL3 KAT8 regulatory NSL complex subunit 3 -2.03447
KRTCAP3 keratinocyte associated protein 3 -2.03447
BCL6 B-cell CLL/lymphoma 6 -2.02673
RNF4 ring finger protein 4 -2.02541
LRRC41 leucine rich repeat containing 41 -2.00024